Standard name
Human Ortholog
Description Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0.05 0 0.07 0.13 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0.05 0 0.1 0.05 0.07 0.07 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.06 0.05 0.07 0.05 0.07 0 0.1 0.07 0.08 0 0.09 0.14 0 0 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0.08 0 0 0 0 0 0 0 0.07 0.11 0 0.07 0.05 0.05 0.06 0.05 0.06 0.08 0.12
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.4 0.25 0.07 0.11 0.05 0.28 0.29 0.15 0.7 0.54 0.68 0.41 0.14 0 0 0.06 0 0.06 0 0 0 0 0 0
Nucleus 0.38 0.43 0.65 0.51 0.45 0.26 0.28 0.22 0.2 0.18 0.21 0.2 0.38 0.27 0.24 0.32 0.4 0.32 0.18 0.2 0.19 0.18 0.05 0.05
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.62 0.48 0.08 0.45 0.23 0.31 0.16 0.15 0.18 0.16 0.14 0.11 0.65 0.67 0.62 0.63 0.57 0.6 0.45 0.48 0.53 0.49 0.47 0.42
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.17 0.24 0.44 0.41 0.48 0.41 0.5 0.6 0.31 0.32 0.25 0.44 0.19 0.37 0.27 0.13 0.19 0.21 0.23 0.13 0.1 0.13 0.27 0.27
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0.05 0.08 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 2 2
Bud 0 1 1 1 1 4 9 14 8 15 13 14 0 0 2 0 0 0 1 4 1 1 8 3
Bud Neck 0 2 7 2 10 2 21 42 4 14 8 24 0 6 3 1 0 0 1 3 4 2 15 14
Bud Site 1 1 0 1 4 7 16 6 31 18 20 23 1 1 1 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Cytoplasm 3 2 5 9 10 17 15 23 13 32 21 27 11 45 81 2 4 7 0 0 2 1 1 2
Endoplasmic Reticulum 0 0 1 0 0 0 0 0 0 0 2 0 0 0 1 2 0 2 0 0 0 2 2 2
Endosome 0 6 0 1 6 20 10 12 0 4 7 7 8 35 62 4 8 7 5 9 10 12 38 53
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 1 1 0 0 1 5 2
Mitochondria 32 34 11 16 11 71 93 49 227 179 206 134 35 20 25 8 0 8 0 1 1 3 3 4
Nucleus 30 58 104 78 91 65 90 71 65 60 63 67 95 129 140 43 49 42 16 30 37 38 27 23
Nuclear Periphery 2 0 0 0 1 0 0 1 0 0 0 0 1 0 1 3 0 1 0 1 1 0 1 2
Nucleolus 50 64 13 68 46 77 52 48 58 52 43 37 164 323 354 85 69 80 42 73 101 102 244 190
Peroxisomes 0 1 0 0 0 0 0 2 0 1 0 0 0 3 5 0 0 2 0 0 0 0 4 1
SpindlePole 14 32 71 63 98 103 159 194 102 106 77 144 48 179 157 18 23 28 21 20 19 26 138 125
Vac/Vac Membrane 0 3 0 1 3 5 4 7 2 3 7 6 2 1 4 6 6 3 2 5 9 16 18 21
Unique Cell Count 80 134 160 152 204 252 321 324 324 329 303 328 252 480 573 134 121 133 95 151 192 210 518 459
Labelled Cell Count 132 204 213 240 281 371 469 470 511 485 467 483 365 742 838 174 159 181 95 151 192 210 518 459


Nucleolus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.6 4.8 5.3 5.2 5.7 4.3 4.3 4.6 3.5 3.6 3.4 3.8 5.5 5.4 5.3 9.0 10.1 9.3 5.1 5.1 5.4
Std Deviation (1e-4) 0.6 0.7 1.0 1.3 1.4 1.2 0.8 1.2 0.7 0.7 0.8 0.7 1.2 1.1 1.2 2.5 2.5 2.3 1.1 1.2 1.4
Intensity Change (Log2) – – – -0.02 0.09 -0.32 -0.29 -0.2 -0.59 -0.58 -0.64 -0.47 0.05 0.02 0.01 0.77 0.94 0.82 -0.06 -0.05 0.03

