Standard name
Human Ortholog
Description Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.06 – 0 0 0 0 0 0.05
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 0.05 0 0 0 – 0 0 0 0 0 0 0 0 0.06 – 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0.05 – 0 0 0 0 0 0 0 0.09 0 – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0
Endosome 0 0 0 0 0.07 0 0.05 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Golgi 0 0 0.27 0.09 0.19 0 0.05 – 0 0 0 0 0.08 0.1 0.2 0.39 0.59 – 0.06 0.06 0 0.07 0.05 0.07
Mitochondria 0.9 0.88 0.81 0.86 0.63 0.83 0.71 – 0.88 0.8 0.89 0.85 0.9 0.91 0.86 0.11 0.06 – 0.81 0.79 0.88 0.76 0.77 0.69
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0
Nuclear Periphery 0.09 0 0 0 0 0.07 0 – 0.05 0.06 0.06 0.06 0.06 0 0 0 0.06 – 0 0 0 0 0 0
Nucleolus 0.08 0 0 0 0.05 0.1 0.09 – 0.1 0.09 0.09 0.05 0 0 0 0.07 0.06 – 0 0 0 0 0 0
Peroxisomes 0 0 0.05 0.07 0.08 0 0.05 – 0 0 0 0 0 0 0 0.05 0.06 – 0 0 0 0.06 0.07 0.06
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Vac/Vac Membrane 0.1 0.19 0.11 0.1 0.26 0.1 0.12 – 0.09 0.08 0.05 0.08 0.12 0.1 0.12 0.21 0.24 – 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 4 3 1 0 0 – 0 0 0 0 0 2 0 2 1 – 2 2 0 3 13 16
Bud 0 3 1 4 2 10 7 – 11 7 3 7 0 2 1 0 0 – 0 1 0 0 2 4
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – 1 0 0 0 0 1
Bud Site 0 1 0 0 0 0 2 – 1 3 2 0 0 0 0 0 0 – – – – – – –
Cell Periphery 1 7 4 11 8 1 6 – 0 5 6 3 2 9 4 2 1 – 0 0 0 0 0 3
Cytoplasm 2 0 3 7 7 13 17 – 6 12 6 13 1 8 9 5 0 – 0 0 0 0 0 0
Endoplasmic Reticulum 0 5 0 1 0 2 1 – 1 3 1 2 0 0 1 3 0 – 0 0 0 0 0 0
Endosome 3 2 5 4 17 4 16 – 3 11 1 3 2 4 6 0 0 – 4 4 2 0 5 4
Golgi 3 5 53 18 44 5 16 – 5 8 5 2 12 28 54 22 10 – 11 13 6 12 18 25
Mitochondria 168 168 159 175 144 300 253 – 237 316 257 250 129 258 236 6 1 – 158 167 190 133 282 238
Nucleus 1 1 0 0 2 7 2 – 3 4 1 0 0 1 0 3 0 – 0 0 0 0 0 1
Nuclear Periphery 17 5 7 4 4 24 15 – 14 24 16 19 9 7 7 1 1 – 1 1 0 2 3 6
Nucleolus 15 6 6 3 11 36 32 – 27 37 25 14 4 6 11 4 1 – 2 2 1 2 6 5
Peroxisomes 4 4 9 14 18 1 19 – 1 16 4 5 4 8 4 3 1 – 6 3 9 9 23 19
SpindlePole 1 0 1 0 6 1 6 – 1 8 2 1 1 1 1 0 0 – 1 1 1 1 1 2
Vac/Vac Membrane 18 36 21 21 58 35 43 – 24 30 15 24 17 28 32 12 4 – 2 10 2 3 5 10
Unique Cell Count 187 191 197 204 227 361 354 269 393 289 293 143 282 276 56 17 196 212 216 176 367 344
Labelled Cell Count 233 243 273 265 322 439 435 334 484 344 343 181 362 366 63 20 196 212 216 176 367 344


