Standard name
Human Ortholog
Description Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.66 0.9 0.88 0.95 0.92 0.85 – 0.82 0.83 0.79 0.8 0.76 0.96 0.97 0.97 0.79 0.79 0.69 0.31 0.46 0.37 0.2 0.1 0.06
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0.05 0.05 0
Endosome 0 0 0.05 0 0 0 – 0 0 0 0 0 0 0 0 0.11 0.09 0.13 0.07 0.08 0.09 0.16 0.2 0.2
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.07 0.08
Mitochondria 0.05 0 0 0 0 0.2 – 0.21 0.3 0.32 0.34 0.39 0 0 0 0.05 0 0.06 0.07 0.11 0.18 0.23 0.14 0.1
Nucleus 0.09 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.06 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Vac/Vac Membrane 0.18 0 0.05 0 0 0.06 – 0.05 0 0 0 0 0 0 0 0.09 0.13 0.14 0.47 0.23 0.2 0.2 0.32 0.41
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 2 0 0 – 2 0 0 1 1 2 3 1 3 0 1 1 9 11 8 16 18
Bud 0 4 5 3 0 17 – 19 14 17 22 29 1 0 1 1 0 1 2 11 11 12 26 25
Bud Neck 0 0 1 2 1 0 – 5 0 0 1 0 2 7 5 2 4 0 1 2 4 3 4 5
Bud Site 1 0 1 0 1 1 – 0 0 1 3 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 2 1 3 2 0 – 0 0 2 0 2 0 4 0 0 0 0 0 1 2 0 0 0
Cytoplasm 126 384 391 338 407 434 – 626 338 376 433 537 200 438 344 227 220 159 83 212 164 67 55 32
Endoplasmic Reticulum 4 13 2 0 0 1 – 1 0 0 1 0 5 8 5 19 11 10 4 5 12 16 26 15
Endosome 6 1 20 8 18 10 – 15 2 3 4 3 1 0 3 31 24 29 18 34 39 55 115 114
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 5 4 6 8 20 42 46
Mitochondria 9 17 7 6 11 104 – 159 122 153 186 274 1 0 0 13 9 13 17 50 79 77 79 57
Nucleus 18 1 2 0 0 2 – 3 0 2 1 3 0 1 0 3 3 1 0 0 1 0 1 0
Nuclear Periphery 11 4 0 0 0 0 – 2 0 1 1 0 0 0 0 0 0 0 0 0 1 0 5 1
Nucleolus 1 0 0 0 2 0 – 2 1 0 2 0 0 0 0 0 0 3 0 0 0 0 0 0
Peroxisomes 0 0 2 1 1 0 – 1 0 0 0 0 0 0 0 0 0 0 0 1 0 1 1 2
SpindlePole 0 0 6 4 1 3 – 7 3 5 6 7 0 0 0 6 6 13 0 7 7 4 9 11
Vac/Vac Membrane 35 11 21 8 19 29 – 36 8 18 12 16 0 3 3 25 35 32 125 104 87 69 185 239
Unique Cell Count 191 427 442 355 441 509 760 406 474 540 706 209 453 354 286 278 230 266 457 444 343 580 580
Labelled Cell Count 214 438 459 375 463 601 878 488 578 673 873 212 464 362 330 313 267 266 457 444 343 580 580


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.4 4.6 4.4 3.9 4.2 3.5 – 3.8 3.6 3.2 3.3 3.2 5.2 5.3 5.6 4.9 5.5 6.3 6.4 7.2 7.6
Std Deviation (1e-4) 0.9 1.0 4.4 1.4 1.3 1.0 – 1.2 1.1 0.9 1.1 0.8 1.0 0.9 1.1 1.4 1.5 2.1 1.6 1.9 2.0
Intensity Change (Log2) – – – -0.19 -0.08 -0.34 – -0.22 -0.31 -0.46 -0.43 -0.45 0.24 0.26 0.35 0.16 0.3 0.51 0.52 0.71 0.77

