Standard name
Human Ortholog
Description Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.05 0.07 0.08 0.08 0 0 0 0 0 0 0 0 0.16 0.17 0.12 0.09 0.13 0.27 0.08 0.09 0.12 0.13 0.06 0.06
Bud 0 0 0.09 0.1 0.05 0.06 0.05 0.05 0 0.05 0.05 0.08 0.05 0 0 0 0 0.08 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.1 0.1 0.06 0.05 0.06
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.28 0.36 0.23 0.23 0.11 0.14 0.06 0.06 0.12 0.09 0.09 0.09 0.63 0.6 0.53 0.36 0.27 0.31 0.28 0.26 0.41 0.33 0.54 0.44
Cytoplasm 0.83 0.78 0.84 0.85 0.89 0.89 0.83 0.87 0.84 0.78 0.8 0.81 0.62 0.58 0.69 0.64 0.65 0.58 0.17 0.26 0.15 0.17 0.11 0.09
Endoplasmic Reticulum 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.07 0 0.3 0.18 0.09 0.22 0.14 0.22
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.06 0.06 0.08 0.17 0.15 0.22 0.24 0.21 0.28 0 0 0 0 0 0 0 0 0.06 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 10 17 18 14 10 9 8 12 8 6 2 2 30 52 36 13 12 7 19 25 31 16 15 14
Bud 9 10 20 18 16 19 21 25 13 18 14 24 10 11 6 2 2 2 0 1 3 0 3 2
Bud Neck 0 2 3 2 6 0 7 8 6 4 1 3 0 0 0 0 1 0 13 28 26 7 13 14
Bud Site 1 0 1 1 0 0 0 0 0 1 0 1 1 0 0 0 0 0 – – – – – –
Cell Periphery 56 91 53 41 35 47 23 29 38 35 24 28 121 187 160 51 25 8 69 70 109 43 138 102
Cytoplasm 168 196 195 152 281 300 340 399 266 297 214 259 119 180 206 89 59 15 41 71 38 22 29 21
Endoplasmic Reticulum 4 12 5 1 3 5 4 2 4 5 9 2 3 5 2 11 6 1 74 50 23 29 36 51
Endosome 2 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 2 1 3 1 4 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0
Mitochondria 6 4 4 10 20 26 68 67 68 91 56 89 2 1 1 4 3 1 10 6 16 2 3 6
Nucleus 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 3 1 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 1 0 0 0 0 0 1 1 0 0 0 0 0 0 0 1 0 0 0 0 0
Nucleolus 1 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 4 7 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 4 2 0 1 4 4 0 2 1 0 0 3 4 3 0 1 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 1 3 1 1 1 0 0 1 2 0 0 0 0 2 0 9 12 5 5 8 12
Unique Cell Count 203 250 233 178 316 338 411 458 316 381 266 319 192 311 300 140 91 26 244 274 265 131 257 232
Labelled Cell Count 258 332 304 244 375 409 477 547 403 460 323 410 287 443 423 176 112 35 244 274 265 131 257 232


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.2 6.2 4.9 4.6 4.4 4.1 3.6 3.8 3.8 3.5 3.4 3.5 6.3 6.7 6.5 7.4 8.6 9.0 6.0 6.2 6.9
Std Deviation (1e-4) 0.8 1.0 0.8 1.0 1.2 1.0 0.8 0.7 1.1 0.9 1.4 1.0 1.0 1.5 1.1 1.4 1.4 1.5 1.3 1.1 1.2
Intensity Change (Log2) – – – -0.08 -0.15 -0.25 -0.44 -0.37 -0.35 -0.49 -0.49 -0.48 0.38 0.47 0.41 0.6 0.82 0.89 0.3 0.35 0.5