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.5519 0.8234 0.436 0.8201 0.2774 0.5967 0.9362 1.424 1.0885 0.6928 1.0096 1.1034 1.7322 2.0221 1.4556 1.4858 1.4791 1.4866
Actin 0.0124 0 0.0001 0.0033 0 0.0039 0.0085 0 0.0006 0 0.0005 0.0001 0.0518 0 0.0029 0 0.0431 0.0068
Bud 0.0003 0.0001 0 0.0066 0 0.0004 0.0004 0 0.0009 0 0.0003 0 0.0004 0.0001 0.0001 0.0001 0.0008 0.0001
Bud Neck 0.0049 0.0012 0.0013 0.0024 0.0013 0.0027 0.0039 0.0004 0.0005 0.0006 0.0009 0.0007 0.0029 0.0014 0.0007 0.0015 0.0013 0.0012
Bud Periphery 0.0006 0.0003 0.0001 0.0175 0.0003 0.0009 0.0006 0.0001 0.0016 0.0001 0.0007 0.0001 0.0006 0.0002 0.0002 0.0004 0.0017 0.0001
Bud Site 0.003 0.001 0.0008 0.0216 0.0002 0.0009 0.0055 0.0003 0.0009 0.0002 0.0004 0.0002 0.0055 0.0019 0.0012 0.001 0.0019 0.0005
Cell Periphery 0.0003 0.0002 0.0002 0.0012 0.0002 0.0002 0.0007 0.0001 0.0002 0.0001 0.0005 0.0001 0.0005 0.0005 0.0003 0.0009 0.0003 0.0001
Cytoplasm 0.0044 0.0004 0.0013 0.0009 0 0.0003 0.0044 0 0.0006 0 0.0001 0 0.0142 0 0.0001 0 0.0002 0.0002
Cytoplasmic Foci 0.0136 0.001 0.0068 0.0106 0.0006 0.0027 0.0055 0.0004 0.0087 0.0003 0.0111 0.0011 0.0197 0.0005 0.0014 0.005 0.0076 0.0035
Eisosomes 0.0001 0 0.0001 0.0001 0 0 0.0001 0 0 0 0.0001 0 0.0006 0 0.0001 0 0.0002 0.0001
Endoplasmic Reticulum 0.0085 0.0001 0.0003 0.0006 0 0.0004 0.003 0 0.0002 0 0.0006 0 0.0016 0 0.0001 0 0.0005 0.0002
Endosome 0.0146 0.0016 0.002 0.0174 0.0002 0.0015 0.0146 0.0001 0.0129 0 0.0153 0.0028 0.0135 0.0002 0.0022 0.0016 0.0272 0.0026
Golgi 0.0033 0.0002 0.0006 0.0056 0.0002 0.0006 0.0089 0.0001 0.0064 0 0.0061 0.0035 0.0174 0.0001 0.001 0.0007 0.0155 0.0024
Lipid Particles 0.0283 0.0046 0.0308 0.0196 0.0053 0.0121 0.0178 0.0021 0.0126 0.0015 0.145 0.0082 0.0444 0.0023 0.0045 0.037 0.0298 0.0087
Mitochondria 0.0013 0.0007 0.0003 0.0125 0.0006 0.0007 0.0108 0.0001 0.0113 0.0001 0.0922 0.001 0.0054 0.0002 0.0101 0.0056 0.0118 0.0146
None 0.003 0.0019 0.0042 0.0014 0.0001 0.0002 0.0013 0 0.0001 0 0.0002 0 0.0144 0 0 0.0001 0.0002 0.0013
Nuclear Periphery 0.0234 0.0031 0.0039 0.0008 0.0007 0.0016 0.0135 0.0001 0.0002 0 0.0032 0.0001 0.0064 0.0001 0.0001 0.0002 0.001 0.0002
Nucleolus 0.6622 0.7897 0.8258 0.7635 0.7339 0.811 0.7764 0.839 0.8542 0.9087 0.5043 0.8874 0.672 0.8738 0.8576 0.8231 0.644 0.8028
Nucleus 0.1342 0.142 0.0836 0.072 0.1381 0.0854 0.0963 0.1468 0.0773 0.0849 0.0853 0.0812 0.0806 0.1062 0.1036 0.1108 0.1355 0.1082
Peroxisomes 0.0061 0.0003 0.0009 0.0026 0.0003 0.0006 0.0018 0.0001 0.0045 0.0001 0.0056 0.0003 0.0143 0.0001 0.0003 0.0013 0.0028 0.0033
Punctate Nuclear 0.0722 0.0485 0.0357 0.0298 0.1166 0.0728 0.0205 0.0096 0.0027 0.0029 0.1101 0.0125 0.0313 0.0096 0.0116 0.0024 0.0685 0.0419
Vacuole 0.0022 0.0025 0.0011 0.008 0.0008 0.0009 0.0034 0.0007 0.0024 0.0003 0.0062 0.0004 0.0017 0.0026 0.0017 0.0054 0.0038 0.0006
Vacuole Periphery 0.001 0.0005 0.0003 0.0021 0.0005 0.0002 0.002 0.0001 0.0011 0 0.0116 0.0002 0.0008 0.0002 0.0002 0.0027 0.0021 0.0006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 27.735 26.357 23.5359 11.6731 20.0856 12.9858 16.8253 8.8409 7.0019 15.7018
Translational Efficiency 0.7662 0.7503 0.6285 0.6753 0.6355 0.6618 0.7054 0.7041 0.6742 0.6998

