Standard name
Human Ortholog
Description Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1; upstream component for regulation through the small GTPase Rho5p; may form a complex with Lmo1p that acts as a GEF for Rho5p; interacts with Ino4p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein; DOCK proteins act as guanine nucleotide exchange factors
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0.09 0.08 0.11 0.09 0.12 0.15
Bud 0 0 0 0.05 0 0.07 0.06 0.06 0.05 0.08 0.07 0.09 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0.07 0 0 0 0.05
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0.1 0.06 0 0.06 0 0 0 0 0.07 0 0.07 0.05 0.16 0.2 0.2 – – – 0.05 0.06 0.08 0.05 0.1 0.17
Cytoplasm 0.9 0.94 0.96 0.95 0.91 0.85 0.8 0.8 0.79 0.76 0.74 0.72 0.97 0.97 0.96 – – – 0.56 0.62 0.52 0.69 0.57 0.46
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0.11 0 0 0 0.06 0.06
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0 0 0 0.06 0.06 0.15 0.21 0.18 0.26 0.29 0.28 0.31 0 0 0 – – – 0.05 0.05 0.14 0.06 0.05 0.05
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 5 4 4 6 4 14 9 4 2 4 2 4 7 6 5 – – – 31 15 56 28 54 85
Bud 2 2 22 20 19 46 49 50 31 56 30 41 7 4 21 – – – 7 1 7 4 11 7
Bud Neck 0 0 11 7 13 18 8 20 9 11 8 9 0 0 1 – – – 12 14 16 10 17 27
Bud Site 0 0 0 1 9 10 10 17 13 11 6 4 0 0 1 – – – – – – – – –
Cell Periphery 31 12 16 22 19 24 17 19 41 26 31 24 63 95 111 – – – 15 11 41 16 45 94
Cytoplasm 274 185 509 364 501 596 626 671 475 538 318 325 386 456 535 – – – 190 127 269 223 262 254
Endoplasmic Reticulum 1 5 2 1 0 2 1 1 1 1 1 2 1 3 4 – – – 38 6 16 5 25 32
Endosome 6 0 0 0 0 0 0 1 0 0 0 0 1 1 4 – – – 7 4 7 2 2 5
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 4 0 2 1 0 1
Mitochondria 11 4 5 25 34 108 162 153 159 202 119 141 0 1 4 – – – 17 9 72 17 24 29
Nucleus 0 1 0 0 0 2 1 4 2 5 1 4 0 1 1 – – – 0 1 0 1 0 0
Nuclear Periphery 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 – – – 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 1 1 0 1 0 0 0 0 0 – – – 0 0 0 0 0 1
Peroxisomes 4 0 0 0 0 0 0 0 0 0 0 0 0 2 2 – – – 1 0 1 0 0 1
SpindlePole 5 0 6 1 14 11 19 26 19 15 5 4 2 0 2 – – – 1 0 3 0 0 2
Vac/Vac Membrane 3 0 0 0 0 0 0 4 1 1 0 3 0 1 2 – – – 3 8 6 6 7 6
Unique Cell Count 305 197 532 385 548 704 784 836 601 705 428 450 397 471 557 338 206 521 323 462 557
Labelled Cell Count 342 214 575 447 613 831 903 971 753 871 521 562 467 570 693 338 206 521 323 462 557


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.3 5.4 3.8 3.6 3.8 3.5 3.5 3.6 3.2 3.1 3.2 3.2 5.6 5.7 5.1 – – – 5.7 5.9 6.2
Std Deviation (1e-4) 1.0 0.7 0.8 0.9 1.1 0.8 0.9 1.3 1.1 0.9 0.9 1.1 0.9 1.1 1.0 – – – 1.7 1.5 1.4
Intensity Change (Log2) – – – -0.09 0.01 -0.11 -0.13 -0.06 -0.25 -0.28 -0.26 -0.26 0.57 0.59 0.42 – – – 0.6 0.63 0.72


