Standard name | |
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Human Ortholog | |
Description | Catalytic subunit of 1,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling; FKS1 has a paralog, GSC2, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 1 | 0 | – | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 2 | 0 | 1 | 0 | – | 9 | 4 | 4 | 1 | 3 | 2 | 3 | 2 | 0 | 0 | 0 | 8 | 4 | 1 | 2 | 11 | 7 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 21 | 21 | 7 | 64 | 56 | 88 | – | 248 | 189 | 256 | 137 | 296 | 175 | 420 | 618 | 25 | 48 | 48 | 4 | 5 | 4 | 7 | 14 | 10 |
Endoplasmic Reticulum | 3 | 0 | 1 | 0 | 8 | 4 | – | 9 | 3 | 1 | 1 | 4 | 8 | 11 | 2 | 7 | 4 | 8 | 2 | 0 | 0 | 1 | 3 | 2 |
Endosome | 15 | 3 | 0 | 6 | 13 | 1 | – | 4 | 0 | 2 | 0 | 0 | 12 | 30 | 7 | 9 | 15 | 9 | 9 | 4 | 2 | 11 | 16 | 33 |
Golgi | 0 | 0 | 0 | 0 | 3 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 1 | 1 |
Mitochondria | 19 | 0 | 20 | 76 | 52 | 74 | – | 174 | 123 | 112 | 73 | 126 | 14 | 2 | 0 | 6 | 7 | 4 | 3 | 1 | 2 | 3 | 4 | 5 |
Nucleus | 11 | 5 | 7 | 50 | 75 | 80 | – | 179 | 75 | 102 | 41 | 50 | 11 | 18 | 2 | 39 | 27 | 48 | 2 | 1 | 4 | 2 | 5 | 16 |
Nuclear Periphery | 2 | 1 | 0 | 2 | 4 | 0 | – | 3 | 3 | 2 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 3 | 6 |
Nucleolus | 0 | 0 | 0 | 3 | 0 | 0 | – | 1 | 0 | 2 | 1 | 0 | 1 | 0 | 0 | 1 | 2 | 2 | 0 | 2 | 0 | 0 | 1 | 3 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 1 | 0 | 1 | – | 2 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 2 | 3 | 0 | 1 | 1 | 4 | 4 |
Vac/Vac Membrane | 140 | 60 | 39 | 203 | 413 | 265 | – | 584 | 319 | 357 | 184 | 270 | 195 | 246 | 159 | 108 | 105 | 116 | 159 | 74 | 67 | 56 | 258 | 431 |
Unique Cell Count | 182 | 80 | 61 | 322 | 525 | 401 | 931 | 522 | 609 | 321 | 556 | 381 | 639 | 747 | 166 | 180 | 195 | 198 | 97 | 85 | 88 | 332 | 528 | |
Labelled Cell Count | 211 | 90 | 76 | 405 | 626 | 514 | 1215 | 717 | 839 | 438 | 750 | 421 | 731 | 790 | 195 | 215 | 243 | 198 | 97 | 85 | 88 | 332 | 528 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.1 | 7.4 | 5.3 | 6.0 | 8.2 | 7.1 | – | 6.6 | 5.9 | 5.8 | 5.5 | 5.3 | 6.4 | 6.1 | 5.4 | 8.9 | 9.5 | 9.2 | 7.3 | 7.5 | 7.6 |
Std Deviation (1e-4) | 2.4 | 2.1 | 1.6 | 2.0 | 2.5 | 3.0 | – | 2.8 | 2.8 | 2.6 | 2.5 | 2.5 | 2.0 | 1.4 | 1.2 | 2.6 | 3.2 | 2.7 | 2.4 | 2.5 | 2.4 |
