Standard name
Human Ortholog
Description Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication; although Air1p and Air2p are homologous TRAMP subunits, they have nonredundant roles in regulation of substrate specificity of the exosome
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.07 0.05 0.07 0.09 0.16 0.21 0.23 0.26 0.28 0.24 0.29 0.05 0.11 0.16 0 0.1 0.16 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0.09 0.16 0.05 0 0 0.06 0 0 0 0.11 0.16
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.26 0.11 0.09 0.09 0.06 0.31 0.55 0.54 0.6 0.6 0.73 0.57 0 0 0 0 0.05 0.05 0 0 0 0 0 0
Nucleus 0.62 0.47 0.82 0.59 0.7 0.55 0.37 0.34 0.28 0.25 0.26 0.26 0.73 0.52 0.41 0.47 0.65 0.6 0.43 0.54 0.49 0.43 0.26 0.16
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.23 0.36 0.09 0.21 0 0 0 0 0 0 0 0 0.17 0.27 0.31 0.24 0.25 0.08 0.28 0.22 0.12 0.25 0.21 0.21
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0.23 0.09 0 0 0 0 0 0 0 0.08 0.27 0.26 0 0 0 0.06 0.05 0.1 0 0.14 0.14
Vac/Vac Membrane 0.06 0.11 0 0 0.09 0.09 0.06 0 0 0.05 0 0 0 0 0 0.24 0.1 0.15 0.06 0.08 0.14 0.15 0.19 0.17
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 2 0 0 1 0 0
Bud 0 1 0 1 3 1 6 12 9 15 14 14 0 0 0 0 0 0 3 0 0 2 5 5
Bud Neck 0 0 0 2 2 4 2 1 3 5 0 6 1 1 1 0 0 0 1 0 0 2 3 8
Bud Site 1 0 0 2 2 4 5 3 11 19 14 10 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0
Cytoplasm 7 3 1 23 53 65 134 110 142 186 123 146 14 43 78 1 2 15 1 2 0 1 4 8
Endoplasmic Reticulum 1 0 0 1 0 1 0 0 0 0 0 0 0 0 0 2 1 2 0 0 0 1 2 0
Endosome 0 0 0 19 23 8 9 3 8 4 1 2 10 35 75 2 0 1 13 3 3 5 42 59
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 2 0 0 1 0 1
Mitochondria 48 5 2 29 35 126 346 260 321 391 367 280 3 2 1 0 1 5 6 0 0 1 6 13
Nucleus 114 21 18 190 399 222 232 161 153 166 132 130 188 203 195 18 13 55 94 44 38 73 100 62
Nuclear Periphery 0 0 0 0 0 0 0 1 1 3 1 2 0 0 0 0 0 0 1 0 1 1 2 4
Nucleolus 43 16 2 69 15 3 6 7 3 1 3 1 44 103 151 9 5 7 61 18 9 42 81 78
Peroxisomes 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1
SpindlePole 1 1 0 75 53 15 23 20 21 19 19 22 20 104 126 1 0 2 12 3 8 6 55 54
Vac/Vac Membrane 11 5 0 5 50 37 39 19 20 33 21 19 8 4 9 9 2 14 13 6 11 25 72 65
Unique Cell Count 184 45 22 321 572 402 634 480 539 655 505 495 257 388 480 38 20 92 219 82 78 170 385 379
Labelled Cell Count 226 52 23 416 635 487 802 597 692 842 695 634 289 498 636 42 24 101 219 82 78 170 385 379


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.8 5.3 5.4 6.0 5.6 4.4 3.9 4.2 3.8 3.8 3.5 3.8 6.9 6.8 6.4 8.4 7.4 8.5 6.2 6.5 6.5
Std Deviation (1e-4) 0.9 0.9 1.4 1.3 1.2 1.3 1.1 1.4 1.7 2.0 1.7 1.4 1.0 1.2 1.3 1.6 1.3 1.6 1.7 1.2 1.1
Intensity Change (Log2) – – – 0.15 0.05 -0.3 -0.46 -0.38 -0.52 -0.5 -0.62 -0.53 0.34 0.32 0.24 0.63 0.44 0.64 0.2 0.26 0.27

