Standard name
Human Ortholog
Description FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 – 0 0 0 0 0 0.07 0.07 0.12 0.06 0.09 0.11 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.05 0 – 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.24 0.14 0.11 0.08 0.33 – 0.23 0.46 0.37 0.41 0.39 0 0 0 0.05 0.07 0.07 0 0 0 0.07 0.13 0.17
Nucleus 0 0.08 0 0.06 0.05 0 – 0 0 0.05 0.05 0 0.07 0.07 0.08 0 0.07 0.05 0 0 0 0 0 0
Nuclear Periphery 0.88 0.83 0.82 0.82 0.76 0.73 – 0.61 0.65 0.63 0.63 0.64 0.81 0.81 0.7 0.72 0.64 0.64 0.91 0.86 0.87 0.87 0.74 0.67
Nucleolus 0.12 0.07 0.13 0.16 0.21 0.26 – 0.26 0.26 0.26 0.27 0.35 0.05 0.05 0 0.1 0.11 0.19 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.29 0.27 0.18 0.1 0.15 0.09 – 0.11 0.05 0.05 0.05 0.05 0.23 0.23 0.26 0.25 0.33 0.26 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 4 5
Bud 0 0 0 0 0 1 – 0 3 2 1 4 1 1 0 1 0 0 2 1 1 1 0 3
Bud Neck 0 0 0 0 0 0 – 0 0 1 1 0 0 0 0 1 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 1 – 3 3 5 5 2 0 0 2 0 0 1 – – – – – –
Cell Periphery 1 0 0 0 0 0 – 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
Cytoplasm 2 3 6 12 11 10 – 18 10 8 10 3 14 14 20 6 9 13 0 0 0 1 1 0
Endoplasmic Reticulum 7 0 0 1 0 1 – 1 1 2 2 1 1 0 2 5 1 0 0 0 0 1 0 1
Endosome 1 0 9 4 18 23 – 43 16 16 11 13 2 1 1 3 4 3 1 2 3 2 5 20
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 1 1 0 0 1 2 2 0 2 0 4 11
Mitochondria 9 28 42 31 31 179 – 187 257 252 194 269 2 2 2 5 7 8 2 2 10 18 38 72
Nucleus 5 9 8 16 18 20 – 34 13 34 24 24 13 13 13 4 7 6 1 0 3 0 2 2
Nuclear Periphery 192 96 253 233 293 392 – 503 365 423 297 440 158 158 119 76 67 75 212 105 296 218 213 290
Nucleolus 26 8 41 46 83 138 – 214 146 176 125 238 9 9 4 10 11 22 1 1 4 2 2 2
Peroxisomes 0 0 1 0 1 5 – 6 2 3 0 3 0 0 0 0 0 0 0 0 1 1 4 7
SpindlePole 0 0 0 0 1 3 – 7 1 6 3 4 5 5 6 3 0 2 0 0 1 0 1 2
Vac/Vac Membrane 63 31 55 29 59 50 – 92 28 33 23 34 46 45 44 26 34 30 6 4 8 1 10 14
Unique Cell Count 218 116 310 284 388 538 829 560 674 471 683 196 196 171 105 104 117 232 122 340 251 290 435
Labelled Cell Count 308 175 415 372 515 823 1108 846 961 696 1035 252 249 214 140 141 162 232 122 340 251 290 435


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.8 7.5 10.5 10.4 9.4 8.0 – 8.3 7.8 7.9 7.7 8.0 9.5 9.5 10.1 8.5 9.7 11.4 11.7 12.3 12.5
Std Deviation (1e-4) 3.8 1.6 2.3 2.5 2.3 2.0 – 2.2 2.0 2.3 2.3 2.2 2.3 2.3 2.5 1.9 2.6 2.8 2.5 2.1 2.3
Intensity Change (Log2) – – – -0.01 -0.15 -0.39 – -0.34 -0.43 -0.4 -0.44 -0.39 -0.14 -0.14 -0.05 -0.29 -0.11 0.12 0.16 0.23 0.26

