Standard name
Human Ortholog
Description GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 – 0 0 0.08 0.15 0.14 – – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0 0 0.12 0.13 0.07 0.2 0.17 0.28 0.41 – 0.45 0.37 0 0 0.07 – – – 0 0 0 0 0 0
Nucleus 0.93 0.94 0.94 0.92 0.92 0.88 0.87 0.8 0.79 – 0.76 0.75 0.89 0.83 0.77 – – – 0.86 0.89 0.87 0.88 0.81 0.72
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0.08 0.1 0.13 – 0.13 0.15 0 0 0.05 – – – 0 0 0 0 0 0.05
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0.07 0.05 0.09 0.14
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 1 1 0 0 1 1
Bud 0 0 0 0 1 1 2 6 1 – 5 1 0 0 0 – – – 2 2 2 0 1 3
Bud Neck 0 0 0 0 0 0 0 0 0 – 1 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 1 1 13 13 20 15 – 20 19 0 0 2 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 6 7 7 9 17 18 22 19 10 – 17 15 24 50 53 – – – 1 1 0 2 0 2
Endoplasmic Reticulum 0 1 0 1 0 1 0 0 1 – 0 0 0 0 1 – – – 0 0 1 0 0 1
Endosome 2 0 0 0 0 0 0 3 0 – 0 0 0 0 0 – – – 2 3 2 0 4 3
Golgi 0 0 0 1 0 0 0 0 0 – 0 0 0 0 0 – – – 3 1 0 0 1 5
Mitochondria 2 11 48 46 27 107 105 239 210 – 208 161 9 8 26 – – – 1 3 3 2 1 5
Nucleus 204 270 368 321 363 477 546 693 399 – 348 329 254 280 286 – – – 222 260 352 213 216 240
Nuclear Periphery 1 0 1 4 2 11 24 20 8 – 9 14 1 3 3 – – – 0 1 0 0 0 1
Nucleolus 5 7 6 6 16 24 50 84 65 – 58 66 4 11 17 – – – 11 6 8 7 11 15
Peroxisomes 1 0 0 0 0 0 0 0 0 – 0 1 3 0 4 – – – 0 0 0 0 1 0
SpindlePole 0 0 0 0 0 0 1 2 0 – 1 1 3 2 4 – – – 1 2 1 0 0 3
Vac/Vac Membrane 4 5 6 3 2 7 5 12 7 – 5 17 1 2 11 – – – 8 4 27 11 23 45
Unique Cell Count 220 286 393 348 393 540 631 861 508 460 440 287 338 371 259 292 403 243 268 335
Labelled Cell Count 225 301 436 392 429 659 768 1098 716 672 624 299 356 407 259 292 403 243 268 335


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.5 7.1 5.7 5.8 6.0 5.4 5.3 4.9 4.5 – 4.5 4.9 6.8 6.6 6.1 – – – 7.3 7.5 7.9
Std Deviation (1e-4) 2.4 1.3 1.1 1.5 1.6 1.3 1.4 1.2 1.3 – 1.2 2.0 1.8 1.8 1.6 – – – 1.7 1.7 1.6
Intensity Change (Log2) – – – 0.04 0.09 -0.07 -0.11 -0.22 -0.32 – -0.32 -0.2 0.27 0.22 0.1 – – – 0.37 0.41 0.48