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.9 10.9 11.1 10.9 13.1 9.3 12.1 – 10.4 11.6 11.2 11.2 12.3 12.7 13.2 22.6 22.2 – 11.0 12.2 12.5
Std Deviation (1e-4) 2.7 2.9 2.3 2.3 7.6 2.5 3.2 – 4.1 5.2 3.5 5.5 2.6 3.3 3.4 7.5 6.1 – 3.2 3.1 3.0
Intensity Change (Log2) – – – -0.03 0.24 -0.25 0.13 – -0.09 0.07 0.02 0.01 0.15 0.19 0.26 1.03 1.0 – -0.01 0.14 0.17


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 –
Bud 0 0 0 0 – 2.4 0 0 0 0 0 0 0 0 –
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 –
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 –
Cell Periphery 1.8 0.9 0 0 – 0 0 0 0 0 0.8 0 0 0 –
Cytoplasm 0 0 1.4 2.0 – 0 1.1 0 1.8 0 0 0 0 0 –
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 –
Endosome 0 2.3 0 1.2 – 0 0.2 0 0 0 0 0 0 0 –
Golgi -4.7 -1.8 -9.4 -7.6 – -8.1 -9.4 -8.4 -9.0 -4.3 -4.9 -1.9 1.8 2.8 –
Mitochondria 1.4 -3.9 0.7 -2.4 – 2.2 -0.1 2.5 1.3 2.4 3.5 1.4 -9.7 -6.8 –
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 –
Nuclear Periphery -1.0 -1.2 1.5 0.4 – 0.8 1.3 1.0 1.4 1.2 -0.7 -0.6 0 0 –
Nucleolus 0 0.9 3.0 2.7 – 2.9 2.8 2.5 1.0 0 0 0.5 0 0 –
Peroxisomes 1.0 1.4 0 0.4 – 0 -0.3 -2.1 -1.9 -0.8 -1.0 -2.0 0 0 –
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 –
Vacuole -0.1 3.9 -0.4 0.5 – -0.6 -1.2 -2.3 -0.9 0.4 -0.3 0.3 2.1 0 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.4449 5.7403 5.0795 4.2724 3.6913 5.3454 7.3334 8.5148 8.1903 8.0658 7.1418 8.4803 9.2884 10.6745 10.2606 9.4095 9.7382 10.6671
Actin 0.0672 0.002 0.0504 0.0019 0.006 0.0065 0.0571 0.0113 0.0156 0.0055 0.0105 0.0002 0.0398 0.0145 0.0091 0.0006 0.008 0.0004
Bud 0.0007 0.0006 0.0002 0.0009 0.0001 0.0001 0.001 0.0002 0.0003 0.0002 0.0003 0 0.0002 0.0024 0.0003 0.0002 0.0002 0
Bud Neck 0.0072 0.0002 0.0002 0.0009 0 0.0001 0.0012 0.0001 0.0004 0.0001 0.0002 0 0.0004 0.0004 0.0002 0.0001 0.0001 0
Bud Periphery 0.0011 0.0009 0.0003 0.0024 0.0003 0.0002 0.0022 0.0005 0.0009 0.0005 0.0004 0 0.0005 0.0027 0.0005 0.0007 0.0015 0.0002
Bud Site 0.0029 0.0045 0.0006 0.0071 0.0002 0.0001 0.0086 0.0015 0.0021 0.0003 0.0009 0 0.0006 0.0131 0.0011 0.0003 0.0002 0
Cell Periphery 0.0005 0.0004 0.0001 0.0008 0.0001 0.0001 0.0009 0.001 0.0047 0.0002 0.0001 0 0.0011 0.0009 0.0003 0.0001 0.0003 0.0001
Cytoplasm 0.0221 0.0003 0.0039 0.0001 0 0.0002 0.0051 0.0001 0.0008 0 0.0049 0 0.002 0.0006 0 0 0.0004 0
Cytoplasmic Foci 0.0056 0.0016 0.0082 0.0009 0.005 0.0013 0.0075 0.0014 0.0046 0.0005 0.0099 0.0002 0.0177 0.0013 0.0018 0.0022 0.0326 0.0005
