Standard name
Human Ortholog
Description Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.09 0.06 0.07 0.07 0.09 0 0.05 0 0 0 0 0 0.18 0.24 0.26 0.18 0.14 0.17 0 0 0 0.07 0.06 0.07
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.4 0.24 0.1 0.18 0.27 0.51 0.59 0.43 0.43 0.58 0.66 0.54 0 0 0 0 0 0 0 0 0 0 0 0.05
Nucleus 0.76 0.82 0.82 0.81 0.74 0.75 0.69 0.76 0.75 0.76 0.71 0.73 0.78 0.73 0.7 0.79 0.77 0.76 0.7 0.79 0.74 0.6 0.53 0.41
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0.07 0.05 0 0.05 0 0 0 0 0 0 0.05 0 0 0 0 0.08 0.07 0.18 0.1 0.15 0.24 0.24 0.33
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 2 2
Bud 1 0 2 1 0 13 12 5 7 18 9 11 0 0 0 0 0 1 1 5 5 2 9 12
Bud Neck 0 0 1 0 0 0 1 0 0 1 0 0 2 1 1 0 0 0 0 0 0 2 3 4
Bud Site 1 0 1 1 6 13 11 22 18 25 19 25 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
Cytoplasm 14 23 39 25 46 33 42 28 27 18 21 10 99 118 160 68 54 70 5 15 16 31 35 46
Endoplasmic Reticulum 0 2 1 0 1 0 0 0 0 0 0 0 1 2 5 14 12 20 1 0 0 2 3 3
Endosome 0 0 18 8 11 0 0 4 1 3 0 0 2 3 7 3 9 8 2 4 4 3 6 11
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 2 1 4 1 0 3 1 0 1 3
Mitochondria 64 94 57 68 131 406 498 311 350 474 482 382 2 0 3 9 13 15 4 3 10 12 22 31
Nucleus 122 326 459 302 364 593 587 555 605 622 512 518 430 353 439 291 300 316 135 331 474 264 293 281
Nuclear Periphery 3 0 1 2 3 3 2 5 8 7 8 8 0 0 1 0 0 0 1 0 1 0 1 5
Nucleolus 0 0 0 1 2 4 12 19 14 21 23 27 0 0 0 1 1 2 0 0 2 2 6 11
Peroxisomes 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0
SpindlePole 2 1 3 1 2 0 2 1 4 2 0 3 3 3 3 1 5 1 3 7 15 8 18 28
Vac/Vac Membrane 10 28 28 14 25 27 27 15 24 15 17 36 20 18 19 10 31 30 34 43 94 105 135 226
Unique Cell Count 160 397 561 371 491 794 849 730 809 818 726 706 549 485 625 370 392 414 194 422 640 442 554 687
Labelled Cell Count 217 474 613 423 591 1092 1194 965 1059 1206 1091 1020 559 498 641 399 429 464 194 422 640 442 554 687


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.7 4.5 4.6 4.4 4.5 3.8 3.9 4.0 3.9 3.8 3.4 3.6 6.0 5.9 5.7 7.1 6.8 7.0 5.9 6.1 6.2
Std Deviation (1e-4) 0.4 0.7 0.9 1.6 2.0 1.2 1.6 1.0 0.8 0.8 0.8 0.8 1.1 0.9 1.1 1.6 1.7 1.9 1.2 1.5 1.5
Intensity Change (Log2) – – – -0.07 -0.01 -0.28 -0.22 -0.21 -0.24 -0.29 -0.41 -0.34 0.39 0.36 0.32 0.63 0.57 0.61 0.37 0.41 0.43