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP7000510WT3HU80HU120HU1600510WT30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Bud 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Bud Site 0 0 3.1 0 0 0 – 0 4.2 0 0 0 – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Cytoplasm 0.8 2.1 1.4 1.6 0.5 0.2 – 1.7 1.5 4.1 6.5 6.4 – – –
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Mitochondria 0.4 -2.5 3.1 1.9 0 0 – 0 8.1 -4.2 -5.0 -2.4 – – –
Nucleus -0.7 -0.7 -2.7 -3.6 -6.0 -6.3 – -7.1 -7.4 -2.4 -4.6 -6.5 – – –
Nuclear Periphery 0 0 2.4 3.6 0 0 – 0 3.2 0 0 0 – – –
Nucleolus 0.2 2.2 2.5 4.4 0 0 – 0 6.9 0 1.5 2.5 – – –
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 – – –
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 – – –
Vacuole 0 0 -0.3 0 -0.2 -0.2 – -0.6 2.1 0 0 1.3 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.9543 5.2354 4.5532 4.5698 4.3905 4.5369 2.3697 2.2604 2.2795 1.7681 1.9575 2.1749 6.6215 6.4155 6.3612 6.502 6.4533 6.545
Actin 0.0054 0 0.0041 0 0.001 0 0.0141 0 0.0029 0 0.0039 0 0 0 0 0 0 0
Bud 0.0001 0 0 0 0 0 0.0003 0 0.0001 0 0.0002 0 0 0 0 0 0 0
Bud Neck 0.001 0 0.0002 0.0001 0.0001 0.0006 0.0008 0 0.0001 0.0001 0.0022 0.0004 0 0.0001 0.0001 0 0.0001 0.0002
Bud Periphery 0.0003 0 0.0001 0.0001 0.0001 0 0.0008 0 0.0001 0 0.0004 0 0 0 0 0 0 0
Bud Site 0.0006 0 0.0011 0 0 0 0.0005 0 0.0005 0 0.0007 0 0 0.0001 0 0 0 0
Cell Periphery 0.0001 0 0 0 0 0 0.0001 0 0 0 0.0001 0 0 0 0 0 0 0
Cytoplasm 0.0006 0.0001 0.0008 0.0001 0.0003 0 0.0024 0.0001 0.0013 0 0.0006 0.0007 0.0001 0.0039 0 0 0 0
Cytoplasmic Foci 0.002 0 0.0018 0 0.0001 0 0.0009 0 0.0015 0 0.0036 0 0 0 0 0 0 0
Eisosomes 0.0001 0 0 0 0 0 0.0002 0 0 0 0.0001 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0007 0 0.0007 0.0001 0.0002 0 0.0016 0 0.0009 0 0.0013 0.0001 0 0.0005 0 0 0 0
Endosome 0.0033 0 0.002 0.0001 0.0011 0 0.0058 0 0.002 0 0.0127 0.0001 0 0.0002 0 0 0 0
Golgi 0.0008 0 0.001 0 0.0001 0 0.0031 0 0.0007 0 0.0057 0 0 0 0 0 0 0
Lipid Particles 0.0039 0 0.0038 0 0 0 0.0043 0 0.0024 0 0.0297 0 0 0 0 0 0 0
Mitochondria 0.0028 0.0001 0.001 0.0003 0.0008 0.0001 0.0222 0.0001 0.0051 0 0.0069 0.0001 0.0001 0.0003 0.0001 0 0 0
None 0.0006 0 0.0024 0 0.0002 0 0.0009 0 0.0005 0 0.0002 0 0 0.0001 0 0 0 0
Nuclear Periphery 0.0068 0.0004 0.0043 0.0024 0.0161 0.0003 0.0212 0.0047 0.0042 0.0002 0.0165 0.0008 0.0013 0.0022 0.0006 0.0004 0.0002 0.0003
Nucleolus 0.0133 0.0077 0.0062 0.009 0.03 0.0351 0.0185 0.0088 0.0072 0.0035 0.0174 0.0219 0.0071 0.0099 0.0061 0.0045 0.0247 0.0198
Nucleus 0.9521 0.9911 0.9651 0.9864 0.9483 0.9635 0.8935 0.9855 0.9647 0.9961 0.8902 0.9725 0.9883 0.9818 0.9927 0.9946 0.9745 0.9791
Peroxisomes 0.0016 0 0.0017 0 0 0 0.0021 0 0.0024 0 0.002 0 0 0 0 0 0 0
Punctate Nuclear 0.002 0.0004 0.0026 0.0005 0.0008 0.0002 0.0032 0.0005 0.0026 0.0001 0.0037 0.0023 0.003 0.0004 0.0003 0.0004 0.0005 0.0005
Vacuole 0.0011 0.0001 0.0005 0.0005 0.0002 0.0001 0.0012 0.0001 0.0004 0 0.0013 0.0008 0 0.0003 0.0001 0 0 0
Vacuole Periphery 0.0009 0 0.0004 0.0004 0.0006 0 0.0024 0.0001 0.0003 0 0.001 0.0001 0 0.0001 0 0 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.7631 14.6637 16.2007 18.0611 10.8702 12.3868 16.5562 16.9004 15.4963 17.4611
Translational Efficiency 0.843 0.6429 0.7453 0.7034 1.0075 0.7955 0.7117 0.5458 0.705 0.642

