Standard name | |
---|---|
Human Ortholog | |
Description | Vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Bud | 0 | 0 | 0 | 1 | 3 | 7 | 12 | 12 | – | 9 | 6 | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3 | – | 1 | 3 | 1 | 5 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 2 | 0 | 1 | 1 | 1 | 0 | 1 | – | 0 | 0 | 2 | 0 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 87 | 131 | 116 | 332 | 517 | 578 | 757 | 691 | – | 579 | 501 | 699 | 246 | 415 | 604 | 238 | 173 | 166 | 27 | 66 | 46 | 24 | 66 | 72 |
Endoplasmic Reticulum | 3 | 2 | 1 | 0 | 0 | 1 | 2 | 0 | – | 1 | 0 | 0 | 0 | 1 | 0 | 10 | 8 | 11 | 2 | 1 | 2 | 0 | 2 | 2 |
Endosome | 0 | 1 | 0 | 0 | 0 | 3 | 3 | 3 | – | 3 | 0 | 3 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 2 | 1 | 0 | 1 | 2 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 2 |
Mitochondria | 9 | 1 | 19 | 7 | 31 | 55 | 97 | 98 | – | 72 | 74 | 134 | 0 | 0 | 0 | 9 | 3 | 1 | 7 | 4 | 3 | 3 | 7 | 18 |
Nucleus | 4 | 0 | 0 | 1 | 2 | 6 | 0 | 14 | – | 6 | 3 | 7 | 1 | 0 | 2 | 0 | 1 | 1 | 2 | 0 | 0 | 1 | 0 | 1 |
Nuclear Periphery | 0 | 0 | 1 | 2 | 0 | 1 | 8 | 6 | – | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | – | 2 | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 3 | – | 3 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 1 |
Vac/Vac Membrane | 14 | 12 | 5 | 29 | 80 | 19 | 15 | 13 | – | 17 | 30 | 31 | 20 | 9 | 7 | 31 | 28 | 23 | 81 | 65 | 80 | 68 | 162 | 205 |
Unique Cell Count | 111 | 145 | 134 | 346 | 567 | 619 | 795 | 766 | 621 | 548 | 786 | 263 | 422 | 609 | 264 | 197 | 181 | 134 | 148 | 142 | 99 | 255 | 316 | |
Labelled Cell Count | 119 | 149 | 142 | 373 | 636 | 675 | 899 | 845 | 698 | 629 | 903 | 272 | 426 | 617 | 293 | 217 | 203 | 134 | 148 | 142 | 99 | 255 | 316 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.1 | 4.7 | 3.6 | 4.1 | 3.9 | 3.6 | 3.2 | 3.4 | – | 3.1 | 3.3 | 3.0 | 5.0 | 5.0 | 4.9 | 5.3 | 5.4 | 5.7 | 5.3 | 5.7 | 5.5 |
Std Deviation (1e-4) | 0.8 | 1.4 | 1.2 | 4.7 | 1.5 | 1.4 | 1.5 | 1.5 | – | 1.2 | 1.5 | 0.9 | 0.8 | 1.4 | 1.6 | 1.4 | 1.0 | 1.5 | 0.8 | 2.5 | 1.6 |
Intensity Change (Log2) | – | – | – | 0.21 | 0.12 | 0.01 | -0.17 | -0.06 | – | -0.2 | -0.1 | -0.26 | 0.49 | 0.49 | 0.46 | 0.56 | 0.59 | 0.66 | 0.56 | 0.67 | 0.62 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 2.6 | 3.1 | 2.8 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -0.2252 | 0.4011 | 0.1801 | -0.2521 | 1.0011 | 0.421 | 0.8672 | 1.7489 | 1.6086 | 1.4848 | 1.0895 | 1.6107 | -0.7168 | 0.3335 | -0.2858 | 0.1431 | -0.5865 | -0.0072 |
Actin | 0.0247 | 0.0001 | 0.0017 | 0.02 | 0.0013 | 0.0026 | 0.0166 | 0 | 0.0142 | 0.0001 | 0.0009 | 0.0001 | 0.0027 | 0.0001 | 0.0001 | 0 | 0 | 0 |
Bud | 0.0005 | 0.0074 | 0.0011 | 0.0007 | 0.0004 | 0.0062 | 0.0008 | 0.0013 | 0.001 | 0.0007 | 0.0004 | 0.0005 | 0.0003 | 0.0007 | 0.003 | 0.0005 | 0.0003 | 0.0003 |
Bud Neck | 0.0033 | 0.0021 | 0.0033 | 0.0005 | 0.0011 | 0.0034 | 0.0018 | 0.0012 | 0.0015 | 0.0014 | 0.0009 | 0.0017 | 0.0025 | 0.0007 | 0.0011 | 0.0003 | 0.0006 | 0.0012 |
Bud Periphery | 0.0008 | 0.0026 | 0.0021 | 0.001 | 0.0007 | 0.0024 | 0.0037 | 0.0038 | 0.0026 | 0.0016 | 0.0007 | 0.0015 | 0.0005 | 0.0016 | 0.0031 | 0.0008 | 0.0003 | 0.001 |
Bud Site | 0.0109 | 0.0244 | 0.0105 | 0.0021 | 0.0008 | 0.0017 | 0.0024 | 0.0017 | 0.0061 | 0.0016 | 0.0009 | 0.0007 | 0.0029 | 0.0017 | 0.004 | 0.0003 | 0.0013 | 0.0004 |
