Standard name | |
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Human Ortholog | |
Description | DNA helicase and DNA-dependent ATPase; role in DNA repair and checkpoint recovery, in the proper timing of commitment to meiotic recombination and the Meiosis I to II transition; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; stimulates Mus81p-Mms4p endonuclease activity independent of catalytic activity; ATPase and ssDNA translocating motor activities inhibited by Dmc1p; functional homolog of human RTEL1 |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Bud | 0 | 0 | 3 | 3 | 1 | 3 | 5 | 11 | 5 | 6 | 7 | 7 | 0 | 2 | 1 | 1 | 1 | 1 | 4 | 1 | 2 | 2 | 4 | 2 |
Bud Neck | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud Site | 0 | 1 | 1 | 3 | 3 | 14 | 28 | 30 | 16 | 10 | 22 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 19 | 8 | 23 | 40 | 35 | 38 | 45 | 45 | 41 | 27 | 21 | 35 | 15 | 31 | 51 | 20 | 34 | 29 | 8 | 4 | 8 | 4 | 11 | 15 |
Endoplasmic Reticulum | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 3 | 1 | 4 | 0 | 0 | 1 | 0 | 0 | 2 |
Endosome | 2 | 1 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 7 | 3 | 3 | 4 | 2 | 0 | 2 | 0 | 0 | 1 | 3 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Mitochondria | 8 | 30 | 127 | 201 | 142 | 272 | 396 | 455 | 295 | 398 | 343 | 513 | 7 | 3 | 34 | 7 | 6 | 12 | 3 | 1 | 6 | 0 | 3 | 6 |
Nucleus | 332 | 66 | 135 | 182 | 266 | 317 | 465 | 520 | 253 | 338 | 297 | 392 | 70 | 79 | 71 | 275 | 241 | 185 | 313 | 82 | 152 | 43 | 75 | 58 |
Nuclear Periphery | 0 | 1 | 0 | 0 | 1 | 1 | 5 | 11 | 3 | 7 | 5 | 8 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 1 | 5 | 7 | 13 | 7 | 6 | 6 | 12 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 2 | 4 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 1 | 0 | 0 | 0 | 0 | 1 | 5 | 3 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 7 | 2 | 4 | 1 | 6 | 4 |
Vac/Vac Membrane | 28 | 11 | 8 | 7 | 9 | 8 | 5 | 8 | 7 | 4 | 7 | 24 | 22 | 27 | 26 | 32 | 20 | 21 | 53 | 14 | 67 | 7 | 54 | 63 |
Unique Cell Count | 367 | 99 | 231 | 311 | 371 | 443 | 645 | 734 | 399 | 524 | 447 | 630 | 106 | 136 | 164 | 321 | 295 | 237 | 396 | 112 | 253 | 62 | 166 | 167 |
Labelled Cell Count | 390 | 118 | 299 | 436 | 460 | 659 | 964 | 1096 | 628 | 798 | 708 | 1024 | 119 | 150 | 188 | 343 | 313 | 258 | 396 | 112 | 253 | 62 | 166 | 167 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.4 | 4.0 | 3.5 | 3.5 | 3.8 | 3.6 | 3.4 | 3.5 | 3.2 | 3.1 | 3.2 | 2.9 | 5.0 | 5.2 | 4.6 | 7.2 | 7.6 | 8.2 | 4.6 | 5.0 | 5.3 |
Std Deviation (1e-4) | 0.7 | 0.9 | 0.8 | 1.2 | 1.1 | 1.2 | 1.1 | 1.1 | 1.3 | 0.7 | 1.2 | 1.0 | 1.3 | 1.4 | 1.7 | 1.6 | 1.6 | 1.7 | 0.7 | 1.8 | 1.2 |
Intensity Change (Log2) | – | – | – | 0.01 | 0.14 | 0.03 | -0.03 | 0.02 | -0.13 | -0.19 | -0.12 | -0.27 | 0.53 | 0.58 | 0.39 | 1.05 | 1.12 | 1.24 | 0.42 | 0.51 | 0.61 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 2.9 | 1.7 | 2.4 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 0.6504 | 1.5635 | 1.3678 | 1.5215 | 1.4779 | 1.3224 | 3.4022 | 3.1237 | 3.0716 | 3.0645 | 2.8821 | 3.2624 | 1.3524 | 0.8107 | 1.5813 | 1.5906 | 1.692 | 1.4981 |
Actin | 0.0001 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0.0346 | 0.0006 | 0.0043 | 0.0252 | 0.0051 | 0.0093 | 0.0135 | 0.0001 | 0.0072 | 0.0002 | 0.0033 | 0.0004 |
Bud | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0.0011 | 0.0003 | 0.0003 | 0.0008 | 0.0005 | 0.0003 | 0.0008 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 |
