Standard name | |
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Human Ortholog | |
Description | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 2 | 4 | 10 | 19 | 13 | 14 | 10 | 13 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 1 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 10 | 2 | 2 | 1 | 7 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 2 | 4 | 4 | 8 | 10 | 14 | 18 | 15 | 11 | 19 | 12 | 14 | 2 | 9 | 12 | 23 | 17 | 20 | 0 | 0 | 0 | 1 | 0 | 0 |
Cytoplasm | 122 | 262 | 142 | 184 | 251 | 161 | 193 | 189 | 127 | 147 | 124 | 122 | 292 | 352 | 384 | 348 | 375 | 385 | 121 | 256 | 144 | 249 | 353 | 301 |
Endoplasmic Reticulum | 1 | 9 | 7 | 10 | 21 | 25 | 16 | 45 | 15 | 26 | 12 | 21 | 6 | 11 | 14 | 10 | 20 | 16 | 0 | 8 | 8 | 13 | 12 | 17 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Golgi | 0 | 0 | 1 | 0 | 1 | 4 | 4 | 5 | 2 | 2 | 0 | 4 | 0 | 2 | 0 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Mitochondria | 0 | 1 | 0 | 0 | 0 | 21 | 41 | 28 | 46 | 40 | 67 | 37 | 0 | 0 | 0 | 2 | 3 | 9 | 0 | 0 | 2 | 4 | 2 | 1 |
Nucleus | 0 | 1 | 0 | 0 | 1 | 1 | 3 | 3 | 0 | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 0 | 2 | 1 | 8 | 14 | 22 | 21 | 7 | 13 | 5 | 5 | 2 | 1 | 1 | 17 | 11 | 5 | 1 | 3 | 2 | 0 | 4 | 1 |
Unique Cell Count | 122 | 271 | 150 | 196 | 280 | 219 | 274 | 289 | 191 | 227 | 204 | 193 | 297 | 361 | 397 | 371 | 398 | 403 | 127 | 275 | 162 | 273 | 383 | 327 |
Labelled Cell Count | 125 | 277 | 156 | 203 | 295 | 244 | 318 | 327 | 224 | 264 | 239 | 219 | 302 | 376 | 411 | 400 | 434 | 441 | 127 | 275 | 162 | 273 | 383 | 327 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 21.8 | 29.4 | 19.0 | 19.5 | 16.7 | 14.3 | 12.7 | 13.6 | 12.1 | 12.5 | 11.7 | 12.4 | 23.6 | 23.4 | 23.2 | 29.1 | 30.1 | 29.6 | 26.8 | 26.7 | 28.4 |
Std Deviation (1e-4) | 3.7 | 5.2 | 3.9 | 3.8 | 2.6 | 2.7 | 2.4 | 2.4 | 2.4 | 2.4 | 2.2 | 2.5 | 5.1 | 3.8 | 4.0 | 8.1 | 7.1 | 7.1 | 5.1 | 5.4 | 5.2 |
Intensity Change (Log2) | – | – | – | 0.03 | -0.19 | -0.42 | -0.59 | -0.49 | -0.65 | -0.6 | -0.7 | -0.62 | 0.31 | 0.3 | 0.29 | 0.61 | 0.66 | 0.64 | 0.49 | 0.49 | 0.58 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 3.2 | 3.3 | 3.1 | 0 | 3.2 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0.7 | 0 | 1.6 | 1.7 | 1.2 | 1.4 | 2.3 | 1.4 | 1.9 | 0 | 0 | 0 | 1.6 | 0.9 | 1.2 |
Cytoplasm | -0.3 | -1.8 | -5.2 | -5.9 | -6.8 | -6.3 | -6.7 | -7.3 | -6.9 | 2.2 | 1.6 | 1.1 | -0.4 | -0.2 | 0.4 |
Endoplasmic Reticulum | 0.2 | 1.1 | 2.3 | 0.5 | 3.4 | 1.2 | 2.3 | 0.5 | 2.1 | 0 | -0.9 | -0.6 | 0 | 0.2 | -0.4 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 3.9 | 5.0 | 3.9 | 6.5 | 5.4 | 7.8 | 5.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 2.3 | 2.9 | 2.6 | 0 | 2.1 | 0 | 0 | 0 | 0 | 0 | 1.8 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 18.4019 | 22.268 | 21.1482 | 19.4442 | 19.3869 | 20.578 | 26.0221 | 27.5711 | 29.2443 | 26.6011 | 24.083 | 25.0616 | 26.7089 | 28.8167 | 28.6332 | 27.7767 | 27.3526 | 25.8378 |
Actin | 0.0005 | 0.0005 | 0.0003 | 0 | 0.0006 | 0.0007 | 0.0003 | 0.0004 | 0.0002 | 0.0001 | 0.0001 | 0.0005 | 0.0004 | 0.0003 | 0.0009 | 0.0001 | 0.0002 | 0.0008 |
Bud | 0.0004 | 0.0007 | 0.0003 | 0.0002 | 0.0006 | 0.0005 | 0.0003 | 0.0003 | 0.0004 | 0.0003 | 0.0004 | 0.0007 | 0.0003 | 0.0003 | 0.0003 | 0.0005 | 0.0003 | 0.0007 |
Bud Neck | 0.0004 | 0.0004 | 0.0005 | 0.0004 | 0.0006 | 0.0011 | 0.0004 | 0.0009 | 0.0007 | 0.0012 | 0.0009 | 0.0018 | 0.0005 | 0.0006 | 0.0006 | 0.0008 | 0.0009 | 0.0015 |
