Standard name
Human Ortholog
Description Subunit of a complex that associates with actin filaments; forms a complex with Tda2p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; involved in mitochondrial migration along actin filaments; recruited to cortical actin patches by SH3 domain-containing proteins Bbc1p and Abp1p

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.65 0.65 0.62 0.62 0.54 0.56 0.48 0.43 0.26 0.37 0.21 0.46 0.63 0.61 0.51 0.73 0.68 0.57 0.6 0.63 0.66
Bud 0.16 0.15 0.1 0.19 0.16 0.13 0.16 0.14 0.09 0.17 0.12 0.11 0.14 0.12 0.1 0.06 0 0 0.11 0.12 0.09
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.1 0.07 0.06
Bud Site 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.07 0.09 0.08 0.07 0.09 0.11 0.06 0.06 0 0.09 0 0 0.1 0.17 0.14 0 0 0 0 0 0
Cytoplasm 0.17 0.16 0.2 0.12 0.31 0.11 0.17 0.2 0.1 0.13 0.12 0.09 0.23 0.19 0.3 0 0.07 0 0.06 0 0.07
Endoplasmic Reticulum 0.1 0.12 0.1 0.09 0.08 0.16 0.24 0.15 0.15 0.12 0.12 0.17 0.11 0.12 0.15 0 0 0 0 0 0
Endosome 0 0 0.05 0.05 0 0 0 0 0 0 0.07 0 0 0 0 0 0.05 0.09 0 0.05 0
Golgi 0 0.16 0.12 0.08 0.07 0.08 0.14 0.06 0.07 0.06 0 0.11 0.11 0.16 0.11 0 0 0 0 0 0
Mitochondria 0.22 0.05 0 0.08 0 0.19 0.18 0.16 0.59 0.4 0.66 0.46 0 0 0 0 0 0.08 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.21 0.08 0.09 0.25 0.08 0.11 0.05 0 0 0.07 0.05 0 0.14 0.13 0.09 0.05 0 0.05 0 0 0
SpindlePole 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 191 138 67 80 74 120 107 119 35 77 29 76 143 172 158 240 179 87 137 240 296
Bud 48 33 11 24 22 28 36 37 12 35 16 19 31 34 32 18 10 5 25 45 39
Bud Neck 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 7 10 7 21 26 26
Bud Site 16 2 1 4 4 6 5 5 0 3 0 4 5 4 0
Cell Periphery 21 20 9 9 13 23 14 16 1 18 4 5 22 47 42 0 1 1 0 1 2
Cytoplasm 50 35 22 15 43 23 38 54 13 28 17 15 53 53 93 12 17 5 12 13 31
Endoplasmic Reticulum 30 26 11 12 11 35 54 42 20 25 17 29 24 33 47 2 2 3 1 4 7
Endosome 1 9 5 6 2 2 2 9 5 8 10 6 6 1 5 7 13 13 10 20 12
Golgi 13 34 13 10 10 17 30 17 9 13 5 19 24 44 35 5 10 3 2 6 3
Mitochondria 66 10 4 10 4 42 39 45 79 84 92 76 2 3 1 9 6 11 5 10 8
Nucleus 1 0 2 1 0 1 1 0 0 0 0 1 0 1 2 0 0 0 1 1 0
Nuclear Periphery 3 0 0 0 0 0 0 0 2 0 1 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 1 0 0 2 7 0 2 1 0 0 0 0 0 0 0 0 0 0
Peroxisomes 62 18 10 32 11 23 11 6 4 14 7 5 32 36 27 17 4 7 4 2 10
SpindlePole 4 5 2 9 5 2 4 7 0 3 1 1 9 10 9 1 0 0 2 2 1
Vac/Vac Membrane 1 1 1 3 1 2 4 15 7 7 2 3 1 2 1 2 2 1 2 2 5
Unique Cell Count 295 213 108 129 138 216 221 274 133 209 139 166 227 282 310 329 263 153 230 382 450
Labelled Cell Count 507 331 159 216 200 324 347 379 187 317 202 259 352 440 452 329 263 153 230 382 450


