Standard name
Human Ortholog
Description Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.06 0.07 0.07 0 0 0 0 0 0 0.1 0.1 0.17 0.09 0.09 0.11 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.06 0.07 0.1 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.9 0.81 0.79 0.67 0.57 0.56 0.65 0.6 0.61 0.64 0.71 0.68 0.78 0.77 0.64 0.78 0.59 0.67 0.87 0.85 0.72 0.78 0.7 0.61
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0.05 0 0.05 0 0 0.09 0.14 0.18 0.13 0.13 0.16 0 0 0 0 0.07 0 0.07 0 0.15 0.06 0.11 0.09
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.1 0.15 0.12 0.24 0.38 0.36 0.23 0.25 0.17 0.18 0.12 0.15 0.14 0.18 0.2 0.15 0.26 0.2 0 0.06 0.07 0.1 0.12 0.21
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 1 0 0 1 0 1 0
Bud 0 0 0 0 0 1 0 0 1 2 0 1 0 0 0 0 0 0 5 1 2 1 7 7
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 2 1 3 3 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3 4 6 12 20 21 14 16 15 12 9 4 13 13 30 7 8 7 1 0 0 0 1 2
Endoplasmic Reticulum 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 3 4 0 0 0 0 0 0 0
Endosome 0 0 1 0 1 0 1 3 0 0 0 0 0 0 2 0 1 0 0 0 1 1 1 5
Golgi 0 0 1 2 6 2 2 3 1 0 0 0 0 0 2 0 0 0 0 0 2 3 0 2
Mitochondria 0 3 2 0 2 2 4 13 22 25 30 18 0 0 0 0 1 1 0 2 2 0 2 2
Nucleus 371 94 165 133 163 178 252 263 226 239 217 247 101 101 113 61 52 43 402 129 187 152 202 233
Nuclear Periphery 0 0 1 0 0 0 2 0 2 4 0 0 0 0 0 0 1 0 1 0 1 0 0 1
Nucleolus 5 6 9 9 11 14 35 60 66 49 40 58 1 1 3 1 6 1 30 6 39 12 32 32
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 2 0 1 3
Vac/Vac Membrane 42 17 26 48 109 114 89 111 61 68 38 54 18 24 35 12 23 13 15 8 17 19 35 81
Unique Cell Count 411 116 208 199 287 319 385 440 369 373 307 363 130 132 177 78 88 64 462 152 261 195 290 379
Labelled Cell Count 421 124 211 204 312 333 399 471 395 402 337 385 134 139 186 84 98 66 462 152 261 195 290 379


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 20.2 15.3 19.5 21.8 22.2 21.4 20.0 18.4 17.6 15.9 16.0 16.5 19.4 19.4 19.5 14.2 16.3 18.9 21.0 21.7 23.3
Std Deviation (1e-4) 3.8 4.3 4.5 4.6 5.1 4.5 4.4 4.6 4.6 4.0 4.5 4.4 4.9 4.9 6.1 5.8 6.2 6.2 4.8 5.4 6.8
Intensity Change (Log2) – – – 0.16 0.19 0.13 0.03 -0.08 -0.15 -0.3 -0.28 -0.24 -0.01 -0.01 -0.0 -0.46 -0.26 -0.05 0.11 0.16 0.25

