Standard name
Human Ortholog
Description Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0.05 0 0.07
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Cytoplasm 0.06 0.06 0.13 0.8 0.73 0.65 0.66 0.66 0.55 0.6 0.5 0.6 0.64 0.69 0.82 0.67 0.73 – 0 0 0.08 0.18 0.26 0.26
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 – 0 0 0 0 0 0
Endosome 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 – 0 0 0 0 0.06 0.05
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.09 0.06 0 0.16 0.1 0.27 0.17 0 0 0 0 0.06 – 0 0 0 0 0 0
Nucleus 0.76 0.59 0.61 0 0 0 0.1 0.06 0.12 0.09 0.08 0.07 0.18 0.06 0 0.1 0.19 – 0.65 0.63 0.58 0.48 0.37 0.34
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nucleolus 0.12 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0.16 0.14 0.07 0.06 0.05 0.06
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0.08 0.07 0.08
Vac/Vac Membrane 0.11 0.32 0.25 0.29 0.33 0.26 0.25 0.29 0.28 0.32 0.21 0.2 0.35 0.39 0.33 0.38 0.23 – 0 0.07 0.12 0.06 0.07 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 – 1 0 0 1 4 0
Bud 0 0 0 0 0 0 0 0 1 2 4 1 0 0 0 0 0 – 1 13 7 11 12 28
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 1 1 6
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 1 1 1 0 1 1 3 0 3 0 0 0 0 0 – 0 0 0 0 0 0
Cytoplasm 7 14 16 63 120 131 152 209 111 148 126 156 136 253 322 46 38 – 1 8 14 40 89 105
Endoplasmic Reticulum 0 0 1 0 0 4 1 1 3 1 4 0 0 2 0 2 3 – 0 0 1 1 3 1
Endosome 0 11 4 2 3 7 9 10 4 6 2 8 9 19 13 3 0 – 4 11 3 7 20 18
Golgi 1 0 0 0 2 0 1 0 0 0 0 0 0 1 0 0 1 – 1 0 0 0 1 1
Mitochondria 5 3 0 2 1 18 13 14 33 24 67 44 0 1 1 2 3 – 2 1 2 1 5 6
Nucleus 86 139 75 1 3 9 23 19 25 21 20 19 39 22 6 7 10 – 85 209 99 106 126 140
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 – 0 0 0 1 2 1
Nucleolus 13 11 2 1 1 0 0 0 0 1 2 1 0 0 1 0 0 – 21 47 11 12 17 22
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
SpindlePole 0 0 2 0 0 0 0 1 0 0 0 0 0 0 0 1 0 – 4 10 6 16 25 31
Vac/Vac Membrane 12 76 30 23 54 53 58 91 56 79 52 52 74 143 129 26 12 – 3 23 21 13 25 30
Unique Cell Count 113 235 122 79 165 203 232 316 202 247 252 258 213 369 395 69 52 132 331 173 221 346 410
Labelled Cell Count 124 254 130 93 185 223 257 346 234 286 277 285 258 441 472 87 67 132 331 173 221 346 410


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.1 10.4 9.4 9.0 10.0 8.3 7.8 8.1 7.0 7.4 6.7 7.0 9.5 9.6 9.3 9.6 9.8 – 8.4 8.9 8.8
Std Deviation (1e-4) 1.2 2.2 1.5 2.8 3.8 3.3 2.3 1.8 1.9 1.6 1.8 1.8 1.4 1.6 1.1 1.9 1.8 – 1.2 1.4 1.6
Intensity Change (Log2) – – – -0.07 0.1 -0.19 -0.27 -0.21 -0.42 -0.34 -0.5 -0.42 0.02 0.03 -0.02 0.03 0.07 – -0.15 -0.08 -0.09