Eisosomes 0.0005 0.0002 0.0003 0.0002 0.0002 0.0003 0.0014 0.0033 0.0007 0.0002 0.0002 0.0001 0.0006 0.0002 0.0011 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.0102 0.0002 0.0006 0.0003 0.0001 0.0011 0.0014 0.0001 0.0006 0.0001 0.0025 0 0.0022 0.0002 0 0 0.0002 0.0002
Endosome 0.0322 0.0057 0.0125 0.0068 0.0075 0.0105 0.0133 0.0053 0.0019 0.0012 0.0152 0.0015 0.01 0.0049 0.0056 0.0047 0.0014 0.0079
Golgi 0.0089 0.0071 0.0293 0.003 0.0152 0.0244 0.0102 0.0098 0.0113 0.002 0.0039 0.0032 0.0078 0.0089 0.0022 0.0051 0.0019 0.0052
Lipid Particles 0.0046 0.0028 0.0043 0.0116 0.0739 0.0041 0.0196 0.0098 0.0095 0.0011 0.0052 0.0096 0.0224 0.0028 0.0029 0.0093 0.005 0.0017
Mitochondria 0.7613 0.9585 0.857 0.9484 0.8597 0.9373 0.8214 0.9398 0.937 0.9844 0.8788 0.9821 0.8285 0.9185 0.9356 0.9581 0.8978 0.9694
None 0.0118 0.0001 0.0015 0.0002 0.0003 0.0005 0.0055 0 0.0008 0.0001 0.0032 0 0.0063 0.0001 0 0 0.001 0
Nuclear Periphery 0.0303 0.0002 0.0049 0.0002 0.0003 0.0075 0.0043 0.0001 0.0003 0.0001 0.0191 0 0.0049 0 0.0001 0 0.0005 0.0005
Nucleolus 0.0008 0.0002 0.0001 0.0013 0.0002 0.0002 0.0021 0.0002 0.0012 0.0001 0.0004 0.0001 0.0005 0.0006 0.0003 0.0003 0.0001 0
Nucleus 0.0099 0.0002 0.0063 0.0008 0.0001 0.0006 0.0061 0.0001 0.0003 0.0001 0.0053 0 0.0007 0.0002 0.0001 0.0001 0.0001 0.0001
Peroxisomes 0.0043 0.0061 0.0081 0.0026 0.0263 0.0011 0.01 0.0047 0.0018 0.0019 0.0299 0.0007 0.016 0.0037 0.0152 0.0137 0.0118 0.001
Punctate Nuclear 0.0052 0 0.0029 0.0001 0.0005 0.0006 0.0062 0 0.0009 0 0.0075 0 0.0041 0 0 0 0.032 0
Vacuole 0.0063 0.0037 0.0022 0.007 0.0009 0.0006 0.005 0.0029 0.0015 0.0005 0.0007 0.0005 0.0126 0.0094 0.0068 0.0013 0.0008 0.0055
Vacuole Periphery 0.0065 0.0048 0.006 0.0024 0.003 0.0025 0.01 0.0079 0.0027 0.0011 0.001 0.0017 0.0211 0.0145 0.0168 0.0029 0.004 0.0073

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 42.7244 53.1381 43.1274 56.3245 46.9645 51.9835 58.7649 67.9926 58.2653 65.4768
Translational Efficiency 1.8788 1.2129 1.6749 1.0448 1.535 2.1301 1.8046 1.5147 1.9351 1.6077

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
172 741 1502 1368 2126 1623 1349 1516 2298 2364 2851 2884

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 909.84 1121.43 1485.80 1461.68 930.77 1077.50 1436.12 1555.49 929.20 1091.27 1462.29 1510.99
Standard Deviation 148.24 214.91 276.30 308.70 150.06 191.11 259.72 304.33 150.03 199.91 269.73 309.97
Intensity Change Log 2 — 0.301655 0.707555 0.683943 — 0.211191 0.625680 0.740873 — 0.256618 0.666733 0.713012

