Standard name
Human Ortholog
Description Putative protein of unknown function; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.99 0.99 0.98 0.95 0.91 0.84 0.79 0.66 0.75 0.72 0.69 0.97 0.99 0.99 0.98 0.99 0.94 0.97 0.98 0.97 0.96 0.93 0.97
Endoplasmic Reticulum 0 0 0 0 0 0 0.05 0.05 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0.06 0.11 0.15 0.24 0.14 0.23 0.21 0 0 0 0 0 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 1 2 1 2 3 5 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 1 0 5 1 0 1 0 0 0 1 0 0 0 0 0 0 1 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 4 2 4 10 8 14 6 7 5 16 3 2 2 2 2 2 0 0 0 0 0 0
Cytoplasm 94 176 291 259 337 336 337 366 158 222 198 311 210 372 408 227 304 266 114 174 276 265 339 401
Endoplasmic Reticulum 0 1 1 2 8 10 20 24 8 13 6 21 1 2 1 5 9 8 0 0 2 1 1 2
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2
Golgi 0 0 1 0 0 1 0 2 1 1 0 0 0 0 0 1 0 0 0 0 1 0 1 0
Mitochondria 0 1 0 0 0 2 1 1 18 10 11 18 0 0 0 3 3 1 0 0 0 1 2 0
Nucleus 1 1 0 4 7 8 7 8 1 6 6 10 2 5 3 7 2 0 1 1 0 2 6 3
Nuclear Periphery 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 0 1 2 11 21 45 68 59 41 63 96 9 1 12 3 6 19 1 1 0 0 5 1
Unique Cell Count 96 177 293 264 353 369 401 466 241 296 276 451 217 377 414 232 306 282 118 178 286 277 367 416
Labelled Cell Count 97 180 298 269 367 389 420 485 258 303 292 478 225 382 426 250 326 297 118 178 286 277 367 416


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.8 10.6 14.2 13.6 14.9 13.2 13.4 12.8 11.8 12.5 12.1 12.4 15.8 16.1 16.2 14.7 19.0 19.6 14.8 14.9 15.6
Std Deviation (1e-4) 2.7 1.8 1.9 2.0 2.2 2.0 2.4 2.2 2.3 2.4 2.3 2.5 2.6 2.4 2.2 3.6 4.5 5.3 2.4 3.2 2.8
Intensity Change (Log2) – – – -0.06 0.08 -0.1 -0.08 -0.15 -0.26 -0.18 -0.23 -0.19 0.16 0.18 0.19 0.05 0.42 0.47 0.06 0.07 0.14

