Standard name
Human Ortholog
Description Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.1 0 0 0.05 0 – 0 0 0 0 0.08 0.1 0.06 0.12 0.13 0.17 0 0 0 0 0 0
Cytoplasm 0.87 0.82 0.92 0.9 0.81 0.71 0.67 – 0.79 0.77 0.63 0.73 0.72 0.68 0.9 0.89 0.9 0.82 0.39 0.4 0.41 0.32 0.09 0.18
Endoplasmic Reticulum 0.08 0.14 0 0.07 0.09 0.16 0.23 – 0 0.08 0.13 0.12 0.32 0.32 0.07 0 0 0.05 0.34 0.37 0.22 0.34 0.7 0.54
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.06 0.05 – 0.11 0.09 0.24 0.11 0 0 0 0 0 0 0.1 0.06 0.17 0.09 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0.08 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.09 0.08 0.05 – 0.05 0.06 0 0 0 0 0.05 0 0 0 0.05 0 0.05 0.05 0 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 3 4 5 11 15 20 – 4 6 6 7 0 0 0 0 3 3 10 11 9 1 2 5
Bud 1 2 0 5 4 5 7 – 9 9 5 4 0 0 0 0 1 2 5 3 2 1 4 5
Bud Neck 0 0 10 1 0 0 0 – 0 3 1 2 0 0 0 0 1 1 6 6 10 1 0 1
Bud Site 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 1 – – – – – –
Cell Periphery 4 4 26 8 13 22 22 – 11 10 9 13 2 15 10 10 12 19 7 3 8 0 2 3
Cytoplasm 285 206 249 274 303 320 372 – 239 263 210 244 18 102 152 75 83 94 146 116 127 15 6 20
Endoplasmic Reticulum 26 35 9 20 32 70 127 – 12 29 42 41 8 48 11 3 4 6 128 107 69 16 54 63
Endosome 0 3 1 0 2 2 5 – 0 3 0 1 0 1 1 1 1 1 2 2 3 1 0 0
Golgi 1 2 0 0 0 0 1 – 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0 0
Mitochondria 9 3 0 2 3 27 27 – 34 30 79 37 0 0 0 1 0 1 37 18 53 4 1 4
Nucleus 1 1 0 3 3 4 6 – 3 3 3 4 2 1 0 0 0 0 0 1 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 1 – 0 0 1 0 0 0 0 0 0 0 1 1 0 1 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 1 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0
SpindlePole 3 0 0 0 3 0 1 – 2 0 1 3 0 1 0 0 0 1 2 0 1 0 1 0
Vac/Vac Membrane 5 9 5 6 34 35 27 – 14 21 6 13 0 0 8 3 2 4 18 12 17 2 2 9
Unique Cell Count 327 252 271 304 373 451 553 301 342 332 334 25 149 169 84 92 115 375 292 310 50 78 118
Labelled Cell Count 337 268 304 324 408 500 616 328 378 363 369 30 169 182 93 107 134 375 292 310 50 78 118


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.4 5.7 6.1 6.1 7.1 6.0 6.1 – 5.4 5.4 4.6 5.1 8.0 7.6 7.0 8.3 8.4 8.1 – 10.0 10.7
Std Deviation (1e-4) 0.8 1.0 0.9 1.6 1.8 1.2 1.1 – 1.4 1.0 0.8 1.0 1.9 1.4 1.6 2.0 2.6 2.4 – 3.0 2.7
Intensity Change (Log2) – – – 0.02 0.23 -0.0 0.01 – -0.18 -0.18 -0.39 -0.25 0.39 0.33 0.2 0.45 0.47 0.42 – 0.72 0.82

