Standard name
Human Ortholog
Description Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.2 0.14 0.18 0.1 0.11 0.08 0.05 0 0.06 0.05 0 0 0.09 0 0 0.18 0.16 0.17 0.09 0 0 0.07 0.14 0.08
Bud 0.23 0.1 0.12 0 0.07 0.07 0.08 0.06 0.08 0.09 0.07 0.07 0.06 0 0 0.06 0.07 0.17 0.3 0.22 0.19 0.13 0.07 0.11
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.18 0.16 0.17 0.16 0.06 0.06
Bud Site 0.12 0.08 0.13 0.09 0 0.06 0 0 0 0 0 0 0.1 0 0 0.1 0.07 0.06 – – – – – –
Cell Periphery 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0.15 0.13 0.17 0 0 0 0 0 0
Cytoplasm 0.48 0.66 0.64 0.76 0.8 0.71 0.76 0.77 0.64 0.64 0.67 0.69 0.78 0.95 0.98 0.61 0.62 0.5 0.33 0.48 0.46 0.43 0.56 0.59
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0
Endosome 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.14 0.15 0.12 0.39 0.34 0.37 0.25 0 0 0 0.06 0 0.22 0 0 0.05 0.05 0 0.06
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0.06 0 0 0 0 0 0
SpindlePole 0.11 0 0.14 0.1 0.05 0.1 0.07 0.06 0 0 0 0 0 0 0 0.08 0.07 0.06 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 65 38 60 29 36 35 27 15 19 17 6 9 10 6 1 16 16 3 32 12 15 3 20 13
Bud 74 27 39 13 25 32 46 32 27 29 24 31 7 3 2 5 7 3 107 66 70 6 10 18
Bud Neck 7 9 13 6 12 13 16 15 1 5 3 11 0 0 0 0 2 0 64 46 62 8 8 9
Bud Site 38 21 44 26 12 28 14 6 10 7 3 4 11 2 1 9 7 1 – – – – – –
Cell Periphery 9 10 9 16 3 2 6 7 9 2 5 7 1 8 1 13 13 3 2 1 2 0 2 1
Cytoplasm 153 174 212 222 272 317 430 431 216 212 219 288 87 190 228 53 63 9 116 142 169 23 80 94
Endoplasmic Reticulum 2 8 6 2 3 3 2 0 2 5 2 4 1 0 0 2 3 0 2 1 1 1 8 5
Endosome 22 7 1 1 1 3 3 4 0 0 0 0 0 0 1 2 0 1 5 4 2 1 1 2
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 2 0 0 0
Mitochondria 14 11 2 6 7 62 83 66 130 114 121 104 3 1 4 5 3 4 3 3 17 2 5 9
Nucleus 6 0 3 2 0 3 3 9 3 2 2 4 0 2 0 1 3 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 2 1 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 3 3 1 1 0 4 4 7 1 1 1 2 2 0 0 1 1 0 0 0 0 0 0 0
Peroxisomes 19 12 2 4 0 15 4 1 3 2 0 1 7 3 2 0 2 1 0 0 1 1 0 0
SpindlePole 35 5 45 30 18 47 38 34 12 9 7 17 2 1 0 7 7 1 8 5 8 0 0 1
Vac/Vac Membrane 4 3 6 4 3 4 3 23 2 8 5 2 0 0 0 3 10 0 4 8 7 1 4 3
Unique Cell Count 320 264 332 292 340 448 568 560 336 332 327 418 112 199 233 87 101 18 353 297 368 54 143 160
Labelled Cell Count 451 328 443 362 392 568 679 652 436 415 398 484 131 216 240 117 138 26 353 297 368 54 143 160


