Standard name
Human Ortholog
Description Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; also enters the nucleus and positively regulates transcription initiation; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation, most often in the 3' UTR; forms cytoplasmic foci upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0.06 0.07 – 0.05 0.05 0 0.06 0.05 0.22 0.25 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.09 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0.08 0.08 0 0.08 – 0.06 0.05 0 0.07 0.06 0 0 0.13 0.1 0.06 0 0 0 0 0 0
Cytoplasm 0.93 0.99 0.94 0.85 0.74 0.65 0.56 – 0.53 0.56 0.45 0.38 0.82 0.56 0.38 0.84 0.89 0.87 0.91 0.94 0.92 0.86 0.8 0.86
Endoplasmic Reticulum 0 0 0 0.06 0.16 0.05 0.14 – 0.11 0.06 0.06 0.16 0.08 0.12 0.09 0 0 0 0 0 0.06 0.09 0.13 0.11
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0.05 – 0 0 0 0 0.05 0.25 0.37 0 0 0.06 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.2 0.1 – 0.31 0.32 0.45 0.39 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0.13 0.17 – 0.12 0.11 0.13 0.1 0 0 0 0 0 0.06 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 0 1 10 10 12 27 – 10 9 6 16 15 91 110 4 5 1 0 0 0 0 0 0
Bud 2 0 0 1 1 0 3 – 1 3 4 3 6 16 38 1 0 0 1 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 8 0 4 22 24 4 32 – 12 9 3 18 17 18 9 31 18 10 0 0 0 2 1 1
Cytoplasm 242 95 110 246 219 140 230 – 115 98 71 96 226 235 165 202 168 155 258 95 121 175 318 331
Endoplasmic Reticulum 11 0 2 17 47 10 58 – 24 11 9 39 21 50 39 9 4 5 8 0 7 17 52 40
Endosome 0 0 0 0 0 0 2 – 0 0 0 0 0 14 25 0 1 0 1 0 0 1 4 1
Golgi 2 0 0 2 10 1 22 – 0 3 0 5 14 104 159 4 1 10 0 0 0 1 1 1
Mitochondria 4 0 0 9 5 43 41 – 67 56 72 99 5 2 6 7 6 5 2 0 0 1 8 2
Nucleus 0 0 2 1 2 1 1 – 3 2 1 0 0 0 0 0 0 0 0 2 0 0 0 0
Nuclear Periphery 0 0 0 0 0 1 0 – 0 0 2 1 0 0 0 0 0 0 2 0 0 0 0 0
Nucleolus 0 0 0 1 0 0 0 – 0 0 0 0 0 2 4 0 0 0 0 0 0 0 1 2
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 1 4 17 0 0 1 0 0 0 0 0 0
Vac/Vac Membrane 3 1 3 6 7 28 69 – 27 19 20 24 1 3 6 3 1 11 3 1 0 2 3 0
Unique Cell Count 261 96 117 288 294 215 414 217 175 159 251 274 417 434 240 189 178 283 102 132 204 398 384
Labelled Cell Count 274 96 122 315 325 240 485 259 210 188 301 306 539 580 261 204 198 283 102 132 204 398 384


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.2 13.6 11.9 13.3 14.1 9.5 12.3 – 9.8 9.5 8.6 9.6 17.1 17.7 17.7 16.5 16.7 17.0 14.8 15.4 15.6
Std Deviation (1e-4) 2.5 2.4 1.6 1.8 2.0 2.1 2.1 – 1.9 2.0 1.8 2.1 2.2 2.5 2.5 2.9 2.9 3.6 2.2 2.2 2.2
Intensity Change (Log2) – – – 0.16 0.25 -0.32 0.05 – -0.28 -0.32 -0.46 -0.31 0.53 0.57 0.58 0.47 0.49 0.52 0.31 0.38 0.4