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1832 269 122 920 2058 1669 239 125 3890 1938 361 1045

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 744.48 976.91 1143.76 1035.98 761.99 880.19 1081.54 1043.51 753.74 893.62 1102.57 1036.88
Standard Deviation 99.00 148.17 150.93 152.60 120.12 130.62 124.31 149.08 111.03 137.33 137.10 152.21
Intensity Change Log 2 — 0.391993 0.619479 0.476691 — 0.208043 0.505243 0.453600 — 0.301880 0.562828 0.465058

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000245 0.000627 0.001304 0.001063 0.000289 0.000343 0.001495 0.001176 0.000268 0.000382 0.001430 0.001076
Bud Neck 0.003638 0.003340 0.005102 0.021670 0.004760 0.008432 0.006030 0.014319 0.004231 0.007725 0.005717 0.020790
Bud Site 0.000640 0.000374 0.000818 0.005108 0.000729 0.000688 0.001083 0.003037 0.000687 0.000645 0.000994 0.004860
Cell Periphery 0.000114 0.000067 0.000045 0.000112 0.000360 0.000090 0.000054 0.000104 0.000244 0.000087 0.000051 0.000111
Cytoplasm 0.005180 0.000279 0.000593 0.007141 0.002699 0.001013 0.000907 0.010353 0.003868 0.000911 0.000801 0.007525
Cytoplasmic Foci 0.000443 0.000579 0.000119 0.001912 0.000081 0.000640 0.000112 0.000268 0.000252 0.000632 0.000114 0.001716
Eisosomes 0.000016 0.000026 0.000059 0.000026 0.000024 0.000021 0.000054 0.000029 0.000020 0.000022 0.000055 0.000026
Endoplasmic Reticulum 0.003073 0.005750 0.005881 0.006261 0.005100 0.005428 0.009446 0.005202 0.004145 0.005473 0.008241 0.006134
Endosome 0.000294 0.000119 0.000152 0.003254 0.000208 0.000830 0.000237 0.001895 0.000249 0.000731 0.000208 0.003092
Golgi 0.000189 0.000371 0.000104 0.001589 0.000049 0.000699 0.000098 0.001630 0.000115 0.000654 0.000100 0.001594
Lipid Particles 0.000339 0.001715 0.000266 0.000454 0.000063 0.000159 0.000387 0.000204 0.000193 0.000375 0.000346 0.000424
Mitochondria 0.001249 0.000772 0.001152 0.003077 0.000517 0.003360 0.001331 0.007155 0.000862 0.003001 0.001270 0.003565
Mitotic Spindle 0.001399 0.001188 0.000183 0.012252 0.000114 0.004106 0.000681 0.038925 0.000720 0.003701 0.000513 0.015443
None 0.012129 0.001193 0.001868 0.006345 0.009301 0.002680 0.002197 0.008481 0.010633 0.002474 0.002086 0.006600
Nuclear Periphery 0.000640 0.000148 0.000255 0.002369 0.000346 0.000994 0.000400 0.000995 0.000485 0.000876 0.000351 0.002205
Nuclear Periphery Foci 0.000568 0.000076 0.000178 0.002129 0.000426 0.000422 0.000206 0.000605 0.000492 0.000374 0.000196 0.001947
Nucleolus 0.018731 0.013812 0.022500 0.007352 0.014194 0.012879 0.015238 0.006110 0.016331 0.013009 0.017692 0.007204
Nucleus 0.949333 0.967917 0.956634 0.909551 0.959899 0.954860 0.955366 0.866978 0.954923 0.956673 0.955794 0.904459
Peroxisomes 0.000265 0.001125 0.001010 0.000614 0.000275 0.000395 0.000587 0.000272 0.000270 0.000496 0.000730 0.000573
Vacuole 0.000680 0.000407 0.001642 0.006535 0.000444 0.001244 0.003884 0.019078 0.000555 0.001128 0.003126 0.008035
Vacuole Periphery 0.000835 0.000113 0.000136 0.001185 0.000122 0.000716 0.000208 0.013184 0.000458 0.000632 0.000183 0.002621

