Standard name
Human Ortholog
Description Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0 0.07 0.08 0.07 0.07 0.07 0 0.05 0.06 0 0 0.09 0.12 0.07 0.05 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.06 0 0 0 0 0.1 0.21 0.23 0.48 0.35 0.45 0.3 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.97 0.95 0.93 0.91 0.89 0.88 0.85 0.87 0.82 0.81 0.79 0.84 0.96 0.89 0.82 0.85 0.8 0.85 0.95 0.9 0.92 0.89 0.77 0.66
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0.07 0 0 0 0.05 0.06 0.07 0.07 0 0 0 0 0 0 0 0 0 0 0 0.06 0.07
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.09 0.06 0 0 0 0.05 0.12 0.16
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 2 3 3 3 6 1 0 0 0 0 0 1 0 0 0 1 2 1
Bud Neck 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 5 1 6 9 7 10 10 0 0 0 0 1 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 5 2 7 22 14 23 20 9 15 13 10 5 19 31 17 7 15 0 3 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 5 2 0 0 0 1 0 0
Endosome 0 0 0 0 0 0 0 1 0 0 0 0 0 0 3 3 0 0 0 0 0 0 2 4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 1 0 0 0 0 2
Mitochondria 13 1 0 2 6 21 67 63 145 113 102 72 2 0 1 6 1 3 1 1 0 1 1 10
Nucleus 222 96 93 88 250 186 276 243 250 259 178 202 176 183 219 204 103 176 216 107 102 141 216 165
Nuclear Periphery 3 1 0 0 3 2 6 1 4 1 4 2 1 0 7 0 2 0 0 0 1 0 0 3
Nucleolus 1 1 3 7 3 4 10 13 19 21 15 9 3 2 12 3 3 9 2 0 0 2 17 18
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 1 0 0 1 3 1 1 3 1 1 5 1 1 0 0 0 0 0 0 1
Vac/Vac Membrane 0 0 3 0 6 6 3 1 2 1 1 0 0 0 8 11 11 13 5 2 3 7 34 40
Unique Cell Count 230 101 100 97 280 212 326 278 304 320 226 241 183 205 267 240 128 208 228 119 111 159 282 251
Labelled Cell Count 239 104 101 104 291 238 388 352 445 421 330 310 188 205 287 248 134 220 228 119 111 159 282 251


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.5 8.7 7.1 6.4 7.0 5.9 5.3 5.3 4.3 4.9 4.3 4.9 8.0 8.4 7.9 11.8 11.0 10.9 8.6 8.9 8.9
Std Deviation (1e-4) 0.9 1.5 1.7 1.3 2.2 2.3 1.9 1.5 1.1 1.6 1.1 1.4 1.8 2.8 2.6 3.3 2.9 2.7 1.8 1.7 1.5
Intensity Change (Log2) – – – -0.15 -0.01 -0.26 -0.42 -0.43 -0.71 -0.53 -0.71 -0.52 0.18 0.24 0.16 0.74 0.64 0.61 0.28 0.32 0.32