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.5 2.0 1.9 0.5 0.5 0.7 0.2 0 0 2.8 2.7 4.7 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 2.9 3.2 4.1 2.5 0 0 0 0 0 0
Nucleus -2.8 -5.2 -5.5 -3.5 -4.9 -4.5 -3.8 -2.2 -2.9 -0.4 -0.6 -3.4 -0.2 -3.6 -2.0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.1 -0.3 0 2.1 3.6 4.7 3.4 3.3 4.2 0 0 -1.5 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 3.0 6.3 5.9 3.1 3.7 1.3 1.8 0 0.8 0.4 1.4 1.9 0.6 2.9 1.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0352 0 0.0012 0.0007 0.0001 0.0119 0.0007 0 0.0044 0.0005 0.0142 0.0001 – – – – – –
Bud 0.0006 0 0.0001 0.0004 0.0002 0.0001 0.0006 0 0.0001 0.0001 0.0002 0.0001 – – – – – –
Bud Neck 0.0009 0 0.0002 0.0003 0.0003 0.0007 0.0005 0 0 0.0002 0.0005 0.0006 – – – – – –
Bud Periphery 0.0007 0 0.0001 0.0005 0.0003 0.0001 0.0003 0 0.0001 0.0001 0.0003 0.0001 – – – – – –
Bud Site 0.002 0 0.0016 0.0009 0.0002 0.0001 0.0042 0 0.0002 0 0.0012 0 – – – – – –
Cell Periphery 0.0005 0 0.0001 0.0009 0.0012 0.0001 0.0002 0 0 0 0.0001 0.0001 – – – – – –
Cytoplasm 0.0112 0.0005 0.0019 0.0042 0.002 0.0014 0.0041 0.0005 0.0009 0.005 0.0039 0.0002 – – – – – –
Cytoplasmic Foci 0.0196 0 0.0098 0.0168 0.0055 0.0024 0.0151 0 0.0013 0 0.0029 0 – – – – – –
Eisosomes 0.0003 0 0.0001 0.0001 0 0 0 0 0 0 0.0001 0 – – – – – –
Endoplasmic Reticulum 0.0071 0 0.0004 0.0003 0.0007 0.001 0.0002 0 0.0006 0.0002 0.0047 0 – – – – – –
Endosome 0.0216 0 0.002 0.0028 0.0016 0.0052 0.0025 0 0.0061 0.0001 0.0238 0 – – – – – –
Golgi 0.0099 0 0.0017 0.003 0.0002 0.0019 0.0011 0 0.0029 0 0.0042 0 – – – – – –
Lipid Particles 0.018 0 0.0085 0.0551 0.01 0.0042 0.001 0 0.0003 0 0.0032 0 – – – – – –
Mitochondria 0.0051 0.0003 0.0039 0.0026 0.0083 0.0014 0.0024 0.0002 0.0029 0.0007 0.0029 0.0005 – – – – – –
None 0.0178 0 0.0018 0.0034 0.0009 0.0002 0.0011 0 0.0002 0 0.0055 0 – – – – – –
Nuclear Periphery 0.0262 0.0097 0.0131 0.0211 0.0369 0.027 0.0196 0.0109 0.0083 0.0327 0.0314 0.0084 – – – – – –
Nucleolus 0.0406 0.007 0.0083 0.0207 0.0482 0.0109 0.0244 0.0054 0.0055 0.0014 0.0253 0.0252 – – – – – –
Nucleus 0.7483 0.9819 0.9396 0.8397 0.8548 0.9235 0.8341 0.9827 0.9652 0.9578 0.8515 0.9634 – – – – – –
Peroxisomes 0.0049 0 0.0031 0.0217 0.0003 0.0036 0.001 0 0.0003 0 0.0009 0 – – – – – –
Punctate Nuclear 0.0196 0.0001 0.0012 0.0023 0.004 0.0007 0.0843 0.0001 0.0003 0.0003 0.0208 0.0002 – – – – – –
Vacuole 0.0051 0.0001 0.0005 0.0017 0.0075 0.0018 0.001 0 0.0001 0.0003 0.0008 0.0006 – – – – – –
Vacuole Periphery 0.0048 0.0002 0.0009 0.0007 0.0166 0.0018 0.0015 0.0001 0.0003 0.0005 0.0015 0.0004 – – – – – –

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 180.0155 145.8725 175.2517 187.8738 155.4387 159.0212 165.2173 177.5365 198.0119 164.5973
Translational Efficiency 1.4824 1.5551 1.2082 1.2662 1.2025 1.6003 1.3256 0.9939 0.9949 1.1584

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1462 469 161 242 1153 531 212 1546 2615 1000 373 1788