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.42 -9.32 -14.24 -6.09 0.28 -1.49 -12.23 -8.18 -8.01 -3.01 -3.60 -15.39 -16.17 -14.78 0.42
Bud Neck 0.37 -2.76 -14.11 -14.50 -11.82 -4.30 -1.92 -7.06 -5.23 -5.65 -4.76 -2.99 -15.27 -11.61 -12.15
Bud Site 1.84 -1.95 -5.91 -6.28 -5.31 0.30 -2.86 -6.02 -6.10 -5.27 0.47 -3.55 -6.72 -6.80 -5.89
Cell Periphery 1.34 4.03 0.26 -1.30 -5.74 2.04 2.25 1.50 -2.89 -5.22 2.21 2.64 1.82 -1.84 -7.08
Cytoplasm 5.58 4.37 -0.98 -7.10 -5.69 3.13 2.74 -2.57 -3.14 -3.07 5.51 5.16 -3.17 -6.86 -6.65
Cytoplasmic Foci -0.05 2.03 -1.02 -0.61 -2.36 -2.25 -0.89 -1.73 1.03 -1.54 -1.37 1.84 -1.79 -0.65 -2.45
Eisosomes -3.61 -9.04 -8.29 -3.46 5.17 0.90 -7.16 -5.43 -6.18 -0.34 -0.76 -11.16 -7.88 -8.34 5.90
Endoplasmic Reticulum -4.64 -5.79 -8.45 -2.32 -1.53 -0.83 -6.50 -3.65 -3.34 0.52 -4.06 -8.60 -7.29 -4.13 1.73
Endosome 3.00 1.65 -2.73 -3.08 -2.94 -2.38 -1.91 -3.01 -1.50 -2.84 -2.10 -0.01 -3.13 -2.04 -3.14
Golgi -0.43 1.01 -1.88 -1.09 -2.26 -2.07 -4.78 -1.84 -0.28 -1.70 -1.87 0.36 -2.48 -0.51 -2.57
Lipid Particles -0.80 0.50 -0.07 0.80 -1.17 -2.51 -5.60 -4.52 -3.62 -1.79 -0.69 -1.69 -1.93 -0.25 -0.62
Mitochondria 0.86 -0.04 -3.32 -7.49 -6.27 -2.79 -3.81 -2.41 -0.45 -1.78 -2.35 -1.78 -6.16 -0.39 -5.53
Mitotic Spindle -0.61 1.78 -5.05 -3.24 -5.63 -3.44 -1.27 -2.95 -2.57 -2.58 -2.87 -0.90 -6.12 -4.71 -4.80
None 7.94 6.87 4.79 -5.93 -3.62 4.86 5.38 0.86 -2.08 -2.32 7.61 8.56 5.01 -3.34 -4.29
Nuclear Periphery 1.64 1.17 -4.31 -6.13 -5.83 -2.58 -2.44 -4.93 -2.64 -4.50 -1.59 0.33 -5.62 -4.30 -6.04
Nuclear Periphery Foci 3.24 0.41 -1.81 -2.87 -1.85 0.03 0.38 -1.78 -1.79 -1.86 0.71 0.72 -2.49 -2.75 -2.77
Nucleolus 2.12 -0.45 6.03 1.86 2.50 1.12 0.26 1.44 0.85 0.89 3.18 0.15 5.66 2.72 2.77
Nucleus -2.81 -1.06 7.23 8.20 6.83 1.41 2.12 5.28 4.98 4.58 -0.54 0.91 9.92 9.67 8.13
Peroxisomes -1.15 -3.95 -0.77 0.91 2.27 -0.92 -1.85 -1.94 -0.37 -0.47 -1.35 -3.85 -1.04 0.49 1.34
Vacuole 1.48 -2.84 -6.21 -6.52 -4.67 -3.47 -3.68 -4.12 -3.99 -2.90 -2.59 -4.02 -7.53 -7.06 -2.90
Vacuole Periphery 1.97 1.88 0.36 -3.50 -3.33 -3.42 -1.71 -1.34 -1.16 -1.31 -0.76 1.55 -1.53 -1.17 -2.31
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Snu114

Snu114


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Snu114-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available