Intensity Change (Log2) | – | – | – | 0.16 | 0.62 | 0.42 | – | 0.3 | 0.15 | 0.12 | 0.05 | 0.0 | 0.26 | 0.19 | 0.01 | 0.74 | 0.83 | 0.78 | 0.46 | 0.5 | 0.52 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1.5 | -0.2 | 1.9 | – | 2.6 | 3.9 | 4.7 | 4.6 | 6.2 | 5.1 | 8.3 | 12.8 | 0.7 | 2.4 | 2.2 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | -1.5 | -5.2 | -2.6 | – | -2.7 | -1.6 | -2.7 | -1.7 | -1.8 | 0 | 0 | 0 | -6.1 | -6.2 | -7.2 |
Nucleus | 0.8 | 0.6 | 1.6 | – | 1.5 | 0.6 | 1.1 | 0.3 | -0.6 | 0 | 0 | 0 | 2.0 | 0.7 | 2.2 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | -0.1 | 2.6 | 0.3 | – | -0.2 | -0.4 | -0.8 | -1.0 | -2.3 | -1.9 | -3.9 | -7.4 | 0.2 | -0.8 | -0.6 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 3.5138 | 8.3122 | 6.6171 | 5.9039 | 5.4512 | 6.5516 | 2.2787 | 8.9059 | 7.5526 | 5.8052 | 4.8155 | 6.204 | 4.2021 | 9.0912 | 9.8737 | 8.3177 | 8.3353 | 9.0068 |
Actin | 0.0067 | 0 | 0.0021 | 0.0002 | 0.0097 | 0.0028 | 0.0063 | 0.0001 | 0.0117 | 0.0315 | 0.0048 | 0 | 0.0108 | 0.0102 | 0.0001 | 0 | 0 | 0 |
Bud | 0.0029 | 0.0004 | 0.0004 | 0.0002 | 0.0004 | 0.0003 | 0.0004 | 0.0007 | 0.0003 | 0.0008 | 0.0002 | 0.0002 | 0.0008 | 0.0005 | 0.0004 | 0.0004 | 0.0004 | 0.0003 |
Bud Neck | 0.001 | 0.0012 | 0.0013 | 0.0007 | 0.0013 | 0.003 | 0.001 | 0.0008 | 0.0006 | 0.0023 | 0.0012 | 0.0015 | 0.0012 | 0.0019 | 0.001 | 0.0037 | 0.0011 | 0.0014 |
Bud Periphery | 0.0018 | 0.0011 | 0.0011 | 0.0004 | 0.001 | 0.001 | 0.0008 | 0.0016 | 0.0006 | 0.0013 | 0.0004 | 0.0007 | 0.0016 | 0.0011 | 0.0009 | 0.0011 | 0.0003 | 0.0008 |
Bud Site | 0.002 | 0.0019 | 0.0013 | 0.001 | 0.001 | 0.0005 | 0.0017 | 0.0008 | 0.0011 | 0.0084 | 0.0009 | 0.0007 | 0.0061 | 0.0033 | 0.0015 | 0.002 | 0.0029 | 0.0005 |
Cell Periphery | 0.0017 | 0.0041 | 0.0031 | 0.0018 | 0.0018 | 0.004 | 0.0024 | 0.005 | 0.0025 | 0.0036 | 0.0011 | 0.0037 | 0.0018 | 0.0041 | 0.0025 | 0.0043 | 0.0014 | 0.0035 |
Cytoplasm | 0.0083 | 0.0029 | 0.0044 | 0.0009 | 0.0012 | 0.001 | 0.0026 | 0.0039 | 0.0144 | 0.0022 | 0.008 | 0.0057 | 0.0046 | 0.007 | 0.0078 | 0.0011 | 0.0033 | 0.0032 |
Cytoplasmic Foci | 0.0188 | 0.013 | 0.0069 | 0.0038 | 0.0105 | 0.0027 | 0.0103 | 0.0029 | 0.0139 | 0.0202 | 0.0328 | 0.0057 | 0.0189 | 0.0091 | 0.0077 | 0.0047 | 0.0114 | 0.0036 |
Eisosomes | 0.0001 | 0 | 0 | 0 | 0.0003 | 0.0001 | 0 | 0 | 0.0001 | 0.0004 | 0.0003 | 0 | 0.0002 | 0.0003 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0052 | 0.0053 | 0.0092 | 0.002 | 0.0037 | 0.0032 | 0.0034 | 0.0076 | 0.0096 | 0.0043 | 0.0035 | 0.0062 | 0.0057 | 0.0037 | 0.0099 | 0.0018 | 0.0007 | 0.0067 |