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 2.4 – 0 0 0 2.3 0 5.3 5.9 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 3.3 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 1.6 1.7 0 1.6 – 0.9 0.7 0 1.4 1.1 0 0 2.8 2.0 0.9
Cytoplasm -2.4 -4.5 -5.8 -7.7 – -7.6 -7.0 -8.5 -10.0 -3.0 -7.5 -10.8 -2.6 -1.5 -1.9
Endoplasmic Reticulum 1.8 4.0 0 3.7 – 3.0 1.9 0 3.9 2.3 3.3 2.7 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 2.7 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 6.0 7.8 0 0 0
Mitochondria 0 0 5.2 3.5 – 6.7 6.8 8.5 7.9 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 3.1 3.9 – 3.0 2.6 3.0 2.4 0 0 0 0 0 1.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.4191 12.7609 11.5561 10.6769 10.0912 11.8397 12.4659 16.419 15.904 15.1859 13.5813 15.0404 14.1901 16.2632 15.8215 15.068 14.8727 15.4731
Actin 0.0063 0.0018 0.0016 0.0011 0.0005 0.0011 0.0145 0.0049 0.001 0.0004 0.0127 0.0019 0.002 0.0015 0.002 0.0042 0.0026 0.0019
Bud 0.0013 0.0004 0.0006 0.0007 0.0002 0.0004 0.0004 0.0006 0.0005 0.0006 0.0006 0.0002 0.0004 0.0024 0.0008 0.0015 0.0004 0.0009
Bud Neck 0.0004 0.0003 0.0008 0.0009 0.0004 0.0014 0.0007 0.0003 0.0005 0.0006 0.0008 0.0011 0.0003 0.0003 0.0005 0.0007 0.0009 0.0014
Bud Periphery 0.0008 0.0002 0.0002 0.0005 0.0001 0.0004 0.0006 0.0002 0.0002 0.0001 0.0003 0.0002 0.0003 0.0006 0.0004 0.0012 0.0001 0.0007
Bud Site 0.0009 0.0007 0.0005 0.0003 0.0001 0.0001 0.0008 0.0013 0.0003 0.0002 0.0004 0.0001 0.0005 0.0022 0.0005 0.0006 0.0004 0.0001
Cell Periphery 0.0006 0.0004 0.0003 0.0005 0.0001 0.0003 0.0006 0.0003 0.0004 0.0001 0.0001 0.0002 0.0004 0.0004 0.0004 0.0005 0.0001 0.0003
Cytoplasm 0.7781 0.8804 0.8491 0.7042 0.8196 0.8168 0.7505 0.9133 0.9001 0.9211 0.8572 0.852 0.7892 0.9313 0.8118 0.7444 0.8368 0.7752
Cytoplasmic Foci 0.0157 0.0093 0.0122 0.0155 0.0251 0.0168 0.019 0.0092 0.0138 0.0098 0.0224 0.0122 0.0181 0.0103 0.015 0.0271 0.0193 0.0167
Eisosomes 0 0 0 0 0 0 0.0001 0 0 0 0.0001 0 0.0001 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0953 0.0505 0.0754 0.1263 0.0172 0.0659 0.0974 0.039 0.0224 0.0179 0.0125 0.0592 0.1031 0.0244 0.073 0.049 0.0689 0.0847
Endosome 0.0544 0.0304 0.0357 0.106 0.106 0.0528 0.061 0.0177 0.0394 0.0304 0.0426 0.0431 0.0476 0.0167 0.0489 0.112 0.0476 0.0565
Golgi 0.013 0.0065 0.0048 0.0137 0.0181 0.0124 0.0106 0.004 0.0061 0.0019 0.0085 0.0102 0.0123 0.0044 0.009 0.0212 0.006 0.0161
Lipid Particles 0.0034 0.0003 0.0001 0.0003 0.0001 0.0001 0.0037 0.0006 0.0001 0 0.0149 0.0007 0.0012 0.0001 0.0005 0.0004 0.0001 0.0001
Mitochondria 0.0072 0.0102 0.0036 0.004 0.0022 0.0239 0.0049 0.0019 0.0022 0.0011 0.0035 0.0096 0.0044 0.0009 0.0232 0.0182 0.0023 0.0372
None 0.0016 0.0006 0.0007 0.0006 0.0005 0.0008 0.005 0.0006 0.0005 0.0006 0.0019 0.0007 0.0071 0.0007 0.001 0.0008 0.0005 0.0011
Nuclear Periphery 0.0045 0.0017 0.003 0.0033 0.0016 0.0012 0.0109 0.0012 0.0014 0.0017 0.0036 0.0013 0.0034 0.0009 0.0024 0.0042 0.0025 0.0014
Nucleolus 0 0 0 0 0 0 0.0001 0 0 0 0.0002 0.0001 0 0 0.0001 0 0 0
Nucleus 0.0016 0.0008 0.0013 0.0011 0.0008 0.0007 0.0027 0.0008 0.0009 0.0013 0.0012 0.0009 0.001 0.0007 0.001 0.0012 0.001 0.0009
Peroxisomes 0.0005 0.0001 0.0001 0.0001 0.0001 0.0001 0.0014 0.0001 0.0001 0.0001 0.0037 0.0002 0.0003 0.0001 0.0002 0.0002 0.0002 0.0001
Punctate Nuclear 0.0002 0.0001 0.0001 0.0001 0.0001 0 0.0012 0.0001 0.0001 0.0001 0.0043 0.0002 0.0004 0.0001 0.0001 0.0002 0.0001 0.0002
Vacuole 0.012 0.004 0.0077 0.0155 0.0048 0.003 0.0111 0.0034 0.0084 0.0091 0.0063 0.0039 0.0064 0.0018 0.0072 0.008 0.0081 0.003
Vacuole Periphery 0.0022 0.0013 0.0023 0.0053 0.0025 0.0019 0.0029 0.0007 0.0015 0.0029 0.0023 0.0018 0.0017 0.0004 0.002 0.0044 0.0021 0.0017

