Standard name
Human Ortholog
Description Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0.05 0 – 0 0.05 0 0 0.07 0.05 0.16 0.05 0.08 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 – 0.06 0 0.13 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.94 0.91 0.98 0.92 0.9 0.83 0.88 – 0.81 0.78 0.75 0.76 0.88 0.89 0.78 0.88 0.87 0.86 0.9 0.87 0.92 0.84 0.84 0.81
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.21 0.07 0 0.08 0.05 0.17 0.13 – 0.3 0.28 0.44 0.36 0.08 0.1 0.06 0.08 0.08 0.13 0 0 0 0.05 0.08 0.07
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 1 – 1 2 2 1 0 1 0 0 0 0 1 2 0 0 0 0
Bud Neck 0 0 0 1 0 0 0 – 0 2 0 2 0 1 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 2 – 4 6 7 13 1 1 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2 6 2 6 9 12 15 – 5 14 3 6 9 8 29 11 15 8 0 0 0 0 1 1
Endoplasmic Reticulum 0 2 0 0 0 0 0 – 0 0 0 0 0 0 0 3 2 2 0 1 0 0 0 0
Endosome 0 0 0 2 1 0 2 – 0 0 0 0 0 1 1 0 1 0 1 1 0 0 0 1
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 3 1 0 1 0
Mitochondria 4 1 0 0 0 5 6 – 16 9 43 15 1 0 0 1 0 5 0 0 0 0 0 1
Nucleus 123 195 189 145 197 200 328 – 222 242 250 288 108 150 144 201 170 144 130 199 184 49 99 133
Nuclear Periphery 0 1 0 0 2 4 5 – 1 1 3 4 0 0 2 1 1 0 0 0 0 0 0 0
Nucleolus 27 14 6 13 12 41 49 – 83 88 146 137 10 16 12 18 15 22 5 9 8 3 9 11
Peroxisomes 0 0 0 0 1 2 0 – 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 2 1 – 0 0 0 3 3 7 6 1 3 0 0 1 0 0 1 0
Vac/Vac Membrane 0 9 0 3 2 2 1 – 1 1 3 3 1 1 1 5 5 3 2 7 2 1 2 9
Unique Cell Count 131 215 192 157 219 241 373 273 310 335 380 123 168 185 228 196 168 145 228 201 59 119 164
Labelled Cell Count 156 228 197 170 224 268 410 333 365 457 473 133 186 196 241 212 184 145 228 201 59 119 164


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.6 11.4 9.8 9.0 9.9 8.7 8.3 – 7.8 8.2 7.4 7.6 9.3 11.2 10.2 13.3 13.7 13.2 7.5 9.3 10.1
Std Deviation (1e-4) 1.6 3.2 1.6 1.8 2.6 2.3 1.7 – 1.9 2.2 2.0 2.2 2.1 10.3 2.7 4.2 5.2 4.5 1.4 1.7 2.0
Intensity Change (Log2) – – – -0.12 0.01 -0.17 -0.24 – -0.32 -0.26 -0.4 -0.36 -0.07 0.19 0.06 0.44 0.48 0.43 -0.39 -0.07 0.05