Actin

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.4 9.9 8.9 9.1 9.6 8.1 8.4 8.6 7.1 7.5 7.0 7.3 10.1 10.3 9.6 9.3 9.2 9.5
Std Deviation (1e-4) 1.1 1.8 1.5 2.0 1.9 1.6 1.6 1.6 1.6 1.5 2.1 1.4 1.6 1.7 1.6 1.5 1.4 1.5
Intensity Change (Log2) 0.04 0.11 -0.12 -0.08 -0.05 -0.31 -0.23 -0.35 -0.29 0.19 0.22 0.12 0.07 0.06 0.1


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 -1.3 -1.1 -2.3 -3.3 -5.6 -4.3 -6.6 -2.6 0.2 -0.2 -2.0
Bud 1.8 1.3 0.7 1.5 0.9 -0.3 1.6 0.3 0.3 0.9 0.5 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.4 0.3 0.7 -0.7 -0.9 0 0.1 -1.9 -2.0 0.4 2.1 1.4
Cytoplasm -1.8 1.9 -2.4 -0.7 -0.1 -2.3 -1.6 -1.7 -2.7 0.6 -0.4 1.9
Endoplasmic Reticulum -0.2 -0.6 1.5 3.0 1.3 1.1 0.5 0.5 1.7 0.1 0.4 1.3
Endosome 0 0 0 0 0 0 0 0.8 0 0 0 0
Golgi -1.1 -1.3 -1.2 0.4 -1.9 -1.4 -1.8 -2.5 -0.1 -0.4 0.9 -0.2
Mitochondria 1.3 0 3.8 3.5 3.3 9.0 6.9 10.0 7.5 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 3.1 -0.4 0.4 -1.5 0 -2.1 -0.8 -1.3 -2.2 1.2 1.0 -0.2
SpindlePole 1.9 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.5051 3.016 2.9681 3.122 2.2928 2.7506 2.9717 3.6646 3.5711 3.0899 2.7715 3.4586 3.8796 4.2056 4.4034 4.3832 4.1683 4.2539
Actin 0.7981 0.6189 0.7906 0.7433 0.6287 0.7376 0.7138 0.6417 0.7546 0.702 0.7535 0.8601 0.8154 0.6348 0.7946 0.811 0.735 0.858
Bud 0.0082 0.0132 0.0322 0.024 0.0145 0.0015 0.0065 0.0073 0.0366 0.0209 0.0094 0.0034 0.0018 0.0161 0.0227 0.0144 0.0114 0.0009
Bud Neck 0.0065 0.0044 0.0138 0.0035 0.0015 0.1035 0.0189 0.0083 0.0128 0.018 0.0042 0.0612 0.0048 0.004 0.0165 0.0123 0.0158 0.0637
Bud Periphery 0.0078 0.012 0.056 0.0564 0.0593 0.0028 0.0106 0.0066 0.0647 0.0663 0.0085 0.0081 0.0025 0.0156 0.0398 0.0157 0.0101 0.001
Bud Site 0.0139 0.0801 0.031 0.0104 0.0026 0.0018 0.0614 0.2161 0.0527 0.0259 0.0059 0.0065 0.0175 0.1268 0.0386 0.0181 0.0057 0.0012
Cell Periphery 0.001 0.0012 0.0006 0.001 0.0007 0.0006 0.001 0.0014 0.0011 0.0013 0.0002 0.0007 0.0003 0.001 0.0004 0.0003 0.0009 0.0002
Cytoplasm 0.0345 0.0748 0.0158 0.0366 0.0456 0.0183 0.0086 0.0375 0.0235 0.0095 0.0856 0.0088 0.0045 0.0907 0.023 0.0117 0.0574 0.0095
Cytoplasmic Foci 0.0232 0.0873 0.0098 0.0124 0.0651 0.0215 0.0414 0.0313 0.0095 0.0362 0.0271 0.0129 0.0317 0.0479 0.0214 0.0346 0.0754 0.0208
Eisosomes 0.0008 0.0014 0.0004 0.0005 0.0003 0.0007 0.0013 0.0011 0.0003 0.0005 0.0003 0.0006 0.0005 0.0002 0.0003 0.0003 0.0002 0.0005