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 1.2 1.5 1.7 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck -2.9 0 0 0 – 0 -2.4 0 -2.7 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -3.5 -3.2 -2.5 -3.2 – -2.9 -3.5 0 -2.8 0 0.2 -1.4 0.6 0.9 1.9
Cytoplasm -0.7 -3.8 -6.7 -7.7 – -4.2 -5.0 -8.2 -5.9 -3.2 -6.2 -0.7 -0.7 -0.5 -2.9
Endoplasmic Reticulum 1.8 2.7 5.1 7.1 – 0.4 2.6 0 4.0 0 8.3 1.6 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.1 3.7 – 5.7 5.0 0 5.7 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0.1 3.8 3.4 2.1 – 1.9 2.6 0 1.5 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.2053 2.1984 1.8673 1.413 1.3432 1.7874 1.328 1.9047 2.177 1.6283 1.2501 1.6439 1.2258 2.0871 2.4209 1.4743 1.5451 1.7103
Actin 0.0075 0.0064 0.0028 0.0033 0.0005 0.0022 0.1005 0.0009 0.0333 0.0901 0.0005 0.0132 0.0094 0.0016 0.026 0.0253 0.0501 0.0254
Bud 0.0004 0.0009 0.0003 0.0005 0.0001 0.0001 0.0013 0.0012 0.0003 0.0006 0.0001 0.0017 0.0007 0.001 0.0042 0.0019 0.0007 0.002
Bud Neck 0.0049 0.0007 0.0011 0.0019 0.0007 0.0013 0.0026 0.0003 0.0022 0.0102 0.0005 0.0117 0.0018 0.001 0.0018 0.0014 0.0016 0.0023
Bud Periphery 0.0006 0.0012 0.0005 0.0009 0.0002 0.0003 0.0031 0.0059 0.0007 0.0013 0.0003 0.004 0.0015 0.0021 0.004 0.0025 0.0012 0.0043
Bud Site 0.007 0.0165 0.0038 0.001 0.0008 0.0002 0.0148 0.0053 0.0013 0.0067 0.0002 0.002 0.0033 0.0235 0.0152 0.0047 0.0044 0.0011
Cell Periphery 0.0009 0.0033 0.0014 0.001 0.0002 0.0005 0.0023 0.0044 0.0023 0.0033 0.0008 0.0024 0.0017 0.0033 0.0014 0.0017 0.0004 0.0006
Cytoplasm 0.3173 0.4665 0.4388 0.3597 0.4913 0.5277 0.3099 0.4339 0.4223 0.3983 0.4687 0.4849 0.3931 0.5311 0.4015 0.4921 0.5397 0.5221
Cytoplasmic Foci 0.0391 0.0251 0.0296 0.0139 0.017 0.0192 0.0364 0.0098 0.0101 0.0126 0.0093 0.0132 0.021 0.0073 0.0243 0.0154 0.025 0.017
Eisosomes 0.0004 0.0002 0.0002 0.0001 0 0.0002 0.0009 0.0002 0.0004 0.0017 0.0001 0.0006 0.0003 0.0001 0.0002 0.0006 0.0002 0.0001
Endoplasmic Reticulum 0.2248 0.2176 0.2271 0.2125 0.2265 0.1691 0.1372 0.2052 0.2294 0.1442 0.1439 0.1009 0.2475 0.2216 0.2102 0.1929 0.1342 0.2119
Endosome 0.046 0.0238 0.0474 0.0612 0.0671 0.0267 0.015 0.015 0.0218 0.0252 0.0567 0.0076 0.02 0.0066 0.0357 0.0346 0.0656 0.014
Golgi 0.009 0.0046 0.0099 0.0235 0.0114 0.0031 0.0061 0.003 0.0071 0.0085 0.016 0.0019 0.0034 0.0013 0.0087 0.0172 0.0179 0.0051
Lipid Particles 0.0327 0.0101 0.0203 0.0295 0.0247 0.0182 0.0083 0.005 0.0069 0.008 0.0225 0.0033 0.0144 0.0067 0.0122 0.0353 0.0301 0.0084
Mitochondria 0.0075 0.0072 0.0132 0.0244 0.0017 0.0024 0.0021 0.0008 0.0018 0.014 0.0025 0.0015 0.0031 0.0042 0.0098 0.0179 0.0062 0.0211
None 0.2497 0.1907 0.1715 0.2199 0.1183 0.201 0.3197 0.2887 0.2433 0.2449 0.2604 0.3346 0.2274 0.1649 0.2174 0.1294 0.083 0.1295
Nuclear Periphery 0.02 0.007 0.0086 0.0192 0.0147 0.0096 0.0064 0.0072 0.0059 0.0074 0.0052 0.0034 0.0234 0.0057 0.0065 0.0086 0.0056 0.007
Nucleolus 0.0013 0.0005 0.0003 0.0005 0.0036 0.0018 0.0007 0.0002 0.0003 0.0008 0.0002 0.0009 0.001 0.0003 0.0007 0.0009 0.0005 0.0003
Nucleus 0.0038 0.0043 0.0033 0.008 0.0055 0.0031 0.0032 0.0028 0.0035 0.0031 0.0026 0.003 0.0089 0.0048 0.0032 0.0033 0.0024 0.0048
Peroxisomes 0.0053 0.0019 0.0103 0.0026 0.0023 0.0017 0.0164 0.0002 0.001 0.0077 0.0004 0.0012 0.004 0.0034 0.0036 0.0032 0.0221 0.0076
Punctate Nuclear 0.0114 0.0022 0.002 0.0016 0.003 0.0014 0.0089 0.0006 0.0012 0.0036 0.0005 0.0031 0.0057 0.0017 0.0037 0.0015 0.0044 0.0084
Vacuole 0.0078 0.0088 0.0065 0.0121 0.0087 0.0077 0.0038 0.0085 0.0042 0.0069 0.007 0.0042 0.007 0.0075 0.0076 0.0084 0.0036 0.0059
Vacuole Periphery 0.0025 0.0005 0.0012 0.0026 0.0016 0.0027 0.0005 0.0009 0.0006 0.0011 0.0016 0.0006 0.0016 0.0003 0.0018 0.0011 0.001 0.0008