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 1.9 2.3 2.0 – 0 2.2 0 0 0 0 5.2 2.2 3.2 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 3.4 0 5.2 2.8 0 0 0 0 0 0
Nucleus -2.8 -3.6 -5.3 -4.2 – -5.7 -6.4 -7.1 -6.9 -4.0 -3.7 -6.2 -4.1 -4.4 -4.6
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 2.1 1.2 4.6 3.8 – 7.4 7.1 9.9 8.6 2.0 2.5 1.5 2.1 2.0 3.5
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.519 6.0547 5.3793 5.4645 4.1959 5.3472 5.3878 5.795 5.4026 4.99 4.6804 5.2775 5.3224 5.7931 5.7937 4.9276 4.2163 4.9799
Actin 0.0113 0 0.007 0 0.0376 0 0.012 0 0.0009 0.0044 0.0052 0.0001 0.009 0.0026 0.006 0.0049 0.0936 0.0038
Bud 0.0003 0 0.0055 0 0.0004 0.0001 0.0006 0 0.0001 0.0004 0.0008 0.0001 0.0007 0.0001 0.0001 0.0002 0.0005 0.0001
Bud Neck 0.0005 0 0.0002 0 0.0023 0.0004 0.0011 0 0.0001 0.0001 0.0003 0.0007 0.0101 0.0015 0.0001 0.0003 0.0002 0.0005
Bud Periphery 0.0005 0 0.0023 0 0.0012 0.0002 0.0015 0 0.0001 0.0006 0.0012 0.0002 0.0014 0.0001 0.0002 0.0002 0.0011 0.0001
Bud Site 0.0004 0 0.0039 0 0.0007 0.0001 0.0017 0 0.0004 0.0005 0.0009 0.0002 0.0082 0.0021 0.0004 0.0013 0.0007 0.0004
Cell Periphery 0.0001 0 0.0002 0 0.0003 0.0001 0.0009 0 0 0 0.0001 0.0001 0.0004 0 0 0.0001 0.0002 0.0001
Cytoplasm 0.0018 0 0.0011 0 0.0027 0 0.002 0 0.0004 0.0008 0.0042 0.0003 0.0222 0.0002 0.0007 0.0016 0.0001 0.0008
Cytoplasmic Foci 0.0079 0 0.001 0 0.0078 0 0.0101 0 0.0037 0.0007 0.0265 0.0002 0.0368 0.0066 0.0127 0.002 0.0034 0.0077
Eisosomes 0.0001 0 0 0 0.0005 0 0.0002 0 0 0 0 0 0.0001 0 0.0001 0.0001 0.0002 0
Endoplasmic Reticulum 0.0017 0 0.0007 0 0.0031 0 0.0014 0 0.0007 0.0009 0.0046 0.0001 0.0023 0 0.0003 0.0018 0.0001 0.0003
Endosome 0.007 0 0.0022 0 0.0216 0 0.0086 0 0.0032 0.0052 0.0704 0.0002 0.026 0.0022 0.0053 0.0083 0.0016 0.0048
Golgi 0.0014 0 0.0009 0 0.0115 0 0.0043 0 0.0016 0.0008 0.018 0.0001 0.0116 0.0015 0.0051 0.0011 0.006 0.0029
Lipid Particles 0.0092 0 0.0008 0 0.0243 0 0.0097 0 0.0019 0.0008 0.0113 0.0001 0.032 0.0028 0.0098 0.0015 0.0037 0.0171
Mitochondria 0.0014 0.0001 0.0031 0 0.0077 0.0015 0.0072 0.0001 0.0011 0.0052 0.0123 0.0002 0.0053 0.0004 0.0025 0.001 0.0144 0.0022
None 0.0077 0 0.0007 0 0.0015 0 0.0024 0 0.0003 0.0008 0.0012 0 0.0095 0.0002 0.0025 0.0022 0.0003 0.0006
Nuclear Periphery 0.0054 0.0002 0.0011 0.0001 0.0259 0.0009 0.0109 0.0002 0.0046 0.0246 0.0199 0.0006 0.0106 0.0001 0.0009 0.0058 0.0006 0.0017
Nucleolus 0.0446 0.0246 0.0236 0.0135 0.132 0.1209 0.0287 0.0154 0.0148 0.0262 0.0922 0.0851 0.0257 0.015 0.0111 0.0146 0.148 0.0875
Nucleus 0.8757 0.9748 0.9437 0.9862 0.6943 0.8749 0.8799 0.9842 0.9573 0.9209 0.7096 0.9033 0.7518 0.9581 0.9346 0.9455 0.7111 0.8569
Peroxisomes 0.0085 0 0.0004 0 0.0168 0 0.002 0 0.0021 0.0006 0.0045 0 0.0172 0.0053 0.0048 0.0004 0.0118 0.008
Punctate Nuclear 0.013 0.0002 0.0006 0.0001 0.0048 0.0003 0.0097 0.0001 0.0055 0.0037 0.0085 0.0083 0.0148 0.0009 0.0025 0.0058 0.0017 0.003
Vacuole 0.0009 0 0.0005 0 0.0011 0.0002 0.0039 0 0.0007 0.0009 0.0044 0.0002 0.0028 0.0002 0.0002 0.0007 0.0002 0.0007
Vacuole Periphery 0.0006 0 0.0004 0 0.0018 0.0003 0.0013 0 0.0005 0.0018 0.0037 0 0.0012 0.0001 0.0002 0.0004 0.0005 0.0009