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 2.6 3.1 1.6 0.5 1.5 0
Bud 0 0 0 0 0 0 0 0 0 -1.4 -2.5 -3.5 -2.8 -2.1 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 8.4 8.7 7.2 2.9 0.9 0.9
Cytoplasm 0.5 1.8 1.8 -0.3 1.2 0.2 -1.7 -0.9 -0.8 -5.1 -6.4 -4.0 -4.4 -3.7 -3.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 2.6 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0003 0.031 0.0046 0.007 0.002 0.0294 0.0567 0.0085 0.0274 0.064 0.0611 0.0065 0.0137 0.0284 0.0026 0.0009 0.0012 0.0018
Bud 0 0.0003 0.0006 0.0003 0.0003 0.0003 0.0007 0.0007 0.0019 0.0009 0.0039 0.0023 0.0004 0.0003 0.0004 0.0002 0.0002 0.0003
Bud Neck 0.0005 0.0042 0.0245 0.0284 0.0433 0.0111 0.0031 0.0064 0.0179 0.0232 0.0067 0.0059 0.001 0.0009 0.0135 0.0012 0.0029 0.0202
Bud Periphery 0.0001 0.0009 0.0058 0.0019 0.0028 0.0018 0.0018 0.0024 0.0152 0.0068 0.0331 0.0162 0.0002 0.0005 0.004 0.0032 0.0048 0.0021
Bud Site 0.0027 0.032 0.0159 0.004 0.0033 0.0009 0.0088 0.1412 0.0594 0.0109 0.007 0.0017 0.002 0.0069 0.0064 0.0021 0.0006 0.0013
Cell Periphery 0.028 0.0387 0.1293 0.0218 0.1225 0.044 0.0851 0.1045 0.1014 0.1629 0.0627 0.1594 0.0003 0.0739 0.1922 0.2086 0.191 0.084
Cytoplasm 0.8814 0.7514 0.674 0.7754 0.729 0.7692 0.3875 0.5222 0.549 0.5294 0.7025 0.6258 0.3602 0.4971 0.6451 0.7266 0.7024 0.7006
Cytoplasmic Foci 0.003 0.009 0.0031 0.0069 0.0017 0.0207 0.0561 0.0148 0.0204 0.007 0.0258 0.0033 0.0098 0.1284 0.0128 0.0016 0.0024 0.0041
Eisosomes 0.0001 0.0011 0.0011 0.0011 0.001 0.0005 0.001 0.0015 0.001 0.0011 0.0007 0.0003 0.0001 0.0007 0.0007 0.0005 0.0004 0.0005
Endoplasmic Reticulum 0.0383 0.0108 0.0151 0.0185 0.0048 0.0057 0.0312 0.0068 0.0048 0.0039 0.0032 0.0029 0.0677 0.0117 0.0082 0.0113 0.0099 0.0302
Endosome 0.0019 0.0029 0.0006 0.0007 0.0002 0.0029 0.0579 0.0137 0.0077 0.0157 0.0399 0.0071 0.0782 0.0095 0.0022 0.0008 0.0003 0.0019
Golgi 0.0002 0.0046 0.0007 0.0006 0.0003 0.0053 0.0154 0.0036 0.0225 0.0207 0.0159 0.0066 0.0024 0.0131 0.0007 0.0003 0.0002 0.0007
Lipid Particles 0.0032 0.0086 0.0066 0.0022 0.002 0.0089 0.0135 0.0025 0.0058 0.0027 0.0043 0.0066 0.0024 0.0442 0.0051 0.0029 0.0033 0.0082
Mitochondria 0 0.0007 0.0001 0.0001 0 0.0017 0.006 0.0003 0.0154 0.0027 0.0203 0.0054 0.0028 0.0037 0.0001 0 0 0.0028
None 0.0343 0.0922 0.1138 0.1271 0.0844 0.0872 0.2002 0.1662 0.1288 0.1421 0.0054 0.1452 0.0233 0.0831 0.0998 0.0347 0.0749 0.1343
Nuclear Periphery 0.001 0.0005 0.0004 0.0003 0.0002 0.0001 0.0181 0.0003 0.0002 0.0003 0.0003 0.0002 0.2399 0.0004 0.0004 0.0005 0.0003 0.0006
Nucleolus 0 0.0002 0.0002 0.0002 0.0001 0.0001 0.0009 0.0003 0.0003 0.0001 0.0002 0.0001 0.0018 0.0002 0.0002 0.0001 0.0001 0.0008
Nucleus 0.0004 0.0003 0.0004 0.0005 0.0003 0.0002 0.0058 0.0005 0.0004 0.0003 0.0004 0.0003 0.1507 0.0002 0.0003 0.0004 0.0003 0.0008
Peroxisomes 0 0.0083 0 0.0002 0 0.0083 0.0147 0.0003 0.0136 0.0007 0.0031 0.0003 0.0005 0.0928 0.0002 0 0 0.0009
Punctate Nuclear 0.0001 0.0006 0.0002 0.0002 0.0001 0.0003 0.0192 0.0003 0.0004 0.0001 0.0003 0.0001 0.0275 0.003 0.0002 0.0001 0.0001 0.0007
Vacuole 0.0043 0.0015 0.0029 0.0025 0.0018 0.0013 0.0106 0.003 0.0063 0.0039 0.003 0.0035 0.0103 0.0008 0.0046 0.0038 0.0046 0.0031
Vacuole Periphery 0.0001 0.0001 0 0 0 0.0001 0.0058 0.0001 0.0002 0.0005 0.0004 0.0003 0.0047 0.0001 0.0001 0 0 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 24.5656 14.0301 17.2007 22.3765 26.0996 22.506 18.5032 18.7326 22.2728 26.701
Translational Efficiency 0.9942 0.9053 0.7542 0.6007 0.5248 0.79 0.87 0.465 0.5229 0.5403

