ORF
Human Ortholog
Description Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.09 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.98 0.94 0.97 0.95 0.93 0.88 0.87 0.89 – 0.72 0.73 0.98 0.99 0.99 0.92 0.98 0.95 0.97 0.96 0.96 0.93 0.97 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 0.08 0.07 0.05 – 0 0.06 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 – 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.08 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0.19 0.18 0 0 0 0 0 0.05 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 0 0 1 – 1 1 0 0 0 0 0 0 0 0 0 0 0 1
Bud 1 1 0 0 0 1 0 2 0 – 6 2 0 0 0 0 0 0 1 0 0 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 5 3 9 1 6 8 12 6 10 – 2 8 3 0 2 5 0 0 0 0 0 0 0 0
Cytoplasm 325 245 440 221 270 467 566 420 312 – 193 329 247 294 272 49 63 21 317 239 486 71 174 164
Endoplasmic Reticulum 1 3 7 0 12 18 52 34 17 – 7 27 3 2 1 2 3 0 1 0 1 0 1 4
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 4 0 0 0
Golgi 0 1 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Mitochondria 0 0 0 0 0 1 2 0 5 – 13 10 0 0 1 0 0 0 0 0 5 0 0 0
Nucleus 2 1 2 2 3 3 18 17 13 – 9 11 4 0 3 4 1 0 0 2 3 1 1 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 0 18 9 2 12 11 19 8 – 51 83 0 0 0 2 1 1 0 2 2 1 2 4
Unique Cell Count 328 250 466 229 284 500 644 481 350 268 450 252 296 276 53 64 22 326 248 509 77 181 180
Labelled Cell Count 335 254 476 233 293 511 661 498 366 282 471 257 296 279 62 68 22 326 248 509 77 181 180


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.4 18.4 12.4 11.7 12.7 11.6 12.2 12.2 10.8 – 9.2 11.2 15.9 16.9 16.6 25.2 23.6 21.0 13.6 14.0 16.3
Std Deviation (1e-4) 2.3 3.2 1.9 2.1 1.8 1.8 1.9 2.0 2.1 – 1.9 2.5 2.5 2.7 3.0 7.1 7.3 3.4 1.8 2.1 3.5
Intensity Change (Log2) – – – -0.08 0.04 -0.1 -0.03 -0.02 -0.2 – -0.44 -0.15 0.35 0.44 0.42 1.02 0.93 0.76 0.13 0.18 0.4