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 94.2088 41.5316 35.0986 46.725 42.6674 84.483 58.1772 54.9129 63.5953 67.7191
Translational Efficiency 0.9298 0.9531 0.8734 1.0221 1.1566 1.5182 0.9964 1.0143 0.9653 0.9982

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
80 1266 564 768 1498 2088 656 2059 1578 3354 1220 2827

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 721.46 819.10 1211.28 1021.31 732.39 761.38 1244.40 1114.75 731.84 783.17 1229.09 1089.37
Standard Deviation 131.53 120.92 193.01 271.84 102.73 108.66 228.58 210.31 104.41 116.84 213.51 232.41
Intensity Change Log 2 — 0.183120 0.747541 0.501430 — 0.056005 0.764766 0.606036 — 0.120484 0.756244 0.555074

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000279 0.000735 0.002628 0.006575 0.000239 0.000940 0.000987 0.006187 0.000241 0.000863 0.001746 0.006292
Bud Neck 0.018089 0.011336 0.005440 0.012616 0.008874 0.020962 0.004596 0.011775 0.009341 0.017328 0.004986 0.012004
Bud Site 0.007834 0.010868 0.009248 0.068325 0.004311 0.014759 0.014414 0.038997 0.004489 0.013291 0.012026 0.046965
Cell Periphery 0.001488 0.000574 0.001148 0.003912 0.000631 0.000518 0.001268 0.004760 0.000675 0.000539 0.001213 0.004529
Cytoplasm 0.446384 0.383041 0.154201 0.275902 0.465165 0.361498 0.209151 0.353188 0.464213 0.369630 0.183747 0.332192
Cytoplasmic Foci 0.194578 0.227821 0.020257 0.070764 0.186017 0.207157 0.026056 0.042772 0.186451 0.214957 0.023375 0.050376
Eisosomes 0.000521 0.000460 0.000144 0.000535 0.000617 0.000697 0.000101 0.000895 0.000612 0.000607 0.000121 0.000797
Endoplasmic Reticulum 0.042659 0.075320 0.489413 0.136799 0.068977 0.062943 0.475308 0.211631 0.067643 0.067615 0.481828 0.191302
Endosome 0.028382 0.027599 0.018046 0.030087 0.012345 0.031930 0.016048 0.015774 0.013158 0.030295 0.016972 0.019662
Golgi 0.003923 0.007497 0.001229 0.010223 0.008184 0.014174 0.001389 0.006332 0.007968 0.011654 0.001315 0.007389
Lipid Particles 0.046611 0.037640 0.019582 0.054955 0.041640 0.045877 0.017987 0.047194 0.041892 0.042768 0.018724 0.049302
Mitochondria 0.007641 0.007044 0.000531 0.004964 0.006151 0.011948 0.000545 0.002198 0.006227 0.010097 0.000539 0.002949
Mitotic Spindle 0.000119 0.004612 0.002102 0.022985 0.002959 0.007002 0.003063 0.010514 0.002815 0.006100 0.002619 0.013902
None 0.002541 0.002417 0.001218 0.008883 0.005089 0.002921 0.002646 0.001887 0.004960 0.002730 0.001986 0.003788
Nuclear Periphery 0.002118 0.002776 0.022779 0.001757 0.002579 0.002046 0.019617 0.001645 0.002556 0.002321 0.021079 0.001675
Nuclear Periphery Foci 0.010763 0.006049 0.102294 0.033141 0.003026 0.002801 0.068520 0.021057 0.003418 0.004027 0.084134 0.024339
Nucleolus 0.000817 0.000869 0.000155 0.000894 0.000848 0.001158 0.000224 0.000338 0.000846 0.001049 0.000192 0.000489
Nucleus 0.102204 0.074936 0.036354 0.024641 0.127505 0.081663 0.040032 0.052678 0.126222 0.079124 0.038332 0.045061
Peroxisomes 0.003315 0.005567 0.000256 0.002311 0.003598 0.007896 0.000364 0.001463 0.003584 0.007017 0.000314 0.001693
Vacuole 0.078657 0.110176 0.112520 0.224735 0.049598 0.117001 0.097096 0.166181 0.051071 0.114424 0.104227 0.182088
Vacuole Periphery 0.001076 0.002664 0.000456 0.004996 0.001647 0.004111 0.000589 0.002536 0.001618 0.003565 0.000527 0.003204

