Standard name
Human Ortholog
Description Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
Bud 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 – – – – – –
Cell Periphery 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm 0 – – 0.06 0.06 0 0 – 0 0 0 0 – 0.05 – 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
Endosome 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 0 – – 0 0 0.21 0 – 0.2 0.1 0.18 0.18 – 0.05 – 0 0 0 0 0 0 0 0 0
Nucleus 0.91 – – 0.94 0.92 0.91 0.95 – 0.88 0.89 0.88 0.84 – 0.95 – 0.91 0.92 0.89 0.87 0.85 0.88 0.9 0.87 0.78
Nuclear Periphery 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
Nucleolus 0.12 – – 0 0 0 0.05 – 0.12 0.1 0.15 0.13 – 0.25 – 0.07 0.06 0.08 0.06 0 0.09 0.08 0.09 0.11
Peroxisomes 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
Bud 0 – – 0 0 1 1 – 1 0 1 2 – 0 – 1 0 0 3 0 0 2 0 6
Bud Neck 0 – – 0 0 0 1 – 0 0 0 2 – 0 – 0 0 0 0 0 0 0 1 0
Bud Site 1 – – 0 0 4 2 – 6 2 2 5 – 0 – 0 0 0 – – – – – –
Cell Periphery 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm 5 – – 15 20 9 6 – 5 6 4 4 – 1 – 6 6 6 0 0 0 0 0 0
Endoplasmic Reticulum 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 1 1 2 0 0 0 0 0 0
Endosome 0 – – 1 1 0 3 – 0 0 0 0 – 0 – 2 3 1 1 0 0 0 0 2
Golgi 0 – – 0 0 0 0 – 0 0 0 0 – 0 – 1 2 0 0 0 0 0 0 2
Mitochondria 2 – – 2 1 66 13 – 61 34 43 57 – 1 – 3 3 7 0 0 0 0 0 1
Nucleus 181 – – 238 319 291 505 – 264 294 206 274 – 19 – 249 255 177 177 22 40 272 400 423
Nuclear Periphery 0 – – 0 2 2 9 – 2 1 1 6 – 0 – 1 1 0 0 0 0 0 0 0
Nucleolus 23 – – 3 7 13 24 – 36 34 35 42 – 5 – 20 18 16 11 0 4 22 42 59
Peroxisomes 1 – – 0 0 0 0 – 0 0 0 0 – 0 – 0 0 1 0 0 0 0 0 0
SpindlePole 1 – – 4 2 1 10 – 2 1 0 3 – 0 – 1 2 1 0 0 0 0 2 5
Vac/Vac Membrane 3 – – 2 4 0 4 – 0 2 1 3 – 0 – 6 6 3 5 0 0 3 13 39
Unique Cell Count 198 254 348 321 532 300 331 235 325 20 273 277 200 205 27 46 301 463 542
Labelled Cell Count 217 265 356 387 578 377 374 293 398 26 291 297 214 205 27 46 301 463 542


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.6 – – 7.7 8.4 5.1 6.3 – 5.5 5.9 5.4 5.7 – 7.5 – 10.7 11.2 10.9 7.8 8.1 8.1
Std Deviation (1e-4) 1.8 – – 1.6 2.1 1.3 1.2 – 1.2 1.3 1.1 1.3 – 1.7 – 2.7 2.5 2.5 1.7 1.6 1.7
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –

RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510HU1200510rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.1804 1.8878 1.6007 1.5297 1.3371 1.4495 3.0565 2.8024 2.8653 2.7329 2.1871 2.8171 4.4517 4.4413 3.7944 4.1694 4.4331 4.3302
Actin 0.0263 0 0.0109 0.013 0.0136 0.0008 0.0057 0 0 0 0 0 0.0367 0 0.0135 0.0002 0.0042 0
Bud 0.0003 0 0.0003 0.0004 0.0004 0.0001 0.0001 0 0 0 0 0 0.0007 0 0.0003 0.0002 0.0008 0
Bud Neck 0.0015 0.0001 0.0016 0.0167 0.0006 0.0011 0.0003 0 0 0 0.0002 0.0006 0.0034 0 0.0006 0.0002 0.0021 0.0006
Bud Periphery 0.0005 0 0.0004 0.0008 0.0009 0.0004 0.0001 0 0 0 0 0 0.0017 0 0.0008 0.0002 0.0029 0
Bud Site 0.0017 0 0.0037 0.0011 0.0009 0.0004 0.0003 0 0 0 0 0 0.0058 0.0001 0.0011 0.0016 0.0022 0
Cell Periphery 0.0001 0 0.0002 0.0002 0.0001 0.0001 0 0 0 0 0 0 0.0004 0 0.0002 0.0002 0.0006 0
Cytoplasm 0.0012 0 0.002 0.0008 0.0004 0.0006 0.0026 0.0006 0.0001 0 0 0 0.0009 0 0.0032 0.0023 0.0205 0
Cytoplasmic Foci 0.0035 0 0.0026 0.0013 0.0026 0.0007 0.0059 0 0 0 0 0 0.0155 0 0.0032 0.0035 0.0138 0
Eisosomes 0.0002 0 0.0003 0.0001 0.0002 0 0.0005 0 0 0 0 0 0.0009 0 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0011 0 0.0021 0.0004 0.0012 0.0006 0.0013 0.0001 0 0 0 0 0.0007 0 0.0016 0.0029 0.003 0
Endosome 0.007 0 0.0055 0.0057 0.0116 0.004 0.0065 0.0003 0 0 0 0 0.0101 0 0.0062 0.0492 0.023 0
Golgi 0.0027 0 0.0015 0.0062 0.0052 0.0005 0.0013 0 0 0 0 0 0.0084 0 0.0017 0.0021 0.0018 0
Lipid Particles 0.0049 0 0.0022 0.0007 0.0113 0.0019 0.0044 0 0 0 0 0 0.011 0 0.0034 0.008 0.005 0
Mitochondria 0.0027 0.0001 0.0074 0.0039 0.0048 0.0059 0.0012 0.0001 0.0001 0 0.0002 0 0.0036 0.0001 0.0057 0.0016 0.0019 0.0001
None 0.0014 0 0.0037 0.0001 0.0012 0.0003 0.0078 0.0001 0 0 0 0 0.0012 0 0.0006 0.0009 0.0081 0
Nuclear Periphery 0.0076 0.001 0.0091 0.004 0.0183 0.0062 0.0071 0.0045 0.0027 0.0001 0.0004 0.0001 0.0023 0.0002 0.0084 0.0102 0.0042 0.0001
Nucleolus 0.0175 0.0134 0.008 0.013 0.0714 0.0341 0.0119 0.0123 0.0071 0.0055 0.0434 0.0407 0.0469 0.0156 0.0135 0.0109 0.0786 0.0267
Nucleus 0.9045 0.9849 0.9256 0.9275 0.8441 0.936 0.9247 0.973 0.9896 0.9942 0.9553 0.9575 0.8192 0.9834 0.9184 0.885 0.8094 0.9718
Peroxisomes 0.003 0 0.0008 0.0009 0.0025 0.0004 0.0032 0 0 0 0 0 0.0134 0 0.0076 0.0003 0.0017 0
Punctate Nuclear 0.0108 0.0006 0.0103 0.0012 0.0064 0.0044 0.0141 0.0081 0.0002 0.0001 0.0003 0.0009 0.0158 0.0004 0.0065 0.0017 0.0134 0.0006
Vacuole 0.0008 0 0.0009 0.0012 0.0009 0.0009 0.0005 0.0006 0.0001 0 0.0001 0 0.001 0 0.0023 0.0146 0.0023 0
Vacuole Periphery 0.0007 0 0.0008 0.0005 0.0014 0.0007 0.0004 0.0003 0.0001 0 0 0 0.0005 0 0.001 0.0044 0.0005 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 33.9341 19.571 18.8792 26.4546 26.9659 30.6332 33.6399 34.7248 30.3263 25.0247
Translational Efficiency 0.4749 1.0028 0.9283 0.7354 0.6803 0.6607 0.6315 0.5976 0.7196 0.6596