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2529 1611 218 1705 1912 2233 185 2124 4441 3844 403 3829

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 803.77 829.70 1072.74 1032.12 823.33 853.79 1081.53 1081.73 812.19 843.69 1076.78 1059.64
Standard Deviation 89.62 116.52 132.04 127.49 94.13 111.95 126.15 141.72 92.10 114.51 129.45 137.79
Intensity Change Log 2 — 0.045807 0.416446 0.360756 — 0.052410 0.393531 0.393798 — 0.049152 0.404896 0.377570

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.005791 0.019246 0.049359 0.099157 0.009949 0.005218 0.062024 0.094058 0.007581 0.011097 0.055173 0.096329
Bud Neck 0.076447 0.065772 0.031892 0.044298 0.062421 0.076806 0.033267 0.045091 0.070408 0.072182 0.032523 0.044738
Bud Site 0.030952 0.073579 0.093587 0.163290* 0.038260 0.046817 0.148591* 0.162601* 0.034099 0.058033 0.118837* 0.162908*
Cell Periphery 0.083053 0.023467 0.041152 0.134516* 0.104987* 0.005415 0.093862 0.094632 0.092496 0.012981 0.065349 0.112392*
Cytoplasm 0.627846* 0.480790* 0.182936* 0.325665* 0.621788* 0.451718* 0.235153* 0.422250* 0.625238* 0.463902* 0.206907* 0.379242*
Cytoplasmic Foci 0.019329 0.120325 0.123635 0.015151 0.022705 0.128267 0.059773 0.009832 0.020782 0.124938 0.094319 0.012200
Eisosomes 0.062762 0.016594 0.008857 0.041442 0.064978 0.007994 0.024649 0.029936 0.063716 0.011598 0.016106 0.035060
Endoplasmic Reticulum 0.006451 0.010164 0.089443 0.010808 0.003848 0.011545 0.037207 0.005200 0.005330 0.010966 0.065464 0.007697
Endosome 0.003729 0.034490 0.035875 0.003740 0.003030 0.047286 0.008621 0.001916 0.003428 0.041924 0.023364 0.002728
Golgi 0.013514 0.035779 0.014032 0.002596 0.012265 0.026121 0.004008 0.001654 0.012976 0.030169 0.009431 0.002073
Lipid Particles 0.013158 0.029026 0.066099 0.007671 0.008234 0.026690 0.015464 0.005821 0.011038 0.027669 0.042854 0.006645
Mitochondria 0.004530 0.004446 0.000132 0.001828 0.003324 0.004266 0.000058 0.001239 0.004011 0.004341 0.000098 0.001501
Mitotic Spindle 0.000106 0.000244 0.001320 0.001720 0.000281 0.001238 0.000127 0.003168 0.000182 0.000822 0.000772 0.002523
None 0.002118 0.000661 0.000066 0.000182 0.001065 0.001127 0.000041 0.000257 0.001665 0.000932 0.000054 0.000223
Nuclear Periphery 0.000109 0.000083 0.000255 0.000123 0.000090 0.000152 0.000123 0.000075 0.000100 0.000123 0.000195 0.000097
Nuclear Periphery Foci 0.000370 0.000697 0.019060 0.001131 0.000429 0.000651 0.007155 0.000681 0.000395 0.000670 0.013595 0.000881
Nucleolus 0.000216 0.000365 0.000062 0.000052 0.000169 0.000294 0.000045 0.000079 0.000196 0.000324 0.000054 0.000067
Nucleus 0.013564 0.008224 0.021119 0.025610 0.013403 0.018156 0.022114 0.027062 0.013495 0.013994 0.021576 0.026415
Peroxisomes 0.013821 0.012526 0.005265 0.003398 0.009027 0.008633 0.002448 0.003080 0.011757 0.010264 0.003972 0.003222
Vacuole 0.021469 0.061041 0.213713* 0.116640 0.019253 0.128845 0.245131* 0.090810 0.020515 0.100429 0.228136* 0.102312
Vacuole Periphery 0.000666 0.002480 0.002140 0.000980 0.000495 0.002760 0.000137 0.000558 0.000592 0.002643 0.001221 0.000746

