Standard name
Human Ortholog
Description Component of the CCR4-NOT core complex, involved in mRNA decapping; involved in transcription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.05 0 0.05 0.05 0.05 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.96 0.96 0.94 0.88 0.89 0.85 0.78 – 0.6 0.49 0.53 0.59 0.97 0.96 0.97 0.89 0.9 0.85 0.95 0.93 0.9 0.69 0.74 0.8
Endoplasmic Reticulum 0 0 0.05 0 0.09 0 0 – 0 0 0 0.06 0 0 0 0 0 0.05 0 0 0 0.21 0.2 0.13
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.19 0.17 – 0.47 0.51 0.52 0.34 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.05 – 0.06 0.07 0.05 0.1 0 0 0 0.13 0.07 0.12 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 1 2 4 – 2 2 0 5 1 0 0 0 0 1 0 0 1 1 0 0
Bud 0 1 1 0 0 0 3 – 2 1 4 0 3 2 1 0 0 1 0 1 1 0 1 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 12 7 10 3 6 2 7 – 8 5 5 4 4 5 6 6 4 4 0 0 0 0 0 0
Cytoplasm 241 323 175 58 108 124 165 – 107 86 70 96 328 351 349 152 118 94 251 316 190 198 259 270
Endoplasmic Reticulum 2 12 9 1 11 4 6 – 2 4 5 10 7 14 7 5 4 6 4 7 6 60 70 44
Endosome 0 0 0 0 0 0 4 – 0 0 0 1 0 0 1 0 0 1 1 1 1 1 0 0
Golgi 0 1 0 1 0 0 1 – 0 0 0 0 0 0 0 0 0 0 0 2 1 1 0 1
Mitochondria 2 0 0 1 1 28 35 – 84 89 69 56 4 1 7 3 4 3 0 1 4 4 4 3
Nucleus 4 0 0 0 1 3 1 – 2 3 4 5 1 0 1 2 2 1 0 1 0 0 0 2
Nuclear Periphery 0 0 0 0 0 0 0 – 1 2 0 1 1 0 0 0 1 0 1 0 0 2 0 1
Nucleolus 0 0 0 0 0 0 0 – 2 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 2 1 2 4 3 10 – 10 12 6 16 0 5 0 23 9 13 3 7 3 8 7 8
Unique Cell Count 252 335 186 66 121 146 212 178 174 132 163 339 367 359 171 131 110 264 339 212 286 352 339
Labelled Cell Count 261 346 196 67 132 166 236 222 205 164 194 349 378 372 191 142 124 264 339 212 286 352 339


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 13.9 13.2 11.0 9.8 9.5 7.6 8.2 – 6.9 6.0 6.2 6.6 10.6 11.1 10.8 15.3 15.7 13.2 10.7 10.9 11.5
Std Deviation (1e-4) 2.3 2.5 1.4 1.6 1.4 1.3 1.4 – 1.4 1.1 1.2 1.3 1.6 1.6 1.6 3.8 3.9 4.1 1.5 1.8 1.7
Intensity Change (Log2) – – – -0.16 -0.2 -0.52 -0.42 – -0.67 -0.88 -0.83 -0.73 -0.05 0.02 -0.02 0.48 0.52 0.26 -0.03 -0.01 0.07