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1600 1228 978 1129 1464 1739 193 90 3064 2967 1171 1219

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 688.87 714.20 868.61 890.50 698.06 825.99 899.76 1156.95 693.26 779.72 873.74 910.17
Standard Deviation 78.40 160.72 110.13 118.37 81.59 101.65 136.20 206.35 80.07 140.64 115.41 144.83
Intensity Change Log 2 — 0.052096 0.334477 0.370384 — 0.242773 0.366189 0.728904 — 0.151213 0.350525 0.561933

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000104 0.000356 0.000917 0.000598 0.000247 0.000274 0.000685 0.000068 0.000172 0.000308 0.000879 0.000559
Bud Neck 0.004469 0.006234 0.015764 0.032075 0.003726 0.005895 0.010148 0.034595 0.004114 0.006035 0.014838 0.032261
Bud Site 0.000669 0.001785 0.003394 0.005364 0.000663 0.001241 0.002286 0.000873 0.000666 0.001466 0.003211 0.005033
Cell Periphery 0.000063 0.000180 0.000068 0.000067 0.000059 0.000064 0.000176 0.000012 0.000061 0.000112 0.000086 0.000063
Cytoplasm 0.005936 0.018521 0.002108 0.004107 0.005259 0.002098 0.015196 0.002111 0.005612 0.008895 0.004265 0.003959
Cytoplasmic Foci 0.004886 0.008330 0.000550 0.000592 0.003981 0.002709 0.003499 0.000079 0.004454 0.005035 0.001036 0.000554
Eisosomes 0.000075 0.000087 0.000066 0.000054 0.000072 0.000069 0.000087 0.000021 0.000074 0.000076 0.000069 0.000052
Endoplasmic Reticulum 0.001081 0.001978 0.003262 0.002265 0.001447 0.001800 0.003148 0.000620 0.001256 0.001874 0.003243 0.002144
Endosome 0.004073 0.002617 0.001638 0.002034 0.002430 0.004680 0.001234 0.000805 0.003288 0.003827 0.001571 0.001943
Golgi 0.001854 0.001179 0.001241 0.001769 0.001327 0.002505 0.000652 0.000316 0.001602 0.001957 0.001143 0.001662
Lipid Particles 0.002414 0.002492 0.000702 0.000290 0.004366 0.001538 0.000985 0.000023 0.003346 0.001933 0.000748 0.000270
Mitochondria 0.002557 0.002514 0.001593 0.002339 0.003230 0.006117 0.000859 0.001494 0.002879 0.004626 0.001472 0.002277
Mitotic Spindle 0.006943 0.012827 0.095896 0.060188 0.011952 0.015546 0.027767 0.025002 0.009336 0.014421 0.084667 0.057590
None 0.008851 0.033930 0.002070 0.001963 0.008232 0.001846 0.020165 0.001382 0.008555 0.015125 0.005052 0.001920
Nuclear Periphery 0.000630 0.000697 0.001341 0.002022 0.001023 0.001119 0.000703 0.001345 0.000818 0.000945 0.001236 0.001972
Nuclear Periphery Foci 0.011594 0.009943 0.018606 0.006219 0.011960 0.008372 0.007029 0.000520 0.011769 0.009022 0.016698 0.005798
Nucleolus 0.692743 0.525973 0.520139 0.538618 0.633743 0.568323 0.344230 0.483710 0.664553 0.550795 0.491147 0.534564
Nucleus 0.245638 0.365941 0.322364 0.331132 0.302069 0.366684 0.551959 0.446015 0.272601 0.366377 0.360205 0.339614
Peroxisomes 0.003950 0.002823 0.004480 0.002405 0.003039 0.003683 0.003226 0.000128 0.003514 0.003327 0.004273 0.002237
Vacuole 0.000968 0.001110 0.003192 0.003999 0.000675 0.003452 0.005594 0.000354 0.000828 0.002482 0.003588 0.003729
Vacuole Periphery 0.000502 0.000482 0.000611 0.001901 0.000499 0.001984 0.000373 0.000527 0.000501 0.001362 0.000572 0.001800