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 22.3008 20.8023 24.0119 29.0657 30.5901 13.5669 23.0781 27.0118 29.4349 28.7298
Translational Efficiency 1.1054 1.2321 1.0117 1.102 0.7985 1.9554 1.0639 0.9155 0.9262 0.7952

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
918 1650 1387 797 1511 1875 229 306 2429 3525 1616 1103

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 756.71 1021.69 1337.64 1386.82 923.29 988.75 1237.31 1387.87 860.33 1004.17 1323.42 1387.11
Standard Deviation 111.46 190.03 211.72 254.91 140.90 159.36 176.03 259.07 153.52 175.16 209.97 256.07
Intensity Change Log 2 — 0.433145 0.821877 0.873968 — 0.098822 0.422351 0.588017 — 0.259050 0.616083 0.723865

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000334 0.000491 0.000600 0.001594 0.000459 0.000491 0.001081 0.000942 0.000412 0.000491 0.000668 0.001413
Bud Neck 0.003911 0.007743 0.013152 0.019537 0.006081 0.010778 0.007805 0.018394 0.005261 0.009357 0.012395 0.019220
Bud Site 0.000645 0.000744 0.000696 0.001875 0.000458 0.001044 0.000917 0.004361 0.000529 0.000904 0.000728 0.002565
Cell Periphery 0.000253 0.000074 0.000017 0.000107 0.000069 0.000056 0.000041 0.000078 0.000138 0.000064 0.000020 0.000099
Cytoplasm 0.000563 0.000216 0.000026 0.000369 0.000341 0.000279 0.000125 0.001470 0.000425 0.000249 0.000040 0.000674
Cytoplasmic Foci 0.000102 0.000111 0.000025 0.000704 0.000212 0.000266 0.000045 0.001938 0.000170 0.000193 0.000027 0.001046
Eisosomes 0.000022 0.000043 0.000063 0.000042 0.000043 0.000055 0.000062 0.000045 0.000035 0.000049 0.000063 0.000043
Endoplasmic Reticulum 0.002849 0.001913 0.000556 0.001269 0.002783 0.002830 0.002736 0.001736 0.002808 0.002401 0.000865 0.001398
Endosome 0.000227 0.000122 0.000012 0.001156 0.000105 0.000578 0.000058 0.001248 0.000151 0.000365 0.000019 0.001181
Golgi 0.000097 0.000216 0.000050 0.002126 0.000121 0.000156 0.000090 0.000181 0.000112 0.000184 0.000056 0.001587
Lipid Particles 0.000046 0.000123 0.000009 0.000113 0.000232 0.000102 0.000053 0.000258 0.000162 0.000112 0.000015 0.000153
Mitochondria 0.000488 0.000939 0.001359 0.003716 0.000636 0.001555 0.001222 0.002610 0.000580 0.001267 0.001340 0.003409
Mitotic Spindle 0.000421 0.000980 0.000053 0.004647 0.000454 0.003923 0.000138 0.005469 0.000441 0.002545 0.000065 0.004875
None 0.006250 0.001333 0.000438 0.001772 0.001101 0.001197 0.002694 0.002834 0.003047 0.001261 0.000758 0.002067
Nuclear Periphery 0.000227 0.000157 0.000045 0.000883 0.000100 0.000357 0.000099 0.000636 0.000148 0.000263 0.000053 0.000815
Nuclear Periphery Foci 0.000179 0.000212 0.000006 0.000447 0.000114 0.000462 0.000032 0.000329 0.000139 0.000345 0.000010 0.000414
Nucleolus 0.045929 0.045743 0.043143 0.028107 0.048458 0.041861 0.041335 0.026447 0.047502 0.043678 0.042887 0.027646
Nucleus 0.936447 0.937397 0.937889 0.928705 0.937099 0.931594 0.938982 0.926611 0.936852 0.934311 0.938044 0.928124
Peroxisomes 0.000307 0.000878 0.001520 0.000926 0.000643 0.000773 0.001819 0.001562 0.000516 0.000822 0.001562 0.001102
Vacuole 0.000549 0.000301 0.000196 0.001233 0.000347 0.000820 0.000555 0.002206 0.000424 0.000577 0.000247 0.001503
Vacuole Periphery 0.000156 0.000264 0.000145 0.000674 0.000144 0.000822 0.000112 0.000645 0.000149 0.000561 0.000141 0.000666