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 90.3559 70.3197 46.5391 78.6937 86.8291 99.8676 93.6793 94.6787 80.5638 94.606
Translational Efficiency 1.4391 2.0816 2.6599 1.9006 1.6051 1.6467 1.532 1.7627 1.8596 1.5718

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2083 1304 250 122 176 2505 1826 865 2259 3809 2076 987

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1098.36 1401.74 1802.49 1674.36 1278.52 1456.27 1643.11 1617.56 1112.40 1437.60 1662.30 1624.58
Standard Deviation 173.63 231.12 222.22 245.02 191.98 222.73 304.94 253.21 181.67 227.12 300.71 252.90
Intensity Change Log 2 — 0.351868 0.714640 0.608259 — 0.187803 0.361954 0.339344 — 0.265942 0.535686 0.469860

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000294 0.000704 0.001124 0.005773 0.001506 0.000220 0.000442 0.003135 0.000389 0.000386 0.000524 0.003461
Bud Neck 0.000352 0.000384 0.004146 0.003843 0.000635 0.000265 0.000810 0.001568 0.000374 0.000306 0.001212 0.001849
Bud Site 0.029667 0.021374 0.037416 0.061238 0.058110 0.014893 0.014207 0.055076 0.031883 0.017112 0.017002 0.055838
Cell Periphery 0.000558 0.000677 0.003453 0.002851 0.001678 0.000352 0.001156 0.003790 0.000645 0.000464 0.001433 0.003674
Cytoplasm 0.606249 0.762884 0.607818 0.429914 0.473223 0.795368 0.873450 0.720278 0.595885 0.784247 0.841462 0.684387
Cytoplasmic Foci 0.224763 0.118036 0.083658 0.180042 0.293574 0.121376 0.028630 0.102327 0.230124 0.120232 0.035257 0.111933
Eisosomes 0.000012 0.000007 0.000008 0.000017 0.000014 0.000006 0.000003 0.000011 0.000012 0.000006 0.000004 0.000012
Endoplasmic Reticulum 0.021603 0.008711 0.014193 0.006020 0.037148 0.009680 0.003061 0.002702 0.022814 0.009348 0.004401 0.003112
Endosome 0.007223 0.005874 0.021411 0.040510 0.016235 0.003914 0.004175 0.010378 0.007925 0.004585 0.006250 0.014103
Golgi 0.028222 0.032392 0.051705 0.055942 0.039127 0.023202 0.019402 0.037738 0.029071 0.026348 0.023292 0.039989
Lipid Particles 0.001144 0.002988 0.027000 0.039447 0.002001 0.001723 0.009060 0.015160 0.001211 0.002156 0.011220 0.018162
Mitochondria 0.005529 0.001804 0.000037 0.000033 0.001654 0.001262 0.000072 0.001705 0.005227 0.001447 0.000068 0.001498
Mitotic Spindle 0.001498 0.002266 0.010798 0.023985 0.009216 0.001473 0.003852 0.005736 0.002099 0.001744 0.004689 0.007992
None 0.000959 0.001042 0.000266 0.000059 0.000883 0.000833 0.000810 0.000186 0.000953 0.000905 0.000745 0.000171
Nuclear Periphery 0.000066 0.000057 0.000196 0.000115 0.000075 0.000019 0.000055 0.000074 0.000066 0.000032 0.000072 0.000079
Nuclear Periphery Foci 0.000848 0.003475 0.019469 0.007269 0.002709 0.000602 0.007004 0.003259 0.000993 0.001586 0.008505 0.003754
Nucleolus 0.000046 0.000072 0.000041 0.000042 0.000030 0.000043 0.000045 0.000042 0.000044 0.000053 0.000044 0.000042
Nucleus 0.001743 0.001963 0.002914 0.002340 0.000981 0.001661 0.003486 0.001823 0.001684 0.001765 0.003417 0.001887
Peroxisomes 0.000296 0.000425 0.000315 0.002928 0.000966 0.000303 0.000258 0.002042 0.000348 0.000345 0.000265 0.002152
Vacuole 0.013646 0.016161 0.094580 0.123240 0.015992 0.009998 0.024928 0.024437 0.013829 0.012108 0.033316 0.036649
Vacuole Periphery 0.055281 0.018703 0.019452 0.014392 0.044243 0.012809 0.005095 0.008532 0.054421 0.014827 0.006824 0.009257