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud 0 0 0 0 0 0 0 0 0 -2.1 -3.3 -0.3 – – –
Bud Neck 0 0 0 0 0 0 0 0 0 0 -3.1 -3.0 – – –
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 7.0 8.6 8.7 – – –
Cytoplasm -0.8 -2.8 -6.2 -8.2 -8.1 -8.3 -9.4 -9.5 -10.2 1.2 0.9 0.3 – – –
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – – –
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.6452 3.0299 2.6697 2.5678 2.7927 2.727 0.4399 0.9277 0.5499 0.2875 0.8252 0.5987 0.2613 1.3192 0.9019 0.9028 1.2807 0.866
Actin 0.0468 0.028 0.0185 0.0873 0.0306 0.0128 0.0337 0.0057 0.0328 0.0336 0.0366 0.0299 0.0212 0.0035 0.0526 0.0296 0.0144 0.0238
Bud 0.0017 0.0011 0.0047 0.0016 0.0017 0.0021 0.0044 0.0034 0.0045 0.016 0.0076 0.0015 0.0014 0.0024 0.0011 0.0012 0.0006 0.0013
Bud Neck 0.0137 0.0029 0.0055 0.0031 0.0221 0.0246 0.012 0.0032 0.0137 0.0077 0.0086 0.0281 0.0017 0.0012 0.0139 0.0096 0.0018 0.0245
Bud Periphery 0.0054 0.0023 0.012 0.0059 0.0068 0.0049 0.0102 0.0085 0.0112 0.0674 0.022 0.0041 0.0033 0.0049 0.0019 0.003 0.0009 0.0071
Bud Site 0.0089 0.0714 0.0335 0.0103 0.0427 0.0017 0.0364 0.1604 0.047 0.0116 0.0214 0.0028 0.0194 0.0523 0.0198 0.0034 0.002 0.0009
Cell Periphery 0.0259 0.0162 0.0147 0.0057 0.0186 0.0089 0.0107 0.0148 0.0075 0.0044 0.0031 0.0053 0.0051 0.0054 0.0036 0.0014 0.0006 0.003
Cytoplasm 0.4552 0.5924 0.5785 0.4055 0.4185 0.614 0.6292 0.6628 0.7009 0.6831 0.6 0.7659 0.6732 0.7463 0.7451 0.7673 0.806 0.792
Cytoplasmic Foci 0.0202 0.0077 0.0116 0.0163 0.0289 0.0073 0.0202 0.0053 0.0177 0.0109 0.0363 0.0172 0.0246 0.0064 0.0092 0.0074 0.0243 0.0138
Eisosomes 0.0016 0.0008 0.001 0.0006 0.0019 0.0004 0.0006 0.0004 0.0004 0.0002 0.0003 0.0003 0.0003 0.0001 0.0003 0.0003 0.0002 0.0002
Endoplasmic Reticulum 0.0096 0.0024 0.0052 0.0051 0.0065 0.0026 0.0073 0.0036 0.0045 0.0062 0.0095 0.0023 0.0045 0.0042 0.0062 0.0051 0.004 0.0075
Endosome 0.0261 0.001 0.0021 0.0015 0.0266 0.0021 0.036 0.0008 0.0085 0.0045 0.0412 0.0068 0.0085 0.0025 0.0083 0.0065 0.046 0.0035
Golgi 0.007 0.0033 0.0033 0.0022 0.0104 0.0013 0.011 0.0007 0.0055 0.0022 0.0374 0.0049 0.0025 0.001 0.0052 0.0023 0.008 0.0014
Lipid Particles 0.0081 0.0006 0.0033 0.0024 0.012 0.0023 0.0099 0.0012 0.0024 0.0004 0.0351 0.0014 0.0056 0.0004 0.0024 0.0019 0.0196 0.0004
Mitochondria 0.0179 0.0023 0.0014 0.0026 0.0048 0.0014 0.0078 0.0002 0.0043 0.0012 0.0135 0.007 0.0014 0.0002 0.0019 0.0023 0.0048 0.0005
None 0.3047 0.2602 0.2948 0.4193 0.3346 0.3091 0.1377 0.1254 0.1285 0.141 0.0668 0.1185 0.1945 0.1657 0.1206 0.1447 0.0129 0.1175
Nuclear Periphery 0.0085 0.0002 0.0005 0.0005 0.0068 0.0003 0.006 0.0003 0.0008 0.0007 0.0071 0.0003 0.0013 0.0003 0.0017 0.0025 0.0146 0.0003
Nucleolus 0.0005 0.0002 0.0004 0.0003 0.0019 0.0002 0.001 0.0002 0.0006 0.0003 0.0145 0.0001 0.0018 0.0001 0.0001 0.0009 0.0014 0
Nucleus 0.0082 0.0004 0.0008 0.0007 0.0024 0.0007 0.0034 0.001 0.0014 0.0019 0.0065 0.0005 0.0055 0.0006 0.0007 0.0022 0.0033 0.0003
Peroxisomes 0.0223 0.0053 0.0054 0.026 0.007 0.0021 0.008 0.0001 0.0037 0.0008 0.0173 0.0013 0.0071 0.0001 0.0028 0.0016 0.0029 0.0011
Punctate Nuclear 0.0023 0.0002 0.0012 0.001 0.0075 0.0004 0.0022 0.0005 0.0009 0.0007 0.0063 0.0006 0.0096 0.0002 0.0005 0.0055 0.0259 0.0003
Vacuole 0.0045 0.0012 0.0014 0.0022 0.0066 0.0009 0.0102 0.0015 0.0029 0.0046 0.0073 0.0011 0.0071 0.002 0.0017 0.0011 0.0031 0.0005
Vacuole Periphery 0.0011 0 0.0001 0.0001 0.001 0.0001 0.0019 0.0001 0.0003 0.0005 0.0014 0.0002 0.0004 0.0001 0.0004 0.0003 0.0027 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.888 10.5458 14.2625 19.7442 15.9121 16.3546 17.4562 19.6169 18.2984 20.5759
Translational Efficiency 0.25 0.2973 0.2836 0.2309 0.1901 0.2203 0.2238 0.1891 0.2012 0.1783