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1548 464 1069 127 1709 1513 1244 104 3257 1977 2313 231

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 833.15 821.64 1134.47 1107.91 842.27 990.44 1097.54 1083.88 837.94 950.82 1114.61 1097.09
Standard Deviation 140.09 212.79 172.03 162.09 128.99 149.58 170.30 160.64 134.46 181.30 172.09 161.88
Intensity Change Log 2 — -0.020070 0.445370 0.411193 — 0.233787 0.381919 0.363850 — 0.113124 0.413821 0.387587

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000415 0.001006 0.000835 0.001758 0.000363 0.000514 0.001004 0.001610 0.000387 0.000629 0.000926 0.001691
Bud Neck 0.005124 0.009313 0.024047 0.015105 0.006391 0.012799 0.020608 0.018893 0.005789 0.011981 0.022197 0.016810
Bud Site 0.000869 0.001887 0.001489 0.002017 0.001648 0.001755 0.001350 0.010036 0.001277 0.001786 0.001414 0.005627
Cell Periphery 0.000136 0.000230 0.000064 0.000057 0.000150 0.000140 0.000042 0.000388 0.000143 0.000161 0.000052 0.000206
Cytoplasm 0.000970 0.008029 0.000365 0.000531 0.003118 0.002232 0.000256 0.005026 0.002097 0.003593 0.000306 0.002555
Cytoplasmic Foci 0.000360 0.000613 0.000054 0.004865 0.001379 0.000358 0.000019 0.001658 0.000894 0.000418 0.000035 0.003421
Eisosomes 0.000036 0.000044 0.000054 0.000044 0.000037 0.000047 0.000046 0.000041 0.000036 0.000047 0.000050 0.000043
Endoplasmic Reticulum 0.003603 0.004632 0.001783 0.002937 0.002686 0.003706 0.002305 0.005257 0.003122 0.003924 0.002064 0.003981
Endosome 0.000328 0.000384 0.000093 0.006369 0.000589 0.000378 0.000076 0.002724 0.000465 0.000379 0.000084 0.004728
Golgi 0.000384 0.000911 0.000134 0.004658 0.000201 0.000356 0.000093 0.003452 0.000288 0.000486 0.000112 0.004115
Lipid Particles 0.000115 0.000180 0.000037 0.000119 0.000271 0.000079 0.000039 0.000701 0.000197 0.000103 0.000038 0.000381
Mitochondria 0.000644 0.001370 0.001292 0.002041 0.000790 0.002374 0.001509 0.005809 0.000721 0.002138 0.001408 0.003737
Mitotic Spindle 0.001570 0.000607 0.001487 0.005460 0.002298 0.002515 0.000336 0.027978 0.001952 0.002067 0.000868 0.015598
None 0.004515 0.014822 0.001379 0.001453 0.006261 0.003957 0.001173 0.006531 0.005431 0.006507 0.001268 0.003739
Nuclear Periphery 0.000105 0.000139 0.000148 0.000257 0.000135 0.000319 0.000150 0.001514 0.000121 0.000277 0.000149 0.000823
Nuclear Periphery Foci 0.000807 0.000928 0.000068 0.000110 0.000337 0.000161 0.000052 0.001580 0.000560 0.000341 0.000060 0.000772
Nucleolus 0.038604 0.050466 0.026488 0.011904 0.047365 0.032060 0.032346 0.015629 0.043201 0.036380 0.029639 0.013581
Nucleus 0.940362 0.899467 0.939029 0.934143 0.924811 0.934679 0.937362 0.875890 0.932202 0.926415 0.938132 0.907917
Peroxisomes 0.000704 0.001395 0.000650 0.000541 0.000794 0.000430 0.000678 0.000953 0.000751 0.000656 0.000665 0.000727
Vacuole 0.000237 0.002143 0.000380 0.003647 0.000231 0.000721 0.000428 0.008119 0.000234 0.001054 0.000406 0.005661
Vacuole Periphery 0.000114 0.001431 0.000129 0.001984 0.000144 0.000421 0.000128 0.006210 0.000130 0.000658 0.000128 0.003887

