Standard name
Human Ortholog
Description Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0.05 0 0 0.05 0.05 0 0 0.14 0 0.08 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0.06 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.06 0.15 0.2 0.06 0.24 0 0 0 0 0 0
Cytoplasm 0 0.06 0 0.08 0.09 0.06 0.06 0.1 0.07 0.09 0.08 0.06 0.11 0.1 0.14 0.2 0.22 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.49 0.72 0.37 0.38 0.41 0.31 0.37 0.34 0.31 0.22 0.3 0.22 0.72 0.75 0.76 0 0 0 0.79 0.81 0.84 0.82 0.79 0.88
Endosome 0 0 0 0.05 0 0.07 0.06 0.11 0.07 0.11 0.07 0.1 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0.23 0.44 0.4 0 0 0 0 0 0
Mitochondria 0 0 0.06 0.1 0.06 0.24 0.2 0.23 0.37 0.31 0.39 0.33 0 0 0 0 0.11 0.24 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.23 0.3 0.4 0.26 0.13 0.17 0.16 0.07 0.09 0.06 0.07 0.08 0.09 0.1 0 0 0 0.08 0.14 0.12 0.09 0.08 0.07 0
Nucleolus 0 0 0 0 0 0 0 0.05 0.07 0.08 0.11 0.12 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.06 0 0 0 0 0 0 0
Vac/Vac Membrane 0.43 0.17 0.36 0.3 0.41 0.31 0.28 0.21 0.13 0.21 0.14 0.18 0.14 0.13 0.05 0.32 0.17 0.24 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 1 2 0 3 0 15 17 14 14 18 23 3 3 4 10 0 2 1 1 11 2 5 1
Bud 0 0 0 2 0 5 6 8 17 13 19 25 0 0 0 2 0 0 1 1 0 1 1 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 1 3 7 3 8 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 10 3 5 8 6 6 6 8 9 16 5 5 24 15 1 6 0 0 0 0 0 0
Cytoplasm 8 5 9 18 24 17 24 40 22 34 35 26 7 8 22 15 4 1 0 0 0 0 1 0
Endoplasmic Reticulum 91 58 107 82 107 85 151 139 95 84 124 99 46 59 118 3 0 0 173 88 317 89 136 148
Endosome 0 1 4 10 10 18 26 43 22 44 28 48 1 1 3 0 0 0 3 0 2 1 2 1
Golgi 8 0 21 7 9 1 6 5 1 0 3 1 2 1 1 17 8 10 0 0 4 2 1 0
Mitochondria 4 1 16 21 15 67 81 92 115 121 164 153 0 0 0 3 2 6 1 0 5 2 4 1
Nucleus 1 0 1 0 2 1 2 3 3 6 5 7 0 0 1 2 0 0 0 0 0 0 0 0
Nuclear Periphery 43 24 114 56 35 46 65 28 28 25 28 37 6 8 2 0 0 2 31 12 33 8 12 6
Nucleolus 0 0 2 2 3 9 18 20 22 32 47 55 0 0 0 0 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 1 1 1 2 4 2 4 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 1 0 1 1 7 5 5 9 10 19 0 0 0 6 1 0 1 0 0 0 1 0
Vac/Vac Membrane 80 14 102 63 107 86 112 85 39 81 58 81 9 10 8 24 3 6 4 1 1 0 3 3
Unique Cell Count 186 81 287 213 262 275 406 403 308 388 419 459 64 79 156 74 18 25 221 109 378 110 173 170
Labelled Cell Count 237 105 389 264 321 345 520 493 394 482 553 602 79 95 183 97 19 34 221 109 378 110 173 170