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2005 1523 1896 1634 1891 2283 1369 2096 3896 3806 3265 3730

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 617.48 746.09 1066.97 919.66 711.03 772.54 858.24 899.16 662.89 761.96 979.45 908.14
Standard Deviation 76.58 96.68 120.10 116.65 97.96 94.46 117.36 115.47 99.30 96.23 157.35 116.43
Intensity Change Log 2 — 0.272957 0.789055 0.574708 — 0.119699 0.271471 0.338667 — 0.192961 0.535207 0.453194

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.008302 0.003585 0.005907 0.003570 0.002906 0.005162 0.000663 0.006523 0.005683 0.004531 0.003709 0.005230
Bud Neck 0.102753 0.036487 0.013621 0.011974 0.034527 0.057979 0.004373 0.012430 0.069638 0.049379 0.009743 0.012230
Bud Site 0.063080 0.047181 0.055663 0.065894 0.022885 0.049497 0.010100 0.075347 0.043570 0.048570 0.036559 0.071206
Cell Periphery 0.006800 0.000395 0.001252 0.000663 0.000728 0.000889 0.000377 0.000735 0.003853 0.000691 0.000885 0.000704
Cytoplasm 0.509238* 0.475245* 0.527002* 0.500243* 0.518281* 0.479333* 0.590385* 0.546122* 0.513627* 0.477697* 0.553578* 0.526024*
Cytoplasmic Foci 0.102165 0.241679* 0.044498 0.051317 0.189770* 0.213125* 0.059568 0.050675 0.144686 0.224551* 0.050817 0.050956
Eisosomes 0.013134 0.000781 0.000325 0.000206 0.001618 0.002768 0.000148 0.000388 0.007545 0.001973 0.000251 0.000308
Endoplasmic Reticulum 0.004112 0.001460 0.004767 0.001727 0.001927 0.001345 0.001626 0.001753 0.003051 0.001391 0.003450 0.001742
Endosome 0.004963 0.019345 0.002255 0.007898 0.010636 0.019107 0.004001 0.003565 0.007716 0.019202 0.002987 0.005463
Golgi 0.008767 0.009480 0.000193 0.001870 0.006655 0.017559 0.000451 0.000685 0.007742 0.014326 0.000301 0.001204
Lipid Particles 0.011843 0.006655 0.002158 0.001384 0.010220 0.007512 0.002039 0.001404 0.011055 0.007169 0.002108 0.001395
Mitochondria 0.011895 0.005507 0.000224 0.001488 0.003874 0.008112 0.000174 0.000523 0.008002 0.007070 0.000203 0.000946
Mitotic Spindle 0.000527 0.001814 0.002544 0.018196 0.002480 0.003447 0.001383 0.009678 0.001475 0.002793 0.002057 0.013409
None 0.006052 0.001244 0.001520 0.000861 0.003641 0.001409 0.005067 0.000656 0.004882 0.001343 0.003007 0.000746
Nuclear Periphery 0.000556 0.000156 0.000443 0.000344 0.000310 0.000079 0.000547 0.000198 0.000437 0.000110 0.000487 0.000262
Nuclear Periphery Foci 0.000636 0.000588 0.003471 0.001492 0.000535 0.000279 0.002073 0.001108 0.000587 0.000403 0.002885 0.001277
Nucleolus 0.000867 0.000575 0.000092 0.000270 0.000770 0.000464 0.000343 0.000108 0.000820 0.000508 0.000197 0.000179
Nucleus 0.104537 0.045064 0.163175* 0.069463 0.120299 0.052653 0.173381* 0.052080 0.112187 0.049616 0.167454* 0.059695
Peroxisomes 0.013923 0.013821 0.001479 0.003437 0.007185 0.014908 0.001369 0.004595 0.010652 0.014473 0.001433 0.004088
Vacuole 0.024849 0.087240 0.169324 0.256128* 0.059880 0.062786 0.141819 0.230778* 0.041852 0.072571 0.157791 0.241883*
Vacuole Periphery 0.001002 0.001700 0.000086 0.001577 0.000875 0.001587 0.000113 0.000649 0.000940 0.001632 0.000097 0.001055

