ORF
Human Ortholog
Description Cytoplasmic protein of unknown function; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P); YKR078W has a paralog, VPS5, that arose from the whole genome duplication
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 – – – – – –
Cell Periphery 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0.1 0.07 0.05 0 0 0 0 0 0
Cytoplasm 0.94 0.98 – 0.99 0.99 0.95 0.96 – 0.85 0.91 0.69 0.8 – – 0.99 0.96 0.98 0.97 0.91 0.95 0.86 0.89 0.91 0.94
Endoplasmic Reticulum 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0.07 0 0.06 0 0 0 0 0 0
Endosome 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.09 0 – 0 0 0.05 0 – 0.2 0.12 0.49 0.33 – – 0 0 0 0 0 0 0.05 0 0 0
Nucleus 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 1 1 – 0 0 0 0 – – 0 1 0 0 0 0 0 0 0 0
Bud 1 0 – 1 0 2 3 – 2 0 3 2 – – 0 0 1 0 0 0 0 1 1 0
Bud Neck 0 0 – 0 2 1 7 – 3 4 3 1 – – 1 0 1 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 0 0 – 1 0 0 0 – – 0 0 0 0 – – – – – –
Cell Periphery 0 3 – 0 2 0 0 – 2 0 0 3 – – 3 35 24 17 0 0 0 0 0 0
Cytoplasm 136 160 – 149 242 214 327 – 179 268 135 182 – – 172 334 342 343 130 156 31 23 73 80
Endoplasmic Reticulum 1 1 – 0 2 0 2 – 1 1 2 0 – – 1 23 11 20 0 0 0 0 0 0
Endosome 0 0 – 0 0 0 0 – 0 0 0 1 – – 0 2 1 2 1 0 0 0 2 0
Golgi 1 0 – 0 0 0 0 – 0 0 0 0 – – 0 1 0 1 0 0 0 0 0 0
Mitochondria 13 0 – 1 0 11 11 – 43 35 96 75 – – 0 3 3 5 2 1 1 0 0 0
Nucleus 0 0 – 1 0 4 3 – 3 1 1 4 – – 1 1 1 1 0 0 0 0 0 0
Nuclear Periphery 1 0 – 0 0 0 0 – 0 0 0 0 – – 0 0 0 0 1 0 0 0 0 0
Nucleolus 0 0 – 0 0 0 0 – 0 1 0 0 – – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 – 1 0 0 0 – – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 0 – 3 4 0 7 – – 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 1 – 0 1 2 1 – 0 1 1 3 – – 0 11 7 2 2 1 1 0 0 2
Unique Cell Count 144 163 150 244 225 339 211 295 195 228 173 349 349 352 143 164 37 26 81 85
Labelled Cell Count 153 165 152 249 235 355 238 315 241 278 178 411 391 391 143 164 37 26 81 85


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.4 5.8 – 5.5 6.0 4.7 4.8 – 4.0 4.1 3.8 3.8 – – 5.7 7.8 7.5 6.7 – 4.7 5.7
Std Deviation (1e-4) 0.7 0.9 – 1.3 1.7 1.3 1.3 – 1.1 0.7 1.1 0.9 – – 1.3 1.2 1.3 1.2 – 0.7 1.6
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –

RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70002468HU16002468rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.8047 0.6288 0.7222 0.5526 0.5215 0.5282 0.4883 0.5884 0.538 0.8956 0.1701 0.4475 -0.6987 -0.7096 -0.8782 -0.9942 -0.8584 -0.5665
Actin 0.0262 0.0025 0.0106 0.0064 0.0083 0.0046 0.0608 0.0001 0.0022 0.0107 0.0001 0.0027 0.0369 0.0013 0.0271 0.0535 0.0005 0.0273
Bud 0.0061 0.0134 0.0162 0.0044 0.0009 0.0033 0.0009 0.0001 0.0005 0.0065 0 0.0008 0.0013 0.0078 0.0002 0.0001 0.0009 0.0003
Bud Neck 0.0188 0.0006 0.0018 0.0013 0.0006 0.0012 0.0049 0.0001 0.0003 0.0011 0.0001 0.0054 0.0032 0.0001 0.0004 0.0001 0.0001 0.0011
Bud Periphery 0.0107 0.0081 0.0064 0.0174 0.0017 0.0046 0.0011 0.0001 0.0012 0.0268 0 0.0012 0.0018 0.0081 0.0002 0.0002 0.0014 0.0003
Bud Site 0.008 0.0246 0.0215 0.0005 0.0025 0.0017 0.012 0.0008 0.0125 0.0042 0 0.0037 0.0097 0.0046 0.0009 0.0002 0.0013 0.0005
Cell Periphery 0.0006 0.0005 0.0006 0.0003 0.0002 0.0002 0.0004 0.0002 0.0003 0.0007 0 0.0002 0.0004 0.0003 0.0001 0 0.0002 0.0001
Cytoplasm 0.1494 0.304 0.1949 0.1778 0.1015 0.3124 0.1989 0.4091 0.2937 0.1915 0.4819 0.3946 0.1741 0.4156 0.3962 0.298 0.3218 0.4475
Cytoplasmic Foci 0.0374 0.0161 0.0191 0.0086 0.0209 0.0169 0.0475 0.0066 0.0237 0.0455 0.0052 0.0275 0.0669 0.0045 0.012 0.0717 0.0074 0.036
Eisosomes 0.0004 0.0001 0.0007 0.0001 0.0002 0.0001 0.0006 0.0002 0.0002 0.0003 0 0.0001 0.0008 0.0001 0.0002 0.0003 0 0.0001
Endoplasmic Reticulum 0.0043 0.0015 0.0012 0.003 0.0024 0.0014 0.0026 0.0027 0.0021 0.0037 0.0011 0.0008 0.0102 0.0009 0.0024 0.0018 0.0058 0.0029
Endosome 0.0279 0.0041 0.0083 0.0103 0.0768 0.008 0.0255 0.0046 0.0227 0.0785 0.0015 0.0043 0.0229 0.0015 0.0091 0.019 0.048 0.006
Golgi 0.0082 0.0005 0.0034 0.0015 0.0258 0.0026 0.0124 0.0003 0.006 0.0559 0.0001 0.0049 0.0061 0.0002 0.0034 0.005 0.0021 0.0092
Lipid Particles 0.0095 0.0005 0.0074 0.0002 0.0278 0.0018 0.0243 0.0003 0.0022 0.0242 0 0.0111 0.0181 0.0001 0.0073 0.0077 0.0011 0.006
Mitochondria 0.0125 0.0008 0.0168 0.0025 0.016 0.0028 0.0319 0.0002 0.0144 0.0186 0.0001 0.0199 0.0058 0.0009 0.0041 0.0017 0.0065 0.0039
None 0.6191 0.6103 0.6674 0.7568 0.6645 0.6207 0.5021 0.5705 0.6018 0.4887 0.5084 0.5125 0.5767 0.5503 0.528 0.5161 0.5526 0.4519
Nuclear Periphery 0.0123 0.0008 0.0017 0.0014 0.0031 0.0021 0.0023 0.0004 0.0006 0.0034 0.0002 0.0002 0.0149 0.0004 0.001 0.0012 0.0106 0.0006
Nucleolus 0.0049 0.0014 0.0009 0.0001 0.001 0.0015 0.0029 0.0001 0.0002 0.0009 0 0.0008 0.0017 0.0001 0.0001 0.0001 0.0005 0.0003
Nucleus 0.0124 0.0028 0.0026 0.0012 0.0049 0.0036 0.0108 0.0009 0.0007 0.0019 0.0004 0.0005 0.0069 0.0008 0.0006 0.0007 0.0058 0.0005
Peroxisomes 0.0196 0.0009 0.0101 0.0002 0.0224 0.0018 0.0407 0 0.0098 0.0233 0 0.0062 0.018 0.0002 0.0032 0.016 0.0002 0.0036
Punctate Nuclear 0.0055 0.0042 0.0053 0.0004 0.0077 0.0068 0.01 0.0004 0.0017 0.0037 0.0002 0.001 0.0177 0.0002 0.0009 0.0037 0.0005 0.001
Vacuole 0.0041 0.0021 0.002 0.0041 0.007 0.0015 0.0065 0.0022 0.0023 0.0078 0.0005 0.0013 0.0038 0.002 0.002 0.0023 0.0222 0.0007
Vacuole Periphery 0.002 0.0003 0.001 0.0015 0.0037 0.0005 0.0013 0.0002 0.001 0.0021 0.0001 0.0003 0.0022 0.0002 0.0004 0.0005 0.0103 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 3.1382 2.8054 6.2452 8.7966 5.6964 2.5092 7.9423 9.1894 10.2932 8.3756
Translational Efficiency 1.678 2.2744 0.9773 0.5396 0.7651 1.7354 0.6789 0.6278 0.5919 0.7473