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.99 -3.13 -1.34 -1.23 -1.12 2.41 1.97 -1.98 -4.76 -4.36 0.06 -1.78 -4.22 -4.22 -4.01
Bud Neck -0.83 -7.70 -6.21 -6.15 0.20 3.88 -1.80 -6.38 -10.56 -5.55 2.52 -9.67 -11.30 -11.83 -4.33
Bud Site 4.64 -2.35 -4.05 -5.12 -2.80 5.52 5.53 0.29 -11.06 -10.88 10.29 8.76 -6.91 -11.64 -11.23
Cell Periphery -1.43 -6.87 -3.04 -2.86 0.90 3.84 1.45 -3.22 -6.35 -4.74 3.56 -6.71 -6.21 -6.61 -4.46
Cytoplasm -15.64 0.12 5.99 11.14 5.04 -12.78 -15.73 -9.06 6.96 13.47 -24.46 -28.89 -6.94 9.47 13.74
Cytoplasmic Foci 16.31 18.96 2.38 -3.83 -5.70 9.49 14.75 10.13 2.67 -12.68 20.69 39.63 16.35 1.06 -13.76
Eisosomes 2.90 2.68 -1.37 -2.85 -2.66 2.19 2.82 0.74 -4.25 -6.23 4.66 6.78 0.10 -4.60 -6.77
Endoplasmic Reticulum 7.04 1.83 5.90 1.25 1.85 3.36 4.20 4.25 6.35 0.55 7.77 10.74 11.91 7.06 1.56
Endosome 2.46 -7.09 -6.41 -6.67 -3.34 6.26 5.99 2.65 -6.54 -5.87 8.03 2.72 -5.30 -8.47 -6.50
Golgi -2.26 -4.47 -2.87 -2.35 -0.19 5.05 6.07 0.50 -4.94 -6.05 2.27 3.88 -3.66 -4.71 -5.55
Lipid Particles -4.13 -8.50 -4.51 -4.29 -1.23 0.92 -9.41 -8.86 -9.25 -3.77 -4.67 -13.90 -10.22 -9.62 -3.73
Mitochondria 3.97 11.04 11.05 2.22 0.50 0.70 2.88 -0.00 -0.42 -1.71 7.01 11.18 4.05 -0.01 -1.71
Mitotic Spindle -1.99 -6.00 -3.44 -3.34 -2.18 1.64 1.06 0.56 -4.71 -1.79 0.78 -3.43 -5.02 -5.50 -2.76
None -0.49 7.42 11.33 6.04 3.72 0.08 0.12 1.04 9.56 5.46 0.41 1.62 8.64 10.20 5.69
Nuclear Periphery 0.39 -4.57 -1.96 -2.58 2.25 2.03 0.67 0.01 -1.41 -0.46 1.94 -0.44 -0.39 -1.40 -0.20
Nuclear Periphery Foci -6.95 -8.86 -5.95 -3.47 4.99 3.91 -5.48 -0.78 -5.61 5.05 -3.72 -12.82 -6.32 -4.86 6.54
Nucleolus -1.03 0.93 0.21 1.07 -0.57 -0.92 -1.12 -1.01 -0.35 0.29 -0.90 -0.31 -0.04 0.80 0.24
Nucleus -0.70 -3.40 -0.92 -0.64 0.54 -3.79 -10.43 -3.56 -1.39 5.77 -0.36 -6.82 -1.16 -1.14 5.52
Peroxisomes -0.96 -0.35 -3.79 -3.55 -3.74 1.56 1.63 -2.09 -5.36 -5.42 0.07 1.27 -6.05 -6.03 -6.27
Vacuole -1.39 -7.90 -6.73 -6.55 -1.36 1.74 -2.17 -2.05 -7.47 0.06 1.56 -9.82 -8.12 -8.77 -0.97
Vacuole Periphery 13.31 9.65 9.18 1.26 1.18 4.30 5.38 4.87 3.11 -2.36 16.84 20.44 17.73 4.25 -1.62
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; also enters the nucleus and positively regulates transcription initiation; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation, most often in the 3' UTR; forms cytoplasmic foci upon DNA replication stress
Localization
Cell Percentages cytoplasm (97%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-5

Lsm1

Lsm1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Lsm1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available