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 2.2 3.8 4.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.0792 0.7334 0.841 0.6678 0.1787 0.6515 2.0467 2.6964 2.4987 2.8551 2.8645 2.8928 1.7535 2.5972 2.4435 1.9276 2.3232 2.599
Actin 0.001 0.0008 0.0006 0.0004 0.0005 0.0006 0.0164 0.0016 0.0009 0.0009 0.0323 0.0064 0.0005 0.0003 0.0008 0.0004 0.0001 0.0011
Bud 0.005 0.0028 0.0074 0.0013 0.0002 0.0002 0.0019 0.005 0.0017 0.0007 0.0054 0.0016 0.0008 0.0007 0.0032 0.0015 0.0002 0.0006
Bud Neck 0.0011 0.0001 0.0039 0.0002 0.0001 0.0013 0.004 0.0009 0.0012 0.0042 0.0014 0.0028 0.0002 0.0003 0.0004 0.0001 0.0001 0.0081
Bud Periphery 0.0028 0.002 0.0049 0.0036 0.0002 0.0002 0.0033 0.0033 0.0027 0.0013 0.0179 0.0036 0.0011 0.0008 0.0046 0.0097 0.0003 0.0009
Bud Site 0.0059 0.0039 0.0045 0.0004 0.0001 0.0012 0.006 0.0143 0.0045 0.0071 0.0013 0.001 0.001 0.0013 0.0053 0.0001 0.0001 0.0004
Cell Periphery 0.0005 0.0004 0.0003 0.0004 0 0.0002 0.0006 0.0004 0.0003 0.0002 0.0003 0.0002 0.0003 0.0002 0.0003 0.0002 0 0.0001
Cytoplasm 0.0636 0.1121 0.1046 0.1116 0.1889 0.1133 0.0893 0.1574 0.1322 0.0525 0.1323 0.1612 0.1677 0.2318 0.1936 0.169 0.2299 0.2376
Cytoplasmic Foci 0.022 0.032 0.0393 0.027 0.0249 0.0265 0.0458 0.061 0.0542 0.0597 0.06 0.0313 0.0371 0.0329 0.0529 0.0248 0.0285 0.0305
Eisosomes 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0011 0.0001 0.0001 0 0.0008 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001
Endoplasmic Reticulum 0.0024 0.0016 0.0015 0.002 0.0024 0.0018 0.0034 0.0032 0.0017 0.0012 0.0033 0.0017 0.0029 0.0028 0.0069 0.0042 0.0013 0.0041
Endosome 0.0273 0.056 0.0694 0.0335 0.1088 0.0232 0.055 0.068 0.097 0.1016 0.1487 0.0409 0.0482 0.0632 0.0813 0.1202 0.07 0.0371
Golgi 0.0035 0.0024 0.0047 0.0012 0.0014 0.0009 0.004 0.0033 0.0078 0.0024 0.008 0.0016 0.0021 0.0021 0.0049 0.0014 0.0043 0.0019
Lipid Particles 0.0017 0.0009 0.0014 0.0009 0.0008 0.0013 0.0062 0.0017 0.0032 0.0015 0.0131 0.0022 0.0021 0.0018 0.0009 0.0006 0.0008 0.0006
Mitochondria 0.002 0.0021 0.0021 0.0007 0.001 0.0016 0.0054 0.0027 0.0045 0.0018 0.0079 0.0045 0.0024 0.0021 0.0052 0.0033 0.0008 0.0026
None 0.841 0.7633 0.7301 0.7964 0.6418 0.8087 0.7226 0.6497 0.6493 0.6555 0.4925 0.7158 0.7062 0.6391 0.6196 0.5795 0.6489 0.6488
Nuclear Periphery 0.0016 0.001 0.0012 0.0009 0.0021 0.0008 0.0063 0.0016 0.0019 0.0014 0.0109 0.0038 0.001 0.0009 0.0011 0.0025 0.0008 0.0012
Nucleolus 0.0021 0.0004 0.0005 0.0006 0.0002 0.0006 0.001 0.0008 0.0013 0.0004 0.0011 0.0006 0.0004 0.0005 0.0005 0.0003 0.0001 0.0002
Nucleus 0.0046 0.0016 0.0019 0.0022 0.0014 0.0033 0.0034 0.0041 0.0066 0.0014 0.0049 0.0018 0.0014 0.0017 0.0017 0.0022 0.0013 0.0014
Peroxisomes 0.0007 0.0008 0.0012 0.0011 0.0008 0.0005 0.0088 0.0022 0.0017 0.0182 0.02 0.0018 0.0009 0.0003 0.001 0.0008 0.0002 0.0018
Punctate Nuclear 0.0023 0.001 0.0025 0.0015 0.0006 0.0091 0.0034 0.0029 0.0037 0.0087 0.0156 0.0058 0.0008 0.0008 0.0009 0.0006 0.0006 0.0007
Vacuole 0.0075 0.0126 0.0139 0.0131 0.0191 0.0038 0.0097 0.0139 0.0203 0.0651 0.0183 0.0093 0.0206 0.015 0.0123 0.0707 0.0102 0.0184
Vacuole Periphery 0.0013 0.0018 0.0043 0.0011 0.0048 0.0006 0.0025 0.0019 0.0032 0.0141 0.004 0.0021 0.0021 0.0015 0.0024 0.0078 0.0015 0.0017