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 2.3 2.5 2.1 2.5 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus -2.1 -1.2 -2.5 -4.3 -4.6 -5.3 -5.9 -5.7 -5.6 -0.9 -2.7 -3.8 -2.6 -1.2 -1.9
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 1.8 2.2 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 2.8 2.8 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.3511 3.7704 3.4862 3.1919 2.9642 3.4558 1.6834 2.5934 2.1995 1.4428 2.1314 2.0553 1.6292 2.2805 1.5905 1.9247 1.3813 1.3155
Actin 0.0032 0 0.0008 0.0002 0.0004 0.001 0.009 0.0001 0.007 0.0361 0.0022 0.0002 0.0218 0 0.0009 0.0007 0.0014 0.0003
Bud 0.0002 0.0001 0.0002 0.0001 0.0002 0.0001 0.0003 0.0002 0.0003 0.0005 0.0001 0.0001 0.0009 0.0008 0.0003 0.0008 0.0005 0.0002
Bud Neck 0.0023 0.0013 0.0023 0.0017 0.0043 0.0046 0.003 0.0015 0.0018 0.0159 0.0007 0.0044 0.0031 0.0028 0.0022 0.0089 0.0025 0.0077
Bud Periphery 0.0004 0.0002 0.0004 0.0002 0.0004 0.0003 0.0007 0.0005 0.0007 0.0018 0.0002 0.0004 0.0015 0.0012 0.0006 0.0012 0.0014 0.0007
Bud Site 0.0016 0.0023 0.0015 0.0007 0.001 0.0005 0.0017 0.0023 0.002 0.0018 0.0012 0.0007 0.0117 0.0022 0.0047 0.0218 0.0023 0.0011
Cell Periphery 0.0005 0.0002 0.0003 0.0001 0.0001 0.0002 0.0003 0.0003 0.0003 0.0005 0.0001 0.0002 0.0006 0.0008 0.0006 0.001 0.0004 0.0005
Cytoplasm 0.0022 0.0006 0.0007 0.0008 0.0013 0.0004 0.0008 0.0032 0.0011 0.0002 0.0004 0.0018 0.0093 0.001 0.0017 0.0006 0.0006 0.0005
Cytoplasmic Foci 0.0068 0.0006 0.0018 0.0004 0.0012 0.0003 0.013 0.0035 0.0043 0.0066 0.0136 0.0003 0.0136 0.0004 0.0044 0.0086 0.0078 0.0009
Eisosomes 0.0001 0 0 0 0 0 0.0001 0 0.0001 0.0001 0 0 0.0015 0 0 0 0.0001 0
Endoplasmic Reticulum 0.0013 0.0004 0.0001 0.0001 0.0005 0.0003 0.0004 0.0004 0.0007 0.0001 0.0007 0.0025 0.0017 0.0002 0.0003 0.0002 0.0002 0.0001
Endosome 0.0074 0.0023 0.0038 0.0005 0.0047 0.0018 0.0097 0.0033 0.0091 0.0048 0.006 0.0048 0.0213 0.0009 0.0093 0.003 0.0423 0.003
Golgi 0.0017 0.0002 0.0012 0.0001 0.0005 0.0004 0.0035 0.0003 0.0018 0.0089 0.0053 0.0003 0.0099 0.0001 0.0034 0.0021 0.011 0.0022
Lipid Particles 0.0106 0.0054 0.0034 0.0005 0.0027 0.0009 0.0168 0.0039 0.0071 0.0682 0.036 0.0006 0.015 0.0019 0.0069 0.0049 0.022 0.0007
Mitochondria 0.0046 0.0002 0.0005 0.0003 0.0006 0.0016 0.0025 0.0004 0.0059 0.0033 0.0022 0.0004 0.0224 0.0003 0.0098 0.0012 0.0775 0.0058
None 0.0032 0.0003 0.0003 0.0005 0.0006 0.0008 0.0005 0.0008 0.0017 0.0002 0.0003 0.001 0.0101 0.0001 0.0008 0.0002 0.0003 0.0001
Nuclear Periphery 0.0113 0.0055 0.0032 0.0041 0.036 0.0037 0.0033 0.0079 0.006 0.0008 0.0809 0.0039 0.0078 0.0039 0.0047 0.0024 0.014 0.0081
Nucleolus 0.4339 0.5232 0.615 0.5444 0.3407 0.4925 0.36 0.3307 0.4901 0.3552 0.1908 0.3836 0.3492 0.3783 0.5556 0.4143 0.1537 0.4106
Nucleus 0.4534 0.4366 0.3471 0.399 0.543 0.4664 0.5418 0.6172 0.4423 0.4755 0.6302 0.5849 0.4498 0.587 0.3714 0.5114 0.6426 0.5388
Peroxisomes 0.0099 0.0001 0.0005 0.0001 0.0005 0.0002 0.0065 0.0004 0.0014 0.0131 0.0227 0.0001 0.0172 0.0001 0.0065 0.0047 0.0026 0.0005
Punctate Nuclear 0.0424 0.015 0.0134 0.0456 0.0586 0.022 0.0197 0.0171 0.0114 0.0041 0.0043 0.0077 0.0176 0.0034 0.0073 0.0023 0.0083 0.014
Vacuole 0.0021 0.0049 0.003 0.0005 0.0019 0.0015 0.0055 0.0048 0.0035 0.0019 0.0007 0.0019 0.0103 0.0118 0.0072 0.0085 0.0052 0.0035
Vacuole Periphery 0.001 0.0005 0.0003 0.0001 0.0008 0.0004 0.0008 0.0011 0.0014 0.0004 0.0013 0.0003 0.0037 0.0027 0.0012 0.0012 0.0032 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 23.9428 22.7695 25.006 20.9155 26.4194 20.3655 19.1085 15.2277 14.7619 23.075
Translational Efficiency 1.8091 1.7065 1.2098 1.1519 1.336 1.3158 1.2697 1.2102 1.4135 1.3211

