Standard name
Human Ortholog
Description Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.06 0.08 0.06 0.06 0 0.05 0 0 0.05 0 0.1 0.07 0.13 0.05 0.06 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.11 0.11 0 0.07 0 0.13 0.14 0.09 0.31 0.26 0.37 0.14 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.86 0.88 0.89 0.88 0.91 0.89 0.87 0.88 0.8 0.81 0.75 0.86 0.88 0.84 0.8 0.8 0.76 0.82 0.74 0.82 0.75 0.64 0.51 0.48
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.17 0.11 0 0 0 0.06 0.12 0.1 0.24 0.26 0.23 0.18 0.16 0.13 0.17 0.11 0.07 0.08 0.11 0.05 0.1 0.13 0.19 0.16
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.08 0.1 0 0 0 0.08 0.13 0.11
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 4
Bud 1 0 0 0 0 0 2 2 4 3 4 4 0 0 0 0 0 0 1 4 3 0 4 6
Bud Neck 0 0 0 0 1 0 1 2 0 0 2 6 0 0 0 0 0 0 1 0 2 0 0 3
Bud Site 1 0 0 1 1 9 8 7 8 13 14 9 1 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Cytoplasm 8 5 13 14 13 19 16 20 9 8 11 5 19 14 25 8 10 4 3 0 0 0 2 5
Endoplasmic Reticulum 0 0 1 0 0 0 0 0 0 0 0 0 0 2 0 5 2 3 0 0 0 1 1 2
Endosome 3 4 2 0 0 0 0 1 0 0 0 0 0 0 3 3 5 0 3 4 2 1 3 6
Golgi 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 1 1 2 1 1 2 2
Mitochondria 24 25 2 12 2 43 54 39 71 80 87 42 3 1 2 7 1 3 1 2 1 0 3 3
Nucleus 186 205 202 157 200 300 328 366 183 247 177 265 166 169 159 136 118 119 174 197 176 42 92 91
Nuclear Periphery 2 1 0 1 0 4 0 1 2 2 4 2 2 1 1 1 0 1 2 0 0 0 1 1
Nucleolus 36 26 2 7 6 21 44 43 56 80 55 56 30 27 34 19 11 11 26 12 24 9 34 29
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0
SpindlePole 0 1 3 2 3 5 5 12 1 1 1 3 1 1 1 0 2 4 8 2 9 1 3 5
Vac/Vac Membrane 9 11 8 3 2 2 2 6 0 0 2 2 0 2 2 12 13 14 10 9 9 5 24 20
Unique Cell Count 217 232 227 178 220 337 377 414 230 304 237 308 189 201 198 169 156 145 236 241 235 67 180 190
Labelled Cell Count 271 279 234 197 228 403 460 499 334 434 357 394 222 217 227 193 165 160 236 241 235 67 180 190


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.7 5.9 6.0 5.6 6.3 5.3 5.1 5.6 4.8 4.7 4.4 4.9 6.4 6.7 6.5 9.1 9.5 8.9 5.8 5.9 7.4
Std Deviation (1e-4) 1.1 1.1 1.0 1.1 1.3 1.7 1.1 1.4 1.2 1.2 1.2 0.9 2.0 1.8 1.6 2.1 2.4 1.9 0.9 1.6 3.9
Intensity Change (Log2) – – – -0.09 0.08 -0.18 -0.22 -0.1 -0.31 -0.35 -0.43 -0.28 0.1 0.16 0.12 0.6 0.67 0.57 -0.04 -0.03 0.3