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1933 1056 1670 1098 1724 1779 1418 189 3657 2835 3088 1287

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 651.92 771.88 900.43 808.71 737.18 731.44 890.95 869.03 692.11 746.50 896.08 817.57
Standard Deviation 71.29 104.83 107.61 110.81 85.34 90.93 105.42 105.45 89.06 98.31 106.72 112.09
Intensity Change Log 2 — 0.243682 0.465919 0.310928 — -0.011277 0.273328 0.237389 — 0.114002 0.366921 0.272369

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000153 0.000621 0.000283 0.000927 0.000121 0.000420 0.000121 0.000254 0.000138 0.000495 0.000209 0.000828
Bud Neck 0.028228 0.024149 0.002662 0.008551 0.010521 0.028507 0.001200 0.009372 0.019880 0.026884 0.001991 0.008671
Bud Site 0.014011 0.031403 0.010833 0.042773 0.005892 0.028900 0.004476 0.016969 0.010184 0.029832 0.007914 0.038983
Cell Periphery 0.000200 0.000147 0.000085 0.000161 0.000134 0.000123 0.000070 0.000138 0.000169 0.000132 0.000078 0.000157
Cytoplasm 0.527934 0.417163 0.538965 0.622455 0.569760 0.450459 0.684260 0.518845 0.547652 0.438057 0.605684 0.607239
Cytoplasmic Foci 0.232150 0.278115 0.006785 0.029578 0.221594 0.252445 0.015033 0.042307 0.227173 0.262007 0.010572 0.031447
Eisosomes 0.000259 0.000116 0.000018 0.000041 0.000138 0.000142 0.000021 0.000069 0.000202 0.000132 0.000020 0.000045
Endoplasmic Reticulum 0.001426 0.000671 0.002226 0.000986 0.000976 0.000448 0.001261 0.000683 0.001214 0.000531 0.001783 0.000942
Endosome 0.019368 0.051733 0.001354 0.006825 0.017195 0.046508 0.001984 0.006209 0.018343 0.048454 0.001643 0.006735
Golgi 0.005379 0.008668 0.000081 0.006755 0.003569 0.009982 0.000163 0.000548 0.004526 0.009493 0.000118 0.005844
Lipid Particles 0.007237 0.003926 0.000679 0.000802 0.004601 0.003761 0.000804 0.001160 0.005994 0.003823 0.000736 0.000855
Mitochondria 0.005293 0.004274 0.000474 0.002626 0.001927 0.006962 0.000294 0.003540 0.003706 0.005961 0.000391 0.002760
Mitotic Spindle 0.001172 0.009604 0.004214 0.017234 0.001561 0.010267 0.008909 0.016631 0.001356 0.010020 0.006370 0.017145
None 0.007254 0.001376 0.005062 0.006923 0.002209 0.000709 0.005700 0.010609 0.004875 0.000958 0.005355 0.007464
Nuclear Periphery 0.000218 0.000163 0.001166 0.000455 0.000188 0.000201 0.000752 0.000536 0.000204 0.000187 0.000976 0.000467
Nuclear Periphery Foci 0.000443 0.000566 0.001577 0.001410 0.000480 0.000263 0.001873 0.000872 0.000460 0.000376 0.001713 0.001331
Nucleolus 0.001259 0.000846 0.000209 0.000244 0.000544 0.000781 0.000118 0.000278 0.000922 0.000806 0.000167 0.000249
Nucleus 0.064873 0.029079 0.381443 0.116507 0.069922 0.025262 0.196517 0.094644 0.067253 0.026683 0.296526 0.113297
Peroxisomes 0.003448 0.013053 0.000203 0.000847 0.002715 0.011389 0.000319 0.001356 0.003102 0.012009 0.000256 0.000921
Vacuole 0.077615 0.121148 0.041560 0.130585 0.084474 0.118925 0.076034 0.269133 0.080849 0.119753 0.057390 0.150932
Vacuole Periphery 0.002082 0.003178 0.000122 0.003315 0.001481 0.003543 0.000090 0.005846 0.001798 0.003407 0.000107 0.003686