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000989 0.004598 0.002320 0.006481 0.000428 0.002356 0.002088 0.004383 0.000470 0.003059 0.002210 0.005378
Bud Neck 0.002885 0.002240 0.002648 0.000605 0.000904 0.001133 0.001344 0.000965 0.001052 0.001480 0.002031 0.000794
Bud Site 0.009978 0.003732 0.001586 0.001697 0.002959 0.002573 0.002589 0.002963 0.003484 0.002936 0.002061 0.002362
Cell Periphery 0.000607 0.000322 0.000094 0.000654 0.000633 0.000179 0.000222 0.000498 0.000631 0.000224 0.000155 0.000572
Cytoplasm 0.003105 0.000434 0.000291 0.000278 0.000278 0.000494 0.000322 0.000348 0.000490 0.000475 0.000305 0.000315
Cytoplasmic Foci 0.009563 0.022447 0.023656 0.003143 0.004124 0.011936 0.011812 0.005946 0.004531 0.015231 0.018052 0.004616
Eisosomes 0.000059 0.000164 0.000140 0.000411 0.000033 0.000095 0.000187 0.000225 0.000035 0.000116 0.000162 0.000314
Endoplasmic Reticulum 0.000202 0.000279 0.000181 0.000362 0.000155 0.000165 0.000122 0.000427 0.000159 0.000201 0.000153 0.000396
Endosome 0.011298 0.019294 0.005786 0.002454 0.008397 0.012124 0.004164 0.006185 0.008614 0.014372 0.005018 0.004415
Golgi 0.018648 0.035590 0.035820 0.023127 0.006214 0.021213 0.021020 0.060339 0.007145 0.025720 0.028817 0.042688
Lipid Particles 0.003232 0.003657 0.006821 0.000467 0.001715 0.003506 0.003767 0.001176 0.001829 0.003553 0.005376 0.000840
Mitochondria 0.904754* 0.865877* 0.853627* 0.940096* 0.955024* 0.918667* 0.925270* 0.882371* 0.951261* 0.902120* 0.887526* 0.909752*
Mitotic Spindle 0.001958 0.003552 0.006302 0.001276 0.001282 0.001319 0.001517 0.002716 0.001333 0.002019 0.004038 0.002033
None 0.004197 0.000532 0.002089 0.001130 0.000300 0.000724 0.001231 0.001129 0.000591 0.000664 0.001683 0.001129
Nuclear Periphery 0.000107 0.000198 0.002641 0.000145 0.000105 0.000105 0.000581 0.000489 0.000105 0.000134 0.001666 0.000326
Nuclear Periphery Foci 0.000164 0.000297 0.001248 0.000126 0.000137 0.000150 0.000295 0.000187 0.000139 0.000196 0.000797 0.000158
Nucleolus 0.000480 0.000273 0.000668 0.000108 0.000115 0.000129 0.000276 0.000195 0.000142 0.000174 0.000483 0.000154
Nucleus 0.003012 0.000117 0.000142 0.000027 0.000080 0.000071 0.000050 0.000049 0.000299 0.000086 0.000099 0.000039
Peroxisomes 0.011836 0.024067 0.005558 0.002175 0.008847 0.013298 0.005969 0.003614 0.009071 0.016674 0.005752 0.002931
Vacuole 0.008160 0.006970 0.014977 0.004473 0.002783 0.005259 0.006698 0.008113 0.003186 0.005795 0.011060 0.006386
Vacuole Periphery 0.004764 0.005363 0.033405 0.010763 0.005487 0.004502 0.010476 0.017684 0.005433 0.004772 0.022556 0.014401