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.9 0.1 0 -0.8 -0.5 -0.9 -1.8 -0.5 -2.6 1.6 0.5 2.5 -0.4 0.3 -1.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 3.2 0 5.1 5.5 4.2 0 0 0 5.3 0 0 0 0 0 0
Nucleus -0.2 0.7 0 -0.7 -0.2 -2.8 -2.4 -4.0 -1.0 -0.4 -1.5 -2.5 -2.4 -3.5 -1.9
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 3.2 4.8 4.5 0 0 0 6.4 5.7 5.2 6.0 4.6 3.3 3.4
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 1.3 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 1.6 2.0 2.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.4284 4.3153 4.2054 3.529 4.338 3.911 2.6457 2.6457 2.4154 2.0137 1.7227 2.0909 2.3882 2.3443 2.0974 2.4727 3.6322 1.7878
Actin 0.0831 0.0001 0.002 0.0079 0.0017 0.0077 0.0216 0.0001 0.0034 0.0044 0.0001 0.0023 0.0286 0 0.0125 0.0065 0.0243 0
Bud 0.0012 0.0003 0.0002 0.0031 0.0001 0.0001 0.0003 0 0.0007 0.0022 0.0001 0.0002 0.0009 0 0.0007 0.0002 0.0037 0
Bud Neck 0.0077 0.0003 0.0013 0.0027 0.0018 0.0019 0.0008 0.0001 0.0004 0.0009 0.001 0.0011 0.0015 0.0001 0.0004 0.0009 0.0016 0.0012
Bud Periphery 0.0023 0.0008 0.0003 0.0058 0.0001 0.0005 0.0005 0.0001 0.0007 0.0054 0.0001 0.0006 0.0018 0 0.0021 0.0003 0.0037 0.0001
Bud Site 0.0174 0.0062 0.0013 0.0384 0.0003 0.0004 0.0011 0.0001 0.005 0.0015 0.0005 0.0002 0.0038 0.0001 0.0005 0.0007 0.004 0.0001
Cell Periphery 0.0006 0.001 0.0002 0.0016 0 0.0001 0.0002 0 0.0001 0.0003 0 0.0001 0.0006 0 0.0001 0.0001 0.0001 0
Cytoplasm 0.0038 0.0002 0.001 0.0024 0.0057 0.0001 0.0038 0.0001 0.0035 0.0023 0.0016 0.0006 0.0013 0.0001 0.0001 0.0004 0.0052 0.0009
Cytoplasmic Foci 0.0227 0 0.0027 0.0101 0.0007 0.0004 0.0226 0 0.0115 0.0006 0.033 0.0008 0.0234 0 0.0002 0.0094 0.0159 0.0003
Eisosomes 0.0006 0 0.0002 0.0003 0 0.0001 0.0002 0 0 0.0001 0 0 0.0002 0 0.0001 0.0001 0.0001 0
Endoplasmic Reticulum 0.0047 0.0001 0.0005 0.0006 0.0032 0.0008 0.0047 0 0.0009 0.0017 0.0006 0.0015 0.0027 0 0.0003 0.0001 0.0018 0
Endosome 0.0346 0.0001 0.002 0.0066 0.0122 0.0015 0.0584 0 0.0081 0.0059 0.0322 0.0041 0.0227 0 0.0012 0.0058 0.0265 0.0001
Golgi 0.0169 0 0.001 0.0052 0.0005 0.0008 0.0152 0 0.0038 0.0012 0.0034 0.0011 0.0112 0 0.0008 0.0109 0.0107 0
Lipid Particles 0.0571 0.0001 0.0009 0.0188 0.0008 0.0029 0.0286 0 0.006 0.0007 0.0144 0.0012 0.0305 0 0.0006 0.05 0.0022 0
Mitochondria 0.0125 0.0006 0.0035 0.0043 0.0005 0.0029 0.025 0.0018 0.0027 0.0141 0.0004 0.0066 0.0125 0.0002 0.0026 0.0036 0.0194 0.0001
None 0.006 0.0001 0.0096 0.0013 0.0021 0.0004 0.0033 0 0.0006 0.0009 0.0001 0.0002 0.0012 0 0.0001 0.0002 0.0025 0.0002
Nuclear Periphery 0.0143 0.0079 0.0021 0.003 0.05 0.0014 0.0192 0.0076 0.009 0.0257 0.0034 0.0025 0.0038 0.0075 0.0013 0.0029 0.0039 0.0007
Nucleolus 0.0246 0.0299 0.0288 0.009 0.073 0.1279 0.0366 0.0348 0.0329 0.039 0.1071 0.1031 0.0258 0.0296 0.0195 0.0348 0.0314 0.0837
Nucleus 0.6257 0.948 0.9324 0.8627 0.7702 0.8459 0.736 0.9538 0.9013 0.8839 0.7922 0.8686 0.772 0.9619 0.9529 0.8452 0.7142 0.8986
Peroxisomes 0.0372 0 0.0053 0.0067 0.0001 0.0013 0.0062 0 0.0042 0.0007 0.0006 0.0011 0.0459 0 0.0004 0.0232 0.0075 0
Punctate Nuclear 0.0139 0.0019 0.0039 0.0063 0.0749 0.0016 0.0059 0.001 0.0034 0.003 0.0076 0.0029 0.004 0.0004 0.0029 0.0038 0.1194 0.0138
Vacuole 0.0104 0.0015 0.0007 0.0028 0.0011 0.0007 0.0065 0.0001 0.001 0.0026 0.0013 0.0006 0.0041 0 0.0004 0.0006 0.0011 0.0001
Vacuole Periphery 0.0029 0.001 0.0002 0.0004 0.0008 0.0003 0.0035 0.0002 0.0007 0.0027 0.0002 0.0006 0.0013 0.0001 0.0003 0.0002 0.0008 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.5538 15.9489 13.0486 15.8848 18.0902 15.5452 18.7102 18.5584 17.2624 22.5457
Translational Efficiency 1.8648 1.4965 1.0946 0.9255 1.1453 1.4961 1.0891 0.7697 0.9273 0.962