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_20510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Cytoplasm 9.4 10.0 9.0 9.4 10.0 7.5 8.5 6.9 8.7 9.0 10.7 13.9 7.6 7.8 –
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Endosome 0 0 0 0 0 0 0 0 0 0 0.8 0 0 0 –
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Mitochondria 0 0 3.4 0 0 4.7 3.6 6.3 4.9 0 0 0 0 0 –
Nucleus -8.6 -11.2 -11.4 -10.3 -12.7 -9.3 -10.9 -11.2 -11.4 -8.0 -13.4 -15.9 -6.9 -5.1 –
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Vacuole 0.7 1.5 0.3 0.1 0.9 0.6 1.5 -0.9 -1.0 1.9 2.8 1.7 1.9 -0.2 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.0712 5.2395 4.3135 4.0603 3.8928 4.2968 6.9726 6.549 7.1212 6.9693 6.3461 6.5196 7.7955 7.6208 7.3661 6.8206 6.7233 6.9966
Actin 0.0071 0.0003 0.0032 0.0094 0.0033 0.0022 0 0.0001 0 0 0.0002 0.0001 0 0.0001 0 0 0 0
Bud 0.0005 0.0006 0.0011 0.0001 0.0015 0.0005 0 0.0002 0.0002 0 0.0001 0.0001 0 0.0002 0.0001 0 0 0.0001
Bud Neck 0.0021 0.0007 0.0023 0.0008 0.0013 0.0039 0.0002 0.0009 0.0003 0.0003 0.0007 0.002 0.0002 0.0006 0.0003 0.0005 0.0006 0.0012
Bud Periphery 0.0009 0.0004 0.0009 0.0001 0.0061 0.0003 0 0.0001 0 0 0.0001 0 0 0.0001 0 0 0 0
Bud Site 0.0034 0.0017 0.0057 0.0004 0.0009 0.0006 0.0001 0.0005 0.0004 0.0001 0.0002 0.0002 0.0002 0.0008 0.0003 0.0001 0 0.0001
Cell Periphery 0.0003 0.0001 0.0003 0 0.0006 0.0001 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.0422 0.0824 0.096 0.1622 0.0211 0.0696 0.0378 0.0652 0.0366 0.0333 0.0703 0.0361 0.0317 0.0664 0.0522 0.0574 0.0734 0.0598
Cytoplasmic Foci 0.0249 0.0042 0.011 0.0304 0.0183 0.0062 0.0003 0.0009 0.0003 0 0.0022 0.0008 0.0002 0.0009 0.0004 0.0007 0.0003 0.0007
Eisosomes 0.0001 0 0 0 0.0001 0 0 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0025 0.0009 0.0029 0.0015 0.0059 0.0029 0.0004 0.0011 0.0006 0.0002 0.0011 0.0005 0.0002 0.0006 0.0005 0.0005 0.0005 0.0005
Endosome 0.0224 0.0019 0.0243 0.016 0.0146 0.0147 0.0004 0.0024 0.0007 0.0001 0.0034 0.0011 0.0003 0.0016 0.0014 0.0008 0.0005 0.0009
Golgi 0.0064 0.0001 0.0061 0.0123 0.0058 0.0037 0 0 0 0 0.0003 0 0 0 0.0001 0 0 0
Lipid Particles 0.005 0.0001 0.0038 0.0213 0.0063 0.003 0 0 0 0 0 0 0 0 0.0001 0 0 0
Mitochondria 0.0084 0.0005 0.0049 0.0019 0.0437 0.0037 0.0001 0.0003 0.0001 0.0001 0.0004 0.0001 0.0001 0.0002 0.0006 0.0001 0.0001 0.0001
None 0.0017 0.0006 0.0122 0.0024 0.001 0.001 0.0009 0.0011 0.0006 0.0001 0.0049 0.0006 0.0004 0.0005 0.0004 0.0008 0.0005 0.0005
Nuclear Periphery 0.0183 0.0127 0.0151 0.013 0.0158 0.0176 0.0049 0.0109 0.0046 0.0037 0.0067 0.0052 0.0041 0.0067 0.0046 0.0041 0.0091 0.0046
Nucleolus 0.0052 0.0022 0.0041 0.0007 0.0044 0.0042 0.0012 0.0029 0.0014 0.0013 0.0025 0.003 0.0011 0.0019 0.001 0.0012 0.0016 0.0018
Nucleus 0.8261 0.8674 0.7847 0.7163 0.8056 0.8301 0.9481 0.8997 0.9462 0.9585 0.8992 0.9388 0.9587 0.9101 0.9353 0.923 0.9047 0.9244
Peroxisomes 0.0042 0.0001 0.0023 0.0045 0.0233 0.003 0 0.0001 0 0 0.0002 0 0 0 0 0 0 0
Punctate Nuclear 0.01 0.0207 0.0122 0.0051 0.0071 0.0278 0.0053 0.0116 0.0072 0.002 0.0061 0.0106 0.0023 0.0077 0.0023 0.0104 0.0082 0.0046
Vacuole 0.0062 0.0022 0.0055 0.0013 0.0083 0.0038 0.0002 0.0016 0.0005 0.0002 0.0011 0.0005 0.0003 0.0014 0.0005 0.0004 0.0004 0.0005
Vacuole Periphery 0.0019 0.0003 0.0013 0.0004 0.0051 0.0011 0 0.0002 0.0001 0 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.9711 30.2835 21.7583 31.4495 25.7956 19.8847 32.0777 30.5072 27.3114 35.6492
Translational Efficiency 1.224 0.8356 1.1838 0.5781 0.7877 1.4831 0.9592 1.0149 1.0828 0.9513