Bud Neck | 0.0002 | 0.0003 | 0.0001 | 0.0001 | 0.0002 | 0.0018 | 0.0092 | 0.001 | 0.0028 | 0.0011 | 0.0003 | 0.0012 | 0.0032 | 0.0001 | 0.0002 | 0.0004 | 0.0011 | 0.0015 |
Bud Periphery | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0.0025 | 0.0002 | 0.0007 | 0.002 | 0.0011 | 0.0006 | 0.0004 | 0.0001 | 0.0003 | 0 | 0.0002 | 0.0001 |
Bud Site | 0.0002 | 0.0003 | 0 | 0 | 0.0001 | 0.0001 | 0.0077 | 0.0069 | 0.0027 | 0.0015 | 0.0012 | 0.0003 | 0.0013 | 0.0002 | 0.0004 | 0 | 0.0004 | 0.0001 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0.0009 | 0.0001 | 0.0003 | 0.0003 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 |
Cytoplasm | 0.0128 | 0.0072 | 0.0011 | 0.0005 | 0.0004 | 0.0011 | 0.014 | 0.0262 | 0.0043 | 0.0007 | 0.0003 | 0.0009 | 0.0181 | 0.0073 | 0.0046 | 0.0126 | 0.0045 | 0.0027 |
Cytoplasmic Foci | 0.0003 | 0.0001 | 0 | 0 | 0 | 0.0003 | 0.0178 | 0.0021 | 0.0062 | 0.0057 | 0.0037 | 0.0037 | 0.006 | 0.0059 | 0.0053 | 0.0003 | 0.007 | 0.0001 |
Eisosomes | 0 | 0 | 0 | 0 | 0 | 0 | 0.0003 | 0 | 0.0001 | 0.0002 | 0 | 0 | 0.0002 | 0.0003 | 0.0001 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0008 | 0.0017 | 0 | 0 | 0 | 0.0001 | 0.0074 | 0.001 | 0.0011 | 0.0008 | 0.0004 | 0.0008 | 0.0028 | 0.0003 | 0.0008 | 0.0002 | 0.0002 | 0.0002 |
Endosome | 0.0008 | 0.0008 | 0 | 0 | 0 | 0.0003 | 0.036 | 0.0038 | 0.0093 | 0.028 | 0.007 | 0.0084 | 0.007 | 0.0089 | 0.0051 | 0.0003 | 0.0023 | 0.0003 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0.0173 | 0.0017 | 0.0034 | 0.0235 | 0.0053 | 0.0069 | 0.0018 | 0.0001 | 0.0013 | 0 | 0.0015 | 0 |
Lipid Particles | 0.0001 | 0 | 0 | 0 | 0 | 0.0009 | 0.0288 | 0.0005 | 0.0076 | 0.0301 | 0.0063 | 0.004 | 0.0072 | 0.0007 | 0.0089 | 0 | 0.0038 | 0 |
Mitochondria | 0.0003 | 0.0004 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0363 | 0.0012 | 0.0039 | 0.0466 | 0.0141 | 0.0111 | 0.0068 | 0.0004 | 0.0074 | 0.0002 | 0.0005 | 0.0005 |
None | 0.0272 | 0.0012 | 0.0006 | 0 | 0.0001 | 0.0031 | 0.0215 | 0.0108 | 0.0034 | 0.0005 | 0.0002 | 0.0003 | 0.0528 | 0.3219 | 0.0106 | 0.0075 | 0.014 | 0.006 |
Nuclear Periphery | 0.0092 | 0.0193 | 0.0028 | 0.0014 | 0.0013 | 0.0033 | 0.029 | 0.0066 | 0.0122 | 0.0043 | 0.0116 | 0.0083 | 0.0143 | 0.0056 | 0.017 | 0.0023 | 0.0022 | 0.0041 |
Nucleolus | 0.0073 | 0.0071 | 0.0044 | 0.0046 | 0.0104 | 0.0124 | 0.0152 | 0.0049 | 0.0043 | 0.0049 | 0.0053 | 0.0127 | 0.0114 | 0.0058 | 0.0039 | 0.0048 | 0.0155 | 0.0149 |
Nucleus | 0.9327 | 0.9559 | 0.9896 | 0.9928 | 0.9864 | 0.971 | 0.6644 | 0.9155 | 0.9191 | 0.7518 | 0.9231 | 0.9212 | 0.8054 | 0.6199 | 0.9095 | 0.9363 | 0.9023 | 0.9614 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0.0173 | 0.0055 | 0.0079 | 0.0055 | 0.0084 | 0.0033 | 0.0071 | 0.0003 | 0.0068 | 0 | 0.0133 | 0 |
Punctate Nuclear | 0.007 | 0.0033 | 0.0011 | 0.0002 | 0.0005 | 0.0049 | 0.0215 | 0.0089 | 0.0023 | 0.0606 | 0.0049 | 0.0054 | 0.0378 | 0.0208 | 0.0086 | 0.0346 | 0.0269 | 0.0071 |
Vacuole | 0.0007 | 0.0014 | 0.0001 | 0.0001 | 0.0003 | 0.0003 | 0.013 | 0.0019 | 0.0027 | 0.0035 | 0.0005 | 0.0005 | 0.0012 | 0.0009 | 0.001 | 0.0001 | 0.0005 | 0.0002 |
Vacuole Periphery | 0.0001 | 0.0005 | 0 | 0 | 0.0001 | 0.0001 | 0.004 | 0.0003 | 0.0012 | 0.0025 | 0.0006 | 0.0006 | 0.0006 | 0.0002 | 0.0006 | 0 | 0.0001 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 28.172 | 26.863 | 10.5897 | 12.5426 | 27.5976 | 14.7039 | 21.927 | 19.0003 | 14.8521 | 24.5134 |
Translational Efficiency | 0.3788 | 0.3752 | 0.3454 | 0.2928 | 0.259 | 0.5308 | 0.3745 | 0.2802 | 0.3113 | 0.3156 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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