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 13.1 13.5 12.0 11.6 10.9 9.3 9.7 9.7 9.1 8.8 8.9 9.1 11.9 11.5 12.0 11.7 15.1 16.4 12.2 13.1 14.1
Std Deviation (1e-4) 2.1 2.0 1.9 2.1 1.8 1.6 1.6 1.7 1.7 1.7 1.8 1.7 1.8 1.9 1.4 2.4 2.9 2.6 2.2 2.3 1.8
Intensity Change (Log2) – – – -0.04 -0.14 -0.37 -0.31 -0.3 -0.39 -0.44 -0.44 -0.39 -0.01 -0.06 0.01 -0.04 0.34 0.46 0.02 0.12 0.24


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 2.5 2.8 2.9 2.5 2.8 3.2 0 0 0 0 0 0
Bud 0 0 0 0 0 4.0 3.1 3.7 4.0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.4 -1.1 -0.4 -1.7 -1.7 -1.2 -1.1 -1.1 0 0 0 4.5 5.1 0 0
Cytoplasm 2.6 3.0 1.7 1.7 3.4 2.2 3.0 2.8 1.6 0 0 4.3 0 0 0
Endoplasmic Reticulum 0.3 0.9 -1.6 0 -0.8 -1.7 -4.5 -2.1 -4.7 5.0 5.9 7.7 -5.5 -3.2 -3.8
Endosome 2.2 1.8 3.1 3.2 4.8 3.4 5.0 3.3 4.7 0 0 0 0 0 0
Golgi -1.9 -2.0 -4.2 -3.9 -4.1 -4.5 -5.4 -4.8 -5.6 0 0 -3.1 3.9 0 0
Mitochondria 1.8 0.1 6.3 5.4 6.1 9.3 8.2 10.1 8.8 0 0 -3.0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -3.1 -6.9 -6.0 -7.0 -10.5 -8.8 -10.6 -10.8 -10.5 -4.6 -4.9 -8.8 -6.6 -3.4 -3.1
Nucleolus 0 0 2.2 2.9 3.1 4.0 4.4 5.4 5.6 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 3.1 0 0 0 0 0 0
Vacuole -1.4 1.3 -1.1 -2.2 -4.2 -6.6 -4.2 -6.8 -5.5 -3.3 -3.9 -7.1 -0.5 -1.6 -1.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.8496 9.172 8.7303 8.6831 7.9633 9.018 11.8533 11.9969 11.3402 10.7714 11.6652 11.5715 11.1955 11.4196 11.4859 11.0696 11.312 11.1669
Actin 0.0077 0.0022 0.0081 0.0054 0.0013 0.0038 0.0006 0.0008 0.0002 0.0001 0.0004 0.0002 0.0051 0.0007 0.0005 0.0484 0.0031 0.0013
Bud 0.0001 0.0002 0.0001 0.0002 0.0001 0.0001 0 0 0 0 0 0 0.0001 0 0 0.0003 0.0001 0
Bud Neck 0.0006 0.0006 0.0004 0.0027 0.0021 0.0015 0.0001 0.0002 0 0.0003 0 0.0001 0.0002 0.0001 0.0002 0.0012 0.0004 0.0003
Bud Periphery 0.0002 0.0002 0.0001 0.0004 0.0002 0.0002 0.0001 0 0.0001 0.0001 0 0 0.0001 0.0001 0 0.0008 0.0003 0.0001
Bud Site 0.0003 0.0038 0.0006 0.0007 0.0003 0.0001 0.0001 0.0001 0 0 0 0 0.0002 0 0 0.0011 0.0001 0
Cell Periphery 0.0002 0.0006 0.0003 0.0005 0.0002 0.0002 0.0002 0.0028 0.0002 0.0006 0.0001 0.0002 0.0004 0.0008 0.0004 0.0011 0.0002 0.0002