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.09 -2.84 -3.01 0.42 -1.01 -4.15 -2.78 -1.75 2.37 -0.95 -5.74 -3.25 -3.23 -0.02 -1.76
Bud Neck 2.04 15.91 13.41 10.04 -1.97 -11.27 9.97 2.71 9.79 -1.41 -4.93 18.44 12.38 16.77 -3.13
Bud Site -6.73 2.39 -1.67 3.32 -3.02 -12.01 2.28 -0.90 6.11 -1.63 -12.40 3.00 -2.93 4.31 -4.14
Cell Periphery 2.03 10.67 6.86 1.16 -1.38 0.75 9.26 3.42 1.84 -0.84 2.63 13.80 6.09 1.35 -2.51
Cytoplasm 10.91 5.79 2.01 -7.33 -2.58 12.97 -2.42 7.57 2.36 8.45 16.21 2.65 6.14 -5.35 4.16
Cytoplasmic Foci -5.50 52.56 46.84 37.57 -10.89 -4.49 44.75 35.29 38.09 -3.18 -6.62 68.91 60.77 56.63 -9.51
Eisosomes 8.35 14.48 13.11 9.67 -8.33 -0.18 6.52 4.02 6.08 -6.60 5.18 15.01 12.90 10.82 -10.31
Endoplasmic Reticulum 3.20 -6.92 -0.16 -6.13 9.65 4.88 -6.41 -2.21 -5.50 2.31 5.23 -8.96 -1.66 -10.21 9.20
Endosome -10.25 17.14 13.55 16.11 -2.37 -12.98 16.53 11.10 19.32 -2.83 -16.34 23.71 17.16 25.33 -2.79
Golgi -3.01 13.73 2.63 4.24 -2.05 -8.28 9.72 8.96 13.98 -0.78 -7.91 16.77 2.58 6.75 -2.05
Lipid Particles 4.05 12.17 11.99 4.49 -1.20 2.36 13.70 11.42 8.66 -1.93 5.28 16.72 16.28 9.46 -1.79
Mitochondria 1.28 7.00 5.29 4.47 -1.28 -4.19 2.82 0.65 3.95 -0.88 -2.65 7.26 4.40 6.11 -1.73
Mitotic Spindle -3.93 -3.37 -3.80 0.38 -1.78 -4.72 -3.61 -2.02 0.16 -0.28 -6.23 -4.87 -4.18 0.51 -1.23
None 5.41 2.50 1.82 -5.23 -0.71 6.28 -3.69 -1.55 -2.31 -0.36 6.89 0.41 -0.34 -6.93 -0.81
Nuclear Periphery 1.23 -23.64 -15.41 -19.04 11.37 -0.17 -20.45 -8.60 -7.41 -0.22 0.25 -31.13 -19.62 -13.43 9.57
Nuclear Periphery Foci -2.05 -10.56 -7.85 -6.42 2.52 5.76 -10.98 -3.74 -4.58 2.64 1.70 -15.14 -8.66 -9.13 3.48
Nucleolus 2.01 8.61 9.00 3.68 0.36 -1.84 7.96 4.53 4.33 -2.58 1.01 10.83 10.35 5.89 -1.59
Nucleus 12.55 -52.52 -16.60 -22.27 29.24 20.08 -27.21 -5.15 -9.05 7.34 23.83 -54.68 -17.27 -25.32 24.47
Peroxisomes -9.37 13.05 11.88 12.71 -2.14 -11.83 7.80 5.03 14.93 -1.05 -15.08 14.44 12.52 20.57 -2.54
Vacuole -9.81 1.04 -21.39 -14.17 -21.04 -8.18 -9.53 -14.15 -12.51 -11.40 -12.87 -6.70 -24.83 -18.89 -20.72
Vacuole Periphery -2.69 12.85 1.78 3.21 -2.10 -4.70 6.12 -0.17 1.15 -1.11 -5.26 12.58 1.11 3.88 -2.41
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Cytoplasmic protein of unknown function; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P); YKR078W has a paralog, VPS5, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (89%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

YKR078W

YKR078W


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ykr078w-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available