Standard name
Human Ortholog
Description mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0.92 0.93 0.98 0.98 0.97 0.95 0.9 0.91 0.78 0.84 0.79 0.8 0.96 0.94 0.96 – 0.95 0.89 0.81 0.82 0.8 0.62 0.56 0.61
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0.09 0.09 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0.06 0 0 0.06 0.1 0.15 0.07 0.39 0.24 0.31 0.3 0 0 0 – 0.07 0 0.09 0.05 0.06 0.18 0.24 0.17
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.08 0.08 – 0 0.08 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 0 0 2 1 0 0 0 0 1 0 – 0 0 1 1 5 1 3 3
Bud 0 1 0 1 0 1 6 3 8 2 7 6 0 1 0 – 0 0 0 0 11 3 4 9
Bud Neck 0 1 13 4 7 2 9 16 2 5 6 8 0 0 0 – 0 0 0 1 2 0 0 2
Bud Site 0 0 0 0 0 0 0 0 1 3 0 4 0 0 0 – 0 0 – – – – – –
Cell Periphery 2 0 4 2 2 1 2 1 2 1 3 1 0 0 0 – 1 0 0 0 2 0 1 1
Cytoplasm 146 198 484 365 352 464 446 642 405 427 436 474 131 207 227 – 95 117 138 180 387 136 131 144
Endoplasmic Reticulum 5 4 0 0 0 0 1 0 1 0 0 0 0 2 0 – 9 12 0 0 2 3 3 1
Endosome 1 0 0 0 1 2 0 2 2 0 3 2 0 0 0 – 1 5 3 5 5 5 5 7
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 – 1 0 2 1 2 4 7 6
Mitochondria 7 13 0 10 22 48 75 49 201 122 170 181 0 0 0 – 7 4 14 10 28 40 55 39
Nucleus 0 0 2 1 3 1 8 7 6 4 3 2 2 0 1 – 2 0 0 0 1 1 1 0
Nuclear Periphery 0 2 0 0 0 0 1 0 1 2 0 2 0 0 0 – 0 0 0 0 0 0 1 1
Nucleolus 0 0 0 1 0 0 1 2 0 1 0 0 0 0 0 – 1 0 0 0 0 0 1 0
Peroxisomes 0 0 0 0 0 2 0 0 0 1 1 0 0 0 0 – 0 0 0 1 0 3 3 7
SpindlePole 0 0 2 1 1 3 1 11 5 6 6 13 0 1 0 – 0 0 1 2 10 6 5 4
Vac/Vac Membrane 2 3 3 6 1 6 0 6 5 6 7 6 9 18 19 – 0 11 3 2 5 2 4 2
Unique Cell Count 159 212 492 372 362 490 497 703 517 509 549 596 137 220 237 100 132 171 219 482 221 236 237
Labelled Cell Count 163 222 509 391 390 530 550 741 640 580 642 699 142 230 247 117 149 171 219 482 221 236 237


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.8 3.2 5.3 5.0 4.2 3.9 3.2 4.4 3.2 3.7 3.6 3.8 16.5 14.5 13.4 4.5 5.9 6.0 6.0 6.2 6.4
Std Deviation (1e-4) 0.6 1.4 1.9 2.1 1.4 1.1 1.2 1.6 1.0 1.1 1.0 1.0 4.5 3.8 3.1 2.3 2.6 2.5 2.4 1.9 2.2
Intensity Change (Log2) – – – -0.07 -0.32 -0.43 -0.73 -0.26 -0.72 -0.5 -0.53 -0.48 1.65 1.46 1.35 -0.22 0.16 0.19 0.18 0.24 0.29


