Standard name
Human Ortholog
Description Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 1.0 0.94 0.99 0.95 0.94 0.82 0.69 0.76 0.66 0.69 0.7 0.98 0.98 0.98 0.93 0.92 0.91 0.96 0.93 0.93 0.96 0.92 0.93
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.05 0 0.13 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.07 0 0.1 0.24 0.16 0.25 0.21 0.18 0 0 0 0.07 0.09 0.09 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 2 0 1 1 0 5 0 0 0 0 0 0 1 0 0 0 2 1
Bud 0 0 0 1 1 0 1 1 1 1 4 4 1 1 0 0 0 0 0 0 0 1 5 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 1 1 7 11 10 3 16 6 3 1 3 4 4 6 7 0 0 0 0 0 0
Cytoplasm 297 17 34 205 237 259 384 281 231 245 159 191 473 640 716 191 227 213 291 28 58 272 492 529
Endoplasmic Reticulum 1 0 0 2 3 3 21 14 8 16 2 8 0 3 5 5 5 4 0 0 1 0 5 3
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 2 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 0 0 0 0 0 0 1
Mitochondria 3 0 1 0 0 3 17 3 16 15 30 16 0 1 1 1 0 1 2 0 0 0 1 2
Nucleus 0 0 1 3 3 9 11 14 9 8 5 12 12 2 4 0 1 1 0 1 0 3 8 4
Nuclear Periphery 0 0 0 1 0 1 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 1
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Vac/Vac Membrane 0 0 0 2 18 11 47 98 50 92 49 49 10 9 16 14 21 20 1 0 0 4 11 12
Unique Cell Count 299 17 36 207 249 277 471 410 304 374 231 273 485 650 729 205 246 233 305 31 63 284 536 568
Labelled Cell Count 301 17 36 215 263 293 495 421 319 394 255 288 497 660 746 219 263 246 305 31 63 284 536 568


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.2 12.4 9.8 11.0 13.3 12.6 12.2 13.4 11.9 12.9 11.5 12.0 14.4 19.7 21.1 35.5 36.0 33.0 11.0 12.6 15.8
Std Deviation (1e-4) 2.2 4.7 1.8 2.0 3.7 3.3 3.0 3.6 3.6 4.0 5.4 3.9 3.6 5.6 6.2 16.5 17.1 14.0 2.3 3.0 3.6
Intensity Change (Log2) – – – 0.17 0.43 0.36 0.31 0.45 0.28 0.39 0.22 0.29 0.55 1.0 1.1 1.85 1.87 1.75 0.16 0.35 0.69