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1927.43 1768.59 1649.56 2292.70 1267.49 1697.23 2129.48 1366.00 1636.45 1730.70 1922.33 1491.43
Standard Deviation 346.32 390.46 252.01 511.98 275.58 317.06 270.55 373.73 455.96 355.18 354.29 506.70
Intensity Change Log 2 — -0.124079 -0.224597 0.250369 — 0.421208 0.748527 0.107983 — 0.117417 0.242240 0.195551

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001372 0.000807 0.001842 0.001567 0.000868 0.001014 0.001611 0.000991 0.001150 0.000917 0.001711 0.001069
Bud Neck 0.025575 0.016976 0.018700 0.051651 0.014771 0.014625 0.035746 0.020885 0.020811 0.015728 0.028388 0.025049
Bud Site 0.003645 0.001083 0.001725 0.002986 0.001194 0.000839 0.001526 0.002446 0.002564 0.000954 0.001612 0.002519
Cell Periphery 0.000161 0.000109 0.000126 0.000292 0.000190 0.000064 0.000115 0.000231 0.000173 0.000085 0.000120 0.000240
Cytoplasm 0.001666 0.003721 0.001452 0.025845 0.001910 0.000576 0.000706 0.040862 0.001774 0.002051 0.001028 0.038829
Cytoplasmic Foci 0.001557 0.000454 0.000181 0.000868 0.000412 0.000220 0.000173 0.000619 0.001052 0.000330 0.000176 0.000653
Eisosomes 0.000034 0.000024 0.000035 0.000026 0.000035 0.000026 0.000043 0.000009 0.000034 0.000025 0.000040 0.000011
Endoplasmic Reticulum 0.001185 0.001845 0.003541 0.003655 0.004077 0.002761 0.002124 0.002899 0.002460 0.002331 0.002736 0.003002
Endosome 0.001255 0.000395 0.000262 0.000883 0.000838 0.000443 0.000182 0.000836 0.001071 0.000420 0.000216 0.000843
Golgi 0.001040 0.000200 0.000165 0.000340 0.000109 0.000225 0.000199 0.000591 0.000630 0.000213 0.000184 0.000557
Lipid Particles 0.000560 0.000165 0.000210 0.000732 0.000066 0.000194 0.000108 0.000212 0.000342 0.000181 0.000152 0.000283
Mitochondria 0.004045 0.001728 0.003015 0.009167 0.001550 0.002032 0.006220 0.003711 0.002945 0.001889 0.004836 0.004449
Mitotic Spindle 0.007705 0.006088 0.000658 0.047530 0.000897 0.002780 0.001178 0.005979 0.004703 0.004331 0.000954 0.011603
None 0.001253 0.002229 0.001054 0.005681 0.003667 0.000955 0.001713 0.014256 0.002317 0.001553 0.001429 0.013096
Nuclear Periphery 0.001191 0.000680 0.001012 0.040925 0.000824 0.000751 0.010857 0.008287 0.001029 0.000718 0.006607 0.012704
Nuclear Periphery Foci 0.000286 0.003042 0.000761 0.013317 0.000243 0.001737 0.000692 0.003602 0.000267 0.002349 0.000722 0.004917
Nucleolus 0.018994 0.017952 0.024492 0.011954 0.037558 0.029055 0.038381 0.007811 0.027179 0.023848 0.032386 0.008372
Nucleus 0.925757 0.940997 0.937124 0.766541 0.929122 0.940159 0.894473 0.881573 0.927241 0.940552 0.912882 0.866004
Peroxisomes 0.000561 0.000428 0.000912 0.000626 0.000459 0.000512 0.001397 0.000152 0.000516 0.000473 0.001188 0.000216
Vacuole 0.001327 0.000844 0.002433 0.014642 0.000864 0.000668 0.002137 0.003043 0.001123 0.000751 0.002265 0.004613
Vacuole Periphery 0.000831 0.000231 0.000299 0.000771 0.000348 0.000364 0.000417 0.001003 0.000618 0.000302 0.000366 0.000971