Cytoplasm 0.0124 0.0512 0.0271 0.0289 0.0103 0.0152 0.0016 0.0052 0.0013 0.0015 0.0009 0.0005 0.007 0.0033 0.0064 0.0034 0.0024 0.0008
Cytoplasmic Foci 0.005 0.0068 0.0054 0.01 0.0044 0.0008 0.0012 0.0012 0.0003 0.0001 0.0005 0.0002 0.0042 0.0008 0.0007 0.0069 0.0014 0.0003
Eisosomes 0.0001 0 0.0005 0 0 0 0.0001 0 0 0 0 0 0.0001 0 0 0.0004 0.0001 0
Endoplasmic Reticulum 0.2762 0.5547 0.6361 0.6323 0.4806 0.4346 0.5776 0.7467 0.8426 0.948 0.7507 0.5778 0.4487 0.6868 0.8078 0.795 0.5816 0.5463
Endosome 0.0248 0.0193 0.0177 0.0285 0.028 0.0061 0.008 0.0076 0.0037 0.0039 0.0044 0.002 0.0214 0.0075 0.0064 0.0123 0.0214 0.0062
Golgi 0.0045 0.0026 0.0024 0.0092 0.0032 0.0013 0.0015 0.0014 0.0006 0.0002 0.0012 0.0006 0.0062 0.0027 0.0012 0.0071 0.0065 0.002
Lipid Particles 0.0236 0.0191 0.0143 0.0096 0.0331 0.0089 0.0132 0.0268 0.0065 0.001 0.0057 0.0104 0.0128 0.046 0.0143 0.0085 0.0126 0.006
Mitochondria 0.007 0.0006 0.0016 0.0028 0.011 0.0009 0.0016 0.0002 0.0007 0.0002 0.0005 0.0002 0.0011 0.0005 0.0002 0.0022 0.0021 0.0004
None 0.0007 0.0005 0.0082 0.0002 0.0013 0.0003 0.004 0.0001 0.0003 0 0.0001 0.0001 0.003 0.0002 0.0001 0.002 0.0004 0.0003
Nuclear Periphery 0.5642 0.2725 0.2257 0.2401 0.3475 0.4566 0.3679 0.1944 0.1361 0.0326 0.2245 0.3966 0.4383 0.2356 0.1507 0.0942 0.323 0.4181
Nucleolus 0.0043 0.0011 0.004 0.0001 0.0005 0.0023 0.0003 0.0001 0 0 0 0 0.0007 0 0 0.0001 0.0003 0
Nucleus 0.0388 0.0309 0.0234 0.0149 0.0586 0.0472 0.0042 0.0018 0.0009 0.0008 0.0043 0.003 0.0162 0.002 0.0025 0.0016 0.0244 0.0062
Peroxisomes 0.0024 0.0002 0.0082 0.0003 0.0004 0.0007 0.0002 0 0 0 0 0 0.0013 0 0 0.0021 0.0001 0
Punctate Nuclear 0.0062 0.0135 0.0043 0.001 0.0018 0.0055 0.002 0.0026 0.0001 0 0.0008 0.0003 0.017 0.0004 0.0005 0.0031 0.0052 0.0005
Vacuole 0.0067 0.0139 0.006 0.0067 0.0077 0.0063 0.006 0.0038 0.0025 0.0094 0.0016 0.0015 0.005 0.0048 0.0034 0.0031 0.0047 0.0023
Vacuole Periphery 0.0139 0.0055 0.0055 0.0052 0.0075 0.0074 0.0096 0.0043 0.0038 0.0014 0.0042 0.0063 0.0109 0.0079 0.0046 0.0051 0.0097 0.0086