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.97 -2.62 -6.78 -6.22 -2.66 -6.20 -4.28 -10.90 -9.39 -8.78 -7.06 -3.63 -12.87 -11.31 -6.70
Bud Neck 1.08 1.95 0.85 -0.93 -5.23 -7.62 3.39 -2.73 6.64 -8.30 -6.03 3.54 -2.59 5.09 -9.57
Bud Site -0.64 -0.52 -8.28 -9.93 -10.04 -7.70 -3.51 -15.39 -9.62 -6.41 -7.82 -4.52 -18.55 -13.96 -12.04
Cell Periphery 1.45 0.43 -2.44 -5.72 -4.41 1.97 -2.94 -9.51 -9.88 -6.56 1.95 -4.12 -10.79 -11.34 -8.22
Cytoplasm 2.01 9.04 5.32 8.51 -8.44 12.45 20.75 12.83 0.94 -11.64 12.56 29.52 16.37 5.38 -16.35
Cytoplasmic Foci -1.73 8.76 6.28 24.27 -10.76 -3.56 31.17 30.86 37.22 -4.96 -5.37 35.58 30.21 45.56 -10.72
Eisosomes 0.58 4.20 0.61 0.01 -5.48 -0.94 8.69 -1.70 -0.95 -7.94 0.10 8.66 -1.06 -1.25 -8.83
Endoplasmic Reticulum -1.94 -19.61 -3.68 -3.34 20.75 1.08 -24.29 -14.05 -15.94 16.67 0.09 -33.89 -13.46 -15.41 25.20
Endosome 0.05 0.98 0.22 0.68 -3.37 -13.70 -3.03 -2.09 12.42 1.39 -13.46 -3.70 -3.89 10.68 -0.25
Golgi -2.56 2.12 -1.98 -0.26 -4.03 -4.95 8.17 3.01 7.30 -4.57 -3.90 9.36 2.14 5.92 -6.33
Lipid Particles 1.00 2.84 -0.55 -3.26 -7.16 -1.68 9.15 -1.14 0.39 -9.39 -0.37 10.45 -1.86 -1.73 -11.97
Mitochondria 0.10 1.26 0.64 1.60 -2.13 -4.21 6.51 4.73 9.11 -5.62 -3.24 6.56 3.88 8.21 -4.18
Mitotic Spindle -3.32 -3.14 -5.93 -4.48 -5.21 -2.53 -1.40 -4.08 -1.89 -1.60 -2.45 -1.14 -6.04 -4.38 -4.69
None 0.14 1.37 -1.71 -1.87 -2.39 2.58 2.08 4.61 1.76 0.69 3.15 3.59 2.03 -0.47 -1.31
Nuclear Periphery -0.70 -7.28 0.24 1.50 7.58 1.31 -6.59 2.13 0.88 6.95 0.65 -9.78 2.02 1.87 10.29
Nuclear Periphery Foci 0.96 -12.06 -3.52 -9.62 11.78 0.54 -14.65 -15.81 -16.10 10.24 -1.26 -23.25 -17.92 -17.98 16.48
Nucleolus -0.32 2.96 0.07 0.51 -3.80 -2.90 7.95 7.24 8.93 -2.32 -2.44 9.46 4.74 7.26 -4.82
Nucleus 1.57 3.51 4.10 13.34 2.60 11.50 19.46 18.84 7.90 -4.25 12.88 22.08 21.79 12.45 -3.27
Peroxisomes -3.18 5.37 2.10 7.19 -7.25 -6.62 6.66 4.61 14.70 -8.46 -6.16 7.10 4.41 16.60 -11.72
Vacuole -2.15 -2.91 -11.13 -15.73 -12.13 -17.23 -8.53 -29.12 -14.27 -10.44 -19.72 -12.36 -35.03 -20.78 -15.12
Vacuole Periphery -5.12 2.85 -3.12 -1.34 -3.82 -7.19 4.65 -0.97 3.75 -3.35 -6.93 5.08 -2.17 2.10 -5.00
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor
Localization
Cell Percentages ER (52%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Yps1

Yps1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yps1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available