Standard name
Human Ortholog
Description SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.75 0.48 0.49 0.54 0.48 0.56 0.44 – 0.43 0.4 0.4 0.42 0.41 0.45 0.47 0.48 0.55 0.46 0.79 0.71 0.63 0.55 0.56 0.5
Bud 0.12 0.15 0.14 0.21 0.2 0.16 0.15 – 0.18 0.13 0.13 0.16 0.07 0.14 0.12 0.1 0.09 0.09 0.05 0 0.07 0.13 0.1 0.1
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.11 0.09 0.09
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.12 0.2 0.09 0.08 0.07 0.09 – 0.09 0.08 0.11 0.09 0.12 0.15 0.25 0.15 0.14 0.12 0 0 0 0 0 0
Cytoplasm 0.06 0.34 0.36 0.27 0.31 0.26 0.27 – 0.21 0.24 0.17 0.17 0.51 0.41 0.36 0.31 0.23 0.33 0 0.1 0.07 0.08 0.11 0.2
Endoplasmic Reticulum 0.06 0.17 0.1 0.17 0.09 0.2 0.19 – 0.16 0.2 0.22 0.15 0.06 0.1 0.09 0.05 0.06 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0.06 0 0.05 – 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.13 0.15 0.12 0 0 0 0 0 0
Mitochondria 0.19 0 0 0 0 0.05 0.08 – 0.2 0.17 0.44 0.27 0 0 0 0.05 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0.05 0 0.07 – 0.05 0 0 0.06 0 0.05 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0.06 0 0.06 – 0 0.05 0 0 0.05 0.06 0 0.07 0.1 0.08 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.06 0 0 – 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 12 61 34 86 98 111 131 – 121 111 89 118 33 86 103 150 186 98 61 105 81 41 130 133
Bud 2 19 10 34 41 32 44 – 50 36 29 44 6 26 26 32 32 19 3 5 8 10 23 25
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 3 0 2 7 7 8 22 23
Bud Site 0 2 0 2 2 5 1 – 7 4 8 6 0 2 1 8 7 3 – – – – – –
Cell Periphery 0 16 14 15 17 15 28 – 24 22 25 24 10 29 55 48 49 26 0 3 1 0 2 4
Cytoplasm 1 44 25 43 64 52 81 – 60 66 38 48 41 78 78 98 79 69 3 14 8 5 26 52
Endoplasmic Reticulum 1 22 7 27 18 41 57 – 46 54 49 42 5 19 19 16 19 12 0 1 3 1 1 3
Endosome 0 0 0 0 12 2 15 – 10 11 2 11 1 1 0 3 2 5 3 3 6 1 8 6
Golgi 0 3 2 2 7 1 2 – 4 5 2 6 1 1 4 41 50 26 0 1 1 0 1 0
Mitochondria 3 0 0 1 0 10 25 – 56 48 98 76 0 0 1 16 8 2 2 1 4 1 9 5
Nucleus 0 1 0 1 0 1 0 – 1 2 1 1 0 0 1 2 0 6 0 0 0 0 0 0
Nuclear Periphery 0 0 0 1 0 0 1 – 2 1 0 0 0 0 2 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 1 0 2 – 1 0 1 2 0 0 0 0 3 1 0 0 0 0 0 0
Peroxisomes 0 3 2 3 11 8 20 – 14 10 4 18 3 9 8 7 7 7 0 1 2 1 0 0
SpindlePole 0 2 1 3 12 1 18 – 9 14 1 9 4 12 8 22 34 17 0 0 0 0 1 1
Vac/Vac Membrane 0 0 2 2 13 0 5 – 6 9 1 6 1 1 0 12 15 12 0 0 0 0 2 1
Unique Cell Count 16 128 69 160 205 200 301 280 276 223 282 81 192 218 313 340 212 78 148 129 76 235 267
