Standard name
Human Ortholog
Description Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0.05 0 0.05 – 0 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.05 0.09 0.11 0.09 0.11 0.09 0.09 0.11 0.09 – 0.06 0.06 0.2 0.27 0.33 0.1 0.09 0.18 0 0 0 0.05 0 0.06
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0.13 0.07 0 0 0.09 0 0 0 0 – 0 0 0.07 0.06 0 0.07 0.06 0 0.1 0 0.08 0.09 0.15 0.1
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.15 0.44 0.59 0.39 0.62 0.63 0.63 0.77 – 0.83 0.79 0.1 0.09 0.31 0.11 0.06 0.09 0 0 0.06 0.06 0.06 0.08
Nucleus 0.66 0.6 0.46 0.43 0.42 0.4 0.42 0.44 0.4 – 0.38 0.36 0.55 0.48 0.31 0.64 0.69 0.58 0.47 0.49 0.31 0.32 0.22 0.16
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0.07 0.08 0.1 0.08 0.08 0.06 – 0.08 0.09 0.06 0 0 0 0.08 0.11 0.09 0.1 0.08 0.11 0.07 0.06
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.07 0 0.09 0.07 0.12 0.08 0 0.05 0 – 0 0 0 0 0 0 0 0.05 0.11 0.09 0.13 0.13 0.14 0.13
Vac/Vac Membrane 0.09 0.21 0 0 0.05 0 0 0 0 – 0 0 0.11 0.09 0.14 0.13 0.1 0.07 0.07 0.16 0.19 0.17 0.23 0.28
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 1 0 0
Bud 0 0 2 2 12 5 5 10 10 – 14 20 0 0 0 0 1 1 0 7 2 3 2 6
Bud Neck 0 0 3 1 3 0 0 4 1 – 2 0 0 0 0 0 0 0 0 0 1 1 2 4
Bud Site 0 1 1 8 7 8 15 14 13 – 14 16 0 1 1 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Cytoplasm 4 26 27 21 33 25 29 45 26 – 21 20 43 53 79 10 8 10 2 10 8 9 9 16
Endoplasmic Reticulum 0 0 2 2 0 1 0 0 0 – 0 0 0 2 2 4 3 3 0 0 1 0 2 4
Endosome 10 20 10 2 27 9 5 9 1 – 1 2 14 12 4 7 5 2 10 15 28 18 47 27
Golgi 0 0 2 0 1 0 1 0 0 – 0 0 1 0 1 1 0 0 1 0 1 0 2 1
Mitochondria 1 43 113 131 111 181 204 268 222 – 276 280 21 17 75 11 5 5 3 13 20 12 18 23
Nucleus 50 175 119 96 122 116 134 185 115 – 128 128 118 94 74 65 59 32 52 185 104 69 72 43
Nuclear Periphery 2 3 1 0 1 1 2 1 3 – 2 5 1 3 4 5 2 0 4 7 13 1 4 5
Nucleolus 3 10 5 15 24 30 26 36 16 – 28 32 12 4 6 4 7 6 10 36 28 24 22 16
Peroxisomes 0 0 0 0 0 1 1 0 1 – 0 0 0 0 0 0 0 0 1 0 0 0 0 0
SpindlePole 5 7 22 15 35 23 13 21 8 – 12 12 5 8 4 1 3 3 11 36 44 28 44 35
Vac/Vac Membrane 7 61 9 4 13 10 14 19 4 – 8 14 24 18 33 13 9 4 7 59 63 35 76 78
Unique Cell Count 76 293 257 223 288 291 322 425 288 333 354 214 196 241 101 86 55 110 383 334 214 326 277
Labelled Cell Count 82 346 316 297 389 410 449 612 420 506 529 239 212 283 121 103 66 110 383 334 214 326 277


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.1 4.4 3.8 3.7 4.1 3.7 3.7 3.7 3.1 – 3.1 3.0 4.6 4.6 3.9 6.9 7.4 7.6 4.6 4.7 5.3
Std Deviation (1e-4) 1.3 0.7 0.9 1.1 1.4 1.4 1.6 1.4 0.9 – 1.1 1.1 1.1 1.1 0.9 1.6 2.0 2.3 1.2 1.5 1.7
Intensity Change (Log2) – – – -0.04 0.09 -0.04 -0.04 -0.05 -0.28 – -0.3 -0.37 0.27 0.27 0.04 0.86 0.96 0.98 0.28 0.29 0.48

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 – –
Bud Neck – – – – – – – – – – – – 0 – –
Bud Site – – – – – – – – – – – – 0 – –
Cell Periphery – – – – – – – – – – – – 0 – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 – –
Endosome – – – – – – – – – – – – 0 – –
Golgi – – – – – – – – – – – – 0 – –