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1881 981 2047 1541 1533 2538 1893 164 3414 3519 3940 1705

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 733.59 910.87 1020.33 1096.37 815.47 913.34 1084.94 1156.51 770.36 912.65 1051.37 1102.15
Standard Deviation 95.34 160.85 149.67 158.03 123.62 140.68 153.29 160.94 116.32 146.59 154.82 159.31
Intensity Change Log 2 — 0.312271 0.475990 0.579689 — 0.163520 0.411912 0.504074 — 0.235879 0.442612 0.540377

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000210 0.001023 0.000614 0.004228 0.000621 0.000313 0.000764 0.001808 0.000394 0.000511 0.000686 0.003995
Bud Neck 0.004348 0.010493 0.018022 0.018350 0.004528 0.012033 0.016602 0.014687 0.004429 0.011604 0.017340 0.017997
Bud Site 0.001133 0.003396 0.002673 0.046686 0.002591 0.003660 0.003304 0.025545 0.001787 0.003587 0.002976 0.044652
Cell Periphery 0.000150 0.000206 0.000101 0.000291 0.000186 0.000098 0.000168 0.000273 0.000166 0.000128 0.000133 0.000289
Cytoplasm 0.075957 0.124020 0.025591 0.272614 0.128403 0.147323 0.040271 0.112160 0.099507 0.140826 0.032644 0.257181
Cytoplasmic Foci 0.003738 0.003466 0.000090 0.014268 0.006835 0.003160 0.000322 0.026405 0.005128 0.003245 0.000202 0.015436
Eisosomes 0.000016 0.000025 0.000012 0.000033 0.000025 0.000013 0.000018 0.000053 0.000020 0.000016 0.000015 0.000035
Endoplasmic Reticulum 0.001906 0.006467 0.002724 0.004837 0.004653 0.002840 0.004371 0.004311 0.003139 0.003851 0.003515 0.004787
Endosome 0.000584 0.001273 0.000202 0.014440 0.001278 0.001116 0.000377 0.085564 0.000896 0.001160 0.000286 0.021281
Golgi 0.000300 0.000294 0.000077 0.019940 0.000328 0.000211 0.000088 0.030218 0.000312 0.000234 0.000082 0.020929
Lipid Particles 0.000581 0.001186 0.000092 0.001000 0.000880 0.000380 0.000188 0.017929 0.000715 0.000605 0.000138 0.002628
Mitochondria 0.001558 0.001424 0.001933 0.003894 0.001431 0.002531 0.002133 0.035015 0.001501 0.002222 0.002029 0.006887
Mitotic Spindle 0.001369 0.005619 0.003707 0.133842 0.003712 0.010056 0.006963 0.088195 0.002421 0.008819 0.005272 0.129451
None 0.017193 0.011543 0.004534 0.014367 0.014055 0.008606 0.007766 0.006023 0.015784 0.009425 0.006087 0.013564
Nuclear Periphery 0.000780 0.001622 0.001208 0.004450 0.000986 0.002143 0.001901 0.002407 0.000872 0.001998 0.001541 0.004253
Nuclear Periphery Foci 0.000536 0.002133 0.000172 0.001692 0.001741 0.000722 0.000370 0.003528 0.001077 0.001115 0.000267 0.001869
Nucleolus 0.010811 0.006455 0.001748 0.000709 0.007367 0.004416 0.001425 0.000709 0.009265 0.004984 0.001593 0.000709
Nucleus 0.876948 0.810941 0.934370 0.367080 0.815024 0.794643 0.906989 0.353824 0.849142 0.799186 0.921215 0.365805
Peroxisomes 0.000602 0.000776 0.000080 0.001194 0.000522 0.000243 0.000082 0.001067 0.000566 0.000392 0.000081 0.001182
Vacuole 0.001056 0.006865 0.001934 0.071264 0.004370 0.005141 0.005760 0.170306 0.002544 0.005622 0.003773 0.080790
Vacuole Periphery 0.000225 0.000772 0.000114 0.004822 0.000467 0.000354 0.000139 0.019972 0.000333 0.000471 0.000126 0.006279