Labelled Cell Count 19 173 97 220 296 279 430 411 393 348 411 105 264 306 455 494 303 78 148 129 76 235 267


Actin

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.5 9.9 9.6 9.2 9.6 8.2 8.2 – 7.3 7.5 7.0 7.4 9.7 9.7 9.9 12.9 13.4 12.8 8.7 9.0 9.2
Std Deviation (1e-4) 1.1 1.5 1.6 1.5 1.7 1.5 1.5 – 1.5 1.6 1.4 1.7 1.4 1.4 1.5 2.5 2.4 2.4 1.2 1.4 1.4
Intensity Change (Log2) – – – -0.08 -0.01 -0.24 -0.23 – -0.41 -0.35 -0.47 -0.39 0.01 0.01 0.04 0.42 0.47 0.41 -0.15 -0.1 -0.07


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.6 -0.2 0.9 -0.9 – -0.9 -1.4 -1.4 -1.1 -1.0 -0.6 -0.3 -0.2 0.8 -0.4
Bud 1.2 1.0 0.3 0 – 0.7 -0.3 -0.3 0.2 -1.4 -0.2 -0.6 -1.0 -1.3 -1.3
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -2.3 -2.7 -3.0 -2.6 – -2.8 -3.0 -1.9 -2.8 -1.3 -1.0 0.8 -1.0 -1.2 -1.7
Cytoplasm -1.4 -0.8 -1.6 -1.5 – -2.6 -2.1 -3.4 -3.5 1.8 0.6 -0.1 -0.8 -2.3 -0.6
Endoplasmic Reticulum 1.3 -0.3 1.9 1.7 – 1.3 1.8 2.2 1.0 -0.9 -0.1 -0.4 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 2.4 2.7 2.3
Mitochondria 0 0 0 0 – 4.1 3.7 6.8 4.9 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 2.3 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.0953 3.4087 2.822 3.4015 1.861 3.2044 4.633 5.642 5.2213 4.8746 5.1258 5.4166 4.6398 5.01 4.4194 4.1453 4.5359 4.6068
Actin 0.7043 0.5886 0.738 0.8475 0.8296 0.854 0.6631 0.4642 0.7192 0.6562 0.7584 0.7854 0.741 0.5332 0.7324 0.7239 0.8813 0.8343
Bud 0.0018 0.0027 0.0298 0.0113 0.0062 0.0014 0.0032 0.007 0.0308 0.0333 0.0071 0.0011 0.0059 0.0076 0.0401 0.0401 0.0134 0.001
Bud Neck 0.0169 0.0055 0.0127 0.0009 0.0059 0.1035 0.0234 0.0115 0.012 0.0021 0.0024 0.1553 0.044 0.0091 0.009 0.0011 0.0281 0.1206
Bud Periphery 0.0024 0.002 0.0382 0.0593 0.0244 0.0023 0.0063 0.0127 0.064 0.1548 0.0552 0.0038 0.0077 0.0065 0.067 0.0962 0.0643 0.0031
Bud Site 0.0607 0.3045 0.0711 0.0014 0.0023 0.0016 0.0591 0.341 0.0565 0.0036 0.0016 0.0032 0.0421 0.2602 0.0237 0.0069 0.0043 0.0012
Cell Periphery 0.0017 0.0016 0.0007 0.0007 0.0003 0.0007 0.0044 0.005 0.0014 0.0011 0.0041 0.001 0.0061 0.0015 0.0015 0.0009 0.0028 0.0008
Cytoplasm 0.0174 0.0468 0.0186 0.003 0.003 0.0171 0.0373 0.1135 0.0382 0.0436 0.0048 0.0107 0.0305 0.1223 0.0536 0.0323 0.002 0.0103
Cytoplasmic Foci 0.0525 0.019 0.0127 0.0117 0.018 0.0097 0.0342 0.0136 0.0159 0.0159 0.0118 0.007 0.0305 0.021 0.0204 0.0205 0.001 0.0055
Eisosomes 0.0017 0.0009 0.0004 0.0004 0.0008 0.0007 0.0021 0.0006 0.0013 0.0009 0.007 0.001 0.0017 0.0004 0.0009 0.0006 0.0003 0.0009