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2.0 0.2 -0.2 -2.0 -3.3 -2.5 -3.6 -3.2 -3.1 1.1 1.8 1.6 -0.3 -0.5 -0.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 3.3 2.6 3.4 3.1 2.8 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 13.014 14.1034 13.0919 11.3324 9.9462 12.4758 6.913 10.4144 9.1402 8.0994 7.5885 8.7611 12.6571 12.6962 12.0036 12.7549 10.1634 12.4853
Actin 0.0002 0.0004 0.0018 0.0002 0.0004 0.0003 0.0322 0.0002 0.0063 0.0134 0.0438 0.0001 0.012 0.0003 0.0005 0.0002 0.0413 0.0004
Bud 0.0002 0.0004 0.0028 0.0002 0.002 0.0004 0.001 0.0001 0.0004 0.0002 0.0002 0.0001 0.0005 0.0001 0.0001 0.0001 0.0012 0.0001
Bud Neck 0.0003 0.0003 0.0005 0.0007 0.0014 0.0011 0.0012 0.0001 0.0012 0.0009 0.0015 0.0008 0.0016 0.0001 0.0003 0.0003 0.003 0.0007
Bud Periphery 0 0.0001 0.0009 0 0.0008 0.0002 0.0009 0 0.0003 0.0001 0.0002 0 0.0004 0 0 0 0.002 0
Bud Site 0.0002 0.0008 0.0007 0.0001 0.0003 0.0001 0.0011 0.0001 0.0017 0.0004 0.0004 0 0.0011 0.0001 0.0002 0.0001 0.0038 0
Cell Periphery 0 0 0 0 0 0 0.0001 0 0.0001 0 0.0001 0 0.0001 0 0 0 0.001 0
Cytoplasm 0.9396 0.957 0.9386 0.9057 0.9324 0.9333 0.818 0.9891 0.9191 0.9264 0.8639 0.9614 0.9146 0.979 0.9593 0.9212 0.8132 0.9464
Cytoplasmic Foci 0.0037 0.0022 0.003 0.0024 0.0031 0.0027 0.0358 0.001 0.0086 0.0066 0.0072 0.0041 0.0131 0.0015 0.0054 0.0053 0.0089 0.0021
Eisosomes 0 0 0 0 0 0 0.0006 0 0 0.0001 0.0003 0 0.0002 0 0 0 0.0004 0
Endoplasmic Reticulum 0.002 0.0015 0.0015 0.0021 0.003 0.0024 0.0029 0.0006 0.0013 0.0021 0.002 0.0014 0.0024 0.0003 0.001 0.0012 0.0083 0.0037
Endosome 0.0014 0.0014 0.0009 0.0017 0.0019 0.0022 0.0236 0.0002 0.0107 0.0138 0.0124 0.0027 0.0069 0.0001 0.0059 0.0343 0.021 0.0051
Golgi 0 0.0001 0.0001 0.0001 0.0001 0.0001 0.0071 0 0.0032 0.0059 0.0052 0 0.0019 0.0001 0.0013 0.0011 0.0093 0.0001
Lipid Particles 0 0.0001 0 0 0 0 0.0113 0 0.0066 0.0058 0.0046 0 0.0026 0.0005 0.0014 0.0012 0.0334 0.0001
Mitochondria 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0048 0.0001 0.0081 0.0013 0.0009 0.0001 0.0027 0.0001 0.0003 0.0002 0.0096 0.0002
None 0.0029 0.0017 0.0025 0.0015 0.0026 0.0016 0.0144 0.0016 0.0019 0.0021 0.0042 0.0016 0.0029 0.0008 0.0047 0.0007 0.0033 0.0009
Nuclear Periphery 0.0049 0.0038 0.0056 0.006 0.0048 0.0052 0.006 0.0007 0.0068 0.0027 0.0066 0.0021 0.0053 0.0008 0.002 0.0029 0.0086 0.009
Nucleolus 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0009 0 0.0002 0.0001 0.0007 0 0.0001 0 0.0003 0 0.0005 0.0001
Nucleus 0.042 0.0278 0.0345 0.0763 0.0433 0.0469 0.0151 0.0058 0.0145 0.0121 0.016 0.0239 0.0258 0.0053 0.0132 0.0259 0.0138 0.0279
Peroxisomes 0 0.0001 0.0001 0.0001 0.0001 0.0001 0.0129 0 0.0053 0.003 0.0021 0 0.0016 0.0105 0.0006 0.0001 0.0092 0
Punctate Nuclear 0.001 0.0011 0.0048 0.0015 0.0016 0.0019 0.0065 0.0002 0.0008 0.0022 0.0265 0.0008 0.0015 0.0003 0.0024 0.0005 0.0045 0.0017
Vacuole 0.0011 0.0008 0.001 0.001 0.0016 0.0011 0.0026 0.0002 0.0023 0.0005 0.0008 0.0006 0.0021 0.0001 0.0008 0.0036 0.0028 0.001
Vacuole Periphery 0.0002 0.0001 0.0002 0.0002 0.0002 0.0003 0.001 0 0.0006 0.0003 0.0004 0.0002 0.0007 0 0.0002 0.0009 0.001 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 35.8831 22.0531 31.9849 55.5094 39.9815 58.2777 50.9304 66.0129 85.3421 64.7434
Translational Efficiency 1.8706 2.1126 1.5316 1.4509 1.8815 1.8592 1.3918 1.4331 1.4125 1.4772

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1000 237 2677 1085 1298 1970 428 1180 2298 2207 3105 2265