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.39 -13.22 -2.87 -1.45 -1.56 -2.61 -15.93 -6.34 -5.80 -4.08 -5.04 -20.67 -5.70 -4.77 -3.39
Bud Neck -4.44 -18.63 -7.47 -4.45 4.09 -6.84 -15.06 -6.32 -4.42 -1.17 -8.79 -23.51 -9.07 -5.50 1.22
Bud Site -2.96 -4.99 -3.42 -1.26 -1.57 -0.19 0.04 -1.88 -1.86 -1.92 -1.20 -1.39 -2.41 -2.09 -2.17
Cell Periphery -1.93 2.16 1.70 3.75 -0.57 0.26 3.37 -0.94 -1.03 -1.89 -0.51 3.95 -0.28 0.02 -1.99
Cytoplasm -3.02 2.05 -1.04 2.66 -2.14 0.47 3.86 -0.03 -0.33 -1.82 -1.77 4.31 -0.26 1.25 -2.54
Cytoplasmic Foci -0.90 1.90 -0.93 -0.77 -1.10 2.03 2.82 0.76 -0.69 -1.22 1.55 3.30 -0.63 -1.02 -1.34
Eisosomes -2.62 -9.86 -3.12 -0.81 1.60 -1.82 -5.06 -3.76 -2.23 -2.23 -2.43 -9.88 -4.78 -1.94 -1.07
Endoplasmic Reticulum -2.64 8.01 0.89 2.76 -3.31 -4.59 2.99 -4.58 -3.64 -4.94 -4.11 8.13 -3.90 -2.40 -5.57
Endosome -0.31 1.92 -1.29 -1.27 -1.39 0.97 2.16 -1.22 -1.59 -1.95 0.75 2.78 -1.55 -1.64 -1.84
Golgi -1.17 1.00 -1.01 -0.64 -1.13 -0.64 1.59 -1.10 -0.99 -1.17 -0.98 1.38 -1.43 -1.24 -1.55
Lipid Particles -0.95 1.98 -0.04 0.88 -1.55 1.90 2.28 -1.02 -1.89 -2.04 1.50 2.78 -0.88 -1.73 -2.33
Mitochondria -4.15 -8.55 -5.22 -2.45 -2.32 -2.22 -3.55 -1.84 -0.97 -1.40 -2.67 -6.37 -2.74 -0.99 -1.78
Mitotic Spindle 1.07 -0.35 -1.36 -1.50 -1.31 -0.18 1.93 -1.86 -1.84 -2.02 -0.16 1.07 -2.30 -2.27 -2.42
None -3.35 3.45 1.20 3.84 -1.84 1.87 4.67 0.47 -0.49 -1.64 -0.83 5.81 1.10 1.67 -2.27
Nuclear Periphery -1.26 -5.12 -4.29 -3.62 -2.82 -3.22 -1.73 -2.85 -2.46 -2.78 -3.63 -4.66 -3.54 -2.81 -3.24
Nuclear Periphery Foci -0.17 1.65 1.57 2.76 -0.55 1.76 2.58 -0.84 -1.28 -1.46 1.15 2.40 0.33 -0.53 -1.52
Nucleolus -2.97 2.75 7.88 8.17 5.22 5.91 3.88 4.91 1.89 2.71 3.24 4.69 8.88 6.18 5.53
Nucleus 5.50 2.77 0.98 -1.86 0.21 -2.06 -0.90 2.69 3.15 2.89 1.76 1.11 2.58 2.01 2.32
Peroxisomes -1.54 0.26 0.93 2.07 1.36 1.11 0.21 -0.73 -2.28 -1.31 0.34 0.32 -0.07 -0.51 -0.55
Vacuole -1.62 -4.04 -1.84 -0.62 -1.68 -2.77 -5.22 -3.36 -3.17 -3.26 -2.71 -6.50 -3.77 -3.21 -3.60
Vacuole Periphery -1.69 -2.81 -1.04 0.18 -1.01 -2.30 0.58 -1.49 -1.34 -1.49 -2.58 -1.39 -1.81 -1.29 -1.80
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Dls1

Dls1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dls1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available