Endoplasmic Reticulum 0.004 0.0009 0.0011 0.0001 0.0003 0.0005 0.0079 0.0013 0.0005 0.0005 0.0011 0.0003 0.0024 0.0014 0.0032 0.0042 0.0001 0.0017
Endosome 0.0219 0.0061 0.0058 0.0037 0.0027 0.0004 0.0424 0.0033 0.0072 0.0076 0.0428 0.0039 0.0096 0.0048 0.0102 0.0149 0.0001 0.0041
Golgi 0.0158 0.0066 0.0069 0.058 0.0109 0.0029 0.0227 0.0046 0.0138 0.0198 0.0065 0.0072 0.0114 0.0172 0.0112 0.0101 0.0011 0.0082
Lipid Particles 0.0229 0.0025 0.0089 0.0001 0.0277 0.0005 0.0274 0.0005 0.0031 0.0026 0.0161 0.0063 0.0099 0.0005 0.0039 0.0076 0 0.0015
Mitochondria 0.012 0.0043 0.0349 0.0009 0.0016 0.0003 0.0092 0.0095 0.0194 0.0476 0.0036 0.0065 0.0053 0.0005 0.0024 0.0021 0.0002 0.0008
None 0.0174 0.0031 0.002 0.0001 0.0005 0.0008 0.0134 0.0065 0.0038 0.0021 0.0009 0.0001 0.0237 0.0007 0.0062 0.005 0 0.0002
Nuclear Periphery 0.0027 0.0001 0.0003 0 0.0001 0 0.0112 0.0003 0.0002 0.0002 0.0017 0.0001 0.0056 0.0003 0.002 0.0036 0 0.0028
Nucleolus 0.0012 0.0001 0.0006 0 0 0 0.0011 0.0001 0.0001 0 0.0007 0.0001 0.0012 0 0.0004 0.0001 0 0
Nucleus 0.0015 0.0001 0.0004 0 0 0 0.0041 0.0005 0.0002 0.0002 0.0008 0.0001 0.0011 0.0003 0.0007 0.0006 0 0.0002
Peroxisomes 0.0318 0.0038 0.0153 0.0008 0.064 0.0034 0.0157 0.003 0.0112 0.0066 0.0641 0.006 0.0148 0.012 0.0075 0.0248 0.0009 0.002
Punctate Nuclear 0.0074 0.0002 0.0005 0 0.0013 0.0001 0.0036 0.0003 0.0004 0.0001 0.0005 0.0001 0.0037 0.0003 0.0022 0.0023 0 0.0004
Vacuole 0.0012 0.0005 0.0007 0 0.0001 0 0.006 0.0008 0.0006 0.0005 0.0067 0.0006 0.0009 0.0002 0.001 0.0016 0.0001 0.0001
Vacuole Periphery 0.0009 0.0001 0.0004 0 0.0001 0 0.0021 0.0002 0.0003 0.0005 0.002 0.0003 0.0009 0.0001 0.0003 0.0006 0 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 24.6555 16.0766 18.4715 25.4603 28.9582 19.1336 25.6934 29.0202 28.5416 27.5424
Translational Efficiency 1.2438 1.703 1.3537 0.9433 0.9443 1.586 0.9498 0.8001 0.8878 0.9953

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1370 1327 1070 866 2442 1119 2280 45 3812 2446 3350 911

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 703.27 965.21 1292.44 1108.26 927.89 943.26 1144.59 1078.53 847.16 955.17 1191.81 1106.79
Standard Deviation 102.10 140.43 186.67 172.79 114.94 135.92 152.28 162.25 154.36 138.82 177.95 172.41
Intensity Change Log 2 — 0.456764 0.877947 0.656146 — 0.023702 0.302805 0.217041 — 0.226518 0.579226 0.422916