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.5546 5.1634 5.3958 4.3528 4.7098 5.2445 5.4977 3.6722 4.0177 4.8982 4.1924 4.4022 1.4463 1.7807 1.3562 1.5871 2.2592 1.8476
Actin 0.0232 0.0044 0.0232 0.0007 0.0056 0.0077 0.2615 0.0001 0.041 0.0052 0.0021 0.0198 0.0366 0.0017 0.0131 0.0129 0.045 0.0036
Bud 0.0004 0.0026 0.0015 0.0001 0.0003 0.0001 0.0009 0.0006 0.0004 0.0005 0.0001 0.0002 0.0003 0.0101 0.0002 0.0001 0.0006 0
Bud Neck 0.0013 0.0002 0.0005 0.0002 0.0005 0.001 0.0065 0.0001 0.0008 0.0013 0.0001 0.0005 0.0002 0.0001 0.0002 0.0001 0.0007 0.0002
Bud Periphery 0.0005 0.0012 0.0016 0.0001 0.0002 0.0001 0.0009 0.0008 0.0005 0.0007 0.0002 0.0002 0.0007 0.0014 0.0002 0.0002 0.0008 0.0001
Bud Site 0.002 0.0048 0.0019 0.0001 0.0008 0.0001 0.0131 0.0003 0.0018 0.0012 0 0.0002 0.0007 0.003 0.0006 0.0001 0.0029 0
Cell Periphery 0.0003 0.0003 0.0002 0.0001 0 0 0.0004 0.0002 0.0002 0.0002 0 0 0.0002 0.0002 0.0001 0 0.0001 0
Cytoplasm 0.538 0.7793 0.632 0.7386 0.6532 0.7883 0.171 0.4724 0.3333 0.2116 0.3002 0.3769 0.1371 0.2294 0.2274 0.1952 0.1957 0.3491
Cytoplasmic Foci 0.0271 0.0057 0.0102 0.0114 0.0281 0.0145 0.0506 0.0031 0.0165 0.0151 0.0553 0.0075 0.0185 0.0124 0.0158 0.0107 0.067 0.0038
Eisosomes 0.0005 0.0001 0.0002 0 0 0 0.0009 0.0001 0.0004 0.0001 0.0001 0.0001 0.0008 0.0001 0.0002 0.0003 0.0002 0.0001
Endoplasmic Reticulum 0.0106 0.0035 0.0054 0.0026 0.0025 0.0033 0.0039 0.0021 0.0052 0.0028 0.0009 0.0013 0.0033 0.0023 0.0021 0.0026 0.0012 0.0013
Endosome 0.0208 0.0027 0.0104 0.0428 0.0163 0.0044 0.0393 0.0022 0.01 0.0431 0.0031 0.0042 0.0132 0.0042 0.0135 0.0052 0.0397 0.0022
Golgi 0.0134 0.001 0.0086 0.0023 0.0363 0.0025 0.0114 0.0001 0.0074 0.0375 0.002 0.0059 0.0081 0.0007 0.0079 0.0045 0.0362 0.0007
Lipid Particles 0.0118 0.0003 0.0097 0.0003 0.0077 0.0002 0.0212 0.0001 0.014 0.0111 0.0013 0.0003 0.0109 0.0027 0.0085 0.0027 0.0531 0.0009
Mitochondria 0.0097 0.0004 0.0109 0.0011 0.0071 0.0009 0.0035 0.0015 0.0023 0.0264 0.0021 0.0021 0.0181 0.0003 0.0053 0.0014 0.0099 0.0007
None 0.3023 0.1819 0.2674 0.191 0.2089 0.1496 0.2854 0.5073 0.5377 0.5818 0.5959 0.5784 0.7191 0.7189 0.6807 0.7576 0.4239 0.6323
Nuclear Periphery 0.0059 0.0022 0.0022 0.0009 0.0008 0.0042 0.0477 0.001 0.0071 0.0026 0.0002 0.0003 0.0079 0.0019 0.0024 0.0008 0.0016 0.0023
Nucleolus 0.0005 0.0002 0.0001 0 0 0.0002 0.0111 0.0001 0.0005 0.0005 0.0001 0 0.0002 0.0002 0.0002 0.0001 0.0006 0.0001
Nucleus 0.0139 0.0061 0.005 0.0048 0.005 0.0181 0.0279 0.0028 0.002 0.0487 0.0006 0.0006 0.0014 0.0027 0.0017 0.0009 0.0006 0.0011
Peroxisomes 0.0107 0.0002 0.0058 0.0005 0.0249 0.0001 0.0221 0 0.0119 0.0033 0.0345 0.0007 0.0127 0.0036 0.0164 0.0033 0.0902 0.0004
Punctate Nuclear 0.0052 0.0015 0.0016 0.0005 0.0009 0.0023 0.0125 0.0003 0.0056 0.0025 0.0011 0.0005 0.0086 0.0029 0.0025 0.0006 0.0275 0.0008
Vacuole 0.0014 0.0016 0.0011 0.0014 0.0005 0.0016 0.005 0.0036 0.0008 0.0024 0.0002 0.0003 0.0006 0.0011 0.0007 0.0004 0.0016 0.0002
Vacuole Periphery 0.0006 0.0002 0.0004 0.0005 0.0002 0.0007 0.0032 0.0011 0.0007 0.0012 0.0001 0.0001 0.001 0.0002 0.0003 0.0002 0.0009 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 39.2236 70.127 37.5351 39.3983 12.5054 88.6862 110.4263 133.37 106.8842 133.2555
Translational Efficiency 2.539 2.1124 2.5427 1.8511 2.4246 2.4925 2.3241 1.8078 2.0304 1.8958