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 1.2 0.6 1.4 0 0.9 0 1.8 0 0 0 0 0 0
Cytoplasm -1.3 -3.0 -4.7 -6.8 -8.2 -10.6 -8.8 -9.5 -10.3 -2.2 -0.8 -0.9 -1.5 0 -3.4
Endoplasmic Reticulum 0 0 0 3.5 3.6 0 3.2 0 3.4 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 4.8 0 3.5 3.5 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 2.6 3.8 5.7 6.6 8.8 6.4 8.5 8.3 0 0 2.5 0 0 4.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.4643 11.3001 10.4873 8.4924 9.3791 10.1918 11.7447 14.7869 13.1625 12.8983 12.8261 13.3056 9.7864 11.9197 10.719 11.6224 8.2472 10.6058
Actin 0.0002 0.0008 0.0001 0.0007 0.0001 0.0002 0.0656 0.001 0.0333 0.0009 0.0002 0.0036 0.0032 0.0001 0.0006 0.0003 0.0003 0.0026
Bud 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0009 0.0001 0.0005 0.0007 0.0001 0.0002 0.0002 0.0001 0.0005 0.0001 0.0002 0.0002
Bud Neck 0.0002 0.0002 0.0002 0.0005 0.0004 0.0006 0.008 0.0001 0.002 0.0011 0.0008 0.0009 0.0003 0.0001 0.0004 0.0003 0.0007 0.0007
Bud Periphery 0 0 0 0 0 0 0.0012 0.0001 0.0004 0.0003 0 0.0001 0.0001 0 0.0004 0 0.0001 0.0001
Bud Site 0.0001 0.0003 0.0001 0 0 0 0.0057 0.0005 0.0054 0.0008 0 0.0002 0.0007 0.0001 0.001 0.0001 0.001 0.0001
Cell Periphery 0 0 0 0 0 0 0.0003 0 0.0001 0 0 0 0 0 0.0001 0.0001 0 0
Cytoplasm 0.9572 0.9708 0.9654 0.9699 0.9598 0.9538 0.7936 0.9765 0.9034 0.9339 0.9885 0.9472 0.9347 0.99 0.9481 0.9545 0.8498 0.945
Cytoplasmic Foci 0.0007 0.0017 0.002 0.0011 0.001 0.0022 0.0197 0.0053 0.0092 0.0104 0.0014 0.0078 0.0041 0.0005 0.0079 0.0024 0.0446 0.0017
Eisosomes 0 0 0 0 0 0 0.0008 0 0.0001 0 0 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0015 0.0006 0.0009 0.0011 0.0027 0.0038 0.0063 0.0002 0.0017 0.001 0.0005 0.0012 0.0015 0.0003 0.0018 0.0088 0.0008 0.0025
Endosome 0.0005 0.0013 0.0005 0.0006 0.0012 0.0032 0.0251 0.0007 0.0125 0.0296 0.0004 0.0054 0.0052 0.0001 0.0066 0.0079 0.0635 0.0037
Golgi 0 0.0001 0 0 0 0.0001 0.0146 0.0016 0.0079 0.0033 0 0.0048 0.0008 0 0.0009 0.0003 0.008 0.0009
Lipid Particles 0 0 0 0 0 0 0.0083 0.0035 0.0036 0.0003 0 0.0002 0.0054 0 0.0012 0.0012 0.0037 0
Mitochondria 0.0001 0.0001 0.0001 0.0002 0.0001 0.0002 0.012 0.0002 0.0027 0.0017 0.0001 0.0129 0.0016 0 0.0021 0.0001 0.0007 0.0096
None 0.0012 0.0008 0.0008 0.0016 0.0009 0.001 0.0059 0.0009 0.0013 0.0017 0.0008 0.0015 0.0038 0.0006 0.0029 0.0015 0.0009 0.0008
Nuclear Periphery 0.0048 0.0015 0.0026 0.0023 0.0039 0.005 0.0047 0.0004 0.0018 0.001 0.0006 0.0007 0.0046 0.0006 0.0028 0.0037 0.0014 0.0038
Nucleolus 0 0 0 0 0 0 0.0008 0.0001 0.0001 0 0 0 0.0004 0 0.0007 0 0.0001 0
Nucleus 0.0324 0.0206 0.0263 0.0206 0.0283 0.0281 0.0128 0.0034 0.009 0.009 0.0061 0.0095 0.0264 0.0072 0.0157 0.0156 0.0171 0.027
Peroxisomes 0 0 0.0001 0 0 0 0.0074 0.0018 0.003 0.0004 0 0.0031 0.004 0 0.0006 0 0.0033 0.0001
Punctate Nuclear 0.0003 0.0005 0.0005 0.0009 0.0003 0.0004 0.0041 0.0035 0.0009 0.0004 0.0002 0.0003 0.0017 0.0002 0.0014 0.0006 0.0011 0.0004
Vacuole 0.0006 0.0005 0.0003 0.0003 0.0008 0.0009 0.0015 0.0001 0.0007 0.0027 0.0002 0.0002 0.0009 0.0001 0.0035 0.0022 0.0024 0.0005
Vacuole Periphery 0.0001 0.0001 0.0001 0.0001 0.0002 0.0003 0.0008 0 0.0003 0.0007 0.0001 0.0001 0.0004 0 0.0009 0.0003 0.0003 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 35.1355 40.0966 30.7452 46.8791 48.4625 47.8176 51.3527 61.1104 70.7018 56.1983
Translational Efficiency 2.0774 1.7477 2.1536 1.708 1.8703 1.7752 1.7029 1.4408 1.4513 1.7784