Ambiguous, Bud, Bud Neck, Cell Periphery, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.3 6.4 6.3 5.8 6.3 4.9 4.9 5.1 4.2 4.0 4.0 4.4 6.0 6.4 6.4 10.0 10.5 9.9 5.8 5.8 6.3
Std Deviation (1e-4) 0.9 1.1 0.7 1.0 1.3 1.0 0.9 1.0 0.8 0.6 0.7 0.8 0.6 0.9 1.1 1.7 2.0 1.7 1.6 1.4 1.5
Intensity Change (Log2) – – – -0.12 -0.01 -0.36 -0.38 -0.3 -0.58 -0.65 -0.67 -0.51 -0.08 0.02 0.03 0.67 0.74 0.65 -0.12 -0.12 0.0


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -2.9 -2.8 -4.3 0 -8.0 0 0 0 0 -2.3 -5.1 -6.7 0.1 -0.5 0
Bud -3.3 -1.9 -2.2 0 -3.2 0 0 0 0 -1.7 -4.2 -4.9 -1.6 -1.4 0
Bud Neck -1.3 -0.3 -0.8 0 -1.0 0 0 0 0 0 0 -3.1 0 0 0
Bud Site -1.7 -4.6 -3.3 0 -7.6 0 0 0 0 -1.0 -4.9 -5.5 -0.7 -1.7 0
Cell Periphery 1.8 -1.8 0 0 -1.6 0 0 0 0 0 0.8 0 0 4.1 0
Cytoplasm 3.3 4.7 2.0 3.8 4.2 0.1 0 0.8 1.5 2.7 8.2 9.6 -0.5 -0.3 -1.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 6.7 0 6.1 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 2.6 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole -1.3 -3.7 -1.3 0 -3.8 0 0 0 0 -3.5 -5.2 -5.9 -1.4 -1.8 0
Vacuole 0 0 0 0 1.9 0 0.5 -0.3 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.5217 1.5338 1.7657 1.857 1.7957 1.5617 1.5609 1.8027 2.0236 1.8129 1.6663 1.6905 1.3612 1.657 1.4639 2.2408 1.3683 1.5724
Actin 0.039 0.0268 0.0202 0.0123 0.004 0.0266 0.0413 0.0106 0.0288 0.0313 0.0007 0.0225 0.1187 0.0065 0.0378 0.002 0.0152 0.0107
Bud 0.0551 0.0531 0.2451 0.0274 0.0111 0.0072 0.0485 0.0463 0.168 0.0702 0.0015 0.0079 0.0539 0.0622 0.2089 0.0315 0.0156 0.0055
Bud Neck 0.0803 0.0062 0.0057 0.0455 0.0415 0.5547 0.0851 0.0048 0.0099 0.0036 0.0526 0.5746 0.0571 0.0058 0.0125 0.0135 0.0242 0.4855
Bud Periphery 0.0908 0.0367 0.3008 0.0812 0.011 0.01 0.0403 0.0358 0.2133 0.0651 0.0017 0.0106 0.0741 0.0447 0.2645 0.0713 0.0346 0.0054
Bud Site 0.1936 0.3048 0.0812 0.065 0.0284 0.0071 0.2204 0.389 0.0927 0.0502 0.0023 0.0233 0.1439 0.2542 0.0343 0.0354 0.0616 0.0131
Cell Periphery 0.003 0.002 0.0019 0.0036 0.0004 0.0009 0.0058 0.0026 0.0027 0.0016 0.0004 0.0008 0.0036 0.0023 0.0013 0.0009 0.0022 0.0005
Cytoplasm 0.2716 0.4446 0.243 0.5295 0.7275 0.2466 0.297 0.39 0.3497 0.5567 0.77 0.2889 0.3822 0.4432 0.3252 0.69 0.5504 0.3317
Cytoplasmic Foci 0.0777 0.03 0.0208 0.0321 0.0674 0.0594 0.0819 0.038 0.0232 0.0388 0.0387 0.0304 0.0335 0.0208 0.022 0.0056 0.0301 0.0829
Eisosomes 0.0004 0.0002 0.0002 0.0003 0 0.0001 0.0003 0.0001 0.0002 0.0004 0 0 0.0008 0.0001 0.0003 0.0001 0.0004 0