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 2.1 1.7 1.9 1.9 0 0 0 0 0 2.4 2.9 1.9 0 1.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.3 4.9 5.2 0 7.0 0 6.2 0 0 0 0 0 0
Nucleus -0.6 -1.1 -1.4 -2.1 -1.5 -2.6 -2.9 -3.2 -2.3 1.2 -1.0 -2.6 -2.0 -2.7 -2.1
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 1.3 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 1.7 1.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.3409 3.201 3.0274 2.7081 3.1292 3.0291 3.8055 4.7361 3.8709 4.0837 4.271 4.1475 3.9466 3.8654 3.7202 3.4104 3.0402 3.6171
Actin 0.0207 0 0.0043 0 0.0267 0.0002 0.0053 0 0.0107 0.0027 0.0027 0.0005 0.0134 0 0.0104 0.0492 0.0082 0.0072
Bud 0.0005 0 0.0001 0 0.0003 0 0.0007 0 0.0005 0.0002 0.001 0.0001 0.0006 0 0.0002 0.0011 0.001 0
Bud Neck 0.0073 0.0001 0.0008 0 0.0004 0.0003 0.0034 0.0001 0.0011 0.0002 0.0002 0.0008 0.002 0 0.0014 0.002 0.0013 0.0003
Bud Periphery 0.0012 0 0.0004 0 0.0005 0.0001 0.0024 0 0.0009 0.0002 0.0018 0.0003 0.0022 0 0.0005 0.0011 0.0026 0.0001
Bud Site 0.0029 0 0.0005 0 0.0009 0 0.0036 0 0.0062 0.0012 0.001 0.0001 0.006 0 0.0008 0.0294 0.0033 0
Cell Periphery 0.0005 0 0.0002 0 0.0001 0 0.0013 0 0.0002 0 0.0001 0.0001 0.0016 0 0.0002 0.0002 0.0006 0
Cytoplasm 0.0063 0 0.0007 0 0.0005 0.0001 0.0029 0 0.0018 0.0137 0.0004 0.0002 0.0032 0 0.0013 0.0004 0.0009 0
Cytoplasmic Foci 0.0107 0 0.0015 0 0.0068 0.0001 0.0114 0 0.0049 0.005 0.0018 0.0003 0.0104 0.0019 0.0028 0.0022 0.0201 0.0006
Eisosomes 0.0002 0 0.0001 0 0.0001 0 0.0001 0 0.0001 0 0 0 0.0002 0 0.0002 0.0001 0.0002 0
Endoplasmic Reticulum 0.002 0 0.0018 0 0.0008 0.0006 0.0022 0 0.0015 0.0012 0.0009 0.0005 0.0017 0 0.0018 0.0002 0.0061 0.0001
Endosome 0.0133 0 0.0085 0 0.0101 0.0019 0.0146 0 0.013 0.0201 0.0336 0.0059 0.0109 0.0001 0.0048 0.0007 0.0186 0.0009
Golgi 0.0045 0 0.0022 0 0.0078 0.0001 0.0034 0 0.0038 0.0043 0.0089 0.0012 0.0032 0.0002 0.0016 0.0012 0.0165 0.0011
Lipid Particles 0.0099 0 0.0035 0 0.0089 0.0001 0.0171 0 0.0105 0.0037 0.0029 0.0019 0.0125 0.0051 0.0039 0.001 0.0165 0.0013
Mitochondria 0.0041 0 0.0019 0.0001 0.0034 0.0002 0.0274 0.0001 0.0082 0.0018 0.0779 0.0009 0.0168 0.0001 0.0098 0.0008 0.0509 0.0076
None 0.0094 0 0.0008 0 0.0006 0.0001 0.0051 0 0.001 0.0025 0.0002 0.0002 0.0015 0 0.008 0.0004 0.0004 0.0001
Nuclear Periphery 0.0226 0.0007 0.0114 0.0011 0.0253 0.0138 0.01 0.0011 0.0119 0.005 0.0019 0.0056 0.0047 0.0008 0.008 0.0007 0.0215 0.0003
Nucleolus 0.0169 0.0063 0.0089 0.0022 0.0139 0.0222 0.0218 0.0073 0.0068 0.0058 0.0092 0.034 0.0135 0.0115 0.009 0.0077 0.0231 0.0227
Nucleus 0.846 0.9927 0.9449 0.9964 0.8748 0.9588 0.8368 0.9911 0.8981 0.9261 0.848 0.9427 0.8722 0.9751 0.9288 0.8965 0.7802 0.954
Peroxisomes 0.0124 0 0.0004 0 0.0059 0 0.0076 0 0.0097 0.0017 0.0009 0.0001 0.0128 0.0048 0.003 0.0012 0.0169 0.003
Punctate Nuclear 0.0038 0.0001 0.0021 0.0001 0.0099 0.0005 0.0086 0.0002 0.0044 0.0028 0.0003 0.0033 0.0023 0.0002 0.0018 0.0032 0.0016 0.0003
Vacuole 0.0029 0.0001 0.0037 0 0.0009 0.0004 0.0101 0 0.003 0.0012 0.0035 0.0008 0.0059 0 0.0011 0.0005 0.0059 0.0001
Vacuole Periphery 0.002 0 0.0014 0 0.0015 0.0004 0.0043 0 0.0014 0.0005 0.0026 0.0006 0.0024 0 0.0007 0.0001 0.0038 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.3114 20.6108 14.5658 16.5712 27.7581 7.6811 19.103 16.7444 11.7122 18.1533
Translational Efficiency 1.5997 1.4874 1.8056 1.1784 0.9616 2.7629 0.9924 0.9688 1.2541 1.4951