Endoplasmic Reticulum 0.0077 0.0014 0.0005 0.0012 0.0005 0.0018 0.0011 0.0003 0.0004 0.0007 0.0045 0.0009 0.0037 0.0008 0.0002 0.0016 0.0009 0.0004
Endosome 0.0211 0.0204 0.015 0.0328 0.022 0.0264 0.0123 0.0032 0.0083 0.0249 0.0244 0.0054 0.0227 0.011 0.0076 0.0265 0.0343 0.0072
Golgi 0.0328 0.0295 0.0155 0.0233 0.0404 0.026 0.0115 0.0055 0.0092 0.0127 0.0249 0.0078 0.0202 0.018 0.0115 0.0203 0.0268 0.0124
Lipid Particles 0.0092 0.0032 0.0025 0.0116 0.0085 0.006 0.006 0.0008 0.0007 0.0124 0.0017 0.0005 0.0082 0.0005 0.0026 0.0014 0.0027 0.0014
Mitochondria 0.0081 0.0132 0.0056 0.0081 0.0722 0.0097 0.0442 0.0006 0.0015 0.005 0.0038 0.0018 0.0031 0.0016 0.0024 0.0032 0.0033 0.0012
None 0.0012 0.0072 0.0005 0.0014 0.0005 0.0013 0.0052 0.0092 0.0055 0.0036 0.0169 0.0005 0.0071 0.0007 0.0002 0.0008 0.0017 0.0008
Nuclear Periphery 0.0023 0.0004 0.0005 0.0006 0.0003 0.0018 0.0028 0.0001 0.0059 0.0068 0.0017 0.0001 0.0132 0.0001 0.0001 0.0034 0.0002 0.0008
Nucleolus 0.0001 0.0002 0.0003 0.0014 0.0001 0.0024 0.0037 0.0001 0.0001 0.0151 0 0 0.0005 0.0002 0.0001 0.0001 0.0002 0.0001
Nucleus 0.0003 0.0003 0.0004 0.0008 0.0003 0.0054 0.0053 0.0002 0.0005 0.0102 0.0007 0.0001 0.0015 0.0004 0.0001 0.0014 0.0003 0.0003
Peroxisomes 0.0195 0.0287 0.0076 0.0128 0.0344 0.0241 0.0327 0.0279 0.0107 0.0118 0.0247 0.02 0.0334 0.028 0.0168 0.0191 0.0135 0.0178
Punctate Nuclear 0.001 0.0012 0.0006 0.0004 0.0011 0.0004 0.0059 0.0003 0.0007 0.0093 0.0006 0.0002 0.005 0.0004 0.0005 0.0019 0.0015 0.0015
Vacuole 0.0019 0.0007 0.0007 0.0147 0.0009 0.0045 0.005 0.0005 0.0005 0.0058 0.0008 0.0002 0.0014 0.0008 0.0005 0.0013 0.0016 0.0002
Vacuole Periphery 0.0009 0.0002 0.0002 0.0026 0.0006 0.0019 0.001 0 0.0002 0.0012 0.0005 0.0001 0.0009 0.0002 0.0001 0.0007 0.0011 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 23.258 19.8242 17.222 22.2559 24.1942 24.3263 31.8997 30.1917 31.6058 24.2989
Translational Efficiency 1.8936 1.764 1.7028 1.8439 1.4153 1.9851 0.9703 1.22 1.2178 1.371

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
426 1286 249 1464 1630 1634 913 2187 2056 2920 1162 3651

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 834.34 910.90 1154.36 1072.38 860.16 925.81 1203.45 1135.94 854.81 919.24 1192.93 1110.45
Standard Deviation 100.25 159.91 206.80 156.20 103.81 128.28 142.84 160.52 103.61 143.26 160.00 161.83
Intensity Change Log 2 0.126657 0.468386 0.362109 0.106111 0.484499 0.401210 0.116264 0.476588 0.382090