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1833 1623 1975 1692 2036 1613 2138 1753 3869 3236 4113 3445

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 799.73 693.70 908.18 930.30 834.65 789.71 982.20 960.68 818.11 741.56 946.66 945.76
Standard Deviation 133.19 97.09 157.95 152.64 147.14 93.06 145.45 142.88 141.78 106.53 156.02 148.53
Intensity Change Log 2 — -0.205201 0.183465 0.218183 — -0.079848 0.234845 0.202885 — -0.139826 0.209933 0.210391

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000107 0.000367 0.000258 0.001434 0.000139 0.000233 0.000240 0.000516 0.000124 0.000300 0.000249 0.000967
Bud Neck 0.009839 0.039836 0.003851 0.010773 0.003836 0.027413 0.002331 0.005580 0.006680 0.033643 0.003061 0.008130
Bud Site 0.004522 0.020174 0.007327 0.032942 0.003962 0.010818 0.006343 0.017939 0.004227 0.015511 0.006815 0.025308
Cell Periphery 0.000180 0.000145 0.000118 0.000351 0.000136 0.000211 0.000122 0.000164 0.000157 0.000178 0.000120 0.000256
Cytoplasm 0.590802* 0.432560* 0.430619* 0.505189* 0.673800* 0.451857* 0.513485* 0.565949* 0.634479* 0.442179* 0.473694* 0.536107*
Cytoplasmic Foci 0.169315 0.238932* 0.004825 0.011707 0.077985 0.219785* 0.007444 0.013143 0.121254 0.229388* 0.006186 0.012438
Eisosomes 0.000121 0.000121 0.000016 0.000037 0.000037 0.000176 0.000022 0.000030 0.000077 0.000149 0.000019 0.000034
Endoplasmic Reticulum 0.001413 0.000919 0.002665 0.002121 0.001799 0.000511 0.001893 0.003064 0.001616 0.000715 0.002264 0.002601
Endosome 0.007590 0.021940 0.000900 0.005310 0.002740 0.016118 0.001363 0.005590 0.005038 0.019038 0.001141 0.005452
Golgi 0.001511 0.004435 0.000069 0.002621 0.000578 0.002835 0.000322 0.002835 0.001020 0.003637 0.000200 0.002730
Lipid Particles 0.005924 0.008280 0.000558 0.000991 0.002168 0.010234 0.000672 0.000974 0.003947 0.009254 0.000617 0.000982
Mitochondria 0.002597 0.013384 0.000670 0.002491 0.001045 0.008562 0.000416 0.002862 0.001780 0.010981 0.000538 0.002680
Mitotic Spindle 0.000884 0.007311 0.003424 0.062429 0.001700 0.004976 0.005871 0.024594 0.001313 0.006147 0.004696 0.043176
None 0.008811 0.005265 0.007074 0.011566 0.005084 0.004901 0.007353 0.008610 0.006849 0.005084 0.007219 0.010062
Nuclear Periphery 0.000348 0.000454 0.001314 0.001593 0.000455 0.000457 0.001240 0.001417 0.000404 0.000455 0.001275 0.001503
Nuclear Periphery Foci 0.001031 0.000532 0.001259 0.001299 0.001349 0.000257 0.001207 0.001871 0.001199 0.000395 0.001232 0.001590
Nucleolus 0.000821 0.002966 0.000297 0.000923 0.000437 0.002454 0.000249 0.000242 0.000619 0.002711 0.000272 0.000577
Nucleus 0.151408* 0.116507 0.505046* 0.235473* 0.190847* 0.175127* 0.400523* 0.253351* 0.172163* 0.145726* 0.450714* 0.244570*
Peroxisomes 0.002990 0.017369 0.000117 0.002239 0.000775 0.011499 0.000132 0.000520 0.001825 0.014443 0.000125 0.001364
Vacuole 0.038955 0.066118 0.029465 0.105182 0.030863 0.049619 0.048160 0.088538 0.034697 0.057894 0.039183 0.096713
Vacuole Periphery 0.000831 0.002385 0.000128 0.003328 0.000264 0.001957 0.000613 0.002211 0.000532 0.002171 0.000380 0.002760