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1070.39 1181.07 1451.38 2048.56 1019.71 1191.25 1948.13 2217.42 1041.76 1190.16 1519.85 2136.53
Standard Deviation 200.10 235.73 302.24 636.19 184.77 247.90 388.17 773.89 193.23 246.64 358.96 716.25
Intensity Change Log 2 — 0.141958 0.439289 0.936474 — 0.224317 0.933931 1.120723 — 0.182727 0.701755 1.029305

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000357 0.000733 0.000128 0.000555 0.000363 0.000570 0.000242 0.002338 0.000360 0.000587 0.000144 0.001484
Bud Neck 0.000523 0.000993 0.000839 0.003304 0.000890 0.001697 0.001797 0.003726 0.000730 0.001622 0.000971 0.003524
Bud Site 0.004122 0.008047 0.002429 0.013277 0.006616 0.007338 0.002182 0.024018 0.005530 0.007414 0.002395 0.018872
Cell Periphery 0.000092 0.000116 0.000047 0.000506 0.000130 0.000067 0.000219 0.000442 0.000114 0.000072 0.000071 0.000472
Cytoplasm 0.848045* 0.802375* 0.760564* 0.616094* 0.786394* 0.836588* 0.571134* 0.714469* 0.813222* 0.832914* 0.734453* 0.667344*
Cytoplasmic Foci 0.040983 0.060469 0.003077 0.014819 0.059772 0.030780 0.006729 0.018594 0.051596 0.033968 0.003580 0.016786
Eisosomes 0.000009 0.000014 0.000002 0.000006 0.000017 0.000008 0.000003 0.000008 0.000014 0.000008 0.000002 0.000007
Endoplasmic Reticulum 0.001027 0.000820 0.000102 0.000434 0.003697 0.000622 0.000201 0.000405 0.002535 0.000643 0.000115 0.000419
Endosome 0.001944 0.002746 0.000281 0.005459 0.003436 0.002679 0.000248 0.006648 0.002786 0.002686 0.000276 0.006078
Golgi 0.001122 0.003135 0.000248 0.006143 0.000780 0.000903 0.000192 0.010488 0.000929 0.001143 0.000240 0.008406
Lipid Particles 0.000987 0.000878 0.000216 0.002699 0.001151 0.000577 0.000700 0.002472 0.001080 0.000609 0.000283 0.002580
Mitochondria 0.000580 0.000070 0.000207 0.001251 0.000828 0.000535 0.000268 0.000634 0.000720 0.000485 0.000216 0.000930
Mitotic Spindle 0.001450 0.010456 0.005105 0.064412 0.002579 0.010452 0.004516 0.026323 0.002088 0.010452 0.005024 0.044569
None 0.004987 0.003307 0.009096 0.013933 0.003395 0.006017 0.018797 0.010147 0.004088 0.005726 0.010433 0.011961
Nuclear Periphery 0.000086 0.000163 0.000137 0.001574 0.000194 0.000256 0.000524 0.000256 0.000147 0.000246 0.000190 0.000888
Nuclear Periphery Foci 0.004945 0.007659 0.000508 0.007087 0.006981 0.002015 0.001723 0.001695 0.006095 0.002621 0.000675 0.004278
Nucleolus 0.000145 0.000132 0.000098 0.000172 0.000357 0.000268 0.000155 0.000113 0.000264 0.000253 0.000106 0.000141
Nucleus 0.063845 0.053197 0.207008* 0.202919* 0.075143 0.065415 0.369674* 0.152628* 0.070227 0.064103 0.229430* 0.176719*
Peroxisomes 0.000315 0.000793 0.000070 0.000277 0.000236 0.000473 0.000029 0.000478 0.000271 0.000507 0.000064 0.000382
Vacuole 0.023732 0.043701 0.009771 0.042769 0.046507 0.032154 0.020608 0.021572 0.036596 0.033394 0.011265 0.031726
Vacuole Periphery 0.000705 0.000198 0.000068 0.002310 0.000535 0.000587 0.000060 0.002550 0.000609 0.000545 0.000067 0.002435