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.509116* 0.736084* 0.606047* 0.570927* 0.639329* 0.619427* 0.668780* 0.588905* 0.612349* 0.670804* 0.655338* 0.581696*
Bud Neck 0.022919 0.001506 0.015848 0.007958 0.007984 0.004266 0.007333 0.008425 0.011079 0.003050 0.009158 0.008238
Bud Site 0.134365* 0.026595 0.196198* 0.258629* 0.095173 0.092230 0.231254* 0.260770* 0.103293* 0.063324 0.223742* 0.259912*
Cell Periphery 0.009307 0.001212 0.001676 0.004850 0.003076 0.001784 0.001647 0.004885 0.004367 0.001532 0.001654 0.004871
Cytoplasm 0.030001 0.008930 0.009821 0.074753 0.029453 0.042951 0.031855 0.105976* 0.029567 0.027968 0.027134 0.093456
Cytoplasmic Foci 0.082391 0.027352 0.031784 0.015272 0.039491 0.026832 0.013723 0.003923 0.048380 0.027061 0.017593 0.008474
Eisosomes 0.003325 0.001724 0.001679 0.002504 0.002470 0.000943 0.000971 0.001984 0.002647 0.001287 0.001123 0.002192
Endoplasmic Reticulum 0.000472 0.000106 0.001465 0.000890 0.000215 0.000072 0.000282 0.000259 0.000269 0.000087 0.000536 0.000512
Endosome 0.005414 0.022531 0.037413 0.006950 0.007323 0.012903 0.003825 0.001393 0.006928 0.017143 0.011022 0.003621
Golgi 0.011318 0.020571 0.016836 0.007799 0.016912 0.022252 0.002062 0.002262 0.015753 0.021512 0.005228 0.004482
Lipid Particles 0.001471 0.013669 0.023476 0.001943 0.001516 0.000944 0.000667 0.000706 0.001506 0.006548 0.005554 0.001202
Mitochondria 0.002562 0.000808 0.000710 0.002837 0.003119 0.007557 0.000158 0.001916 0.003003 0.004585 0.000277 0.002285
Mitotic Spindle 0.000471 0.000539 0.008693 0.003569 0.001082 0.002262 0.000531 0.001159 0.000956 0.001503 0.002280 0.002125
None 0.000115 0.000027 0.000015 0.000033 0.000050 0.000094 0.000019 0.000027 0.000064 0.000064 0.000018 0.000029
Nuclear Periphery 0.000015 0.000005 0.000030 0.000054 0.000002 0.000003 0.000007 0.000018 0.000005 0.000004 0.000012 0.000033
Nuclear Periphery Foci 0.000574 0.000071 0.000638 0.000380 0.000051 0.000015 0.000162 0.000048 0.000160 0.000039 0.000264 0.000181
Nucleolus 0.000175 0.000012 0.000005 0.000121 0.000013 0.000159 0.000003 0.000003 0.000046 0.000094 0.000003 0.000050
Nucleus 0.000342 0.000026 0.000346 0.000721 0.000139 0.000214 0.000229 0.000395 0.000181 0.000131 0.000254 0.000525
Peroxisomes 0.184988* 0.137883* 0.037202 0.026856 0.151540* 0.163349* 0.028107 0.012023 0.158470* 0.152133* 0.030056 0.017971
Vacuole 0.000395 0.000267 0.010003 0.010875 0.000943 0.000800 0.008242 0.004455 0.000829 0.000565 0.008620 0.007030
Vacuole Periphery 0.000264 0.000082 0.000114 0.002079 0.000118 0.000945 0.000142 0.000468 0.000148 0.000565 0.000136 0.001114