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.24 -2.87 -0.96 -5.09 2.58 -1.65 -8.67 -3.93 -0.53 6.07 1.25 -5.84 -0.43 -2.52 7.29
Bud Neck 5.81 3.75 -6.09 -8.25 -7.50 -0.52 -8.69 -8.47 -7.27 4.49 5.29 -4.98 -5.64 -9.20 0.92
Bud Site 3.30 2.04 -2.92 -7.24 -5.82 1.33 -2.86 -5.78 -6.31 0.74 3.65 -0.79 -2.05 -7.74 -0.73
Cell Periphery 1.51 0.27 -7.17 -7.99 -7.19 4.30 0.47 -1.32 -9.03 -2.16 4.09 0.40 -4.65 -10.08 -5.21
Cytoplasm -1.39 0.94 -6.11 -5.03 -6.23 2.46 1.92 -14.24 -15.17 -15.04 -0.49 2.28 -15.49 -14.34 -15.99
Cytoplasmic Foci 1.37 2.08 -1.52 -2.56 -2.98 0.92 -0.06 -0.62 -2.61 -0.81 1.74 1.66 -0.15 -2.98 -2.96
Eisosomes 3.94 -0.80 -1.00 -3.94 -0.21 3.75 -4.63 11.81 9.06 10.43 5.41 -4.22 12.32 7.30 11.57
Endoplasmic Reticulum -2.92 -6.46 -7.52 -4.58 0.79 3.25 6.50 3.12 -1.45 -4.14 0.76 -2.05 -5.17 -4.09 -1.65
Endosome 1.21 1.63 -0.92 -4.08 -6.70 0.92 1.25 0.30 -1.52 -3.64 1.45 1.99 0.15 -2.44 -4.47
Golgi 1.21 1.19 0.28 -4.56 -7.18 -1.30 -4.76 -2.12 -1.39 -0.86 0.98 0.68 -0.23 -1.77 -1.39
Lipid Particles 0.76 0.39 -3.78 -5.98 -5.68 -1.15 -2.64 -3.40 -0.85 -0.74 0.39 -0.04 -1.52 -3.73 -3.59
Mitochondria 4.47 0.79 -6.59 -12.18 -8.38 -3.30 -12.10 -12.97 -8.70 5.22 3.39 -6.59 -6.17 -12.86 1.57
Mitotic Spindle 0.35 2.45 -5.32 -5.33 -5.75 -1.12 -1.81 -5.18 -3.54 -1.23 0.02 -0.22 -6.01 -5.50 -4.90
None -1.76 1.57 -7.56 -5.12 -7.87 3.34 1.86 -5.47 -8.80 -7.49 1.79 1.87 -7.72 -8.67 -8.69
Nuclear Periphery 2.72 -0.82 -6.33 -6.48 -6.20 0.30 -2.26 -8.49 -8.57 -0.80 2.42 -2.29 -10.23 -10.58 -3.56
Nuclear Periphery Foci -1.92 -1.06 -3.88 -1.45 -3.35 -1.48 -1.73 -4.83 -1.88 -4.26 -2.42 -1.70 -5.76 -1.69 -4.85
Nucleolus 0.34 -1.22 4.97 3.63 3.37 2.16 -0.96 9.82 6.14 5.52 1.40 -1.97 10.33 6.88 6.36
Nucleus -2.21 -0.72 11.05 11.55 10.73 -1.71 5.22 10.39 10.50 0.18 -2.97 3.93 13.37 14.18 5.24
Peroxisomes 1.14 -2.92 0.53 -0.65 3.22 -0.64 -4.80 4.04 4.35 6.21 0.37 -5.49 5.79 4.48 7.72
Vacuole 2.31 -1.78 -7.50 -7.84 -7.03 0.54 -5.07 -6.12 -6.96 -0.53 2.44 -4.01 -8.15 -9.77 -5.03
Vacuole Periphery 1.75 1.30 0.55 -3.56 -2.17 -0.18 -1.76 -1.74 -1.64 -1.36 1.53 0.80 -1.04 -2.00 -1.60
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle
Localization
Cell Percentages nucleus (41%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-5

Rpn1

Rpn1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rpn1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available