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0.2 -0.4 -0.1 -0.8 0.9 – 0 -0.2 0 0 0 0 0 0
Cytoplasm 1.2 0.4 -0.7 -3.7 -3.8 -2.8 – -8.5 -8.8 2.3 3.5 2.8 -0.6 1.4 0.2
Endoplasmic Reticulum 0 2.3 2.1 4.8 4.2 2.8 – 1.1 3.6 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleus 0 0 0 2.9 3.4 3.5 – 0 2.6 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 -2.6 -1.3 -2.2 0.1 -1.3 – 6.8 7.0 -3.2 -3.4 -3.3 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.8855 9.5334 7.5913 7.5279 7.5036 8.1355 9.7405 12.2972 11.4388 10.645 10.2145 11.4373 9.521 11.116 10.1795 10.1034 9.3956 10.3597
Actin 0.0076 0.0003 0.0017 0.0002 0.0013 0.001 0.026 0.001 0.0064 0.007 0.0002 0.0063 0.0142 0.001 0.0044 0.0001 0.0022 0.0006
Bud 0.0001 0.0001 0.0004 0.0001 0.0002 0.0002 0.0006 0.0003 0.0046 0.0002 0 0.0003 0.0008 0.0004 0.0006 0 0.0001 0.0001
Bud Neck 0.0015 0.0002 0.001 0.0002 0.0007 0.0008 0.0021 0.0003 0.0012 0.0007 0.0008 0.0024 0.0017 0.0002 0.0006 0.0003 0.0006 0.0013
Bud Periphery 0.0001 0 0.0005 0 0.0001 0.0001 0.0005 0.0001 0.0037 0.0001 0 0.0007 0.0009 0.0001 0.0006 0 0 0
Bud Site 0.0008 0.0005 0.0007 0.0001 0.0002 0.0001 0.0028 0.002 0.003 0.0003 0 0.0004 0.0029 0.0009 0.0023 0 0.0001 0
Cell Periphery 0.0001 0 0.0001 0 0 0 0.0002 0 0.0002 0 0 0 0.0002 0 0.0001 0 0 0
Cytoplasm 0.9298 0.983 0.9415 0.9752 0.9181 0.9583 0.8228 0.9706 0.943 0.9215 0.9704 0.9504 0.8996 0.9684 0.9376 0.9785 0.936 0.9523
Cytoplasmic Foci 0.0073 0.0007 0.0045 0.0015 0.0041 0.0051 0.0218 0.0035 0.006 0.0038 0.0016 0.0024 0.0113 0.0016 0.0048 0.0009 0.0121 0.0039
Eisosomes 0.0003 0 0 0 0 0 0.0002 0 0 0.0001 0 0 0.0002 0 0 0 0 0
Endoplasmic Reticulum 0.007 0.0024 0.0074 0.0056 0.0064 0.0043 0.0065 0.0018 0.0017 0.0036 0.0055 0.002 0.0079 0.0021 0.0027 0.0014 0.003 0.0034
Endosome 0.0051 0.0005 0.0083 0.0036 0.0349 0.007 0.0341 0.0005 0.002 0.0079 0.0007 0.0038 0.0087 0.0016 0.0107 0.0005 0.0024 0.0042
Golgi 0.0008 0 0.0006 0.0002 0.0013 0.0008 0.0136 0.0002 0.0015 0.0062 0 0.001 0.0024 0.0002 0.002 0 0.0028 0.0003
Lipid Particles 0.0012 0 0.0003 0.0001 0.0004 0.0001 0.0136 0.0001 0.0012 0.0057 0 0.0009 0.0015 0.0005 0.003 0 0.001 0.0001
Mitochondria 0.0004 0.0001 0.0018 0.0001 0.0021 0.0005 0.0028 0.0002 0.0008 0.0073 0.0001 0.0008 0.0033 0.0005 0.0055 0.0001 0.0003 0.0002
None 0.0078 0.0011 0.008 0.0013 0.0026 0.0021 0.0043 0.0017 0.0011 0.0014 0.0009 0.0011 0.0058 0.003 0.003 0.0018 0.0028 0.0016
Nuclear Periphery 0.0077 0.0021 0.0053 0.0038 0.0123 0.0038 0.0099 0.0017 0.0017 0.0034 0.0031 0.0023 0.0103 0.003 0.0027 0.0017 0.0027 0.0043
Nucleolus 0.0005 0 0.0002 0 0.0001 0 0.0005 0.0002 0.0001 0.0001 0 0.0002 0.0002 0.0001 0.0001 0 0 0
Nucleus 0.0121 0.0079 0.0114 0.0063 0.0103 0.0128 0.014 0.0082 0.012 0.0276 0.0154 0.0226 0.0218 0.0147 0.0143 0.0139 0.0197 0.0258
Peroxisomes 0.0051 0 0.0004 0 0.0002 0.0001 0.0116 0.0058 0.0072 0.0012 0 0.0007 0.0017 0.0002 0.0011 0 0.0128 0.0001
Punctate Nuclear 0.0033 0.0004 0.0024 0.0003 0.0018 0.0014 0.0091 0.0012 0.002 0.0012 0.0005 0.0008 0.0029 0.0008 0.0019 0.0003 0.0008 0.0009
Vacuole 0.0013 0.0005 0.0031 0.0011 0.0019 0.0011 0.0023 0.0003 0.0006 0.0007 0.0006 0.0008 0.0013 0.0005 0.0013 0.0003 0.0004 0.0006
Vacuole Periphery 0.0003 0.0001 0.0005 0.0002 0.001 0.0004 0.0008 0.0001 0.0001 0.0003 0.0001 0.0001 0.0005 0.0001 0.0005 0.0001 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 74.4722 56.6102 69.5639 67.5894 48.6067 88.102 69.9455 74.0192 90.6648 65.7731
Translational Efficiency 0.8182 0.8522 0.7783 0.9844 0.7953 0.6943 0.8372 0.6939 0.6474 0.6621