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1306 1049 1474 1393 1650 1323 231 115 2956 2372 1705 1508

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 721.05 851.83 1063.82 1076.71 781.27 806.81 1056.57 1103.26 754.66 826.72 1062.84 1078.73
Standard Deviation 556.74 131.46 155.59 164.01 98.79 118.90 131.10 154.63 378.53 126.60 152.53 163.47
Intensity Change Log 2 — 0.240466 0.561083 0.578459 — 0.046408 0.435495 0.497880 — 0.142809 0.497137 0.537116

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000300 0.000985 0.001170 0.001279 0.000383 0.000949 0.001578 0.001755 0.000346 0.000965 0.001225 0.001315
Bud Neck 0.006475 0.010030 0.037486 0.038386 0.005625 0.010149 0.011360 0.021264 0.006001 0.010096 0.033946 0.037080
Bud Site 0.002046 0.002643 0.002497 0.005329 0.000845 0.002409 0.002014 0.032655 0.001376 0.002512 0.002431 0.007413
Cell Periphery 0.000214 0.000193 0.000071 0.000151 0.000119 0.000150 0.000105 0.000284 0.000161 0.000169 0.000076 0.000161
Cytoplasm 0.044031 0.007681 0.000877 0.010167 0.014166 0.009153 0.003856 0.005832 0.027361 0.008502 0.001281 0.009837
Cytoplasmic Foci 0.008503 0.001340 0.000039 0.001927 0.002329 0.002991 0.000303 0.002773 0.005057 0.002261 0.000075 0.001991
Eisosomes 0.000032 0.000039 0.000050 0.000039 0.000026 0.000039 0.000069 0.000054 0.000029 0.000039 0.000053 0.000041
Endoplasmic Reticulum 0.001622 0.004475 0.003036 0.003848 0.002436 0.003855 0.005813 0.005084 0.002077 0.004130 0.003412 0.003942
Endosome 0.001815 0.001326 0.000181 0.001668 0.000546 0.001824 0.000275 0.011113 0.001107 0.001604 0.000194 0.002388
Golgi 0.000575 0.001227 0.000155 0.002400 0.000575 0.001777 0.000211 0.000939 0.000575 0.001533 0.000162 0.002289
Lipid Particles 0.001238 0.000538 0.000078 0.000311 0.000370 0.001607 0.000264 0.000760 0.000754 0.001134 0.000103 0.000345
Mitochondria 0.002359 0.002413 0.002299 0.005567 0.002956 0.007995 0.001183 0.002956 0.002692 0.005526 0.002148 0.005368
Mitotic Spindle 0.004175 0.004401 0.003480 0.023732 0.003695 0.008633 0.002496 0.046962 0.003907 0.006762 0.003347 0.025503
None 0.033408 0.012868 0.001555 0.004693 0.009685 0.011392 0.010575 0.004632 0.020166 0.012044 0.002777 0.004688
Nuclear Periphery 0.000629 0.001087 0.000475 0.003829 0.000743 0.000591 0.000310 0.001250 0.000693 0.000810 0.000452 0.003632
Nuclear Periphery Foci 0.002506 0.001705 0.000145 0.002574 0.001934 0.001215 0.000486 0.009324 0.002186 0.001432 0.000191 0.003089
Nucleolus 0.098902 0.101069 0.052304 0.036979 0.094961 0.081637 0.064954 0.026282 0.096702 0.090230 0.054018 0.036163
Nucleus 0.788427 0.842761 0.891917 0.850653 0.857148 0.848270 0.890449 0.805762 0.826786 0.845834 0.891718 0.847230
Peroxisomes 0.000921 0.001049 0.000808 0.000515 0.000515 0.002336 0.001430 0.001094 0.000694 0.001767 0.000892 0.000559
Vacuole 0.001493 0.001188 0.001102 0.003008 0.000559 0.001989 0.002098 0.012865 0.000971 0.001635 0.001237 0.003759
Vacuole Periphery 0.000330 0.000982 0.000275 0.002946 0.000384 0.001040 0.000173 0.006360 0.000360 0.001015 0.000261 0.003206