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 26.9123 28.0676 29.2575 30.3572 30.0467 17.1845 28.0413 31.4673 27.7332 34.1005
Translational Efficiency 0.5716 0.486 0.5156 0.4347 0.4538 0.9387 0.5078 0.4557 0.5464 0.4503

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
228 1086 543 1281 2296 1854 2306 1137 2524 2940 2849 2418

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1163.11 1165.04 1330.20 1233.89 1077.46 1153.67 1351.11 1301.44 1085.20 1157.87 1347.12 1265.65
Standard Deviation 142.23 201.61 185.28 192.54 154.16 176.85 189.31 178.12 155.07 186.46 188.73 188.93
Intensity Change Log 2 — 0.002392 0.193656 0.085226 — 0.098596 0.326511 0.272474 — 0.049457 0.259072 0.178308

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002606 0.000424 0.001249 0.006841 0.001569 0.000664 0.001621 0.002584 0.001663 0.000575 0.001550 0.004839
Bud Neck 0.002783 0.000385 0.003126 0.002263 0.000320 0.000307 0.000688 0.002041 0.000543 0.000336 0.001153 0.002158
Bud Site 0.007349 0.000798 0.003699 0.013799 0.001377 0.000999 0.001419 0.005723 0.001917 0.000925 0.001853 0.010002
Cell Periphery 0.000634 0.000380 0.000301 0.002562 0.000465 0.000389 0.000334 0.000764 0.000480 0.000386 0.000328 0.001716
Cytoplasm 0.016321 0.005312 0.028570 0.015869 0.003627 0.014744 0.009489 0.005616 0.004773 0.011260 0.013125 0.011048
Cytoplasmic Foci 0.014955 0.002241 0.010264 0.005407 0.001806 0.006977 0.001188 0.004201 0.002994 0.005228 0.002918 0.004840
Eisosomes 0.000083 0.000019 0.000032 0.000209 0.000047 0.000027 0.000032 0.000065 0.000050 0.000024 0.000032 0.000142
Endoplasmic Reticulum 0.598832* 0.822427* 0.250944* 0.826479* 0.848482* 0.736820* 0.806659* 0.865899* 0.825931* 0.768442* 0.700743* 0.845015*
Endosome 0.041625 0.020382 0.017645 0.023723 0.019607 0.014745 0.014481 0.026965 0.021596 0.016827 0.015084 0.025248
Golgi 0.010995 0.002009 0.000534 0.006867 0.002646 0.004253 0.000723 0.005849 0.003400 0.003424 0.000687 0.006388
Lipid Particles 0.033276 0.011143 0.016950 0.034733 0.018472 0.018028 0.010950 0.028784 0.019809 0.015485 0.012094 0.031936
Mitochondria 0.005031 0.001945 0.000939 0.000644 0.001381 0.003000 0.000662 0.000691 0.001711 0.002611 0.000715 0.000666
Mitotic Spindle 0.012335 0.000528 0.006523 0.002838 0.000892 0.000978 0.001652 0.001449 0.001926 0.000812 0.002580 0.002185
None 0.000053 0.001346 0.000382 0.001307 0.002121 0.001295 0.001135 0.000760 0.001934 0.001314 0.000992 0.001050
Nuclear Periphery 0.072805 0.040290 0.316967* 0.004471 0.028845 0.084609 0.062111 0.007368 0.032816 0.068238 0.110685* 0.005833
Nuclear Periphery Foci 0.139906 0.082857 0.289041* 0.037224 0.065216 0.097067 0.079124 0.032299 0.071963 0.091818 0.119133 0.034908
Nucleolus 0.000056 0.000039 0.000829 0.000019 0.000045 0.000311 0.000025 0.000009 0.000046 0.000211 0.000179 0.000014
Nucleus 0.002668 0.000690 0.026092 0.001146 0.000445 0.005130 0.001593 0.000423 0.000645 0.003490 0.006263 0.000806
Peroxisomes 0.001317 0.000132 0.000706 0.000462 0.000381 0.000908 0.000142 0.000126 0.000465 0.000621 0.000250 0.000304
Vacuole 0.030819 0.005133 0.024398 0.011757 0.001495 0.006730 0.005655 0.007182 0.004144 0.006140 0.009228 0.009606
Vacuole Periphery 0.005550 0.001517 0.000808 0.001378 0.000761 0.002020 0.000315 0.001201 0.001194 0.001834 0.000409 0.001295