Mitochondria – – – – – – – – – – – – 0 – –
Nuclear Periphery – – – – – – – – – – – – 0 – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 – –
Peroxisomes – – – – – – – – – – – – 0 – –
SpindlePole – – – – – – – – – – – – 0 – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 – –
Cytoplasm – – – – – – – – – – – – 0 – –
Nucleus – – – – – – – – – – – – 0 – –
Vacuole – – – – – – – – – – – – 3.3 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.607 0.9691 1.023 0.4159 1.0984 1.2964 -0.1833 -0.4664 -0.1874 -0.8513 -0.4629 -0.4092 3.4876 3.7254 3.171 3.8078 3.4493 3.4275
Actin 0.0802 0.0004 0.0214 0.0007 0.0092 0.0091 0.0123 0.0001 0.0006 0.0001 0.0023 0.0011 0.0152 0.0002 0.0008 0.0014 0.0003 0.0001
Bud 0.0007 0.0007 0.0002 0.0007 0.0004 0.0002 0.0006 0.0012 0.0002 0.0001 0.0002 0.0002 0.0003 0.0004 0.0003 0.0001 0.0001 0.0001
Bud Neck 0.0046 0.0012 0.0021 0.0025 0.0037 0.0076 0.0022 0.0008 0.0015 0.0012 0.0017 0.005 0.0032 0.0006 0.001 0.0017 0.0012 0.0063
Bud Periphery 0.0014 0.001 0.0002 0.0008 0.0008 0.0006 0.0012 0.0005 0.0002 0.0001 0.0003 0.0007 0.0002 0.001 0.0002 0.0002 0.0001 0.0001
Bud Site 0.003 0.003 0.0022 0.0009 0.0021 0.0006 0.0016 0.0039 0.0034 0.0001 0.0003 0.0003 0.0085 0.0011 0.0022 0.0011 0.0003 0.0003
Cell Periphery 0.0003 0.0002 0.0002 0.0001 0.0002 0.0001 0.0002 0.0001 0.0001 0 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0
Cytoplasm 0.0189 0.0512 0.0122 0.0311 0.0338 0.0193 0.0147 0.0241 0.0046 0.0062 0.0069 0.0043 0.0101 0.0263 0.0309 0.0275 0.0219 0.0094
Cytoplasmic Foci 0.0149 0.0056 0.0032 0.0016 0.0077 0.0015 0.0068 0.0027 0.0015 0.0008 0.0009 0.0018 0.0116 0.0051 0.0012 0.0047 0.0171 0.0004
Eisosomes 0.001 0 0.0002 0 0.0002 0.0001 0.0001 0 0 0 0.0001 0.0001 0.0001 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0069 0.0034 0.0009 0.0025 0.0038 0.0036 0.004 0.0011 0.0003 0.0004 0.0036 0.0008 0.0008 0.0027 0.001 0.002 0.001 0.0005
Endosome 0.02 0.0061 0.0036 0.0024 0.0189 0.0091 0.0159 0.0017 0.0014 0.0003 0.0047 0.0015 0.0035 0.0031 0.0029 0.0074 0.0107 0.0006
Golgi 0.0113 0.0002 0.0011 0.0002 0.0041 0.0047 0.0048 0 0.0004 0 0.0009 0.0003 0.0017 0.0001 0.0001 0.0006 0.0008 0
Lipid Particles 0.0199 0.0018 0.0016 0.0002 0.0094 0.0058 0.0062 0.0002 0.0006 0.0001 0.001 0.0009 0.0063 0.0005 0.0006 0.0035 0.0375 0.0001
Mitochondria 0.0067 0.0007 0.0007 0.0005 0.0077 0.0072 0.0048 0.0003 0.0004 0.0002 0.0348 0.0055 0.0006 0.0067 0.0004 0.0009 0.0007 0.0003
None 0.0642 0.054 0.0164 0.0425 0.0543 0.0317 0.0064 0.0196 0.0029 0.0337 0.0013 0.0104 0.0289 0.0797 0.0348 0.1529 0.0496 0.036
Nuclear Periphery 0.0465 0.0241 0.0202 0.0313 0.0691 0.0336 0.0498 0.0281 0.0179 0.0148 0.0553 0.0285 0.0062 0.0119 0.0254 0.0169 0.0064 0.0062
Nucleolus 0.0191 0.0243 0.0515 0.0616 0.0316 0.065 0.0205 0.0281 0.0262 0.0396 0.0399 0.0526 0.039 0.0262 0.0315 0.0551 0.1078 0.0877
Nucleus 0.6114 0.746 0.8201 0.7376 0.5197 0.7091 0.7506 0.8141 0.8644 0.7853 0.6675 0.7907 0.8122 0.7539 0.8284 0.6056 0.7134 0.806