Cell Periphery | 0.0013 | 0.001 | 0.0008 | 0.0002 | 0.0003 | 0.0008 | 0.0017 | 0.0019 | 0.0023 | 0.0009 | 0.0014 | 0.0017 | 0.0012 | 0.001 | 0.0008 | 0.0005 | 0.0005 | 0.0011 |
Cytoplasm | 0.106 | 0.1556 | 0.1194 | 0.1334 | 0.0705 | 0.1232 | 0.0522 | 0.0327 | 0.0346 | 0.014 | 0.0408 | 0.0336 | 0.0677 | 0.0827 | 0.1084 | 0.0592 | 0.0852 | 0.0313 |
Cytoplasmic Foci | 0.0673 | 0.0458 | 0.0591 | 0.0554 | 0.0753 | 0.0882 | 0.0323 | 0.0212 | 0.0267 | 0.0277 | 0.0273 | 0.0146 | 0.0224 | 0.0161 | 0.0212 | 0.0307 | 0.0153 | 0.0136 |
Eisosomes | 0.0007 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0.0006 | 0 | 0 | 0 | 0.0004 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0082 | 0.0069 | 0.004 | 0.0013 | 0.0065 | 0.0034 | 0.0064 | 0.0082 | 0.0053 | 0.0021 | 0.0018 | 0.0033 | 0.0083 | 0.0113 | 0.0051 | 0.0021 | 0.002 | 0.0039 |
Endosome | 0.218 | 0.1778 | 0.228 | 0.2746 | 0.2568 | 0.2133 | 0.2311 | 0.1544 | 0.2226 | 0.3027 | 0.2487 | 0.1793 | 0.2296 | 0.1545 | 0.1988 | 0.2492 | 0.147 | 0.1746 |
Golgi | 0.0109 | 0.0031 | 0.0078 | 0.0141 | 0.0159 | 0.0064 | 0.0154 | 0.0033 | 0.0092 | 0.0085 | 0.0073 | 0.0046 | 0.0037 | 0.0019 | 0.0034 | 0.0016 | 0.0015 | 0.002 |
Lipid Particles | 0.0266 | 0.0094 | 0.0241 | 0.043 | 0.0748 | 0.0319 | 0.0141 | 0.0108 | 0.0175 | 0.0129 | 0.0039 | 0.009 | 0.0193 | 0.0056 | 0.0054 | 0.0018 | 0.0022 | 0.0049 |
Mitochondria | 0.015 | 0.0093 | 0.008 | 0.0245 | 0.0142 | 0.0052 | 0.0217 | 0.0098 | 0.0357 | 0.0335 | 0.0296 | 0.0056 | 0.0045 | 0.003 | 0.0199 | 0.0017 | 0.0006 | 0.0015 |
None | 0.2652 | 0.2463 | 0.2292 | 0.1056 | 0.0709 | 0.125 | 0.1088 | 0.0683 | 0.0741 | 0.022 | 0.0666 | 0.0302 | 0.1526 | 0.0924 | 0.0846 | 0.0619 | 0.1211 | 0.0351 |
Nuclear Periphery | 0.0077 | 0.0057 | 0.0064 | 0.002 | 0.039 | 0.0186 | 0.0115 | 0.0162 | 0.0063 | 0.0031 | 0.0025 | 0.009 | 0.0132 | 0.0228 | 0.0058 | 0.0036 | 0.0039 | 0.006 |
Nucleolus | 0.0026 | 0.002 | 0.0033 | 0.0008 | 0.003 | 0.0038 | 0.0036 | 0.0027 | 0.0041 | 0.0057 | 0.0019 | 0.0024 | 0.0028 | 0.0018 | 0.0015 | 0.0009 | 0.001 | 0.0013 |
Nucleus | 0.005 | 0.0076 | 0.0079 | 0.002 | 0.0257 | 0.0102 | 0.0119 | 0.0077 | 0.0082 | 0.0061 | 0.0041 | 0.0107 | 0.0052 | 0.0073 | 0.0047 | 0.0032 | 0.017 | 0.0049 |
Peroxisomes | 0.0139 | 0.0007 | 0.0105 | 0.0332 | 0.0417 | 0.0072 | 0.0024 | 0.003 | 0.0041 | 0.0028 | 0.0007 | 0.0022 | 0.0017 | 0.0003 | 0.0008 | 0.0004 | 0.0003 | 0.0009 |
Punctate Nuclear | 0.0061 | 0.0012 | 0.002 | 0.001 | 0.0049 | 0.005 | 0.0035 | 0.0005 | 0.0008 | 0.0018 | 0.0006 | 0.0003 | 0.0027 | 0.0005 | 0.0005 | 0.0008 | 0.0003 | 0.0004 |
Vacuole | 0.1837 | 0.2702 | 0.2373 | 0.2385 | 0.2625 | 0.3133 | 0.4065 | 0.5663 | 0.4376 | 0.4814 | 0.5084 | 0.6094 | 0.3957 | 0.5287 | 0.4606 | 0.4739 | 0.5453 | 0.6239 |
Vacuole Periphery | 0.0213 | 0.0206 | 0.0334 | 0.046 | 0.0337 | 0.0282 | 0.0512 | 0.0848 | 0.0848 | 0.0695 | 0.0505 | 0.0795 | 0.0601 | 0.0652 | 0.0671 | 0.1064 | 0.0543 | 0.0918 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 18.2193 | 21.3766 | 31.7247 | 29.9746 | 38.3859 | 26.1757 | 19.0408 | 27.7864 | 30.8216 | 24.8211 |
Translational Efficiency | 2.6004 | 1.6436 | 1.2294 | 1.9689 | 1.568 | 1.7296 | 1.9164 | 1.5894 | 1.6749 | 1.8858 |
Dataset | Hit |
---|---|
Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
---|
Gene | Images |
---|
Gene | Images |
---|