Endoplasmic Reticulum 0.0045 0.0023 0.0024 0.0045 0.0044 0.0019 0.0099 0.0024 0.0042 0.0035 0.0025 0.0011 0.0051 0.0019 0.0036 0.0031 0.007 0.0006
Endosome 0.0407 0.0071 0.0112 0.0382 0.0409 0.013 0.0295 0.0085 0.026 0.028 0.0586 0.0077 0.0191 0.0025 0.0232 0.0041 0.0744 0.0076
Golgi 0.0128 0.0035 0.003 0.0104 0.0041 0.011 0.011 0.002 0.0117 0.0076 0.0177 0.0037 0.0087 0.0008 0.0063 0.0003 0.0085 0.0019
Lipid Particles 0.0151 0.001 0.004 0.0026 0.0198 0.0023 0.0144 0.0003 0.0049 0.0051 0.0108 0.0005 0.0054 0.0003 0.0026 0.0002 0.0109 0.0021
Mitochondria 0.0242 0.006 0.008 0.0054 0.0059 0.0115 0.0291 0.0004 0.0038 0.03 0.0019 0.0055 0.004 0.0005 0.0125 0.0003 0.009 0.0005
None 0.0345 0.056 0.0348 0.099 0.0064 0.033 0.0309 0.0557 0.0465 0.0749 0.0065 0.0136 0.0619 0.1379 0.0319 0.1359 0.0545 0.0394
Nuclear Periphery 0.0114 0.0007 0.0012 0.0036 0.0014 0.0006 0.0184 0.0006 0.0013 0.0014 0.001 0.0004 0.0042 0.0006 0.0022 0.0006 0.0092 0.0001
Nucleolus 0.0038 0.0005 0.0004 0.0007 0.0012 0.0003 0.0006 0.0004 0.0004 0.0007 0.0004 0.0002 0.0019 0.0011 0.0003 0.0001 0.0124 0.0002
Nucleus 0.0095 0.002 0.0013 0.021 0.0016 0.0007 0.0061 0.0018 0.0016 0.0023 0.0012 0.0011 0.0022 0.0067 0.0009 0.0008 0.021 0.0004
Peroxisomes 0.0165 0.007 0.0075 0.0017 0.0094 0.008 0.0131 0.0034 0.0044 0.0105 0.0078 0.0037 0.0063 0.001 0.0032 0.0001 0.0094 0.0093
Punctate Nuclear 0.0075 0.001 0.002 0.0023 0.0063 0.0028 0.003 0.0025 0.0016 0.0019 0.0074 0.0012 0.0086 0.0016 0.0012 0.0004 0.027 0.0013
Vacuole 0.0058 0.0074 0.0044 0.0112 0.0059 0.0016 0.0115 0.0045 0.004 0.0144 0.013 0.002 0.004 0.005 0.0042 0.0035 0.0174 0.001
Vacuole Periphery 0.002 0.0009 0.0008 0.0025 0.0014 0.0004 0.002 0.0003 0.001 0.0017 0.0032 0.0004 0.001 0.0003 0.001 0.0005 0.0049 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 22.6299 8.836 10.0076 18.6484 24.6192 15.0783 15.9873 11.9011 11.8447 23.1497
Translational Efficiency 1.5384 2.4336 1.4636 1.0212 1.2668 2.2851 1.007 1.4047 1.5123 1.3192

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1490 518 788 1229 1749 447 769 107 3239 965 1557 1336

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 777.32 823.52 1132.62 1006.19 822.03 776.74 1076.40 1001.90 801.46 801.85 1104.85 1005.85
Standard Deviation 90.89 107.51 139.99 123.07 94.23 108.19 110.06 127.44 95.35 110.32 129.20 123.43
Intensity Change Log 2 — 0.083295 0.543083 0.372322 — -0.081759 0.388951 0.285476 — 0.000821 0.465921 0.328338