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1370 820 2224 1808 1671 1977 698 992 3041 2797 2922 2800

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1103.08 1148.07 1468.49 1540.58 1202.82 1312.66 1446.83 1558.35 1157.89 1264.41 1463.32 1546.88
Standard Deviation 208.67 264.43 220.48 252.19 233.24 199.07 231.40 268.94 227.97 232.64 223.33 258.38
Intensity Change Log 2 — 0.057673 0.412796 0.481936 — 0.126073 0.266475 0.373599 — 0.093756 0.338324 0.426440

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000161 0.000338 0.000136 0.002075 0.000150 0.000371 0.000302 0.001543 0.000155 0.000361 0.000176 0.001887
Bud Neck 0.000735 0.000534 0.000738 0.004070 0.000275 0.000641 0.001457 0.001230 0.000483 0.000610 0.000910 0.003064
Bud Site 0.003270 0.003640 0.001884 0.024724 0.001839 0.003787 0.003721 0.006596 0.002484 0.003744 0.002323 0.018302
Cell Periphery 0.000080 0.000079 0.000051 0.000084 0.000059 0.000039 0.000131 0.000187 0.000068 0.000051 0.000070 0.000121
Cytoplasm 0.816636 0.857341 0.673101 0.591810 0.847864 0.867511 0.672257 0.717666 0.833796 0.864530 0.672899 0.636399
Cytoplasmic Foci 0.045631 0.014181 0.003280 0.029275 0.009333 0.018785 0.010397 0.008542 0.025686 0.017435 0.004980 0.021929
Eisosomes 0.000009 0.000006 0.000001 0.000014 0.000002 0.000004 0.000011 0.000010 0.000005 0.000005 0.000004 0.000012
Endoplasmic Reticulum 0.002900 0.000752 0.000124 0.001141 0.000594 0.000395 0.001308 0.000464 0.001633 0.000499 0.000407 0.000902
Endosome 0.003011 0.001295 0.000199 0.026161 0.000277 0.001009 0.002577 0.000797 0.001509 0.001093 0.000767 0.017175
Golgi 0.000833 0.001018 0.000273 0.021423 0.000247 0.000855 0.001196 0.000682 0.000511 0.000903 0.000493 0.014075
Lipid Particles 0.000745 0.000436 0.000206 0.003356 0.000165 0.000656 0.000996 0.000519 0.000426 0.000592 0.000394 0.002351
Mitochondria 0.000177 0.001533 0.000184 0.010069 0.000088 0.000772 0.000399 0.000349 0.000128 0.000995 0.000236 0.006625
Mitotic Spindle 0.003307 0.003073 0.001836 0.101233 0.000578 0.002024 0.008581 0.010444 0.001807 0.002332 0.003447 0.069067
None 0.005562 0.009685 0.009473 0.006486 0.009464 0.007796 0.007636 0.009089 0.007706 0.008350 0.009034 0.007408
Nuclear Periphery 0.000435 0.000114 0.000190 0.000901 0.000061 0.000101 0.000534 0.000264 0.000229 0.000105 0.000272 0.000675
Nuclear Periphery Foci 0.004655 0.003697 0.000593 0.002651 0.001750 0.001692 0.004412 0.002861 0.003059 0.002280 0.001505 0.002726
Nucleolus 0.000290 0.000543 0.000075 0.000612 0.000084 0.000226 0.000249 0.000497 0.000177 0.000319 0.000117 0.000571
Nucleus 0.069913 0.081644 0.300050 0.105475 0.119780 0.078277 0.210070 0.192731 0.097315 0.079264 0.278556 0.136388
Peroxisomes 0.000267 0.000150 0.000110 0.002607 0.000039 0.000692 0.000093 0.000091 0.000142 0.000533 0.000106 0.001715
Vacuole 0.040763 0.019000 0.007461 0.056970 0.006923 0.013727 0.073518 0.042152 0.022168 0.015273 0.023241 0.051720
Vacuole Periphery 0.000620 0.000941 0.000034 0.008862 0.000427 0.000639 0.000155 0.003286 0.000514 0.000728 0.000063 0.006887