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.70 -2.64 -5.75 -1.43 -4.08 -4.33 -3.98 -6.03 -2.57 -2.96 -6.07 -5.70 -8.79 -3.32 -5.01
Bud Neck 0.56 0.20 2.00 3.94 5.78 -0.80 -1.54 -0.26 0.52 1.23 -1.54 -3.49 1.13 2.97 5.17
Bud Site 1.33 1.79 1.77 1.81 -0.15 0.41 0.34 -0.10 -0.46 -0.40 0.64 1.81 1.36 0.73 -0.52
Cell Periphery 1.19 2.37 -0.13 -1.58 -3.20 1.47 1.25 0.40 -2.40 -1.60 1.41 1.64 0.19 -3.02 -3.48
Cytoplasm 1.49 1.56 1.57 1.60 0.17 -1.08 -0.64 -1.03 0.70 -0.36 0.15 1.29 1.18 1.09 -0.17
Cytoplasmic Foci -3.98 -5.02 2.83 8.19 11.77 -6.49 -5.59 -2.29 4.84 4.18 -9.21 -11.39 -0.12 9.53 11.77
Eisosomes -4.56 -6.73 -6.72 -4.44 -5.19 -7.69 -8.05 -5.42 -3.61 -0.96 -9.26 -12.51 -9.02 -6.17 -4.68
Endoplasmic Reticulum -1.07 0.38 -1.58 -0.94 -2.17 -0.27 1.24 -4.04 -3.70 -4.55 -1.40 0.23 -4.38 -3.48 -4.59
Endosome -2.24 1.95 3.16 7.39 5.67 -2.48 4.10 1.98 4.29 -2.38 -4.16 3.89 4.50 8.59 1.16
Golgi -2.56 -2.79 -0.73 3.03 3.86 -8.04 -6.97 -13.24 -8.86 -8.67 -10.53 -12.62 -14.13 -5.83 -4.81
Lipid Particles -0.29 -2.37 2.02 5.51 9.27 -2.63 -2.60 1.18 3.79 3.55 -3.06 -5.83 2.51 6.07 9.02
Mitochondria 1.87 2.68 -2.04 -7.25 -11.61 6.27 5.30 10.68 4.64 5.56 8.94 12.53 8.44 -1.28 -4.04
Mitotic Spindle -1.28 -3.58 1.03 2.01 4.49 -0.04 -0.50 -1.96 -2.03 -1.74 -1.32 -4.07 -1.39 -0.03 2.97
None 1.14 0.67 0.96 -8.48 8.15 -1.28 -13.63 -12.75 -1.19 1.10 -0.18 -4.15 -2.05 -2.00 7.24
Nuclear Periphery -1.72 -6.86 -1.04 1.02 6.77 0.01 -3.31 -2.24 -2.25 0.42 -1.07 -7.53 -2.38 -2.09 5.96
Nuclear Periphery Foci -1.53 -6.25 0.51 1.96 6.45 -0.34 -2.96 -1.10 -0.84 1.78 -1.58 -7.07 -0.47 0.87 6.66
Nucleolus 0.52 -0.36 0.90 1.70 3.78 -0.27 -2.57 -0.90 -0.77 0.81 -0.49 -3.65 -0.17 0.31 3.56
Nucleus 1.41 1.39 1.44 3.12 3.90 0.23 0.85 0.76 0.86 -0.00 1.36 1.27 1.61 2.70 3.27
Peroxisomes -2.69 1.85 2.90 6.77 3.45 -2.18 1.83 3.77 5.31 1.85 -4.04 2.57 5.05 8.62 3.53
Vacuole 0.23 -1.25 0.70 1.52 7.25 -2.88 -4.64 -5.11 -2.29 -1.15 -3.01 -8.82 -3.92 -0.65 4.74
Vacuole Periphery -0.22 -8.84 -2.14 -3.10 8.98 1.16 -4.32 -7.59 -8.53 -4.16 0.81 -12.41 -7.48 -8.61 5.15
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages mitochondrion (99%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Pam17

Pam17


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pam17-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available