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 -0.2 -1.9 -1.0 – -0.4 -1.2 -0.7 -1.4 0 -2.7 -2.4 -0.9 -1.0 -0.7
Cytoplasm -1.6 -1.5 -2.8 -4.6 – -7.8 -9.5 -8.6 -7.9 1.5 0.8 1.8 -1.8 -1.3 -2.5
Endoplasmic Reticulum 0 1.5 -1.0 -1.0 – -2.1 -1.3 -0.5 0.5 -1.8 -0.6 -1.9 -0.9 -0.8 0.2
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 6.2 5.8 – 10.7 11.2 11.1 8.7 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 2.5 – 2.8 3.2 0 4.0 0 0 0 4.9 0 4.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.2665 10.7277 9.6079 9.4311 9.0232 9.801 8.0062 10.6956 9.345 9.4641 8.5451 9.9153 8.1731 10.1436 9.3261 9.1713 8.6734 9.5077
Actin 0.0137 0.0006 0.0122 0.001 0.0005 0.0011 0.0208 0.0019 0.005 0.0373 0.003 0.002 0.0085 0.0003 0.0009 0.0004 0.001 0.0015
Bud 0.0009 0.0004 0.0007 0.0026 0.0007 0.0005 0.001 0.0006 0.0018 0.0009 0.0009 0.0005 0.0004 0.0003 0.0004 0.0005 0.0002 0.0002
Bud Neck 0.0008 0.0003 0.0009 0.0011 0.0011 0.0012 0.0022 0.0006 0.0026 0.001 0.0007 0.0012 0.0029 0.0002 0.0005 0.0013 0.0007 0.0009
Bud Periphery 0.0012 0.0002 0.0006 0.0023 0.0002 0.0008 0.0013 0.0005 0.0015 0.0007 0.0008 0.0004 0.0004 0.0002 0.0003 0.0003 0.0002 0.0001
Bud Site 0.0016 0.0013 0.0014 0.0021 0.0005 0.0002 0.0021 0.0034 0.0028 0.0025 0.0003 0.0001 0.0012 0.0007 0.0007 0.0001 0.0001 0.0001
Cell Periphery 0.0011 0.0003 0.0009 0.0008 0.0001 0.0006 0.0007 0.0015 0.0004 0.0003 0.0001 0.0001 0.0005 0.0017 0.0004 0.0002 0.0001 0.0001
Cytoplasm 0.6153 0.9111 0.7805 0.7682 0.8418 0.8112 0.6447 0.9313 0.8148 0.7122 0.7862 0.8031 0.7576 0.9188 0.8472 0.8118 0.8608 0.8668
Cytoplasmic Foci 0.0404 0.0098 0.021 0.0267 0.0253 0.0211 0.025 0.0092 0.0216 0.0244 0.0218 0.0163 0.0148 0.0111 0.0167 0.015 0.0134 0.0131
Eisosomes 0.0005 0 0.0006 0 0 0 0.0001 0.0001 0 0.0001 0 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0951 0.0333 0.0351 0.0437 0.0129 0.0527 0.081 0.0143 0.0279 0.0138 0.0134 0.0667 0.098 0.0265 0.0414 0.0301 0.0305 0.0426
Endosome 0.1084 0.0269 0.0652 0.1012 0.0793 0.0691 0.0998 0.0183 0.067 0.1123 0.068 0.0685 0.0609 0.0255 0.0557 0.0919 0.0545 0.0454
Golgi 0.0164 0.0028 0.0104 0.0064 0.0057 0.0086 0.0165 0.0028 0.0094 0.0113 0.0259 0.0075 0.0063 0.0023 0.0058 0.0029 0.0024 0.0039
Lipid Particles 0.0116 0.0001 0.0074 0.0003 0.0002 0.0021 0.006 0.0003 0.0011 0.0021 0.0166 0.0006 0.0023 0.0003 0.0007 0.0001 0.0009 0.0009
Mitochondria 0.0217 0.0013 0.014 0.0084 0.0078 0.0119 0.0185 0.0032 0.0053 0.0021 0.0098 0.0071 0.0041 0.0013 0.0051 0.0022 0.0018 0.0104
None 0.0126 0.0013 0.0111 0.004 0.0009 0.0015 0.0037 0.0006 0.0009 0.0009 0.001 0.0009 0.0025 0.0007 0.001 0.0007 0.0015 0.001
Nuclear Periphery 0.013 0.0018 0.0099 0.0026 0.0021 0.0016 0.0216 0.0009 0.0043 0.0033 0.0233 0.005 0.0099 0.0013 0.0027 0.0021 0.0163 0.0033
Nucleolus 0.0004 0 0.0007 0.0001 0 0 0.0009 0 0.0001 0.0001 0.0009 0 0.0002 0 0.0001 0 0.0001 0
Nucleus 0.0044 0.001 0.0027 0.0021 0.0015 0.001 0.011 0.0011 0.0021 0.0022 0.0027 0.0101 0.0032 0.0009 0.0014 0.0013 0.0041 0.0014
Peroxisomes 0.0076 0.0001 0.0022 0.0002 0.0003 0.0052 0.0028 0.0001 0.0007 0.0034 0.0025 0.0002 0.0062 0.0001 0.0005 0.0001 0.0001 0.0006
Punctate Nuclear 0.0058 0.0001 0.0008 0.0002 0.0001 0.0006 0.0027 0.0001 0.0007 0.0026 0.0136 0.0002 0.0043 0.0001 0.0002 0.0001 0.001 0.0003
Vacuole 0.0206 0.0057 0.0182 0.0213 0.0148 0.0062 0.0301 0.008 0.0257 0.0551 0.0053 0.0062 0.0133 0.0063 0.0155 0.0312 0.0074 0.0052
Vacuole Periphery 0.007 0.0015 0.0036 0.0045 0.0042 0.0029 0.0074 0.0013 0.0044 0.0112 0.0031 0.0033 0.0028 0.0013 0.0027 0.0079 0.0028 0.0021