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1590 854 2495 112 1743 576 1029 728 3333 1430 3524 840

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 987.86 1343.14 2004.58 1748.70 1112.79 1197.07 1560.17 1650.84 1053.19 1284.30 1874.81 1663.89
Standard Deviation 139.31 230.80 304.68 385.74 175.66 207.03 246.63 306.30 171.14 232.83 352.58 319.77
Intensity Change Log 2 — 0.443231 1.020921 0.823904 — 0.105326 0.487522 0.569019 — 0.274112 0.762965 0.694504

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000156 0.001310 0.000124 0.062634 0.000122 0.001150 0.000322 0.007980 0.000139 0.001246 0.000182 0.015268
Bud Neck 0.000388 0.001236 0.000554 0.034877 0.000622 0.001972 0.003086 0.002022 0.000510 0.001533 0.001293 0.006402
Bud Site 0.002593 0.010817 0.000525 0.087308 0.001927 0.022828 0.004131 0.035808 0.002245 0.015655 0.001578 0.042674
Cell Periphery 0.000086 0.000524 0.000051 0.001070 0.000050 0.000145 0.000151 0.000165 0.000067 0.000371 0.000080 0.000285
Cytoplasm 0.855942 0.849751 0.673732 0.185999 0.835816 0.760356 0.666086 0.707930 0.845417 0.813743 0.671499 0.638340
Cytoplasmic Foci 0.038788 0.037835 0.001679 0.061300 0.025202 0.088363 0.006646 0.024867 0.031683 0.058187 0.003129 0.029724
Eisosomes 0.000008 0.000010 0.000001 0.000129 0.000005 0.000014 0.000008 0.000009 0.000007 0.000012 0.000003 0.000025
Endoplasmic Reticulum 0.001087 0.001319 0.000061 0.007443 0.001220 0.002384 0.000723 0.000260 0.001156 0.001748 0.000255 0.001217
Endosome 0.001149 0.003010 0.000095 0.166905 0.001638 0.007448 0.000871 0.004220 0.001405 0.004798 0.000322 0.025911
Golgi 0.000479 0.002513 0.000171 0.161419 0.000346 0.005948 0.000167 0.010407 0.000409 0.003897 0.000170 0.030542
Lipid Particles 0.000481 0.001460 0.000166 0.003953 0.000520 0.001492 0.000810 0.001340 0.000501 0.001473 0.000354 0.001689
Mitochondria 0.000087 0.000411 0.000172 0.039199 0.000078 0.004376 0.000349 0.003103 0.000082 0.002008 0.000224 0.007916
Mitotic Spindle 0.000303 0.005056 0.001578 0.062375 0.000511 0.014129 0.009026 0.035929 0.000412 0.008711 0.003753 0.039455
None 0.010511 0.002661 0.013762 0.003304 0.006014 0.001285 0.006873 0.007484 0.008159 0.002107 0.011751 0.006927
Nuclear Periphery 0.000069 0.000121 0.000174 0.001233 0.000207 0.000222 0.000611 0.000217 0.000141 0.000162 0.000302 0.000353
Nuclear Periphery Foci 0.004605 0.007050 0.000499 0.005317 0.003555 0.005285 0.003242 0.003410 0.004056 0.006339 0.001300 0.003664
Nucleolus 0.000233 0.000518 0.000293 0.000112 0.000189 0.001221 0.007848 0.000166 0.000210 0.000801 0.002499 0.000159
Nucleus 0.063892 0.046715 0.302783 0.020185 0.076992 0.031347 0.215589 0.100329 0.070743 0.040525 0.277323 0.089643
Peroxisomes 0.000319 0.000723 0.000009 0.005687 0.000195 0.001807 0.000083 0.003100 0.000254 0.001160 0.000031 0.003445
Vacuole 0.018619 0.025763 0.003533 0.070452 0.044518 0.042106 0.073219 0.040510 0.032163 0.032346 0.023881 0.044502
Vacuole Periphery 0.000206 0.001197 0.000036 0.019101 0.000272 0.006123 0.000159 0.010744 0.000240 0.003181 0.000072 0.011858