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -11.34 -16.50 -5.81 -2.13 -3.63 4.41 -4.40 -5.90 -8.13 -3.99 -3.98 -12.70 -5.42 -4.63 -3.55
Bud Neck -7.77 -16.32 -9.25 -0.58 6.96 -11.50 -11.15 -5.88 0.43 3.27 -14.06 -19.45 -10.06 -0.15 6.66
Bud Site -7.11 -4.54 -10.02 -8.18 -8.72 -1.50 -1.75 -3.35 -3.14 -3.15 -4.69 -4.50 -10.16 -8.83 -9.19
Cell Periphery -3.12 3.30 -2.08 1.28 -5.56 7.23 2.54 -2.08 -7.89 -4.18 4.25 3.90 -1.41 -5.01 -4.72
Cytoplasm -5.23 14.12 -18.76 -10.57 -32.06 -1.88 16.27 1.81 3.12 -7.38 -7.11 21.20 -15.37 -9.62 -31.72
Cytoplasmic Foci 0.98 6.84 -0.84 -1.91 -9.04 4.06 7.82 2.09 -0.77 -3.42 3.64 10.35 1.14 -2.44 -9.42
Eisosomes -6.54 0.01 -13.63 -5.74 -14.14 8.21 1.90 -8.86 -11.60 -9.66 2.36 1.24 -13.07 -14.71 -14.31
Endoplasmic Reticulum -13.05 -9.75 -11.71 3.98 -6.83 6.31 -1.90 -3.36 -5.95 -2.59 -5.26 -6.48 -7.66 -3.90 -3.87
Endosome -4.56 4.08 -5.18 -3.65 -5.87 1.34 6.61 -1.72 -1.79 -1.95 -1.77 7.56 -4.64 -4.19 -5.62
Golgi 0.02 1.36 -2.91 -2.94 -3.14 1.57 3.16 -1.42 -1.51 -1.58 0.92 2.40 -3.10 -3.20 -3.34
Lipid Particles -1.47 6.02 -9.66 -0.93 -22.75 6.27 7.60 -1.88 -2.37 -2.45 1.03 9.40 -6.97 -6.44 -12.00
Mitochondria 0.19 -1.74 -2.55 -6.66 -2.32 -1.69 -2.81 -1.91 -1.23 -1.26 -1.43 -2.98 -4.00 -2.06 -2.55
Mitotic Spindle -3.55 -4.32 -14.10 -12.42 -12.89 -3.74 -2.44 -4.62 -4.09 -4.29 -5.79 -4.62 -14.56 -12.68 -13.45
None 4.15 10.68 4.96 0.25 -7.92 3.97 5.58 2.29 -0.45 -1.61 6.69 11.53 4.99 -1.52 -6.86
Nuclear Periphery -5.41 -4.99 -10.27 -8.13 -8.87 -6.10 -9.13 -10.17 -5.76 -4.63 -7.34 -10.07 -11.35 -7.40 -7.77
Nuclear Periphery Foci -3.63 3.28 -6.28 1.89 -11.99 3.83 4.77 -1.50 -4.08 -4.62 -0.14 5.55 -1.96 -1.77 -11.31
Nucleolus 3.70 9.43 12.31 8.49 9.29 2.88 7.45 9.22 9.94 5.55 5.50 12.05 15.55 13.58 11.65
Nucleus 6.95 -9.48 40.87 29.47 51.32 1.86 -11.60 13.14 12.73 16.92 7.87 -14.60 41.23 35.76 53.05
Peroxisomes -0.10 2.20 1.42 1.22 -3.57 2.25 3.72 2.22 0.09 -3.60 1.22 3.31 1.94 0.82 -3.95
Vacuole -7.17 -6.15 -28.10 -26.27 -27.70 -1.64 -6.12 -12.08 -12.01 -11.67 -7.44 -7.75 -30.04 -29.18 -28.99
Vacuole Periphery -1.31 1.70 -2.65 -0.54 -2.97 0.98 2.88 -1.28 -1.43 -1.64 -0.78 3.35 -2.58 -2.06 -3.38
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion
Localization
Cell Percentages nucleus (82%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-5

Sfp1

Sfp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sfp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available