Standard name | |
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Human Ortholog | |
Description | Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 14 | 20 | 27 | 9 | 31 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Bud | 0 | 2 | 2 | 2 | 3 | 0 | 0 | 0 | 4 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 4 | 12 | 5 | 19 | 18 | 24 | 36 | 40 | 43 | 23 | 49 | 2 | 2 | 1 | 5 | 9 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 258 | 345 | 403 | 317 | 323 | 306 | 355 | 344 | 335 | 339 | 191 | 238 | 138 | 177 | 185 | 250 | 201 | 247 | 242 | 333 | 396 | 77 | 187 | 196 |
Endoplasmic Reticulum | 1 | 2 | 9 | 1 | 15 | 11 | 31 | 44 | 28 | 50 | 22 | 27 | 1 | 2 | 1 | 10 | 13 | 10 | 0 | 3 | 4 | 0 | 4 | 4 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 10 | 14 | 13 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 2 | 5 | 2 | 2 | 8 | 0 | 1 | 1 | 1 | 0 | 3 | 0 | 6 | 4 | 0 | 0 | 1 |
Unique Cell Count | 258 | 349 | 410 | 321 | 347 | 321 | 401 | 420 | 403 | 438 | 242 | 325 | 139 | 180 | 186 | 256 | 210 | 249 | 247 | 351 | 412 | 83 | 200 | 213 |
Labelled Cell Count | 259 | 353 | 426 | 325 | 364 | 337 | 415 | 451 | 443 | 478 | 265 | 366 | 141 | 183 | 188 | 268 | 223 | 263 | 247 | 351 | 412 | 83 | 200 | 213 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 128.7 | 80.0 | 73.4 | 64.6 | 54.7 | 47.8 | 44.2 | 38.5 | 36.8 | 34.0 | 31.9 | 31.4 | 97.4 | 91.6 | 78.5 | 135.4 | 137.8 | 131.8 | 139.6 | 158.3 | 137.7 |
Std Deviation (1e-4) | 31.6 | 21.2 | 17.7 | 13.9 | 15.9 | 11.7 | 11.8 | 10.1 | 9.6 | 8.8 | 9.3 | 7.8 | 21.2 | 21.0 | 18.2 | 50.2 | 51.1 | 49.2 | 40.6 | 41.8 | 42.5 |
Intensity Change (Log2) | – | – | – | -0.18 | -0.42 | -0.62 | -0.73 | -0.93 | -0.99 | -1.11 | -1.2 | -1.22 | 0.41 | 0.32 | 0.1 | 0.88 | 0.91 | 0.84 | 0.93 | 1.11 | 0.91 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 3.7 | 4.6 | 5.1 | 0 | 6.4 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | -1.2 | 1.8 | 1.8 | 2.1 | 3.5 | 4.1 | 4.1 | 3.6 | 5.9 | 0 | 0 | 0 | -0.8 | 0.9 | -1.8 |
Cytoplasm | 0.5 | -3.6 | -2.3 | -5.6 | -7.9 | -7.5 | -9.2 | -8.4 | -10.1 | 0.8 | 0 | 1.1 | -0.6 | -1.9 | 1.0 |
Endoplasmic Reticulum | 0 | 1.7 | 1.0 | 3.6 | 4.9 | 3.3 | 5.3 | 4.0 | 3.8 | 0 | 0 | 0 | 1.3 | 2.5 | 1.4 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 3.7 | 0 | 3.9 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 95.6918 | 134.2757 | 124.0292 | 135.0129 | 112.2588 | 132.6041 | 92.853 | 128.5473 | 124.0284 | 115.0633 | 100.5563 | 129.0351 | 116.9913 | 140.0868 | 129.6387 | 117.7763 | 105.5942 | 121.2015 |
Actin | 0.0154 | 0.0003 | 0.0033 | 0.0004 | 0.001 | 0.001 | 0.0054 | 0.0001 | 0.0045 | 0 | 0.0165 | 0.0193 | 0.0163 | 0.0002 | 0.0078 | 0.0084 | 0.0003 | 0.0002 |
Bud | 0.0021 | 0.0005 | 0.0027 | 0.0024 | 0.0073 | 0.0013 | 0.0011 | 0.0001 | 0.0001 | 0.0002 | 0.001 | 0.0001 | 0.0005 | 0.0002 | 0.0005 | 0.0009 | 0.0008 | 0.0003 |
Bud Neck | 0.0009 | 0.0005 | 0.0019 | 0.0012 | 0.001 | 0.004 | 0.0005 | 0.0001 | 0.0006 | 0.0002 | 0.0007 | 0.0005 | 0.0003 | 0.0001 | 0.0003 | 0.0008 | 0.0003 | 0.0007 |
Bud Periphery | 0.0026 | 0.0002 | 0.0039 | 0.0007 | 0.0042 | 0.0007 | 0.001 | 0 | 0.0001 | 0 | 0.0017 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.0009 | 0.0004 | 0.0001 |
Bud Site | 0.0016 | 0.0002 | 0.0012 | 0.0003 | 0.0016 | 0.0002 | 0.0009 | 0.0001 | 0.0007 | 0 | 0.0008 | 0.0002 | 0.0004 | 0.0001 | 0.0005 | 0.0014 | 0.0001 | 0 |