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 4.85 2.80 5.65 1.39 3.24 -2.70 3.52 -2.77 -0.00 -8.15 1.74 3.54 2.41 0.80 -1.53
Bud Neck 15.10 22.47 22.84 12.60 1.67 -8.38 16.13 12.61 21.34 -6.79 7.44 26.00 25.32 24.64 -1.81
Bud Site 4.17 4.37 3.71 -0.18 -0.47 -10.16 6.61 -10.38 -2.08 -15.09 -2.02 5.39 -3.38 -1.66 -8.37
Cell Periphery 12.10 10.70 11.87 -1.76 5.77 -2.54 7.60 2.48 5.10 -4.55 11.35 10.93 11.87 3.39 3.86
Cytoplasm 3.98 5.39 7.80 3.68 2.70 5.14 -2.48 2.77 -1.94 4.66 6.37 2.75 7.08 1.14 3.84
Cytoplasmic Foci -23.95 19.45 16.73 35.32 -2.01 -4.20 28.77 34.11 40.22 4.03 -20.13 34.33 35.91 53.38 1.14
Eisosomes 15.13 15.76 15.89 9.87 5.62 -5.64 13.11 11.52 14.24 -6.77 12.52 16.89 16.83 15.97 -1.37
Endoplasmic Reticulum 4.49 -2.45 3.94 -1.75 13.50 2.35 -0.51 0.76 -2.05 1.70 5.08 -3.11 3.96 -2.74 12.82
Endosome -12.04 9.45 -0.73 10.38 -4.88 -7.50 9.32 10.93 17.65 3.43 -14.39 12.57 7.86 19.60 -2.97
Golgi -0.81 18.38 12.43 11.61 -2.09 -11.89 13.31 14.60 20.76 -0.43 -10.35 22.83 19.22 23.42 -2.21
Lipid Particles 6.28 13.81 15.08 10.32 7.30 3.65 12.23 13.22 14.75 4.70 7.00 18.39 20.06 17.96 8.76
Mitochondria 5.93 13.82 12.40 6.20 -2.31 -5.27 9.84 9.04 10.77 -4.20 1.39 16.40 14.99 12.29 -3.31
Mitotic Spindle -1.70 -2.56 -6.57 -5.59 -5.24 -0.71 1.02 -3.62 -3.15 -4.80 -1.71 -0.86 -7.37 -6.10 -6.87
None 6.14 6.03 6.90 1.80 1.57 3.17 -0.52 4.40 3.85 4.53 6.70 3.85 8.14 4.11 4.84
Nuclear Periphery 1.67 -0.34 0.23 -8.13 4.22 2.46 -3.55 0.14 -9.86 12.39 2.50 -1.58 0.38 -12.76 11.87
Nuclear Periphery Foci 0.14 -10.69 -4.12 -7.93 10.05 2.90 -10.68 -4.93 -10.05 7.40 1.40 -14.66 -5.48 -12.81 13.13
Nucleolus 1.32 3.71 2.49 2.16 -2.46 2.54 4.51 7.35 4.02 4.42 2.43 5.40 5.13 4.21 -0.17
Nucleus 17.54 -14.10 7.46 -9.49 20.66 19.25 -9.64 16.81 -3.01 21.84 25.54 -16.72 17.32 -8.64 31.07
Peroxisomes 0.07 14.06 11.36 11.37 -3.57 -8.50 9.89 5.25 13.06 -3.84 -4.97 17.17 12.09 17.40 -5.27
Vacuole -21.13 -37.53 -44.44 -33.58 -12.36 -1.18 -20.20 -40.24 -39.74 -13.46 -16.46 -40.86 -60.27 -52.03 -17.38
Vacuole Periphery -3.24 8.74 0.56 2.73 -3.19 -3.72 5.76 2.20 5.73 -2.31 -4.94 10.06 2.01 5.78 -3.97
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1; upstream component for regulation through the small GTPase Rho5p; may form a complex with Lmo1p that acts as a GEF for Rho5p; interacts with Ino4p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein; DOCK proteins act as guanine nucleotide exchange factors
Localization
Cell Percentages cytoplasm (35%), ER (3%), mixed (43%)
Cell Cycle Regulation Yes
ER - S/G2 (0.00093)
Subcompartmental Group N/A

Dck1

Dck1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dck1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available