Peroxisomes 0.0117 0.0003 0.0008 0.0002 0.002 0.0011 0.0019 0 0.0002 0 0.0003 0.0001 0.0025 0.0002 0.0002 0.0016 0.0044 0
Punctate Nuclear 0.0528 0.0702 0.039 0.0802 0.217 0.0866 0.0897 0.0715 0.0721 0.1169 0.1755 0.0925 0.0481 0.0753 0.036 0.1123 0.0248 0.045
Vacuole 0.0028 0.0048 0.0019 0.0018 0.0025 0.0019 0.0031 0.0014 0.0008 0.0001 0.0012 0.0013 0.0008 0.0028 0.0015 0.0032 0.0015 0.0007
Vacuole Periphery 0.0015 0.0007 0.0004 0.0006 0.0018 0.0016 0.0025 0.0004 0.0003 0.0001 0.0012 0.0013 0.0002 0.0022 0.0004 0.0008 0.0003 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.8529 14.1543 3.501 7.7201 19.2459 22.7482 11.628 7.4456 8.2983 23.0441
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
151 90 1398 857 1457 1700 1086 76 1608 1790 2484 933

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 546.00 782.51 888.85 810.21 644.38 718.18 883.86 899.45 635.14 721.41 886.67 817.48
Standard Deviation 92.54 105.57 125.81 129.15 84.03 94.78 121.67 146.75 89.58 96.38 124.04 132.94
Intensity Change Log 2 — 0.519208 0.703039 0.569395 — 0.156434 0.455906 0.481131 — 0.334204 0.574534 0.522287

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000142 0.001045 0.000749 0.000979 0.000239 0.000477 0.000894 0.001022 0.000230 0.000506 0.000812 0.000983
Bud Neck 0.007375 0.015029 0.014995 0.017281 0.005977 0.011285 0.009336 0.002993 0.006108 0.011473 0.012521 0.016117
Bud Site 0.002409 0.004450 0.002779 0.029575 0.001078 0.006969 0.005055 0.002522 0.001203 0.006842 0.003774 0.027372
Cell Periphery 0.000333 0.000141 0.000091 0.000360 0.000117 0.000157 0.000124 0.000144 0.000137 0.000157 0.000105 0.000342
Cytoplasm 0.261633 0.067376 0.025211 0.187617 0.150188 0.140818 0.027124 0.069987 0.160653 0.137126 0.026047 0.178035
Cytoplasmic Foci 0.128753 0.051109 0.001011 0.026632 0.029388 0.036637 0.000775 0.009791 0.038719 0.037365 0.000908 0.025260
Eisosomes 0.000137 0.000108 0.000026 0.000059 0.000045 0.000061 0.000035 0.000079 0.000054 0.000064 0.000030 0.000060
Endoplasmic Reticulum 0.002230 0.006388 0.004942 0.004701 0.001782 0.002564 0.007133 0.012551 0.001824 0.002756 0.005900 0.005341
Endosome 0.004466 0.003344 0.000781 0.020693 0.001749 0.006136 0.001833 0.007152 0.002004 0.005995 0.001241 0.019590
Golgi 0.000845 0.004847 0.000469 0.012409 0.000444 0.001735 0.000872 0.012536 0.000482 0.001891 0.000645 0.012419
Lipid Particles 0.022561 0.007385 0.000384 0.002413 0.008152 0.010694 0.000544 0.002480 0.009505 0.010528 0.000454 0.002418
Mitochondria 0.004541 0.009065 0.002053 0.017366 0.004989 0.013983 0.002145 0.045547 0.004947 0.013736 0.002093 0.019662
Mitotic Spindle 0.002750 0.052726 0.023542 0.114375 0.006420 0.024798 0.014440 0.084370 0.006076 0.026202 0.019563 0.111931
None 0.041696 0.010664 0.007947 0.022491 0.034943 0.020007 0.010704 0.029437 0.035577 0.019537 0.009152 0.023057
Nuclear Periphery 0.002193 0.002710 0.002068 0.002710 0.004677 0.005772 0.001698 0.003554 0.004444 0.005618 0.001907 0.002779
Nuclear Periphery Foci 0.003553 0.015297 0.001021 0.002306 0.006272 0.004385 0.001016 0.026492 0.006017 0.004934 0.001019 0.004276