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.74 -0.00 -1.20 -1.02 -1.20 -4.43 -7.28 -1.63 -0.50 -1.24 -2.71 -2.51 -1.97 -0.99 -1.88
Bud Neck -2.66 -6.51 -2.75 -2.46 -2.50 -4.99 -5.48 -7.08 -0.74 3.26 -4.42 -7.14 -5.49 -3.07 -1.88
Bud Site -4.43 7.46 -4.70 -2.99 -5.01 -8.20 -7.21 -5.20 3.01 -2.91 -8.79 -1.15 -6.47 0.28 -6.31
Cell Periphery -1.01 -1.08 -5.74 -0.31 -5.63 -6.57 -11.13 -12.33 -3.73 -0.75 -1.21 -8.62 -11.81 0.29 -7.86
Cytoplasm 2.64 42.45 16.18 15.15 7.95 6.07 31.85 18.25 7.82 -7.81 5.54 50.14 24.20 17.72 -0.04
Cytoplasmic Foci -0.45 20.85 1.15 1.33 -8.49 -10.99 12.23 3.32 12.11 -7.03 -9.07 25.11 5.93 12.05 -12.30
Eisosomes -0.60 11.69 -3.41 -2.84 -4.61 -5.29 -9.76 -4.33 3.01 5.07 -2.49 5.03 -4.51 -0.10 -6.91
Endoplasmic Reticulum -0.35 7.19 0.07 0.23 -1.40 -1.52 2.26 5.23 3.18 11.75 -1.36 7.06 5.63 3.90 -0.05
Endosome -3.53 9.85 -2.51 -2.28 -2.64 -4.89 2.00 2.06 5.46 0.80 -5.85 7.76 -2.03 0.80 -2.94
Golgi -2.80 2.83 -2.05 -1.85 -2.08 -3.96 1.17 -1.31 2.27 -1.43 -4.87 2.57 -2.38 -0.34 -2.51
Lipid Particles -3.15 -0.03 -6.73 -4.95 -6.74 -4.89 -10.45 -5.61 -2.63 -2.03 -4.77 -6.20 -7.41 -3.82 -6.32
Mitochondria -1.45 -8.12 -1.44 -1.35 -1.40 -2.14 -10.54 -1.13 1.84 -0.42 -2.34 -14.38 -1.82 0.74 -1.49
Mitotic Spindle -3.61 -5.02 -4.14 -3.23 -3.74 -3.58 -6.74 -4.57 0.29 1.19 -4.86 -8.11 -5.71 -1.85 -2.94
None 7.65 -1.90 3.09 -2.57 5.47 7.28 -0.09 0.31 -9.71 0.54 10.03 -3.94 3.57 -8.36 10.03
Nuclear Periphery -5.65 -16.50 -6.68 -6.06 -4.26 0.02 -16.76 -6.44 -3.34 13.48 -0.94 -18.98 -11.97 -8.91 3.80
Nuclear Periphery Foci -3.56 11.86 -0.65 2.50 -6.23 -3.04 -1.61 -1.08 2.30 0.38 -4.81 9.51 -0.37 4.25 -6.95
Nucleolus -0.79 -0.58 0.97 1.05 0.97 -1.30 -2.75 1.96 1.38 2.80 -1.53 -2.73 1.62 1.75 2.94
Nucleus 5.07 -63.16 -0.92 -2.52 27.64 15.17 -24.84 -7.55 -16.78 15.00 13.75 -64.42 -8.93 -15.46 36.33
Peroxisomes -1.16 1.62 -1.66 -0.94 -2.27 -5.28 1.33 -1.03 2.50 -1.33 -3.85 2.23 -1.26 1.14 -1.98
Vacuole -5.49 4.86 -11.85 -11.29 -12.14 0.54 -16.76 -14.24 -13.85 0.04 -1.20 -7.76 -19.43 -18.80 -16.30
Vacuole Periphery -1.96 4.32 -1.80 -1.03 -1.93 -2.65 2.62 -1.68 1.82 -1.83 -3.12 5.75 -2.08 1.02 -2.31
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

YKR018C

YKR018C


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ykr018c-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available