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.51 0.83 -2.11 -4.74 -3.75 1.56 -0.18 -1.15 -2.47 -1.04 2.06 0.05 -3.40 -5.27 -3.62
Bud Neck 2.91 -0.59 0.47 -7.17 1.69 0.13 -3.53 -2.51 -2.53 -1.94 1.97 -4.32 -4.57 -5.27 -2.69
Bud Site 2.37 1.22 -1.95 -7.51 -5.09 0.92 -0.52 -3.98 -4.43 -3.85 2.33 -0.21 -7.31 -8.66 -7.45
Cell Periphery 0.82 1.00 -3.29 -4.44 -4.57 1.02 2.02 -3.01 -3.50 -4.20 1.46 2.36 -4.65 -5.02 -5.20
Cytoplasm 2.26 -1.91 0.04 -6.05 3.05 -7.18 -6.19 -2.78 4.50 2.39 -5.47 -7.31 -6.11 -0.58 1.04
Cytoplasmic Foci 3.45 1.05 2.55 -3.07 2.39 -4.75 0.95 -2.41 1.88 -3.11 -2.65 -0.11 -2.32 0.36 -2.44
Eisosomes 1.92 1.50 -2.27 -4.54 -4.20 1.15 0.77 -1.08 -3.32 -2.54 1.70 1.06 -3.44 -5.16 -4.66
Endoplasmic Reticulum -8.79 12.48 -8.62 0.25 -39.32* 12.34 5.68 -1.28 -11.57 -5.82 7.41 14.82 -1.70 -8.93 -16.07
Endosome 3.64 4.03 3.00 -1.87 -2.96 3.67 3.82 -3.59 -6.16 -6.27 3.66 4.93 -2.49 -6.38 -7.65
Golgi 1.68 1.96 0.74 -3.34 -4.55 -1.62 3.88 -2.58 -1.13 -4.34 -0.04 4.14 -2.71 -2.75 -6.16
Lipid Particles 3.25 2.18 -0.22 -6.42 -3.89 0.13 3.36 -2.82 -2.84 -4.84 2.04 3.59 -4.36 -6.16 -7.40
Mitochondria 0.73 0.98 1.05 1.45 1.44 -2.41 2.78 1.92 3.30 -0.07 -1.38 2.25 2.28 3.59 0.27
Mitotic Spindle 2.21 0.96 1.71 -3.04 1.89 -0.15 -1.44 -1.20 -1.17 0.14 1.73 -1.11 -0.68 -2.93 0.50
None -2.86 -4.73 -2.18 0.04 -1.57 1.66 1.83 2.16 1.15 0.71 1.33 1.97 1.59 0.63 -0.14
Nuclear Periphery 3.02 -14.51 6.66 12.06 23.58 -13.15 -10.25 9.89 18.84 17.90 -10.91 -18.21 13.68 22.33 26.81
Nuclear Periphery Foci 3.91 -8.33 7.16 7.84 21.50 -6.23 -3.14 7.96 13.24 11.03 -4.51 -9.71 9.69 14.99 19.49
Nucleolus 1.26 -2.89 2.35 2.52 3.03 -2.91 1.38 2.30 3.26 1.72 -2.81 -2.59 2.46 3.36 3.14
Nucleus 1.60 -6.06 1.18 -2.28 6.94 -5.99 -4.34 -1.14 5.09 2.04 -5.39 -7.51 -1.62 4.55 6.96
Peroxisomes 1.25 0.61 0.92 -2.99 1.23 -2.18 3.56 4.00 3.15 0.44 -0.93 1.74 1.36 1.96 -0.49
Vacuole 4.83 0.96 3.37 -4.42 4.26 -6.08 -7.25 -6.39 -0.86 -1.71 -2.29 -6.06 -5.62 -3.86 -0.55
Vacuole Periphery 1.27 1.50 1.30 0.34 -1.88 -3.38 3.81 -1.05 1.49 -2.16 -1.69 2.58 -0.30 1.52 -3.55
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
Localization
Cell Percentages ER (88%)
Cell Cycle Regulation No
Subcompartmental Group ER-5

Ice2

Ice2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ice2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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Images are not yet available