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.16 1.34 -0.91 0.84 -5.26 -0.41 -2.11 -2.01 -0.66 -1.20 -0.54 1.88 -2.22 -0.29 -3.76
Bud Neck -3.51 -6.07 -12.30 -8.12 -8.21 -3.57 -9.33 -8.91 -4.16 3.68 -4.57 -8.14 -14.57 -5.86 -7.26
Bud Site -3.45 1.60 -2.91 1.39 -4.58 -0.28 1.29 -2.51 -2.49 -4.27 -1.68 3.01 -3.46 -1.69 -6.90
Cell Periphery -1.64 2.41 -8.79 -6.86 -9.59 6.06 -8.12 -7.50 -8.76 -0.80 4.64 -1.14 -11.07 -12.28 -10.66
Cytoplasm 4.02 21.62 29.62 11.52 14.80 -5.97 24.05 12.93 19.81 -14.42 -1.65 23.26 28.27 29.02 7.72
Cytoplasmic Foci -3.24 16.28 10.42 7.19 -9.01 9.66 15.91 14.08 6.41 -3.69 7.36 25.34 17.53 10.43 -13.87
Eisosomes -2.76 7.38 2.49 3.92 -10.41 8.01 6.15 8.88 1.79 3.21 5.92 13.44 8.98 3.55 -8.41
Endoplasmic Reticulum 0.79 7.08 6.73 3.43 -1.49 3.89 4.18 4.59 4.45 5.36 4.14 5.31 5.38 4.96 1.25
Endosome -1.15 5.01 2.05 2.53 -2.41 2.00 9.76 4.96 2.59 -1.55 0.61 11.20 5.28 3.51 -3.28
Golgi -0.69 1.71 0.09 0.72 -1.93 -0.24 2.82 -1.38 -1.30 -1.89 -0.26 2.79 -1.05 -0.84 -2.74
Lipid Particles 0.01 0.97 -2.95 -4.87 -10.23 3.46 -4.71 -4.03 -5.10 -1.89 1.75 1.51 -5.11 -7.60 -7.69
Mitochondria 1.63 1.07 0.79 -3.49 -1.11 0.48 0.74 1.04 1.01 2.77 0.59 1.26 1.25 0.73 0.03
Mitotic Spindle -1.36 -4.29 -5.56 -1.52 -3.65 -4.39 -3.21 -3.83 0.70 0.21 -5.03 -4.77 -6.70 -1.21 -3.38
None 2.49 -5.74 -1.87 -3.81 1.68 -4.41 -7.23 -6.88 -1.72 4.49 -2.81 -12.56 -4.94 -2.27 4.21
Nuclear Periphery -1.43 -17.40 -4.27 -3.54 -2.81 -1.36 -14.76 -7.91 -1.81 11.83 -2.19 -15.79 -5.52 -3.18 -1.75
Nuclear Periphery Foci -1.22 10.05 2.39 1.93 -4.59 8.50 5.59 8.53 -0.65 3.31 7.33 13.77 7.48 -0.12 -5.80
Nucleolus 0.44 0.30 -1.28 -1.83 -3.81 0.27 0.56 1.24 2.73 10.35 -0.16 1.04 1.06 2.23 0.29
Nucleus 1.77 -40.16 -25.53 -21.51 3.88 1.99 -27.42 -16.74 -19.19 18.85 1.12 -47.91 -29.59 -30.47 14.80
Peroxisomes -2.44 2.78 1.23 3.09 -0.90 -2.31 7.34 1.06 2.55 -1.06 -2.45 4.47 1.61 3.26 -1.29
Vacuole -4.07 -2.13 -19.08 -7.86 -18.68 2.84 -5.39 -10.98 -13.35 -2.60 -1.30 0.77 -20.43 -18.82 -21.32
Vacuole Periphery 1.19 1.48 0.69 -1.35 -2.27 -0.06 3.31 0.26 0.29 -1.28 0.44 2.66 0.72 0.41 -2.29
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Gre3

Gre3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gre3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available