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 28.3431 20.8196 30.898 37.3864 31.9053 21.0809 28.0013 30.158 29.5954 33.8051
Translational Efficiency 2.3213 2.4197 1.6716 1.2938 1.8418 2.7083 1.3477 1.3643 1.2895 1.3211

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2007 1270 198 1235 1974 1753 2286 484 3981 3023 2484 1719

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1081.72 1241.39 1576.62 1332.74 999.56 1201.43 1244.67 1305.40 1040.98 1218.22 1271.13 1325.04
Standard Deviation 148.32 212.94 191.91 190.00 195.04 179.57 194.92 197.66 177.88 195.29 214.44 192.58
Intensity Change Log 2 — 0.198629 0.543508 0.301068 — 0.265388 0.316398 0.385127 — 0.231076 0.438884 0.342050

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000202 0.000441 0.001727 0.001258 0.000162 0.000285 0.000117 0.001426 0.000183 0.000351 0.000245 0.001305
Bud Neck 0.000545 0.000604 0.007019 0.001734 0.001208 0.000410 0.001698 0.002103 0.000873 0.000492 0.002122 0.001838
Bud Site 0.024880 0.039137 0.048394 0.035039 0.018520 0.024613 0.010983 0.044766 0.021727 0.030714 0.013965 0.037777
Cell Periphery 0.000339 0.000680 0.001442 0.000940 0.000221 0.000258 0.000173 0.001190 0.000280 0.000436 0.000274 0.001011
Cytoplasm 0.682116* 0.676527* 0.567015* 0.751985* 0.580233* 0.701517* 0.575613* 0.780879* 0.631597* 0.691018* 0.574928* 0.760120*
Cytoplasmic Foci 0.191533* 0.173753 0.114633 0.068470 0.225364* 0.184431* 0.056172 0.069196 0.208308* 0.179945 0.060832 0.068675
Eisosomes 0.000010 0.000008 0.000014 0.000009 0.000016 0.000007 0.000006 0.000013 0.000013 0.000008 0.000006 0.000010
Endoplasmic Reticulum 0.013318 0.016690 0.010607 0.002003 0.015037 0.005560 0.004521 0.000639 0.014171 0.010236 0.005006 0.001619
Endosome 0.008215 0.011280 0.030127 0.009000 0.019004 0.008662 0.015922 0.006075 0.013565 0.009762 0.017054 0.008177
Golgi 0.022023 0.025307 0.019017 0.011633 0.022018 0.030115 0.004496 0.011238 0.022020 0.028095 0.005653 0.011522
Lipid Particles 0.001037 0.002101 0.015685 0.005754 0.002228 0.001258 0.002397 0.008248 0.001627 0.001612 0.003456 0.006456
Mitochondria 0.002215 0.000599 0.000039 0.001023 0.003183 0.001715 0.000548 0.001527 0.002695 0.001246 0.000508 0.001165
Mitotic Spindle 0.000422 0.001418 0.013009 0.004866 0.001478 0.001370 0.001796 0.002938 0.000946 0.001390 0.002689 0.004323
None 0.000502 0.000172 0.000174 0.000132 0.001135 0.000213 0.000359 0.001736 0.000816 0.000196 0.000344 0.000583
Nuclear Periphery 0.000042 0.000052 0.000458 0.000046 0.000261 0.000024 0.000310 0.000067 0.000150 0.000036 0.000322 0.000052
Nuclear Periphery Foci 0.000378 0.001384 0.015970 0.001361 0.000879 0.000371 0.001102 0.002613 0.000627 0.000796 0.002287 0.001714
Nucleolus 0.000090 0.000031 0.000069 0.000105 0.000328 0.000110 0.000240 0.000072 0.000208 0.000077 0.000227 0.000095
Nucleus 0.001821 0.001409 0.007975 0.002836 0.004706 0.001486 0.011112 0.002426 0.003251 0.001454 0.010862 0.002720
Peroxisomes 0.000320 0.000386 0.000648 0.001105 0.000491 0.000413 0.000455 0.001732 0.000405 0.000402 0.000471 0.001281
Vacuole 0.019724 0.026830 0.137977 0.091902 0.063903 0.015967 0.298270* 0.056187 0.041630 0.020531 0.285493* 0.081846
Vacuole Periphery 0.030269 0.021191 0.008003 0.008797 0.039624 0.021215 0.013710 0.004931 0.034908 0.021205 0.013255 0.007708