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.12 -15.16 -17.78 -4.22 -2.41 -4.97 -10.94 -9.45 -6.69 -1.42 -7.14 -18.30 -20.15 -7.36 -2.16
Bud Neck -3.36 -21.45 -22.55 -20.18 -2.74 -5.47 -5.00 -8.79 -7.00 -3.52 -6.29 -23.04 -24.56 -21.60 -3.89
Bud Site -0.23 -1.94 -5.09 -4.33 -3.32 -4.51 -4.54 -1.93 -1.72 -1.42 -2.50 -5.01 -6.69 -5.27 -3.43
Cell Periphery 0.72 6.30 3.14 1.61 -5.25 -1.08 -0.14 -2.27 -1.73 -2.08 -0.21 4.87 0.73 0.94 -5.31
Cytoplasm 9.98 12.72 9.22 -1.64 -7.51 2.39 5.09 2.42 0.69 -1.34 9.39 14.50 7.90 -1.28 -7.45
Cytoplasmic Foci 6.15 7.41 6.68 1.40 -2.30 -0.13 3.32 2.27 2.68 -0.99 4.53 8.25 6.75 3.24 -2.33
Eisosomes -1.63 -7.49 -4.26 -1.81 3.99 -5.37 -9.49 -6.47 -4.97 0.38 -4.87 -14.32 -9.74 -4.17 4.56
Endoplasmic Reticulum -9.95 -9.76 -13.34 -0.03 -4.96 -4.99 -8.35 -5.62 -4.31 -0.76 -10.33 -10.99 -13.29 -2.96 -3.70
Endosome 1.00 2.94 1.70 1.10 -3.64 -3.26 -0.28 -1.40 -0.89 -1.38 -1.07 3.39 0.10 1.21 -3.41
Golgi -1.31 2.43 -1.16 0.16 -2.21 -1.85 0.98 -0.32 1.77 -1.89 -2.26 2.43 -1.17 0.83 -2.25
Lipid Particles 1.76 3.33 2.80 1.72 -3.24 -2.31 -0.39 -1.53 1.66 -1.18 -0.99 4.00 2.88 2.82 -2.99
Mitochondria -0.14 -0.83 -4.03 -4.17 -5.22 -2.73 1.28 -0.43 2.88 -5.62 -2.64 0.02 -3.28 0.57 -5.72
Mitotic Spindle -0.51 -1.30 -7.91 -7.49 -7.27 -2.19 -1.91 -3.94 -3.66 -3.64 -2.09 -1.99 -9.07 -7.90 -8.08
None 6.42 11.58 10.33 3.96 -8.29 -1.04 0.76 3.37 3.83 1.24 5.00 12.96 11.15 6.08 -5.00
Nuclear Periphery -1.12 -0.71 -6.18 -3.94 -6.02 1.42 0.12 -3.92 -4.18 -3.94 -0.48 -0.29 -6.57 -5.89 -6.51
Nuclear Periphery Foci 1.54 5.25 3.08 1.64 -2.93 1.20 2.09 -1.26 -1.54 -1.73 1.94 6.46 2.12 0.40 -3.27
Nucleolus 0.64 8.03 10.49 10.02 3.32 3.00 2.83 6.93 5.30 3.41 2.53 9.50 13.45 11.12 4.17
Nucleus -6.99 -11.57 -4.85 2.53 7.24 0.83 -0.24 2.88 2.63 2.81 -4.37 -8.87 0.33 4.00 7.64
Peroxisomes -0.55 0.20 1.27 2.54 3.76 -3.39 -5.53 -2.78 2.20 2.19 -3.32 -2.35 0.20 3.61 4.83
Vacuole 1.13 -0.28 -5.65 -6.74 -5.12 -2.57 -2.68 -3.91 -3.62 -1.37 -1.45 -2.91 -7.98 -6.95 -3.99
Vacuole Periphery -1.67 0.12 -1.99 -0.59 -2.03 -2.52 1.49 -1.12 -0.67 -1.22 -2.90 0.73 -2.15 -0.74 -2.27
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators
Localization
Cell Percentages nucleus (94%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Swi6

Swi6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Swi6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available