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
27 791 1318 889 1758 2237 114 1046 1785 3028 1432 1935

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 871.08 726.00 874.79 899.89 740.26 843.66 1029.49 970.27 742.24 812.92 887.11 937.94
Standard Deviation 348.48 102.46 123.54 138.26 105.47 111.67 126.57 129.81 114.23 120.94 130.68 138.28
Intensity Change Log 2 — -0.262836 0.006132 0.046943 — 0.188630 0.475826 0.390354 — -0.037809 0.240985 0.214901

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003015 0.000943 0.001001 0.000798 0.000247 0.000373 0.001835 0.001167 0.000289 0.000522 0.001068 0.000997
Bud Neck 0.009274 0.009562 0.027422 0.026898 0.005712 0.012762 0.013794 0.058329 0.005766 0.011926 0.026337 0.043889
Bud Site 0.028084 0.002377 0.002638 0.004737 0.000573 0.002241 0.011080 0.010766 0.000989 0.002277 0.003310 0.007996
Cell Periphery 0.000368 0.000195 0.000068 0.000091 0.000067 0.000076 0.000077 0.000089 0.000072 0.000107 0.000069 0.000090
Cytoplasm 0.084247 0.031222 0.006888 0.017594 0.014866 0.010317 0.006299 0.004513 0.015916 0.015778 0.006841 0.010523
Cytoplasmic Foci 0.033375 0.004569 0.000182 0.001016 0.002106 0.002482 0.002215 0.001462 0.002579 0.003028 0.000344 0.001257
Eisosomes 0.000114 0.000051 0.000033 0.000048 0.000034 0.000034 0.000074 0.000051 0.000035 0.000039 0.000036 0.000050
Endoplasmic Reticulum 0.016260 0.007561 0.005553 0.004335 0.002592 0.003471 0.009690 0.004352 0.002799 0.004539 0.005882 0.004344
Endosome 0.012209 0.004024 0.000758 0.001254 0.000989 0.002060 0.000862 0.003019 0.001159 0.002573 0.000767 0.002208
Golgi 0.000748 0.001203 0.000228 0.000336 0.000305 0.000748 0.000994 0.002754 0.000312 0.000866 0.000289 0.001643
Lipid Particles 0.007971 0.001897 0.000249 0.000349 0.000972 0.000957 0.001273 0.000307 0.001078 0.001202 0.000330 0.000327
Mitochondria 0.002769 0.004426 0.001853 0.002204 0.001938 0.006390 0.001809 0.006336 0.001951 0.005877 0.001850 0.004438
Mitotic Spindle 0.001435 0.001955 0.003745 0.025263 0.002564 0.012182 0.003183 0.027159 0.002547 0.009510 0.003700 0.026288
None 0.007800 0.020285 0.003184 0.007058 0.008758 0.004984 0.003609 0.002512 0.008744 0.008981 0.003218 0.004601
Nuclear Periphery 0.004515 0.003896 0.001669 0.002448 0.002524 0.003339 0.002088 0.003829 0.002554 0.003484 0.001702 0.003195
Nuclear Periphery Foci 0.019258 0.007524 0.002328 0.001918 0.004477 0.002486 0.003170 0.002194 0.004700 0.003802 0.002395 0.002067
Nucleolus 0.043288 0.192100 0.169191 0.261694 0.287351 0.206958 0.246677 0.304404 0.283659 0.203077 0.175360 0.284782
Nucleus 0.660985 0.697118 0.769620 0.634043 0.661717 0.721436 0.681026 0.554515 0.661706 0.715084 0.762567 0.591053
Peroxisomes 0.003260 0.002201 0.000629 0.000829 0.000701 0.001113 0.002950 0.001727 0.000740 0.001397 0.000813 0.001315
Vacuole 0.056379 0.005030 0.002287 0.006033 0.000967 0.003770 0.006642 0.008463 0.001805 0.004099 0.002634 0.007346
Vacuole Periphery 0.004647 0.001860 0.000475 0.001053 0.000539 0.001821 0.000651 0.002051 0.000601 0.001831 0.000489 0.001592