Endosome | 0.2734 | 0.1569 | 0.2036 | 0.2123 | 0.2889 | 0.125 | 0.3396 | 0.1438 | 0.3381 | 0.2679 | 0.3812 | 0.2101 | 0.3197 | 0.1313 | 0.2923 | 0.1084 | 0.2966 | 0.192 |
Golgi | 0.0172 | 0.0052 | 0.0096 | 0.012 | 0.0147 | 0.0083 | 0.0185 | 0.0068 | 0.0209 | 0.0145 | 0.0315 | 0.0108 | 0.0235 | 0.006 | 0.0157 | 0.0039 | 0.0079 | 0.0099 |
Lipid Particles | 0.0309 | 0.0137 | 0.0108 | 0.0176 | 0.0519 | 0.0204 | 0.0334 | 0.0152 | 0.0205 | 0.0102 | 0.0523 | 0.0254 | 0.0378 | 0.0216 | 0.021 | 0.0244 | 0.0113 | 0.0498 |
Mitochondria | 0.0485 | 0.0095 | 0.0159 | 0.0054 | 0.0486 | 0.0103 | 0.0176 | 0.0038 | 0.0065 | 0.0056 | 0.0082 | 0.0049 | 0.0352 | 0.028 | 0.0062 | 0.0026 | 0.0005 | 0.0066 |
None | 0.0019 | 0.0001 | 0.0003 | 0.0001 | 0.0012 | 0.0001 | 0.0004 | 0.0001 | 0.0012 | 0.0011 | 0.0266 | 0.0002 | 0.001 | 0.0004 | 0.0002 | 0.0002 | 0.0001 | 0.0002 |
Nuclear Periphery | 0.0135 | 0.006 | 0.0178 | 0.0035 | 0.0301 | 0.0155 | 0.0055 | 0.0125 | 0.01 | 0.0037 | 0.0322 | 0.0074 | 0.0217 | 0.0182 | 0.0071 | 0.0033 | 0.0011 | 0.0343 |
Nucleolus | 0.0048 | 0.005 | 0.0032 | 0.0015 | 0.0058 | 0.005 | 0.0088 | 0.0026 | 0.0013 | 0.0074 | 0.0021 | 0.0025 | 0.0029 | 0.0057 | 0.0021 | 0.081 | 0.0031 | 0.0055 |
Nucleus | 0.007 | 0.004 | 0.0097 | 0.0012 | 0.0034 | 0.0062 | 0.0046 | 0.0025 | 0.0016 | 0.0032 | 0.0041 | 0.0028 | 0.0038 | 0.0028 | 0.0027 | 0.0124 | 0.0017 | 0.0231 |
Peroxisomes | 0.003 | 0.0009 | 0.0008 | 0.0005 | 0.0047 | 0.0005 | 0.0016 | 0.0002 | 0.003 | 0.0018 | 0.0052 | 0.0003 | 0.0059 | 0.0027 | 0.0004 | 0.0016 | 0.0007 | 0.0006 |
Punctate Nuclear | 0.0015 | 0.0001 | 0.0003 | 0.0002 | 0.0029 | 0.0002 | 0.0005 | 0.0001 | 0.0009 | 0.0015 | 0.0218 | 0.0001 | 0.0009 | 0.0002 | 0.0001 | 0.0005 | 0.0001 | 0.0002 |
Vacuole | 0.3693 | 0.5788 | 0.4938 | 0.5591 | 0.3849 | 0.5453 | 0.4018 | 0.5768 | 0.3951 | 0.4745 | 0.3111 | 0.5313 | 0.3336 | 0.5661 | 0.4728 | 0.5954 | 0.5523 | 0.4466 |
Vacuole Periphery | 0.1803 | 0.1896 | 0.2041 | 0.1755 | 0.132 | 0.2446 | 0.1388 | 0.2125 | 0.1459 | 0.1336 | 0.0706 | 0.1796 | 0.1625 | 0.1759 | 0.1476 | 0.147 | 0.103 | 0.2112 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 483.2171 | 459.1177 | 288.3021 | 288.8552 | 440.4131 | 360.7434 | 402.9323 | 292.6923 | 236.4283 | 460.8302 |
Translational Efficiency | 0.8251 | 0.7702 | 0.6771 | 0.5813 | 0.6054 | 0.8943 | 0.6781 | 0.5038 | 0.4765 | 0.527 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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