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.3103 11.8841 7.8386 11.7776 26.3332 14.763 14.1855 10.8133 7.5259 27.9962
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
215 377 488 1084 2926 1647 546 1826 3141 2024 1034 2910

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 803.47 784.74 881.08 822.26 683.67 742.64 869.79 778.91 691.87 750.48 875.12 795.06
Standard Deviation 100.34 102.18 107.00 127.66 75.06 98.03 93.83 103.72 82.79 100.16 100.42 115.15
Intensity Change Log 2 — -0.034029 0.133029 0.033350 — 0.119363 0.347367 0.188157 — 0.038519 0.235531 0.106586

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000191 0.000496 0.000878 0.002897 0.000219 0.000419 0.000518 0.000265 0.000217 0.000433 0.000688 0.001246
Bud Neck 0.007409 0.025420 0.005621 0.009502 0.037914 0.034669 0.008720 0.015101 0.035826 0.032946 0.007258 0.013015
Bud Site 0.031129 0.022274 0.013843 0.038655 0.014779 0.018225 0.005937 0.024355 0.015898 0.018979 0.009668 0.029682
Cell Periphery 0.000134 0.000126 0.000235 0.000214 0.000215 0.000212 0.000123 0.000322 0.000209 0.000196 0.000176 0.000282
Cytoplasm 0.303867 0.329164 0.401102 0.407144 0.444858 0.314179 0.334329 0.425410 0.435207 0.316970 0.365842 0.418606
Cytoplasmic Foci 0.115180 0.288324 0.069091 0.077704 0.200567 0.301294 0.056725 0.087731 0.194722 0.298878 0.062561 0.083996
Eisosomes 0.000114 0.000135 0.000083 0.000076 0.000380 0.000233 0.000075 0.000091 0.000362 0.000215 0.000079 0.000086
Endoplasmic Reticulum 0.001178 0.001090 0.005845 0.002576 0.002262 0.001222 0.004042 0.001962 0.002188 0.001197 0.004893 0.002191
Endosome 0.031633 0.047461 0.016382 0.027148 0.019318 0.067573 0.014840 0.031071 0.020161 0.063826 0.015568 0.029610
Golgi 0.000487 0.007597 0.002900 0.009460 0.006063 0.017169 0.000275 0.002616 0.005682 0.015386 0.001514 0.005165
Lipid Particles 0.003921 0.007290 0.005125 0.003304 0.012731 0.013895 0.004918 0.011187 0.012128 0.012664 0.005016 0.008251
Mitochondria 0.000228 0.007300 0.000522 0.005360 0.007568 0.017827 0.000470 0.002641 0.007065 0.015866 0.000495 0.003654
Mitotic Spindle 0.000591 0.009312 0.011551 0.045159 0.001563 0.004374 0.012473 0.009089 0.001497 0.005294 0.012038 0.022526
None 0.000536 0.000729 0.003518 0.009618 0.003490 0.004145 0.003519 0.004678 0.003287 0.003509 0.003519 0.006518
Nuclear Periphery 0.000652 0.000470 0.002098 0.002286 0.000347 0.000387 0.002631 0.001908 0.000367 0.000402 0.002380 0.002049
Nuclear Periphery Foci 0.000943 0.000486 0.006118 0.003215 0.000193 0.000343 0.003403 0.001679 0.000244 0.000369 0.004684 0.002251
Nucleolus 0.000582 0.001270 0.000884 0.000709 0.001460 0.002489 0.001252 0.001707 0.001400 0.002262 0.001079 0.001335
Nucleus 0.128145 0.089901 0.320256 0.125972 0.146163 0.062173 0.401879 0.204641 0.144930 0.067338 0.363357 0.175336
Peroxisomes 0.003993 0.019202 0.003407 0.008441 0.005818 0.018956 0.006137 0.005042 0.005693 0.019002 0.004849 0.006308
Vacuole 0.368196 0.138739 0.129885 0.217809 0.091999 0.114069 0.137427 0.165273 0.110905 0.118665 0.133868 0.184843
Vacuole Periphery 0.000891 0.003214 0.000655 0.002752 0.002094 0.006148 0.000306 0.003231 0.002012 0.005602 0.000471 0.003052