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.76 -2.57 -2.08 -1.09 -1.80 -0.96 -7.50 -1.55 -0.89 -0.90 -1.32 -5.36 -2.59 -1.28 -2.04
Bud Neck 1.35 -3.36 -10.62 -10.63 -6.82 -2.83 -12.02 -9.33 -5.27 4.08 -1.40 -10.00 -14.88 -10.80 -4.33
Bud Site -0.86 1.02 -4.48 -3.27 -4.62 -2.66 -5.48 -3.84 -1.56 -0.46 -2.43 -1.55 -6.13 -3.72 -4.55
Cell Periphery -0.26 -0.04 0.90 0.89 1.13 3.35 -9.06 -5.13 -6.14 -0.75 3.09 -5.19 -4.44 -6.30 -1.15
Cytoplasm -4.84 24.94 25.19 28.13 3.99 -2.83 27.93 24.49 27.20 -7.53 -6.40 40.80 36.85 43.08 -0.64
Cytoplasmic Foci 10.98 18.62 15.70 3.90 -5.61 -7.54 -0.43 -1.35 6.27 -0.89 4.76 17.06 12.54 8.11 -6.06
Eisosomes 3.08 10.42 1.94 -1.86 -11.14 -4.51 -13.59 -4.89 -2.98 3.21 0.85 -0.22 -4.53 -4.76 -4.61
Endoplasmic Reticulum 3.06 4.00 3.74 2.53 -2.58 1.70 -3.71 1.93 -0.19 5.85 3.58 3.90 4.07 1.28 1.12
Endosome 4.38 9.76 -1.56 -3.75 -5.46 -3.08 -3.87 -4.42 1.30 2.83 2.04 5.56 -2.96 -3.76 -4.89
Golgi -0.29 2.40 -3.02 -2.69 -3.84 -1.62 -0.84 -0.79 1.32 0.58 -1.19 1.34 -3.32 -2.44 -3.70
Lipid Particles 1.85 3.48 -4.13 -4.70 -5.28 -1.33 -11.68 -9.83 -1.49 1.95 -0.60 -5.85 -7.01 -3.29 -5.13
Mitochondria -1.00 -1.50 -2.98 -0.30 -2.87 -1.79 -3.32 -1.82 1.43 1.27 -1.82 -4.97 -3.15 -0.55 -2.76
Mitotic Spindle 0.20 0.01 -8.17 -8.10 -8.71 -2.02 -4.58 -3.86 -2.92 1.22 -0.52 -4.02 -9.44 -9.14 -7.79
None -2.08 -3.20 -1.42 1.36 3.54 2.15 3.34 2.66 0.40 -1.06 -0.39 -1.00 0.77 1.35 3.07
Nuclear Periphery 2.39 0.72 -2.95 -13.73 -10.61 -1.92 -18.95 -16.72 -11.24 9.55 1.98 -4.49 -7.31 -17.05 -6.06
Nuclear Periphery Foci 0.73 5.40 4.49 5.72 -3.92 0.27 -6.46 -4.16 -4.40 2.73 1.82 3.78 2.76 1.41 -1.86
Nucleolus -0.76 3.81 -1.52 0.30 -5.15 -2.48 -5.73 -1.57 -0.31 -0.18 -1.54 1.48 -2.94 -0.49 -3.70
Nucleus -2.84 -49.24 -19.09 -14.52 31.47 10.57 -15.59 -12.90 -22.19 4.71 6.22 -46.62 -19.44 -26.99 28.57
Peroxisomes 1.62 0.91 -2.00 -2.87 -2.32 -2.18 -4.95 -1.87 2.05 1.26 -1.83 -0.02 -2.72 0.64 -2.02
Vacuole 5.80 8.65 -21.70 -25.43 -28.69 -8.20 -17.52 -18.34 -15.89 4.30 2.83 -9.71 -30.44 -32.07 -21.66
Vacuole Periphery -0.68 4.94 -2.18 -1.14 -3.89 -0.45 1.02 -0.89 -0.67 -1.47 -0.64 2.68 -2.17 -1.68 -3.88
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative protein of unknown function; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Log1

Log1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Log1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available