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2171 669 282 1900 1603 1660 353 1351 3774 2329 635 3251

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 936.92 883.73 1207.73 1196.45 823.95 972.37 1272.98 1222.04 888.94 946.91 1244.00 1207.08
Standard Deviation 137.49 200.59 159.35 194.91 147.77 145.00 158.56 199.47 152.54 167.78 162.18 197.22
Intensity Change Log 2 — -0.084320 0.366300 0.352762 — 0.238949 0.627581 0.568663 — 0.075986 0.494465 0.457818

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000209 0.000689 0.000856 0.000723 0.000365 0.000445 0.000751 0.000965 0.000275 0.000515 0.000797 0.000823
Bud Neck 0.002764 0.003765 0.010856 0.019565 0.003498 0.009287 0.008473 0.023361 0.003076 0.007701 0.009531 0.021143
Bud Site 0.000232 0.000976 0.000735 0.001634 0.000495 0.001375 0.000535 0.003462 0.000343 0.001260 0.000624 0.002394
Cell Periphery 0.000306 0.000352 0.000037 0.000076 0.000340 0.000208 0.000029 0.000445 0.000321 0.000249 0.000033 0.000229
Cytoplasm 0.000144 0.004578 0.000135 0.000711 0.001879 0.000551 0.000099 0.001392 0.000881 0.001708 0.000115 0.000994
Cytoplasmic Foci 0.000006 0.000816 0.000017 0.000156 0.000093 0.000520 0.000010 0.002407 0.000043 0.000605 0.000013 0.001091
Eisosomes 0.000042 0.000036 0.000044 0.000030 0.000042 0.000040 0.000043 0.000028 0.000042 0.000039 0.000044 0.000029
Endoplasmic Reticulum 0.007357 0.006274 0.003176 0.002995 0.008283 0.007321 0.003520 0.003072 0.007750 0.007020 0.003367 0.003027
Endosome 0.000122 0.000435 0.000067 0.000509 0.000225 0.000815 0.000051 0.002064 0.000166 0.000706 0.000058 0.001155
Golgi 0.000012 0.000297 0.000053 0.000463 0.000101 0.000404 0.000038 0.003111 0.000050 0.000373 0.000045 0.001563
Lipid Particles 0.000014 0.000155 0.000042 0.000054 0.000136 0.000777 0.000031 0.000085 0.000066 0.000598 0.000036 0.000067
Mitochondria 0.000342 0.001537 0.001299 0.004269 0.001070 0.001532 0.001005 0.004836 0.000651 0.001533 0.001136 0.004505
Mitotic Spindle 0.000235 0.001944 0.000058 0.004901 0.000171 0.003743 0.000117 0.007712 0.000208 0.003226 0.000091 0.006070
None 0.001145 0.022859 0.000919 0.001369 0.005703 0.001584 0.000804 0.001496 0.003081 0.007695 0.000855 0.001422
Nuclear Periphery 0.000211 0.000191 0.000175 0.001257 0.000279 0.000543 0.000166 0.001087 0.000240 0.000442 0.000170 0.001186
Nuclear Periphery Foci 0.000037 0.000738 0.000027 0.000369 0.000259 0.000479 0.000028 0.000572 0.000131 0.000554 0.000027 0.000453
Nucleolus 0.008445 0.016578 0.013828 0.012377 0.010463 0.009631 0.011342 0.013720 0.009302 0.011626 0.012446 0.012935
Nucleus 0.977456 0.935627 0.966143 0.944622 0.965237 0.958858 0.971763 0.925150 0.972266 0.952185 0.969267 0.936530
Peroxisomes 0.000094 0.000638 0.000608 0.000195 0.000327 0.000563 0.000456 0.000523 0.000193 0.000585 0.000524 0.000332
Vacuole 0.000618 0.001053 0.000812 0.001977 0.000821 0.000933 0.000655 0.003368 0.000704 0.000968 0.000724 0.002555
Vacuole Periphery 0.000209 0.000461 0.000112 0.001749 0.000213 0.000392 0.000084 0.001143 0.000211 0.000412 0.000097 0.001497