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.94 0.84 0.84 -2.26 -0.12 -1.65 -6.00 -5.03 -4.29 1.67 -3.33 -8.73 -7.45 -5.43 -0.68
Bud Neck -0.02 -5.09 -5.44 -11.96 -0.87 -9.40 -4.22 -24.95 -22.07 -12.86 -9.13 -17.14 -28.33 -24.25 -10.65
Bud Site 1.15 1.11 0.98 -3.10 -2.14 -3.39 -1.53 -8.70 -7.32 -0.48 -2.40 -3.47 -8.79 -7.70 -4.97
Cell Periphery 1.30 2.24 2.09 4.46 -2.29 -0.64 -1.63 -2.42 -1.44 0.12 -2.86 -0.33 -2.21 1.34 -2.64
Cytoplasm 2.51 3.61 3.20 3.69 -3.59 2.25 3.22 3.79 1.95 -0.68 0.15 5.08 2.41 2.69 -3.01
Cytoplasmic Foci 1.80 2.05 2.02 3.96 -1.91 -0.35 0.30 2.63 3.23 0.55 -0.40 4.72 3.62 5.19 -2.02
Eisosomes 1.89 2.30 1.87 -0.30 -6.30 -0.50 -3.84 -6.19 -5.44 2.16 -1.85 -0.97 -7.24 -5.57 -5.86
Endoplasmic Reticulum 1.44 1.74 1.84 3.44 1.44 -3.50 -6.16 -6.93 -4.22 4.09 -6.16 -10.11 -8.14 -1.97 3.13
Endosome 1.28 1.76 1.67 3.28 -3.81 -3.71 0.05 -3.82 -1.01 -3.53 -4.30 2.10 -3.12 1.67 -5.12
Golgi -1.59 2.05 1.12 3.12 -6.46 -1.76 -1.09 -2.33 -1.63 -0.89 -2.86 0.57 -2.41 -0.82 -2.59
Lipid Particles 1.95 2.47 2.41 4.22 -2.42 -0.02 -0.36 5.13 4.03 1.41 -0.61 5.44 5.36 5.62 -0.82
Mitochondria -1.80 0.69 -0.04 3.24 -3.02 -4.40 -0.06 -3.06 0.79 -3.05 -4.85 -0.25 -3.08 2.00 -3.62
Mitotic Spindle -1.03 -2.96 -7.73 -7.47 -6.65 -4.64 -1.87 -9.35 -7.09 -2.62 -4.24 -2.64 -11.74 -9.36 -10.07
None -3.37 1.54 0.46 5.81 -3.84 3.36 2.22 5.90 2.95 1.09 -0.19 5.72 4.22 5.24 -2.72
Nuclear Periphery 0.17 1.11 0.47 0.50 -2.54 -1.20 0.23 -2.34 -1.66 -2.25 -1.33 1.03 -1.91 -0.73 -4.79
Nuclear Periphery Foci 1.08 1.64 1.65 3.76 0.13 2.91 0.54 3.67 0.32 1.36 1.43 2.81 3.97 2.58 0.57
Nucleolus -10.51 -9.58 -13.09 -3.96 -6.12 9.86 1.93 0.82 -7.70 -1.56 10.52 12.02 2.73 -7.93 -9.78
Nucleus -0.73 -1.69 0.36 5.05 10.70 -6.93 0.01 11.99 18.66 4.90 -6.61 -9.28 9.10 17.26 18.72
Peroxisomes 0.68 2.21 1.99 3.39 -2.49 -1.96 -2.10 -3.45 -1.57 1.20 -3.45 -0.21 -3.12 0.86 -2.78
Vacuole 2.71 2.83 2.40 -2.96 -4.55 -4.85 -4.02 -7.50 -5.55 -2.04 -3.76 -2.94 -8.32 -6.33 -7.23
Vacuole Periphery 1.41 2.18 1.90 2.50 -4.95 -3.40 -1.04 -5.64 -0.26 -5.61 -3.99 0.54 -4.74 1.13 -8.21
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication; although Air1p and Air2p are homologous TRAMP subunits, they have nonredundant roles in regulation of substrate specificity of the exosome
Localization
Cell Percentages nucleus (59%), nucleolus (14%), mixed (24%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Air1

Air1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Air1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available