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.6 0.8 -0.1 – 0.2 -0.2 0 0.2 0 2.9 2.9 4.5 0 0 4.1
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome -1.2 1.2 1.0 – 1.6 0 -0.5 -0.5 -1.0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -1.0 -2.4 6.3 – 3.4 9.6 7.6 8.2 8.1 -4.9 -4.9 -4.5 -2.5 -1.9 -1.9
Nucleus 1.9 1.4 0.9 – 1.2 -0.2 1.8 1.7 0.8 2.2 2.2 2.6 0 0 0
Nuclear Periphery 0.1 -1.9 -2.9 – -6.7 -5.1 -5.9 -5.6 -5.5 -0.3 -0.3 -3.0 -2.0 -3.6 -3.8
Nucleolus 1.0 2.8 4.3 – 4.5 4.4 4.5 4.4 7.0 -3.2 -3.2 -3.9 -1.0 -0.7 1.4
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole -2.6 -0.9 -3.6 – -3.0 -6.1 -6.6 -5.9 -6.5 1.6 1.4 2.1 1.6 3.2 1.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.9405 7.5887 7.5501 7.095 6.8585 7.0226 7.3003 8.7797 7.616 7.0453 6.3028 7.4224 7.4377 7.9676 7.2414 6.9452 6.8572 7.3882
Actin 0.0157 0.0001 0.0096 0.0174 0.0003 0.0016 0.0208 0.0002 0.0238 0.0003 0.0013 0.0004 0.0809 0.0017 0.0326 0.0237 0.005 0.0002
Bud 0.0002 0 0.0001 0.0001 0 0 0.0007 0 0.0002 0 0 0 0.0011 0.0001 0.0003 0.0002 0 0
Bud Neck 0.0006 0 0.0001 0.0002 0 0.0001 0.0028 0 0.0002 0 0.0001 0 0.0007 0 0.0009 0.0004 0 0
Bud Periphery 0.0007 0.0001 0.0003 0.0002 0.0001 0 0.0021 0.0001 0.0004 0.0001 0.0001 0.0001 0.0046 0.0004 0.0008 0.0005 0.0002 0
Bud Site 0.0005 0 0.0001 0.0002 0 0.0002 0.0054 0 0.0109 0 0 0 0.001 0.0001 0.0188 0.0018 0 0
Cell Periphery 0.0001 0 0 0.0001 0 0 0.0007 0 0.0003 0 0 0 0.0006 0.0001 0.0003 0.0001 0 0
Cytoplasm 0.0003 0 0.0001 0.0016 0 0.0001 0.0107 0.0181 0.0015 0 0.0002 0.0004 0.0021 0.0001 0.0043 0.0001 0 0
Cytoplasmic Foci 0.002 0 0.0002 0.0029 0.0001 0.0019 0.0144 0.0002 0.0045 0.0006 0.02 0.0002 0.0017 0.0002 0.0023 0.0077 0.0003 0
Eisosomes 0.0003 0 0.0001 0.0001 0 0 0.0009 0 0.0002 0 0 0 0.0016 0.0001 0.0006 0.0001 0.0001 0
Endoplasmic Reticulum 0.0017 0.0005 0.0008 0.0023 0.0005 0.0002 0.0119 0.0022 0.0011 0.0006 0.0006 0.0019 0.02 0.002 0.006 0.0015 0.0006 0.0002
Endosome 0.0023 0.0002 0.0013 0.0037 0.0006 0.0005 0.0337 0.0017 0.0016 0.0015 0.0075 0.0077 0.0312 0.0009 0.0053 0.0014 0.0015 0.0001
Golgi 0.0019 0.0001 0.0006 0.0013 0.0003 0.0006 0.0077 0.0001 0.0032 0.002 0.0085 0.0006 0.0086 0.0018 0.0027 0.003 0.0017 0.0001
Lipid Particles 0.0117 0.0013 0.0019 0.0024 0.003 0.0046 0.0551 0.0013 0.0024 0.0458 0.0462 0.0015 0.0064 0.0404 0.0093 0.0081 0.0078 0.0008
Mitochondria 0.0084 0.0009 0.0018 0.0025 0.002 0.0012 0.011 0.0033 0.0139 0.0013 0.0188 0.0114 0.0358 0.0439 0.0303 0.0055 0.0061 0.0006
None 0.0008 0.0001 0.0008 0.0045 0.0002 0.0001 0.0117 0.0004 0.0003 0.0001 0.0002 0.0001 0.0126 0.0004 0.0193 0.0005 0.0003 0.0001
Nuclear Periphery 0.891 0.9497 0.9184 0.9117 0.9411 0.9565 0.7006 0.859 0.8382 0.8998 0.8437 0.9452 0.6799 0.8041 0.7893 0.8039 0.9333 0.96
Nucleolus 0.0009 0.0005 0.0004 0.0005 0.0031 0.0003 0.0132 0.001 0.0005 0.0005 0.0012 0.0003 0.0019 0.0005 0.001 0.0165 0.0012 0.0006
Nucleus 0.0083 0.0066 0.0203 0.0054 0.0159 0.0068 0.0255 0.0458 0.0402 0.0168 0.0123 0.0118 0.0121 0.0423 0.01 0.0058 0.0088 0.0205
Peroxisomes 0.0022 0 0.0003 0.0008 0.0001 0.0061 0.009 0 0.0036 0.0003 0.0087 0.0001 0.0014 0.0002 0.005 0.0221 0.0005 0
Punctate Nuclear 0.0023 0.0003 0.0007 0.0065 0.0009 0.0024 0.0117 0.0058 0.0005 0.0009 0.002 0.0003 0.0038 0.0004 0.002 0.0455 0.0018 0.0004
Vacuole 0.0011 0.0006 0.0005 0.0005 0.0006 0.0001 0.0061 0.0023 0.0007 0.0004 0.001 0.0004 0.0041 0.001 0.0013 0.0007 0.0003 0.0002
Vacuole Periphery 0.0472 0.039 0.0416 0.0352 0.0311 0.0166 0.0443 0.0585 0.0519 0.0289 0.0275 0.0174 0.088 0.0592 0.0577 0.0508 0.0302 0.0162