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -10.62 -6.84 -24.74* -20.07* -6.76 6.48 -6.70 -26.07* -27.94* -3.95 -5.35 -9.60 -36.27* -34.13* -7.58
Bud Neck 3.15 8.92 11.41 7.51 -2.48 -4.10 6.40 6.72 11.16 -2.66 -0.64 11.07 13.29 13.43 -3.62
Bud Site -13.90 -7.91 -25.54 -15.56 -7.63 -3.23 -7.99 -26.44* -24.12 -1.06 -12.23 -10.94 -37.23 -28.36 -5.44
Cell Periphery 21.33* 6.01 -8.75 -20.78 -10.71 30.47* 1.34 3.08 -24.78 -0.07 39.03 4.49 -4.45 -31.90* -6.46
Cytoplasm 21.09 36.24 44.92 19.39 -10.95 25.11 25.80 28.46 4.09 -12.24 33.61 43.42 50.26 15.62 -17.17
Cytoplasmic Foci -27.01 -13.50 2.41 27.08 13.83 -32.86* -6.91 7.87 38.52 9.22 -43.38 -14.46 7.86 46.58 15.95
Eisosomes 24.27* 27.53 9.63 -11.97 -15.54 27.45* 10.18 15.22 -15.97 -1.38 38.16* 22.20 18.26 -19.63 -8.98
Endoplasmic Reticulum -3.83 -9.10 -4.00 -0.47 8.60 -7.95 -4.56 -2.31 6.25 4.37 -7.86 -9.86 -3.88 4.21 9.46
Endosome -18.40 -8.60 -0.00 17.74 8.53 -26.43* -5.61 3.13 26.99 6.61 -32.02* -9.17 2.20 32.06 9.44
Golgi -14.76 -0.01 16.73 22.28 6.58 -12.20 10.97 17.15 23.81 3.69 -18.88 3.86 24.67 32.36 7.29
Lipid Particles -11.41 -8.58 5.81 14.22 9.45 -16.01* -2.78 3.34 17.76 3.74 -18.64 -8.46 7.45 22.57 9.63
Mitochondria 0.19 12.93 4.38 4.39 -3.07 -1.90 8.60 5.26 9.07 -8.58 -0.97 15.43 7.21 8.70 -5.46
Mitotic Spindle -1.30 -1.50 -2.94 -2.63 -0.46 -2.01 1.68 -3.22 -1.90 -3.40 -2.30 -1.34 -4.23 -2.73 -2.56
None 4.12 6.44 6.05 3.11 -2.53 -0.13 8.28 6.38 2.13 -8.78 2.39 8.51 7.56 2.90 -6.86
Nuclear Periphery 1.37 -6.96 -0.82 -1.53 4.51 -1.18 -3.24 0.99 1.32 3.49 -0.73 -7.41 -0.12 0.66 5.93
Nuclear Periphery Foci -4.15 -11.24 -11.55 -4.37 10.77 -1.52 -9.93 -3.82 -0.07 9.53 -2.90 -13.27 -10.89 -1.89 12.75
Nucleolus -1.36 15.39 16.40 2.56 1.28 -3.64 4.44 1.68 5.28 -1.67 -2.39 10.34 5.14 4.30 -1.32
Nucleus 9.61 -2.54 -10.25 -14.92 -1.21 -6.00 -3.81 -12.50 -8.40 -2.30 -0.98 -4.15 -16.23 -15.39 -2.34
Peroxisomes 1.51 9.05 13.92 16.02 2.51 0.64 11.99 10.21 10.82 -1.63 2.74 13.36 17.14 18.47 1.55
Vacuole -18.90 -14.68 -24.80 -14.33 6.47 -34.12* -14.25 -25.04 6.29 9.17 -37.56* -20.39 -35.04 -3.79 11.32
Vacuole Periphery -11.07 -0.86 -0.84 4.16 0.67 -12.84 3.53 -0.33 9.71 -2.44 -17.17 -0.66 -0.77 9.23 0.49
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication
Localization
Cell Percentages cell periphery (32%), cytoplasm (5%), mixed (57%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Yeh2

Yeh2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yeh2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available