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.48 -13.25 -13.93 -7.44 3.29 -0.99 -7.06 7.54 9.25 8.60 -6.68 -13.95 -12.13 -8.85 4.33
Bud Neck -2.76 -15.48 -20.92 -19.44 -13.00 -4.19 -6.38 -4.55 -4.28 -3.11 -4.64 -17.37 -21.61 -20.46 -13.66
Bud Site -2.81 -9.48 -11.83 -9.48 -5.68 -2.24 -5.72 -1.32 0.69 4.97 -3.69 -10.43 -11.77 -10.50 -5.65
Cell Periphery -4.95 -1.45 -1.92 4.27 -0.78 -0.31 -1.84 7.15 4.10 2.86 -3.87 -2.67 -2.15 2.62 1.11
Cytoplasm -5.20 3.37 -0.54 4.62 -3.47 2.83 -1.26 1.81 -0.32 1.85 -2.68 1.97 -0.57 1.61 -2.05
Cytoplasmic Foci -2.38 6.89 6.79 6.01 -0.34 2.39 1.32 6.33 6.73 2.56 -0.47 7.63 8.68 7.35 1.66
Eisosomes -2.06 0.87 5.77 4.69 3.84 1.92 -3.29 18.06 16.20 8.90 -0.61 -0.78 8.03 6.33 6.35
Endoplasmic Reticulum -7.08 -12.02 -9.66 -4.29 3.45 -2.73 -5.69 6.14 7.42 7.04 -6.73 -12.84 -8.56 -4.49 4.85
Endosome 1.94 3.74 2.21 -0.15 -2.85 -2.68 1.08 4.14 5.22 3.00 -0.79 4.00 1.95 2.47 -2.45
Golgi 3.49 2.28 0.66 -0.75 -0.18 -2.05 1.70 5.42 4.80 6.16 -0.70 1.89 0.44 0.78 -0.15
Lipid Particles 0.03 4.90 5.91 4.12 3.13 3.13 3.49 5.01 7.22 4.90 2.79 5.64 6.69 6.22 4.34
Mitochondria 0.06 2.27 -0.14 -0.18 -2.93 -2.48 4.58 2.69 3.98 -1.47 -2.41 4.28 0.81 2.89 -3.23
Mitotic Spindle -2.62 -14.63 -13.52 -12.16 1.89 -0.92 -3.27 -1.69 -1.51 0.34 -2.64 -14.56 -13.19 -12.26 1.26
None -6.30 6.79 6.66 8.55 -0.05 7.19 -1.30 7.18 0.65 2.87 -3.31 4.51 9.32 8.18 2.61
Nuclear Periphery -0.72 -5.62 -5.16 -5.18 -2.75 -0.28 0.03 -0.73 -0.63 -0.73 -0.83 -5.20 -4.85 -4.26 -2.98
Nuclear Periphery Foci 1.02 -3.21 4.45 3.99 7.47 3.05 -0.17 11.35 9.04 4.11 2.87 -3.31 6.77 4.50 7.98
Nucleolus 17.80 18.44 21.64 4.11 2.68 8.01 11.31 5.06 2.71 -2.97 18.60 19.95 21.03 7.85 0.93
Nucleus -14.94 -7.19 -9.06 5.28 -1.10 -9.24 -8.00 -4.72 -1.97 1.82 -17.73 -7.97 -7.50 5.70 1.06
Peroxisomes 2.01 -0.43 2.98 0.81 2.68 -0.60 -1.32 11.07 7.59 7.01 0.80 -1.11 3.96 2.56 3.44
Vacuole -1.01 -4.72 -6.99 -6.83 -3.66 -3.73 -2.75 0.55 3.91 2.81 -3.81 -5.58 -7.07 -5.52 -2.95
Vacuole Periphery 0.03 -2.32 -6.88 -7.08 -6.21 -3.05 -0.84 -0.26 2.97 0.49 -3.03 -2.54 -6.96 -1.24 -6.23
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis
Localization
Cell Percentages nucleolus (79%)
Cell Cycle Regulation No
Subcompartmental Group nucleolus-1

Dhr2

Dhr2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dhr2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available