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.561366* 0.726622* 0.538374* 0.747793* 0.687006* 0.631949* 0.594860* 0.475583* 0.641852* 0.683310* 0.576818* 0.734346*
Bud Neck 0.017456 0.013543 0.019615 0.010901 0.029910 0.022221 0.016535 0.016187 0.025434 0.017513 0.017519 0.011162
Bud Site 0.077382 0.118576* 0.282982* 0.110647* 0.151820* 0.188148* 0.313458* 0.072674 0.125067* 0.150404* 0.303724* 0.108771*
Cell Periphery 0.012942 0.007460 0.004873 0.043384 0.018090 0.018981 0.007468 0.009064 0.016240 0.012731 0.006639 0.041689
Cytoplasm 0.040881 0.040650 0.030595 0.011157 0.035537 0.038681 0.043183 0.012733 0.037458 0.039749 0.039162 0.011235
Cytoplasmic Foci 0.060059 0.018623 0.021771 0.002403 0.016891 0.020032 0.002868 0.070401 0.032405 0.019268 0.008906 0.005762
Eisosomes 0.019448 0.006876 0.003834 0.042846 0.011742 0.007626 0.002656 0.030598 0.014511 0.007219 0.003032 0.042241
Endoplasmic Reticulum 0.000832 0.000400 0.004346 0.003189 0.000218 0.001259 0.000547 0.020517 0.000439 0.000793 0.001760 0.004045
Endosome 0.007320 0.007440 0.022511 0.004494 0.001773 0.006087 0.001576 0.049417 0.003767 0.006821 0.008263 0.006714
Golgi 0.019136 0.010857 0.011454 0.004722 0.004487 0.011622 0.001251 0.039347 0.009751 0.011207 0.004510 0.006432
Lipid Particles 0.007747 0.001760 0.015526 0.001751 0.001189 0.001952 0.000525 0.101815* 0.003546 0.001848 0.005316 0.006694
Mitochondria 0.011645 0.002547 0.000883 0.003645 0.002454 0.006643 0.000876 0.000398 0.005757 0.004421 0.000879 0.003484
Mitotic Spindle 0.000200 0.000663 0.005224 0.000823 0.000302 0.001762 0.000930 0.002200 0.000265 0.001166 0.002302 0.000891
None 0.000365 0.000028 0.000017 0.000043 0.000090 0.000041 0.000030 0.000012 0.000189 0.000034 0.000026 0.000042
Nuclear Periphery 0.000039 0.000002 0.000048 0.000033 0.000002 0.000005 0.000005 0.000042 0.000016 0.000003 0.000019 0.000034
Nuclear Periphery Foci 0.000106 0.000037 0.000447 0.000146 0.000028 0.000046 0.000026 0.001220 0.000056 0.000041 0.000160 0.000199
Nucleolus 0.000252 0.000004 0.000011 0.000005 0.000005 0.000007 0.000002 0.000019 0.000094 0.000005 0.000005 0.000006
Nucleus 0.002649 0.000189 0.000627 0.000159 0.000407 0.000196 0.000195 0.000525 0.001213 0.000192 0.000333 0.000177
Peroxisomes 0.159142* 0.041615 0.021502 0.004143 0.036824 0.039949 0.010737 0.069757 0.080784 0.040853 0.014175 0.007384
Vacuole 0.000816 0.001707 0.015081 0.005246 0.001163 0.002397 0.002171 0.027225 0.001038 0.002023 0.006295 0.006331