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.78 -6.13 -2.62 -2.04 0.95 -3.62 2.75 -6.58 -5.89 -6.81 -6.39 -2.63 -3.79 -3.23 -3.56
Bud Neck -0.70 -8.54 -9.58 -8.34 7.07 8.07 -2.85 -5.28 -9.96 -2.22 6.02 -7.78 -9.32 -13.10 1.55
Bud Site -6.18 -4.75 -4.33 1.47 2.58 -4.30 6.94 -8.37 -6.12 -11.00 -6.98 7.53 -8.60 -3.29 -12.57
Cell Periphery -5.36 -4.50 -3.61 -1.29 1.67 -1.58 3.11 -6.85 -6.51 -7.25 -5.09 0.87 -5.85 -4.40 -5.95
Cytoplasm 0.56 6.19 -6.90 -6.59 -9.12 -12.77 0.56 -15.41 -5.47 -15.73 -8.60 7.34 -16.35 -7.94 -20.60
Cytoplasmic Foci 2.66 9.29 23.96 18.25 6.18 6.27 34.93 25.25 18.25 -3.33 6.06 41.15 35.78 26.79 -2.92
Eisosomes 2.48 -3.17 1.20 -0.82 3.84 6.85 8.23 1.63 -5.06 -6.49 7.20 8.73 3.04 -3.51 -5.11
Endoplasmic Reticulum -1.54 1.65 8.96 7.73 3.26 6.40 7.45 10.77 7.72 6.77 3.15 9.15 13.24 9.35 5.05
Endosome -3.80 -7.28 -0.87 2.76 6.98 11.36 3.46 12.02 3.02 9.50 6.32 -3.69 8.46 2.82 10.62
Golgi -2.52 2.43 8.32 9.06 2.15 -4.93 20.16 5.09 7.53 -2.68 -5.55 24.06 9.87 12.28 -4.88
Lipid Particles -5.17 -7.98 -11.75 -8.37 5.28 1.98 -0.65 -6.37 -6.80 -6.28 0.05 -8.02 -12.06 -10.36 -7.05
Mitochondria 8.22 11.79 2.45 -0.73 -1.90 4.24 7.79 1.53 0.29 -0.74 7.07 9.42 3.23 0.36 -1.18
Mitotic Spindle -2.28 -6.22 -3.94 -2.91 3.73 0.19 -0.90 -0.96 -1.07 -0.55 -1.29 -4.11 -3.64 -3.17 -1.32
None 4.80 4.08 4.99 0.90 1.59 3.90 3.08 -0.29 -0.93 -0.83 5.07 3.16 0.66 -0.83 -0.46
Nuclear Periphery -0.40 -2.41 -0.42 0.07 2.37 3.00 -0.59 2.29 -1.36 5.35 2.78 -3.32 2.27 -1.28 7.48
Nuclear Periphery Foci -3.41 -5.57 -8.90 -0.46 5.15 3.07 -1.08 -5.62 -7.56 -4.94 -1.11 -5.77 -8.52 -6.25 1.15
Nucleolus 1.65 0.20 -0.35 -7.82 -1.65 2.59 1.32 4.11 0.70 8.13 2.71 -0.51 3.11 -0.53 6.93
Nucleus 1.95 -5.73 -4.18 -5.61 4.72 5.64 -7.37 3.91 -3.23 10.39 5.60 -10.36 0.18 -5.40 10.43
Peroxisomes -2.37 -5.40 -10.14 -9.04 -3.83 1.73 1.05 -4.61 -4.85 -4.73 0.11 -2.33 -9.08 -8.92 -8.18
Vacuole -3.18 -10.41 -18.55 -15.85 4.12 17.05 -35.46 -0.81 -10.20 29.17 11.86 -41.39 -13.49 -20.27 29.83
Vacuole Periphery 4.55 12.53 13.66 7.66 -0.92 8.52 13.97 15.98 9.36 5.83 9.37 17.35 20.83 11.85 5.56
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the CCR4-NOT core complex, involved in mRNA decapping; involved in transcription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-5

Not3

Not3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Not3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available