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -11.12 -2.77 -2.71 12.69 1.08 1.59 -1.05 4.58 2.85 4.75 -5.64 -2.17 3.50 10.41 5.11
Bud Neck 5.03 1.43 3.47 -8.03 2.80 3.48 0.53 -0.36 -5.28 -0.96 6.65 1.31 2.23 -9.18 0.76
Bud Site 9.16 -2.86 -8.92 -27.91* -3.10 0.43 -11.76 -20.36 -21.11 -2.58 7.26 -11.78 -23.02 -33.95* -3.65
Cell Periphery 3.78 3.59 2.06 -5.53 -5.29 2.00 2.87 -2.84 -5.18 -7.40 4.37 4.57 -0.70 -7.59 -9.02
Cytoplasm 4.67 3.59 -8.17 -15.79 -13.62 -3.81 -1.97 -17.07 -13.25 -12.11 0.60 -0.89 -18.88 -19.92 -14.37
Cytoplasmic Foci 6.68 5.26 8.20 4.48 3.18 4.21 7.56 13.96 12.52 5.30 7.33 9.07 14.74 12.12 4.95
Eisosomes 1.64 1.52 0.89 -1.14 -1.00 4.81 4.43 1.42 -5.73 -4.62 3.63 4.33 1.30 -2.97 -3.87
Endoplasmic Reticulum 1.24 -2.62 -1.24 -6.68 2.22 3.42 -1.48 -1.06 -5.21 0.61 2.56 -3.03 -2.84 -8.22 0.72
Endosome -7.28 -4.81 -1.06 6.94 4.60 -3.47 2.92 6.76 8.25 3.20 -7.40 -2.43 4.05 10.79 4.61
Golgi -3.42 -1.27 1.55 5.86 2.36 -2.43 9.89 9.48 11.39 -0.30 -3.33 7.20 8.39 12.48 0.66
Lipid Particles -5.50 -3.62 -0.99 5.33 3.54 1.25 1.99 1.85 0.29 -0.16 -4.96 -3.07 0.58 5.29 3.25
Mitochondria 3.31 3.30 -0.26 -2.55 -2.61 -3.72 6.13 1.94 4.86 -4.27 -2.16 6.81 1.34 3.18 -5.02
Mitotic Spindle 0.09 -2.23 -3.24 -3.46 1.35 -1.68 1.13 -0.13 1.65 -1.49 -1.11 -1.57 -2.18 -1.29 0.18
None 3.41 4.27 3.53 -0.38 -2.83 -0.97 1.26 2.29 1.42 -0.01 -0.15 2.63 3.68 1.32 -0.38
Nuclear Periphery 0.88 -0.94 -1.01 -1.69 -0.52 -1.32 -4.20 -1.25 -1.18 -0.65 0.48 -2.39 -1.87 -2.05 -1.18
Nuclear Periphery Foci 0.94 -0.02 0.53 -2.08 1.69 1.67 -3.54 -0.12 -3.04 3.71 1.03 -0.90 0.12 -2.41 2.11
Nucleolus 1.00 1.02 0.46 -0.99 -1.05 -1.11 1.39 1.46 1.18 0.49 -0.38 1.16 0.13 0.49 -1.05
Nucleus 1.28 -0.62 -1.04 -5.81 -0.29 -0.45 -2.58 -5.83 -1.24 0.06 0.55 -2.30 -4.15 -3.97 -0.65
Peroxisomes 3.42 10.58 12.70 16.89 1.36 -1.50 20.16 25.09* 26.09 5.28 0.96 22.68 27.35 30.87 4.13
Vacuole 0.89 -3.29 -8.22 -8.32 0.98 0.40 -5.19 -5.36 -6.17 3.36 0.85 -6.14 -9.30 -10.36 2.80
Vacuole Periphery 0.86 0.70 -2.39 -2.73 -2.69 -1.50 -0.20 -1.74 0.82 -1.42 -1.33 0.11 -3.02 -1.23 -2.97
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of a complex that associates with actin filaments; forms a complex with Tda2p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; involved in mitochondrial migration along actin filaments; recruited to cortical actin patches by SH3 domain-containing proteins Bbc1p and Abp1p
Localization
Cell Percentages actin (89%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Aim21

Aim21


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Aim21-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available