Vacuole Periphery 0.000218 0.000402 0.000280 0.002470 0.000061 0.000397 0.000101 0.000266 0.000117 0.000400 0.000158 0.002361

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -12.22 2.80 -12.45 -1.25 -14.15 4.30 9.22 3.67 2.71 2.04 -4.51 8.52 -7.23 -3.67 -12.88
Bud Neck 1.74 -0.67 3.10 1.35 3.82 2.70 6.09 1.65 0.71 0.01 4.25 4.93 7.62 3.51 3.82
Bud Site -5.34 -18.27 -3.94 0.80 13.89 -3.74 -18.73 3.58 5.02 10.69 -4.05 -25.99 2.03 4.87 21.78*
Cell Periphery 3.76 5.90 -7.57 -9.24 -10.01 -0.37 7.92 2.51 2.50 -0.44 2.59 9.65 -6.78 -7.64 -9.58
Cytoplasm 0.04 0.22 7.83 7.40 6.83 -0.92 -3.42 4.71 4.86 6.63 -0.87 -2.66 9.32 8.97 10.81
Cytoplasmic Foci 10.61 8.94 16.31 8.67 10.30 -1.28 9.66 -2.29 -2.14 -2.87 6.24 13.11 12.76 6.83 2.51
Eisosomes 6.71 8.48 -5.26 -8.65 -9.44 3.47 10.95 -1.10 -1.35 -1.65 7.40 13.57 -6.83 -8.72 -9.86
Endoplasmic Reticulum 1.24 -3.87 -2.63 -3.38 0.98 -1.43 -1.88 -1.85 -1.75 -1.82 -0.96 -4.13 -3.74 -3.22 -2.28
Endosome -0.10 -6.03 1.93 1.96 6.88 -4.74 0.34 -3.39 -3.08 -3.40 -4.10 -5.11 -2.21 0.02 0.92
Golgi 4.12 3.91 6.85 3.24 3.17 -4.77 5.36 -2.44 -1.92 -2.68 -1.28 6.52 2.03 2.68 -1.27
Lipid Particles 4.63 -3.07 4.46 -0.07 5.88 -1.06 1.97 -3.02 -3.00 -3.04 2.73 -2.10 -1.66 -2.56 -0.66
Mitochondria 7.00 8.99 4.28 -0.69 -1.87 -2.81 3.28 4.06 4.36 1.92 1.51 9.14 1.55 0.61 -1.87
Mitotic Spindle -1.10 -3.68 -1.98 -0.41 3.18 -1.55 -1.96 -1.13 -0.36 -0.79 -1.83 -4.16 -1.98 0.33 2.50
None 5.36 5.37 5.05 -1.38 -1.40 4.00 4.32 6.81 4.49 2.19 6.48 6.51 5.70 -0.72 -0.99
Nuclear Periphery 1.58 -0.62 0.19 -2.91 0.96 -1.50 -2.76 -1.86 -1.76 -1.69 1.46 -0.70 -1.41 -2.98 -0.81
Nuclear Periphery Foci 1.37 -4.37 -0.35 -2.50 4.47 -1.16 -0.81 -2.28 -2.24 -2.26 0.94 -4.17 -2.56 -3.23 0.45
Nucleolus 1.89 1.80 1.87 -1.06 2.89 -0.79 3.82 -1.85 -1.48 -2.26 1.87 1.85 1.85 -0.38 -0.03
Nucleus 2.85 1.29 2.84 -0.09 3.15 3.06 2.18 -0.58 -1.46 -1.20 3.24 1.71 3.17 -0.48 3.21
Peroxisomes 18.13* 21.98 26.31* 12.59 7.05 -0.85 11.17 -1.39 -1.25 -2.52 11.77 23.36 24.19 13.00 3.78
Vacuole -1.74 -8.08 -3.46 -3.00 5.01 -1.96 -3.41 -2.08 -2.00 -1.89 -2.43 -8.62 -3.90 -3.38 0.94
Vacuole Periphery -0.79 -0.64 -2.14 -1.93 -2.08 -2.23 -0.72 -1.36 0.61 -1.03 -1.99 -0.83 -2.25 -1.95 -2.21
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins
Localization
Cell Percentages actin (86%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Bzz1

Bzz1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Bzz1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available