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 31.6079 29.4543 29.2265 37.6733 42.4713 29.1015 37.9191 38.4477 30.3176 40.3916
Translational Efficiency 1.2546 1.573 1.3138 0.7081 0.906 1.4912 1.0151 0.9522 1.1312 1.0994

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
116 169 262 1381 1453 728 36 1868 1569 897 298 3249

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1286.74 1178.50 1446.52 1345.62 829.66 1128.75 1499.00 1299.88 863.45 1138.12 1452.86 1319.32
Standard Deviation 198.54 209.29 215.72 224.04 161.73 187.21 304.14 215.03 203.57 192.55 228.87 220.07
Intensity Change Log 2 — -0.126769 0.168866 0.064550 — 0.444134 0.853408 0.647786 — 0.124562 0.476910 0.321928

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000942 0.000824 0.000177 0.000256 0.000813 0.000204 0.005986 0.000387 0.000823 0.000321 0.000878 0.000332
Bud Neck 0.004409 0.001921 0.000870 0.002756 0.000492 0.000305 0.009810 0.001479 0.000782 0.000610 0.001950 0.002022
Bud Site 0.004972 0.000714 0.000052 0.000503 0.000188 0.000128 0.005445 0.000592 0.000541 0.000239 0.000704 0.000554
Cell Periphery 0.000084 0.000076 0.000017 0.000063 0.000143 0.000023 0.000271 0.000054 0.000139 0.000033 0.000047 0.000058
Cytoplasm 0.000866 0.000395 0.000513 0.000474 0.001347 0.000180 0.001889 0.000978 0.001311 0.000220 0.000679 0.000764
Cytoplasmic Foci 0.017745 0.001813 0.000206 0.002305 0.001026 0.000559 0.042447 0.001490 0.002262 0.000795 0.005309 0.001836
Eisosomes 0.000018 0.000008 0.000002 0.000006 0.000016 0.000004 0.000053 0.000004 0.000016 0.000005 0.000009 0.000005
Endoplasmic Reticulum 0.003956 0.003256 0.001098 0.001368 0.009015 0.003045 0.007727 0.001555 0.008641 0.003085 0.001898 0.001476
Endosome 0.016883 0.002077 0.000187 0.001659 0.002099 0.001112 0.027765 0.000684 0.003192 0.001294 0.003519 0.001098
Golgi 0.028642 0.000935 0.000134 0.002011 0.000584 0.000498 0.130954 0.000788 0.002658 0.000580 0.015937 0.001308
Lipid Particles 0.004993 0.004031 0.000130 0.003972 0.006198 0.002107 0.035317 0.001168 0.006109 0.002469 0.004380 0.002360
Mitochondria 0.003171 0.003628 0.000924 0.003780 0.013497 0.005142 0.012029 0.003869 0.012733 0.004857 0.002265 0.003832
Mitotic Spindle 0.092577 0.011979 0.011689 0.040234 0.002070 0.007190 0.105589 0.014949 0.008762 0.008092 0.023032 0.025697
None 0.000121 0.000546 0.000779 0.000662 0.006639 0.000397 0.000579 0.000827 0.006157 0.000425 0.000755 0.000757
Nuclear Periphery 0.546671 0.659709 0.770326 0.569671 0.566617 0.687776 0.278809 0.679848 0.565143 0.682488 0.710948 0.633017
Nuclear Periphery Foci 0.215466 0.277536 0.179100 0.304529 0.324101 0.261124 0.228568 0.234280 0.316070 0.264216 0.185076 0.264139
Nucleolus 0.011162 0.003839 0.011771 0.017032 0.027264 0.006389 0.005162 0.016043 0.026073 0.005909 0.010973 0.016464
Nucleus 0.014516 0.008440 0.018684 0.018131 0.023717 0.007612 0.011122 0.023570 0.023037 0.007768 0.017771 0.021258
Peroxisomes 0.001888 0.001360 0.000248 0.000315 0.000874 0.000519 0.000777 0.000203 0.000949 0.000678 0.000312 0.000250
Vacuole 0.015897 0.006217 0.000640 0.008279 0.003749 0.005114 0.040688 0.004039 0.004648 0.005322 0.005478 0.005841
Vacuole Periphery 0.015021 0.010696 0.002455 0.021994 0.009550 0.010572 0.049012 0.013191 0.009954 0.010595 0.008080 0.016933