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -9.63 -12.49 -13.50 -2.37 0.47 -2.11 -8.56 -5.31 -4.59 -1.53 -8.42 -15.36 -11.00 -6.38 -1.05
Bud Neck -1.99 -8.72 -17.87 -15.73 -7.80 -6.17 -7.64 -13.93 -9.23 -9.66 -6.81 -11.76 -22.39 -14.48 -12.79
Bud Site -3.17 -6.50 -4.01 -2.07 -2.77 -2.88 -1.41 -4.57 -2.92 -4.36 -4.13 -5.71 -6.05 -3.12 -5.08
Cell Periphery -0.33 2.12 1.81 3.92 -3.67 1.88 5.42 -0.08 -0.61 -1.31 0.84 3.73 0.96 0.48 -1.53
Cytoplasm -2.97 0.17 -4.55 2.34 -4.72 2.30 3.26 0.52 -2.20 -3.55 -1.66 3.26 -1.21 0.94 -5.61
Cytoplasmic Foci -1.98 -4.26 -2.44 1.66 -2.22 -1.89 1.91 -2.71 -1.94 -2.85 -2.85 1.64 -2.95 -0.71 -3.08
Eisosomes 1.16 -0.53 2.33 1.75 5.15 0.36 -1.16 3.95 3.98 6.60 0.82 -1.06 3.89 4.20 8.38
Endoplasmic Reticulum 2.10 9.38 11.76 8.05 0.25 1.46 8.10 8.25 8.83 1.29 1.73 12.47 13.82 12.61 1.41
Endosome -2.56 2.90 -2.77 0.04 -3.26 -1.92 4.75 -3.08 -1.48 -3.45 -2.44 5.65 -3.79 -0.73 -4.31
Golgi -1.41 -9.65 -1.88 -0.30 -1.65 -1.59 1.01 -2.51 -2.15 -2.59 -2.31 0.17 -2.94 -2.02 -2.96
Lipid Particles -2.82 -4.44 -3.29 1.77 -1.33 -1.30 0.94 0.52 1.47 -3.12 -1.55 0.63 -0.02 1.56 -3.00
Mitochondria -2.94 -7.69 -5.51 -3.25 -3.98 -0.81 -0.02 -3.42 -3.16 -3.91 -2.58 -2.36 -6.20 -4.52 -5.67
Mitotic Spindle -1.38 0.66 -4.38 -2.31 -4.55 -3.05 0.58 -4.91 -2.64 -4.95 -3.32 0.78 -6.57 -3.04 -6.71
None -4.92 0.65 -1.31 4.82 -2.33 3.73 4.48 3.59 -0.20 -2.40 -3.33 4.39 2.82 4.66 -3.53
Nuclear Periphery 0.61 0.37 -5.64 -5.74 -5.70 -2.68 2.38 -8.05 -4.93 -8.84 -2.91 1.96 -8.56 -6.14 -8.96
Nuclear Periphery Foci -2.88 0.29 -3.52 1.47 -3.75 -0.85 2.09 -1.55 -0.23 -3.50 -2.22 2.07 -3.21 0.60 -5.07
Nucleolus -4.40 -2.49 -4.80 0.71 -0.34 0.54 -0.49 -4.30 -4.35 -2.58 -2.54 -2.17 -6.42 -3.52 -2.06
Nucleus 6.83 4.33 12.16 -0.10 6.81 1.96 -1.49 9.18 7.37 9.77 7.05 2.15 14.84 6.15 11.97
Peroxisomes -2.47 -6.03 -7.14 1.84 4.25 -0.84 -0.53 -0.96 0.04 -0.85 -2.25 -3.27 -1.72 1.37 1.94
Vacuole -1.48 -1.03 -3.49 -2.12 -3.04 -0.81 -0.21 -4.00 -3.77 -3.94 -1.78 -1.03 -5.31 -4.46 -4.98
Vacuole Periphery -1.02 1.33 -2.75 -1.93 -3.00 -1.49 3.57 -3.04 -2.14 -3.56 -1.75 2.55 -3.70 -2.80 -4.15
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene
Localization
Cell Percentages nucleus (100%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Ipi1

Ipi1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ipi1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available