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000660 0.003133 0.002896 0.003252 0.000699 0.001076 0.001721 0.003972 0.000681 0.002180 0.002316 0.003309
Bud Neck 0.094377 0.072677 0.057336 0.052463 0.099988 0.093563 0.092653 0.073993 0.097407 0.082352 0.074779 0.054188
Bud Site 0.326265* 0.327871* 0.334507* 0.404417* 0.308217* 0.306969* 0.464179* 0.535956* 0.316519* 0.318189* 0.398552* 0.414952*
Cell Periphery 0.001026 0.000607 0.000439 0.000389 0.000666 0.000424 0.000518 0.000343 0.000832 0.000522 0.000478 0.000386
Cytoplasm 0.406949* 0.342930* 0.361102* 0.413381* 0.397617* 0.316508* 0.240107* 0.225311* 0.401910* 0.330691* 0.301343* 0.398318*
Cytoplasmic Foci 0.102882 0.128743 0.041918 0.019606 0.108996 0.146179 0.027319 0.041056 0.106184 0.136819 0.034708 0.021324
Eisosomes 0.000215 0.000240 0.000085 0.000065 0.000174 0.000212 0.000111 0.000117 0.000193 0.000227 0.000098 0.000069
Endoplasmic Reticulum 0.001347 0.000433 0.001436 0.000471 0.000830 0.000385 0.001170 0.000492 0.001068 0.000410 0.001305 0.000472
Endosome 0.010370 0.029247 0.007095 0.003230 0.012114 0.037775 0.004059 0.007096 0.011312 0.033198 0.005595 0.003540
Golgi 0.006408 0.007308 0.000439 0.005477 0.004760 0.011197 0.000483 0.003176 0.005518 0.009110 0.000461 0.005292
Lipid Particles 0.001547 0.002165 0.001636 0.000607 0.001773 0.002750 0.000738 0.000349 0.001669 0.002436 0.001193 0.000586
Mitochondria 0.001458 0.000976 0.000286 0.001537 0.002360 0.005787 0.000105 0.002386 0.001945 0.003205 0.000196 0.001605
Mitotic Spindle 0.000643 0.002130 0.004713 0.009793 0.001760 0.001854 0.003439 0.004624 0.001246 0.002002 0.004084 0.009379
None 0.003452 0.000508 0.000730 0.000533 0.001209 0.001322 0.000224 0.000226 0.002241 0.000885 0.000480 0.000509
Nuclear Periphery 0.000037 0.000084 0.000243 0.000107 0.000036 0.000037 0.000149 0.000096 0.000036 0.000062 0.000197 0.000106
Nuclear Periphery Foci 0.000603 0.000456 0.003422 0.001021 0.000497 0.000278 0.002013 0.000870 0.000546 0.000373 0.002726 0.001009
Nucleolus 0.000488 0.000553 0.000190 0.000174 0.000330 0.000310 0.000089 0.000106 0.000403 0.000441 0.000140 0.000168
Nucleus 0.009923 0.007302 0.029380 0.008052 0.010444 0.005636 0.017918 0.004758 0.010204 0.006531 0.023719 0.007788
Peroxisomes 0.002727 0.013449 0.002632 0.002258 0.002867 0.012798 0.003178 0.002100 0.002803 0.013147 0.002902 0.002245
Vacuole 0.027061 0.057940 0.149204 0.070300 0.043362 0.051718 0.139530 0.088724 0.035863 0.055058 0.144426 0.071776