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.60 -6.62 -3.01 -1.49 -1.73 -1.63 -2.95 -5.53 -2.86 -2.29 -4.92 -6.19 -4.36 -2.34 -2.35
Bud Neck -12.75 4.56 1.51 14.09 -3.58 -12.82 1.39 -2.87 11.74 -4.24 -18.09 4.71 -0.04 18.32 -5.28
Bud Site -8.93 -2.10 -6.18 2.10 -4.09 -5.14 -1.14 -4.43 0.42 -3.09 -10.23 -2.34 -7.60 1.95 -5.14
Cell Periphery 2.64 4.78 0.49 -0.49 -0.91 -3.83 1.69 1.05 5.05 -0.80 -1.59 4.13 0.79 1.66 -1.11
Cytoplasm 16.65 24.67 22.11 3.92 -1.67 25.83 31.12 29.41 2.65 0.40 29.85 39.15 36.37 4.61 -0.81
Cytoplasmic Foci -9.80 36.12 35.49 41.71 -4.44 -24.30 26.77 25.14 40.13 -4.67 -23.36 43.18 41.86 57.82 -6.40
Eisosomes -0.01 17.64 13.39 16.56 -10.38 -17.13 4.54 -1.29 17.00 -7.68 -13.38 17.56 11.39 22.95 -12.84
Endoplasmic Reticulum 1.95 -7.41 -5.04 -11.81 3.81 6.23 -4.01 -3.74 -8.72 -1.31 5.55 -8.19 -5.94 -13.00 0.80
Endosome -10.92 14.35 10.37 15.69 -4.75 -12.10 7.85 0.16 11.52 -3.39 -16.31 16.12 7.73 19.29 -5.33
Golgi -7.34 9.67 2.19 7.49 -1.96 -7.31 2.44 -0.62 3.51 -1.45 -10.37 8.01 0.71 7.56 -2.28
Lipid Particles -2.29 10.43 9.48 7.73 -6.50 -9.05 6.48 4.55 10.39 -5.99 -7.83 12.12 10.45 12.76 -8.86
Mitochondria -7.59 3.00 1.90 9.35 -3.68 -7.91 1.83 -0.84 7.47 -2.82 -10.81 3.49 1.04 11.94 -4.27
Mitotic Spindle -4.39 -4.41 -8.88 -6.15 -7.29 -2.73 -3.48 -6.76 -4.69 -4.37 -5.09 -5.39 -11.14 -7.71 -8.41
None 2.79 2.36 0.28 -3.19 -2.94 0.08 -3.17 -3.37 -2.69 -0.84 2.43 0.76 -1.33 -4.16 -2.82
Nuclear Periphery -2.00 -22.85 -27.26 -23.75 -9.86 0.21 -25.72 -21.46 -21.41 -6.45 -1.38 -34.23 -34.15 -31.86 -11.51
Nuclear Periphery Foci 4.05 -2.87 -1.78 -6.82 1.78 7.08 -0.38 -2.14 -13.60 -2.34 8.03 -2.31 -2.68 -14.57 0.00
Nucleolus -6.53 5.07 0.12 5.87 -2.45 -4.62 3.41 2.72 4.95 -1.78 -7.68 6.06 0.70 7.62 -2.64
Nucleus 6.71 -52.43 -24.35 -29.77 25.17 2.81 -37.32 -20.34 -21.96 14.20 6.68 -62.59 -31.23 -36.19 27.63
Peroxisomes -11.46 7.95 4.69 13.34 -1.79 -10.02 2.77 2.19 11.03 -2.12 -15.26 7.75 5.02 17.29 -2.22
Vacuole -9.33 -4.32 -28.18 -22.37 -24.59 -6.45 -15.07 -26.03 -22.21 -14.81 -11.36 -14.29 -38.30 -31.35 -27.66
Vacuole Periphery -6.58 4.23 -0.34 4.45 -2.96 -5.00 -0.36 -1.44 2.57 -0.92 -8.01 1.84 -1.33 4.63 -2.34
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (66%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Tis11

Tis11


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tis11-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available