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – -1.7 1.8 1.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.9264 2.3062 2.077 2.2202 1.7668 2.2015 1.9243 1.2526 1.6961 0.9247 1.2838 1.1425 0.6093 0.6294 0.2266 1.1189 0.3719 0.3667
Actin 0.0209 0.0002 0.0016 0.0065 0.0034 0.0005 0.0349 0.0002 0.0226 0.0187 0.0097 0.0008 0.0087 0.0001 0.0001 0.0089 0.0032 0.0023
Bud 0.0002 0.0001 0.0024 0.0001 0.0001 0.0001 0.0011 0.0001 0.0004 0.0003 0.0007 0.0001 0.0035 0.0003 0.0001 0.0003 0.0002 0.0012
Bud Neck 0.0025 0.0005 0.0005 0.0315 0.001 0.0042 0.0072 0.0003 0.0088 0.0019 0.0033 0.0019 0.0099 0.0003 0.0015 0.047 0.001 0.0028
Bud Periphery 0.0005 0.0001 0.0009 0.0002 0.0001 0.0001 0.003 0.0001 0.0007 0.0008 0.0015 0.0001 0.0018 0.0001 0.0001 0.0004 0.0004 0.0006
Bud Site 0.0015 0.0012 0.0007 0.0012 0.0004 0.0003 0.004 0.0005 0.0071 0.0009 0.0019 0.0002 0.0032 0.0009 0.0006 0.0004 0.0004 0.0003
Cell Periphery 0.0002 0.0001 0.0001 0.0006 0.0001 0.0001 0.0008 0 0.0004 0.0001 0.0001 0 0.0002 0 0 0.0001 0.0001 0
Cytoplasm 0.0324 0.05 0.0259 0.0283 0.0261 0.0318 0.0483 0.0618 0.0384 0.017 0.0493 0.0431 0.0235 0.04 0.0179 0.0112 0.044 0.0226
Cytoplasmic Foci 0.0122 0.0012 0.0036 0.0027 0.0035 0.0023 0.0111 0.0011 0.003 0.0015 0.0061 0.0016 0.0104 0.0021 0.0009 0.0008 0.0021 0.0088
Eisosomes 0.0007 0.0001 0.0002 0.0015 0.0002 0 0.0004 0 0.0003 0.0007 0.0001 0 0.0001 0 0 0.0001 0.0001 0
Endoplasmic Reticulum 0.0026 0.0015 0.0029 0.0025 0.0008 0.0008 0.0089 0.0031 0.0021 0.0021 0.0048 0.001 0.0028 0.0007 0.0008 0.0035 0.0032 0.001
Endosome 0.0111 0.0019 0.0084 0.0089 0.0031 0.0019 0.0287 0.0009 0.0051 0.0087 0.0273 0.0018 0.0108 0.0008 0.0008 0.0045 0.0047 0.0012
Golgi 0.0017 0.0001 0.0008 0.0007 0.0005 0.0001 0.0051 0 0.0029 0.0013 0.0039 0.0005 0.0045 0 0 0.0006 0.0008 0.0004
Lipid Particles 0.0042 0.0002 0.0061 0.0012 0.0021 0.0003 0.0101 0.0001 0.001 0.0035 0.0073 0.0045 0.0118 0.0001 0.0002 0.0004 0.001 0.001
Mitochondria 0.003 0.0008 0.0053 0.001 0.0015 0.0004 0.0094 0.0005 0.0012 0.0043 0.0079 0.001 0.0039 0.0002 0.0002 0.001 0.0017 0.0004
None 0.2072 0.142 0.1565 0.1428 0.1159 0.0843 0.0949 0.076 0.0738 0.0177 0.07 0.0388 0.0355 0.0482 0.0265 0.0034 0.1146 0.0314
Nuclear Periphery 0.0277 0.0254 0.016 0.0298 0.012 0.0067 0.0579 0.0068 0.0154 0.0396 0.0352 0.0158 0.024 0.0128 0.0119 0.0269 0.0432 0.0063
Nucleolus 0.0105 0.0134 0.0104 0.0052 0.012 0.0193 0.0187 0.004 0.0043 0.0073 0.0131 0.0093 0.0126 0.0094 0.0066 0.009 0.0067 0.0102
Nucleus 0.6187 0.7105 0.717 0.661 0.7437 0.8129 0.5819 0.8223 0.7841 0.809 0.6859 0.8301 0.7858 0.8405 0.8824 0.8383 0.7561 0.8598
Peroxisomes 0.0092 0.0001 0.001 0.0015 0.0038 0.0001 0.0082 0.0001 0.0007 0.0058 0.0029 0.0019 0.0078 0 0 0.0001 0.0002 0.0006
Punctate Nuclear 0.0298 0.0483 0.0375 0.0715 0.0678 0.0325 0.0555 0.0201 0.0257 0.0562 0.0597 0.0459 0.0363 0.0427 0.0489 0.041 0.008 0.0483
Vacuole 0.0026 0.0021 0.0014 0.0007 0.0015 0.001 0.0065 0.0014 0.0014 0.0013 0.0069 0.0012 0.002 0.0007 0.0004 0.0012 0.0031 0.0005
Vacuole Periphery 0.0007 0.0004 0.0008 0.0005 0.0004 0.0002 0.0035 0.0004 0.0005 0.0013 0.0023 0.0005 0.0008 0.0002 0.0001 0.0009 0.0053 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.358 6.7715 5.583 9.1872 13.6405 9.253 5.8957 6.1613 8.0404 14.1846
Translational Efficiency 0.6433 0.8044 0.6363 0.5453 0.5922 1.4362 0.6964 0.5726 0.5407 0.5002