Bud Periphery | 0.0002 | 0.0003 | 0.0002 | 0.0001 | 0.0002 | 0.0007 | 0.0003 | 0.0002 | 0.0006 | 0.0005 | 0.0002 | 0.0008 | 0.0004 | 0.0004 | 0.0004 | 0.0002 | 0.0001 | 0.0008 |
Bud Site | 0.0002 | 0.0016 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0.0002 | 0.002 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0.0003 | 0.0002 | 0.0001 | 0.0001 |
Cell Periphery | 0.0006 | 0.0007 | 0.0005 | 0.0001 | 0.0002 | 0.0004 | 0.0011 | 0.0011 | 0.0009 | 0.0007 | 0.0002 | 0.0007 | 0.0015 | 0.0024 | 0.0019 | 0.0007 | 0.0002 | 0.0008 |
Cytoplasm | 0.8757 | 0.9593 | 0.934 | 0.8386 | 0.8645 | 0.8742 | 0.9288 | 0.8964 | 0.9393 | 0.8829 | 0.8984 | 0.8758 | 0.8862 | 0.8951 | 0.9115 | 0.8714 | 0.9296 | 0.8739 |
Cytoplasmic Foci | 0.0067 | 0.0038 | 0.0056 | 0.007 | 0.0143 | 0.0097 | 0.003 | 0.0081 | 0.0026 | 0.0092 | 0.0061 | 0.0061 | 0.0029 | 0.0029 | 0.0035 | 0.0036 | 0.006 | 0.0078 |
Eisosomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0583 | 0.0157 | 0.0197 | 0.0229 | 0.0347 | 0.0469 | 0.0445 | 0.0642 | 0.0308 | 0.0405 | 0.0554 | 0.0724 | 0.0738 | 0.0683 | 0.0461 | 0.0379 | 0.0285 | 0.0745 |
Endosome | 0.027 | 0.0061 | 0.0192 | 0.0391 | 0.0501 | 0.033 | 0.0064 | 0.0091 | 0.006 | 0.0193 | 0.0157 | 0.0148 | 0.0088 | 0.0066 | 0.0083 | 0.0152 | 0.0195 | 0.02 |
Golgi | 0.0035 | 0.0007 | 0.0012 | 0.0009 | 0.004 | 0.005 | 0.0013 | 0.0027 | 0.0009 | 0.0015 | 0.0025 | 0.0039 | 0.0021 | 0.0017 | 0.002 | 0.0005 | 0.0014 | 0.0036 |
Lipid Particles | 0.0003 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0004 | 0.0005 | 0.0002 | 0 | 0 | 0.0001 | 0.0002 | 0.0004 | 0.0006 | 0.0002 | 0.0001 | 0.0002 |
Mitochondria | 0.0024 | 0.0013 | 0.0008 | 0.0439 | 0.0054 | 0.0146 | 0.0016 | 0.001 | 0.0006 | 0.0018 | 0.0015 | 0.0102 | 0.0021 | 0.0069 | 0.0045 | 0.0005 | 0.0008 | 0.0049 |
None | 0.0008 | 0.0004 | 0.0003 | 0.0003 | 0.0004 | 0.0005 | 0.0005 | 0.0003 | 0.0003 | 0.0004 | 0.0003 | 0.0006 | 0.0004 | 0.0003 | 0.0003 | 0.0002 | 0.0003 | 0.0005 |
Nuclear Periphery | 0.0047 | 0.001 | 0.0015 | 0.0044 | 0.0023 | 0.0016 | 0.0012 | 0.0012 | 0.001 | 0.0023 | 0.0014 | 0.001 | 0.0026 | 0.0018 | 0.0017 | 0.002 | 0.0015 | 0.0014 |
Nucleolus | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0014 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0.0022 | 0.0015 | 0.0011 | 0.0016 | 0.0014 | 0.0012 | 0.0008 | 0.002 | 0.001 | 0.0016 | 0.0012 | 0.0009 | 0.0012 | 0.0012 | 0.001 | 0.0015 | 0.0011 | 0.0009 |
Peroxisomes | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 |
Punctate Nuclear | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0013 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0.0139 | 0.005 | 0.0125 | 0.0341 | 0.0153 | 0.0069 | 0.008 | 0.0061 | 0.013 | 0.0338 | 0.0133 | 0.0075 | 0.0146 | 0.0096 | 0.0145 | 0.0606 | 0.0075 | 0.006 |
Vacuole Periphery | 0.0019 | 0.0006 | 0.0018 | 0.006 | 0.0047 | 0.0027 | 0.001 | 0.0008 | 0.0012 | 0.0037 | 0.0022 | 0.0019 | 0.0017 | 0.0008 | 0.0013 | 0.0039 | 0.0018 | 0.0015 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 127.7566 | 117.7915 | 127.6894 | 106.4399 | 111.4184 | 87.0325 | 95.797 | 75.4908 | 80.2706 | 101.1821 |
Translational Efficiency | 1.376 | 1.6381 | 1.2205 | 1.4263 | 1.4384 | 1.6784 | 1.6309 | 1.6022 | 1.4857 | 1.4345 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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