Cell Periphery | 0.0058 | 0.0013 | 0.0108 | 0.0048 | 0.0032 | 0.0099 | 0.0113 | 0.0026 | 0.0014 | 0.0002 | 0.0047 | 0 | 0.0009 | 0.0013 | 0.0007 | 0.0013 | 0.0012 | 0.0002 |
Cytoplasm | 0.6678 | 0.977 | 0.91 | 0.9163 | 0.7952 | 0.7813 | 0.846 | 0.9897 | 0.973 | 0.9803 | 0.8609 | 0.9642 | 0.9199 | 0.9946 | 0.9524 | 0.8843 | 0.8678 | 0.9464 |
Cytoplasmic Foci | 0.0021 | 0.0005 | 0.0005 | 0.0004 | 0.002 | 0.0009 | 0.012 | 0.0002 | 0.0017 | 0.0003 | 0.0072 | 0.001 | 0.0054 | 0.0002 | 0.0047 | 0.012 | 0.0144 | 0.0013 |
Eisosomes | 0.0005 | 0 | 0.0009 | 0 | 0 | 0 | 0.0009 | 0 | 0.003 | 0 | 0.0007 | 0.0001 | 0.0004 | 0 | 0.0003 | 0.0004 | 0.0002 | 0 |
Endoplasmic Reticulum | 0.0068 | 0.0006 | 0.0051 | 0.0004 | 0.0013 | 0.0035 | 0.0049 | 0.0007 | 0.0013 | 0.0005 | 0.0034 | 0.0048 | 0.0033 | 0.0005 | 0.001 | 0.0023 | 0.0031 | 0.0119 |
Endosome | 0.0067 | 0.0001 | 0.0017 | 0.0004 | 0.0045 | 0.0041 | 0.0076 | 0.0001 | 0.0006 | 0.0002 | 0.0093 | 0.0012 | 0.0023 | 0.0001 | 0.0005 | 0.0041 | 0.0015 | 0.0037 |
Golgi | 0.0011 | 0 | 0.0003 | 0 | 0.0004 | 0.0002 | 0.002 | 0 | 0.001 | 0 | 0.0058 | 0.002 | 0.0026 | 0 | 0.0003 | 0.0021 | 0.0002 | 0.0002 |
Lipid Particles | 0.0013 | 0.0001 | 0.0005 | 0.0001 | 0.0004 | 0.0002 | 0.008 | 0.0004 | 0.002 | 0 | 0.0126 | 0.0005 | 0.0041 | 0 | 0.0017 | 0.0132 | 0.0036 | 0.0001 |
Mitochondria | 0.054 | 0.0057 | 0.0084 | 0.0007 | 0.0068 | 0.0018 | 0.0039 | 0.0001 | 0.0012 | 0.0001 | 0.011 | 0.0013 | 0.0042 | 0 | 0.004 | 0.0153 | 0.0346 | 0.0005 |
None | 0.0058 | 0.0006 | 0.0009 | 0.0003 | 0.0007 | 0.0004 | 0.0107 | 0.0002 | 0.0016 | 0.0002 | 0.0084 | 0.0001 | 0.0053 | 0.0001 | 0.0082 | 0.0046 | 0.0172 | 0.0005 |
Nuclear Periphery | 0.0802 | 0.002 | 0.0133 | 0.0106 | 0.0081 | 0.0502 | 0.0158 | 0.0008 | 0.0014 | 0.002 | 0.0121 | 0.0015 | 0.0094 | 0.0004 | 0.0023 | 0.0035 | 0.0087 | 0.0063 |
Nucleolus | 0.0085 | 0.002 | 0.0031 | 0.0014 | 0.0019 | 0.0025 | 0.0168 | 0.0001 | 0.0005 | 0.0003 | 0.0065 | 0 | 0.0065 | 0 | 0.0039 | 0.0035 | 0.0022 | 0.0004 |
Nucleus | 0.059 | 0.0032 | 0.0095 | 0.0179 | 0.0139 | 0.0379 | 0.0151 | 0.001 | 0.0015 | 0.0043 | 0.0051 | 0.0013 | 0.0075 | 0.0006 | 0.0033 | 0.011 | 0.0068 | 0.0144 |
Peroxisomes | 0.0007 | 0.0002 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0.0018 | 0 | 0.0014 | 0 | 0.0018 | 0.0004 | 0.0019 | 0 | 0.001 | 0.0027 | 0.0043 | 0 |
Punctate Nuclear | 0.0056 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0061 | 0 | 0.0002 | 0 | 0.0026 | 0.0001 | 0.001 | 0 | 0.0005 | 0.001 | 0.0001 | 0.0002 |
Vacuole | 0.0426 | 0.0043 | 0.0157 | 0.0285 | 0.083 | 0.0547 | 0.0226 | 0.0036 | 0.0018 | 0.0088 | 0.0201 | 0.0008 | 0.0055 | 0.0014 | 0.0037 | 0.0146 | 0.0234 | 0.006 |
Vacuole Periphery | 0.0286 | 0.0006 | 0.006 | 0.0131 | 0.0631 | 0.0447 | 0.0057 | 0.0001 | 0.0003 | 0.0021 | 0.007 | 0.0002 | 0.0022 | 0.0001 | 0.0023 | 0.0115 | 0.0088 | 0.0063 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 239.3616 | 215.0879 | 251.6883 | 277.5523 | 223.2573 | 199.648 | 225.2421 | 221.7417 | 223.008 | 260.4632 |
Translational Efficiency | 0.9333 | 1.0309 | 0.9649 | 0.8624 | 0.9816 | 1.0167 | 0.8856 | 0.7285 | 0.7867 | 0.8262 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✔ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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