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1952 1435 2416 974 1768 1668 285 202 3720 3103 2701 1176

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 704.22 767.02 822.57 714.07 670.50 738.98 862.61 1232.46 688.19 751.95 826.79 803.11
Standard Deviation 78.33 101.78 100.90 103.18 86.61 89.53 99.31 150.94 84.07 96.41 101.48 225.75
Intensity Change Log 2 — 0.123238 0.224112 0.020039 — 0.140298 0.363471 0.878232 — 0.131584 0.293765 0.501767

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000086 0.000365 0.000239 0.000626 0.000179 0.000178 0.000391 0.000034 0.000130 0.000264 0.000255 0.000524
Bud Neck 0.002556 0.007220 0.012656 0.006379 0.003302 0.006186 0.002344 0.031789 0.002911 0.006664 0.011567 0.010744
Bud Site 0.000673 0.003248 0.002402 0.002733 0.000886 0.003311 0.000878 0.001072 0.000774 0.003282 0.002241 0.002448
Cell Periphery 0.000137 0.000187 0.000133 0.000142 0.000256 0.000134 0.000043 0.000105 0.000193 0.000159 0.000124 0.000135
Cytoplasm 0.075647 0.088590 0.016152 0.023161 0.059966 0.072100 0.003301 0.036297 0.068194 0.079726 0.014796 0.025417
Cytoplasmic Foci 0.011707 0.020699 0.000303 0.000568 0.005979 0.011004 0.000375 0.000046 0.008985 0.015488 0.000310 0.000478
Eisosomes 0.000023 0.000040 0.000015 0.000023 0.000021 0.000029 0.000024 0.000006 0.000022 0.000034 0.000016 0.000020
Endoplasmic Reticulum 0.001159 0.003451 0.003239 0.005673 0.001013 0.002507 0.004365 0.000512 0.001090 0.002944 0.003358 0.004787
Endosome 0.000852 0.002630 0.000519 0.000688 0.000515 0.001809 0.000229 0.000115 0.000692 0.002189 0.000489 0.000590
Golgi 0.000762 0.000696 0.000037 0.000389 0.000080 0.000712 0.000032 0.000018 0.000438 0.000705 0.000036 0.000326
Lipid Particles 0.002411 0.004020 0.000178 0.000360 0.001235 0.002593 0.000272 0.000025 0.001852 0.003253 0.000188 0.000303
Mitochondria 0.002158 0.004565 0.001201 0.000831 0.001278 0.003838 0.000384 0.000530 0.001739 0.004174 0.001115 0.000779
Mitotic Spindle 0.001886 0.006014 0.001110 0.001990 0.001494 0.006559 0.000180 0.000560 0.001700 0.006307 0.001012 0.001744
None 0.005001 0.009926 0.003908 0.005924 0.008658 0.005538 0.003316 0.002581 0.006739 0.007567 0.003845 0.005350
Nuclear Periphery 0.001330 0.001584 0.000904 0.000906 0.000956 0.001290 0.000396 0.000652 0.001152 0.001426 0.000850 0.000863
Nuclear Periphery Foci 0.000395 0.000875 0.000084 0.000801 0.000415 0.000362 0.000111 0.000002 0.000404 0.000599 0.000087 0.000664
Nucleolus 0.003870 0.006482 0.001741 0.004735 0.003531 0.004431 0.003306 0.001851 0.003709 0.005379 0.001906 0.004240
Nucleus 0.885732 0.826617 0.952049 0.939314 0.908179 0.867627 0.977192 0.922981 0.896400 0.848662 0.954702 0.936509
Peroxisomes 0.001226 0.003294 0.000081 0.000159 0.000496 0.003422 0.000125 0.000011 0.000879 0.003363 0.000085 0.000133
Vacuole 0.002231 0.008523 0.002852 0.004210 0.001291 0.005807 0.002682 0.000707 0.001784 0.007063 0.002834 0.003608
Vacuole Periphery 0.000159 0.000971 0.000197 0.000388 0.000270 0.000565 0.000053 0.000106 0.000212 0.000753 0.000182 0.000340