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.45 1.91 1.72 1.32 -2.27 7.17 -1.38 4.64 -3.91 1.49 4.34 -0.19 5.71 -0.26 1.17
Bud Neck 2.08 4.06 1.91 -0.85 -4.28 1.87 -3.41 -5.22 -6.09 2.97 0.89 -2.73 -5.49 -5.03 -0.58
Bud Site 1.51 1.76 1.58 0.44 -3.01 0.92 -2.34 -1.15 -1.31 2.13 1.34 -0.54 -0.13 -1.46 0.42
Cell Periphery 0.37 3.44 1.04 0.37 -3.16 7.11 -1.90 4.28 -2.63 3.18 6.39 4.96 4.49 -2.35 -0.86
Cytoplasm 1.78 1.02 1.61 -0.41 0.04 3.15 -0.97 -0.21 -2.79 0.89 3.21 0.88 0.62 -3.00 -0.43
Cytoplasmic Foci 2.45 2.76 2.41 -0.33 -3.33 1.66 -3.05 -0.97 -2.09 3.01 2.49 -1.61 0.56 -2.41 1.84
Eisosomes 1.75 3.09 2.50 0.60 -3.96 5.40 -1.68 5.88 -0.03 2.17 5.27 2.09 6.02 0.06 1.24
Endoplasmic Reticulum 0.74 3.16 2.86 1.23 -1.69 7.94 0.46 11.44 3.05 2.80 7.66 10.28 12.06 3.34 1.12
Endosome 3.07 3.57 3.23 0.44 -4.61 2.10 -3.06 5.25 0.99 3.23 3.32 -0.29 4.66 0.47 2.12
Golgi 2.39 2.47 2.30 -1.79 -5.05 0.41 -3.54 -0.51 -0.76 3.53 2.31 -2.60 1.45 -2.41 2.89
Lipid Particles 0.18 1.97 0.38 0.08 -5.01 3.71 -2.22 6.87 1.09 2.59 3.21 0.87 5.01 0.19 1.19
Mitochondria -0.28 2.34 -0.66 -0.17 -4.58 3.84 0.37 5.73 0.77 1.82 4.09 6.60 5.76 0.73 -2.43
Mitotic Spindle 3.83 3.82 2.56 -3.84 -4.25 -2.36 -3.00 -6.73 -2.76 2.59 0.28 -2.24 -6.62 -6.22 -0.41
None -1.39 -1.09 -2.13 -0.34 0.20 5.18 5.07 4.84 -1.73 -1.21 5.16 4.45 4.88 -1.51 -0.05
Nuclear Periphery -3.59 -7.04 -1.23 4.62 14.48 -11.30 6.06 -11.94 1.26 -8.31 -11.66 -8.62 -7.82 6.10 4.98
Nuclear Periphery Foci -2.96 1.60 -5.32 -1.52 -13.16 7.28 2.78 12.75 3.57 -0.27 6.28 13.53 8.15 0.18 -9.00
Nucleolus 2.01 0.34 -0.69 -6.00 -1.61 8.36 6.31 3.78 -5.09 -3.64 8.87 4.45 3.67 -7.06 -2.02
Nucleus 1.78 0.87 0.93 -2.18 -0.05 5.90 0.43 -0.98 -6.68 -0.71 6.03 0.84 0.11 -7.06 -0.81
Peroxisomes 0.48 1.87 1.78 1.23 -0.92 2.01 0.25 6.35 2.09 1.65 1.18 4.87 5.72 2.08 0.70
Vacuole 2.17 3.50 1.99 -0.79 -9.14 -1.16 -3.03 -0.68 0.68 3.00 -0.40 -0.81 -1.61 -0.61 0.26
Vacuole Periphery 0.53 1.83 -1.05 -3.09 -11.35 -0.50 -3.09 -2.83 -1.20 2.80 -0.36 1.01 -5.45 -3.31 -4.53
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication
Localization
Cell Percentages nuclear periphery (91%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Nup100

Nup100


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nup100-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available