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.76 -4.75 -3.13 -2.37 -1.13 -3.02 -4.59 -0.57 2.22 3.85 -3.71 -6.18 -3.11 -1.74 0.36
Bud Neck -6.11 -0.38 -1.69 5.61 -1.51 1.43 15.12 12.09 9.15 -3.64 1.37 17.37 14.37 11.60 -4.28
Bud Site 0.39 1.60 0.14 -0.45 -3.17 -1.62 5.36 -2.23 -0.83 -5.60 -1.65 3.66 -2.96 -1.25 -5.79
Cell Periphery -0.58 -5.56 -1.31 -0.91 4.17 0.10 5.98 -0.65 -0.65 -1.72 0.44 1.69 -0.24 -0.44 -0.73
Cytoplasm -0.94 -2.07 -2.61 -1.83 -0.45 16.21 13.56 4.77 -9.65 -9.26 15.85 12.61 6.80 -8.82 -7.09
Cytoplasmic Foci -12.04 4.25 5.08 19.47 0.92 -15.10 30.01 25.43 34.54 -7.84 -17.03 31.26 30.25 41.34 -5.42
Eisosomes -2.09 0.44 2.17 6.83 3.33 3.48 7.42 7.38 9.50 -0.44 3.77 7.32 7.57 10.60 1.88
Endoplasmic Reticulum 0.16 -11.78 -5.04 -4.96 9.19 2.78 -6.79 1.02 -2.56 8.82 2.94 -10.32 0.12 -4.25 12.86
Endosome -3.56 2.33 2.53 6.76 0.40 -17.06 4.69 -3.50 12.32 -6.33 -17.51 5.14 -1.37 15.41 -5.36
Golgi -4.85 -1.33 -2.73 1.85 -1.13 -7.68 16.28 6.38 10.16 -3.48 -7.90 7.44 4.56 9.72 -2.16
Lipid Particles -2.68 -1.98 0.71 4.08 5.88 -1.00 10.55 2.40 2.89 -4.89 -0.54 10.42 5.51 5.22 -3.22
Mitochondria -3.27 -5.00 -2.61 2.00 -2.21 -6.02 18.07 10.74 9.30 -5.50 -6.01 17.94 9.04 9.30 -4.74
Mitotic Spindle -2.73 -4.33 -7.83 -4.55 -4.07 -2.99 -3.26 -5.84 -3.74 -0.16 -3.87 -5.10 -9.51 -6.78 -2.80
None -0.66 -5.54 -4.24 -4.16 -1.99 -0.61 0.15 -0.57 0.19 -0.67 -0.23 0.17 -1.74 -0.99 -1.94
Nuclear Periphery 1.73 -10.27 -6.20 -7.21 -0.36 -1.00 -16.82 -11.24 -10.79 4.29 -0.84 -22.31 -13.18 -12.77 2.80
Nuclear Periphery Foci 2.62 -8.16 -2.42 -3.20 4.67 -2.43 -7.87 -4.96 -4.37 3.73 -2.38 -12.05 -5.89 -5.36 6.29
Nucleolus -2.60 -2.84 -1.55 1.73 0.82 -1.81 0.26 -1.36 1.37 -1.04 -1.87 1.22 0.18 1.94 -1.13
Nucleus 2.66 -11.18 -2.00 -7.87 12.71 21.04 -20.28 -10.60 -24.72 14.62 20.08 -24.51 -9.61 -26.01 18.80
Peroxisomes -5.46 0.82 -0.59 5.24 -1.58 -10.12 1.67 2.48 10.99 -0.21 -11.26 3.32 2.44 12.13 -1.27
Vacuole 10.50 9.84 3.00 -13.39 -12.36 -5.01 -9.44 -17.93 -12.55 -1.12 -1.84 -8.70 -22.92 -20.36 -8.36
Vacuole Periphery -3.23 0.75 -1.52 2.37 -1.91 -6.21 11.43 -0.96 4.57 -5.03 -6.46 10.45 -0.14 5.70 -5.27
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (26%), vacuole (3%), mixed (41%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Kch1

Kch1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Kch1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available