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.70 -4.82 -11.11 -3.83 -7.46 -0.13 -2.32 1.11 5.22 4.55 -2.33 -2.76 -6.31 -5.79 -5.51
Bud Neck -6.73 -9.72 -5.01 -0.86 2.95 -2.89 0.08 -3.57 -3.21 -3.59 -6.20 -9.24 -5.58 -3.32 -0.34
Bud Site -4.49 -4.95 -2.65 0.56 -0.33 -3.63 -0.96 -0.55 3.21 0.77 -5.59 -5.03 -2.64 1.13 -0.04
Cell Periphery -2.57 0.40 -0.08 2.17 -0.42 0.85 1.49 1.10 1.13 -1.78 0.47 1.07 0.90 1.55 -0.58
Cytoplasm -2.48 17.54 12.24 12.89 -2.13 -2.59 17.36 3.54 5.16 -5.11 -3.30 21.56 12.49 14.46 -3.57
Cytoplasmic Foci -4.29 10.17 9.89 11.35 -1.89 -3.99 6.71 7.77 10.36 1.99 -5.39 12.42 12.12 14.90 -1.27
Eisosomes -7.12 5.20 -1.34 5.76 -5.88 -1.68 -1.53 2.76 8.57 7.31 -4.39 1.70 -0.19 5.91 -3.40
Endoplasmic Reticulum -10.05 -13.47 -15.17 -6.54 -7.79 -5.13 -7.64 5.54 6.84 8.49 -9.94 -16.70 -14.87 -6.64 -5.01
Endosome -4.61 2.22 0.94 4.95 -0.82 -3.68 0.61 3.68 4.98 2.59 -5.74 1.53 0.75 5.79 -0.38
Golgi 0.14 2.21 1.06 1.33 -1.26 -2.42 1.73 3.04 2.66 3.07 -1.19 2.31 0.61 1.73 -1.24
Lipid Particles -2.24 7.48 6.78 5.43 -3.42 -2.55 2.22 3.28 6.46 4.85 -3.21 7.00 6.47 7.74 -2.26
Mitochondria -2.58 1.44 2.04 4.93 1.66 -2.83 1.43 1.34 4.39 -0.20 -3.73 1.27 2.14 6.28 1.80
Mitotic Spindle -2.91 -0.24 -0.47 2.23 -0.35 -3.10 1.24 1.15 3.92 -0.11 -4.23 -0.31 -0.44 3.15 -0.26
None -3.73 1.65 -0.64 2.82 -1.79 2.85 5.18 6.53 4.00 0.66 -0.90 4.63 1.85 2.42 -1.58
Nuclear Periphery -1.90 3.37 1.68 2.86 -0.19 -3.29 5.07 1.88 4.19 -1.18 -3.34 2.60 1.22 3.19 -0.15
Nuclear Periphery Foci -2.89 2.68 -1.58 0.93 -3.57 0.19 1.11 2.46 6.11 3.13 -1.97 3.03 -1.25 0.12 -3.39
Nucleolus -2.87 2.95 -1.29 1.96 -5.75 -1.66 0.04 1.37 2.46 1.20 -3.14 3.63 -1.28 1.81 -5.01
Nucleus 7.69 -12.71 -7.72 -13.58 2.84 6.07 -9.73 -1.10 -4.35 3.71 9.41 -14.44 -6.79 -14.04 3.89
Peroxisomes -3.83 3.72 3.50 6.81 -2.60 -3.38 2.17 3.12 4.03 5.06 -4.74 4.39 4.20 6.58 -1.58
Vacuole -7.19 -1.82 -3.69 2.93 -2.56 -7.79 -3.00 2.43 8.55 3.37 -10.32 -4.06 -4.14 3.45 -1.53
Vacuole Periphery -4.82 -1.04 -1.54 2.93 -1.23 -1.94 2.07 1.55 3.56 -0.68 -4.87 0.54 -0.88 3.04 -1.20
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p
Localization
Cell Percentages nucleus (94%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Rtt109

Rtt109


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rtt109-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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