Vacuole Periphery 0.001559 0.001248 0.000311 0.002867 0.001302 0.003223 0.000298 0.004251 0.001420 0.002163 0.000305 0.002978

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.46 -2.17 -5.14 0.39 -0.15 -1.82 -3.94 -1.59 -1.46 -1.30 -2.74 -3.00 -5.20 -1.08 -1.40
Bud Neck 2.78 7.89 10.75 5.31 2.11 0.66 4.80 3.42 2.60 0.72 2.46 8.82 13.93 7.76 4.18
Bud Site 0.16 4.16 4.43 3.02 -0.36 0.07 -1.87 -2.68 -2.55 -1.85 0.06 1.52 3.26 2.44 1.50
Cell Periphery 2.07 5.12 6.05 1.84 2.72 3.24 3.45 3.82 1.01 1.41 2.79 6.21 7.85 2.32 3.47
Cytoplasm 3.99 1.80 -3.43 -6.56 -4.69 5.06 9.23 4.24 1.43 0.32 6.29 7.31 -3.19 -7.96 -8.84
Cytoplasmic Foci -3.02 13.31 18.30 13.12 5.81 -3.82 18.61 8.06 8.91 -1.47 -4.76 22.45 25.54 18.07 4.27
Eisosomes -0.41 6.90 8.05 3.18 2.26 -1.09 4.27 0.73 1.29 -0.65 -0.95 8.02 9.69 4.73 3.27
Endoplasmic Reticulum 2.53 -0.76 2.63 0.24 6.92 2.71 -2.01 1.39 -0.58 2.98 3.49 -1.91 3.32 -0.07 7.02
Endosome -5.45 3.57 8.63 7.94 6.60 -6.36 8.62 2.37 6.78 -0.61 -8.29 8.57 12.11 11.73 5.02
Golgi -0.83 13.73 2.54 2.68 -2.57 -4.14 11.61 1.50 4.05 -1.21 -3.92 17.90 2.09 4.29 -2.71
Lipid Particles -0.63 -1.03 3.57 1.50 4.07 -1.30 4.02 6.42 3.34 4.13 -1.19 1.94 4.70 2.78 3.41
Mitochondria 1.88 5.08 1.33 -0.03 -2.27 -1.81 3.17 0.38 1.75 -1.08 -1.38 4.40 1.82 2.47 -2.85
Mitotic Spindle -1.69 -3.24 -4.13 -2.96 -0.77 -0.11 -1.89 -1.37 -1.34 -0.30 -1.19 -3.65 -3.89 -3.33 -1.33
None 3.96 3.81 3.96 -0.16 0.68 -0.20 3.12 2.57 1.48 -0.21 2.78 4.70 4.43 1.08 -0.41
Nuclear Periphery -0.97 -10.71 -6.04 -1.89 4.52 -0.05 -9.65 -2.04 -2.01 2.66 -0.97 -14.45 -6.70 -3.54 4.50
Nuclear Periphery Foci 0.73 -9.40 -1.10 -1.55 7.05 2.63 -7.98 -2.23 -3.16 4.48 1.60 -12.29 -1.54 -2.14 6.91
Nucleolus -0.63 2.89 2.82 1.20 0.37 0.25 3.23 2.43 2.24 -0.13 -0.64 4.17 3.17 1.40 -0.35
Nucleus 0.80 -11.74 -5.35 -3.96 8.72 3.98 -6.46 1.15 -1.45 6.17 2.47 -12.89 -5.87 -6.29 8.55
Peroxisomes -5.68 1.24 2.36 6.09 0.67 -4.57 0.72 -0.12 3.71 -0.40 -7.24 1.30 2.41 7.74 0.72
Vacuole -6.85 -18.84 -21.07 -13.82 2.01 -1.82 -18.80 -5.43 -5.05 2.11 -6.07 -26.38 -20.66 -16.23 4.37
Vacuole Periphery 1.32 6.48 -0.29 -0.79 -2.29 -1.93 6.01 -0.80 0.08 -1.30 -1.54 8.99 -0.71 0.39 -2.59
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress
Localization
Cell Percentages cytoplasm (56%), bud neck (22%), mixed (20%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Pxl1

Pxl1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pxl1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available