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.46 -10.06 -2.57 -2.25 -1.95 -0.80 -7.27 -6.52 -6.32 -0.04 -2.95 -9.36 -3.04 -2.81 -2.17
Bud Neck -5.29 -12.93 -10.76 -8.40 -4.92 -5.58 -2.87 -5.46 -3.80 -4.25 -7.29 -12.68 -11.57 -8.51 -6.04
Bud Site -0.09 -0.17 -3.41 -3.47 -3.75 -3.47 -4.77 -2.08 -1.87 -1.85 -2.49 -2.70 -3.31 -2.86 -3.01
Cell Periphery 1.66 2.19 1.36 -1.32 -4.63 0.63 1.29 -0.41 -1.61 -2.46 1.73 2.77 0.92 -2.10 -5.42
Cytoplasm 2.00 3.70 1.04 -1.32 -4.19 -0.23 1.00 -0.98 -0.82 -1.46 0.41 2.53 -0.50 -0.89 -2.95
Cytoplasmic Foci 0.28 1.33 -1.18 -1.29 -1.59 0.32 1.42 -0.99 -1.09 -1.33 0.48 1.77 -1.30 -1.57 -2.06
Eisosomes -7.51 -17.56 -9.55 -1.03 5.73 -3.73 -5.00 -1.73 1.34 2.99 -6.38 -12.49 -5.27 0.74 6.39
Endoplasmic Reticulum 3.81 10.17 5.26 2.72 -5.34 -0.33 -0.41 2.18 2.30 1.83 2.63 13.16 6.24 4.71 -3.09
Endosome 1.87 3.70 -1.60 -1.95 -2.22 -2.99 1.56 -1.60 -0.61 -1.71 -2.20 4.71 -2.26 -1.64 -2.74
Golgi -0.88 1.42 -1.46 -1.33 -1.53 -0.27 0.52 -1.01 -0.90 -2.75 -0.85 1.62 -1.48 -1.39 -1.57
Lipid Particles -1.01 3.10 -1.28 0.21 -2.38 0.95 1.19 0.35 -0.86 -1.26 0.67 1.58 0.48 -0.36 -2.76
Mitochondria -3.42 -11.48 -6.51 -5.46 -4.59 -2.80 -6.31 -7.58 -3.23 -5.35 -3.68 -10.66 -7.91 -5.51 -5.64
Mitotic Spindle -0.95 1.30 -3.63 -3.22 -3.89 -3.24 -0.51 -2.09 -0.92 -1.94 -3.34 1.51 -4.18 -2.56 -4.38
None 4.43 5.30 3.68 -1.59 -4.14 -0.20 -1.61 -1.53 -1.42 -0.11 3.82 5.14 1.55 -2.17 -3.61
Nuclear Periphery 1.22 5.03 -2.68 -2.92 -3.35 -2.36 -1.22 -2.05 -0.99 -1.96 -1.83 5.81 -3.45 -2.77 -3.88
Nuclear Periphery Foci -0.03 2.05 -1.14 -1.10 -2.19 -1.65 1.76 -0.88 0.89 -1.70 -1.46 3.09 -1.51 -0.36 -2.54
Nucleolus 0.13 0.38 3.30 3.52 3.24 2.44 1.60 2.38 1.21 0.70 1.87 1.35 4.60 3.43 3.26
Nucleus -0.41 0.09 2.75 3.21 2.92 1.50 -0.14 2.54 1.95 2.38 0.85 0.24 3.90 3.44 3.73
Peroxisomes -1.62 -10.30 -5.94 -0.59 2.82 -0.30 -4.07 -2.02 -1.75 0.08 -1.24 -7.63 -3.91 -1.72 1.83
Vacuole 1.18 1.38 -0.66 -1.92 -2.11 -1.18 -0.64 -1.98 -1.49 -1.83 0.00 1.43 -1.78 -1.99 -2.89
Vacuole Periphery -1.31 0.68 -1.67 -1.32 -1.78 -2.08 1.33 -1.66 0.65 -1.75 -2.29 0.54 -2.19 -0.15 -2.25
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
Localization
Cell Percentages nucleus (100%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Pap1

Pap1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pap1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available