Nucleolus 0.020543 0.043685 0.025506 0.011615 0.049445 0.039752 0.013448 0.030709 0.046731 0.039950 0.020234 0.013170
Nucleus 0.475313 0.678034 0.882888 0.479212 0.688505 0.654367 0.896068 0.540301 0.668485 0.655557 0.888650 0.484188
Peroxisomes 0.003341 0.015961 0.000441 0.003243 0.002583 0.006191 0.000433 0.025215 0.002654 0.006683 0.000438 0.005033
Vacuole 0.014130 0.009886 0.002752 0.038837 0.002701 0.011413 0.006021 0.041091 0.003775 0.011336 0.004181 0.039021
Vacuole Periphery 0.001056 0.000750 0.000344 0.005126 0.000305 0.001798 0.000303 0.052027 0.000376 0.001745 0.000326 0.008947

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.27 -14.12 -9.94 -0.94 -2.97 -1.38 -8.67 -6.69 -5.36 -1.74 -1.79 -9.77 -8.70 -6.08 -2.53
Bud Neck -1.70 -8.15 -5.52 -1.48 2.87 -3.82 -8.69 -1.71 1.38 5.48 -4.11 -14.56 -8.58 -5.30 1.66
Bud Site -1.99 -2.23 -6.56 -4.49 -5.97 -4.40 -4.69 -4.34 0.66 0.43 -4.48 -7.37 -7.68 -4.71 -5.67
Cell Periphery 1.63 2.10 0.82 -3.23 -6.46 -2.55 -0.96 -2.12 -0.49 -1.48 -0.91 1.91 -4.04 -3.52 -5.96
Cytoplasm 8.33 12.30 6.79 -3.62 -13.21 1.39 20.10 4.72 4.21 -2.28 3.33 24.18 5.63 3.06 -13.24
Cytoplasmic Foci 4.75 9.40 8.63 3.62 -5.96 -1.77 14.19 8.96 10.98 -1.87 0.90 16.33 10.95 11.22 -6.22
Eisosomes 0.08 6.95 3.70 2.71 -10.50 -4.21 0.54 -3.96 -3.25 -4.04 -2.62 5.78 -5.99 -3.85 -10.40
Endoplasmic Reticulum -2.86 -3.99 -7.37 -2.23 -6.31 -2.22 -14.65 -6.75 -6.48 -3.60 -2.84 -16.83 -14.75 -13.62 -5.74
Endosome -0.34 4.08 -2.48 -1.90 -5.24 -6.36 1.10 -2.10 1.32 -2.41 -6.16 3.98 -4.49 -1.61 -5.22
Golgi -1.18 0.90 -2.98 -0.05 -3.42 -3.68 -0.18 -1.35 -0.88 -1.32 -3.80 0.19 -3.58 -2.19 -3.58
Lipid Particles 2.42 4.23 3.89 3.36 -6.67 -2.19 9.39 5.94 8.84 -3.61 -1.03 10.35 8.37 11.33 -6.93
Mitochondria -1.12 1.31 -1.60 -0.01 -2.87 -5.66 3.15 -1.10 -0.18 -1.39 -5.83 3.35 -1.69 2.28 -3.21
Mitotic Spindle -3.14 -7.33 -11.52 -1.76 -6.66 -5.06 -5.49 -2.81 -2.10 -1.75 -5.85 -9.58 -12.34 -9.44 -7.79
None 4.05 4.69 3.93 -0.72 -3.15 5.25 9.54 2.26 0.43 -0.94 5.92 11.22 8.11 2.92 -3.09
Nuclear Periphery -1.08 -1.41 -3.65 -1.55 -4.22 -1.62 3.62 -1.01 -0.02 -3.09 -1.91 2.77 -1.40 0.79 -5.93
Nuclear Periphery Foci -2.04 1.59 0.26 2.11 -2.46 1.95 3.68 -1.17 -1.45 -1.69 1.10 4.18 1.15 0.20 -2.88
Nucleolus -2.22 -2.71 0.84 3.12 6.99 2.64 9.22 3.16 1.98 -0.73 1.96 5.11 8.55 7.15 4.92
Nucleus -3.26 -12.93 -3.70 1.00 17.30 2.06 -16.93 1.14 0.56 5.68 0.59 -19.34 4.94 4.54 20.12
Peroxisomes -2.11 4.56 2.94 2.58 -2.51 -4.47 5.12 -0.69 -0.11 -1.04 -4.87 6.73 1.45 5.16 -2.16
Vacuole -0.55 2.63 -6.76 -3.59 -12.12 -7.63 -6.09 -3.78 -3.33 -3.30 -6.03 -4.09 -12.92 -11.11 -12.06
Vacuole Periphery 0.38 1.29 -1.52 -2.36 -3.40 -3.64 0.58 -1.40 -1.28 -1.40 -3.51 1.00 -2.68 -1.34 -2.75
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18
Localization
Cell Percentages nucleus (78%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Smc6

Smc6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Smc6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available