Standard name | |
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Human Ortholog | |
Description | ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 4 | 1 | 7 | 8 | 13 | – | 13 | 7 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 3 | 3 | 2 | 1 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | – | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud Site | 0 | 0 | 1 | 3 | 5 | 13 | 17 | 26 | 29 | – | 21 | 19 | 0 | 0 | 1 | 1 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 12 | 11 | 18 | 23 | 20 | 43 | 42 | 58 | 35 | – | 20 | 30 | 29 | 38 | 44 | 58 | 48 | 51 | 1 | 1 | 3 | 7 | 0 | 1 |
Endoplasmic Reticulum | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 1 | 0 | 0 | 12 | 16 | 17 | 1 | 0 | 1 | 0 | 2 | 0 |
Endosome | 1 | 0 | 0 | 0 | 3 | 0 | 1 | 0 | 0 | – | 0 | 0 | 1 | 1 | 0 | 7 | 7 | 3 | 5 | 3 | 2 | 2 | 3 | 2 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 1 | 2 | 0 | 2 | 0 | 0 | 2 |
Mitochondria | 2 | 47 | 110 | 114 | 93 | 240 | 329 | 498 | 406 | – | 269 | 351 | 6 | 4 | 11 | 35 | 10 | 70 | 2 | 3 | 3 | 1 | 3 | 6 |
Nucleus | 275 | 272 | 378 | 250 | 413 | 451 | 466 | 514 | 319 | – | 217 | 226 | 245 | 176 | 180 | 626 | 582 | 659 | 278 | 277 | 381 | 169 | 162 | 139 |
Nuclear Periphery | 0 | 4 | 1 | 1 | 3 | 4 | 5 | 7 | 2 | – | 3 | 1 | 2 | 2 | 2 | 27 | 12 | 7 | 1 | 0 | 0 | 0 | 2 | 4 |
Nucleolus | 2 | 2 | 1 | 2 | 7 | 9 | 10 | 10 | 13 | – | 12 | 3 | 2 | 3 | 8 | 14 | 7 | 8 | 1 | 0 | 3 | 5 | 15 | 14 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 2 | 0 | 1 | 1 | 4 | 1 | 10 | 11 | 3 | – | 3 | 2 | 2 | 1 | 1 | 10 | 4 | 4 | 1 | 1 | 4 | 1 | 4 | 3 |
Vac/Vac Membrane | 3 | 7 | 4 | 1 | 12 | 8 | 8 | 14 | 13 | – | 8 | 14 | 3 | 6 | 6 | 33 | 29 | 22 | 5 | 16 | 45 | 28 | 57 | 56 |
Unique Cell Count | 294 | 302 | 429 | 296 | 479 | 589 | 650 | 801 | 530 | 362 | 418 | 281 | 221 | 234 | 737 | 671 | 742 | 309 | 309 | 458 | 220 | 258 | 241 | |
Labelled Cell Count | 300 | 343 | 514 | 395 | 564 | 770 | 896 | 1148 | 834 | 568 | 655 | 292 | 231 | 253 | 825 | 717 | 844 | 309 | 309 | 458 | 220 | 258 | 241 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.2 | 5.0 | 4.3 | 4.2 | 4.4 | 4.0 | 3.9 | 3.6 | 3.3 | – | 3.2 | 2.9 | 5.8 | 5.6 | 5.1 | 7.8 | 8.3 | 7.5 | 6.4 | 6.1 | 6.9 |
Std Deviation (1e-4) | 1.1 | 0.9 | 0.8 | 1.1 | 1.0 | 1.2 | 1.9 | 1.1 | 1.2 | – | 0.9 | 1.0 | 1.3 | 1.4 | 1.1 | 2.1 | 1.8 | 1.6 | 2.3 | 1.3 | 1.5 |
Intensity Change (Log2) | – | – | – | -0.05 | 0.02 | -0.12 | -0.16 | -0.25 | -0.39 | – | -0.43 | -0.59 | 0.42 | 0.38 | 0.25 | 0.85 | 0.94 | 0.8 | 0.57 | 0.51 | 0.67 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 2.0 | 0 | 2.1 | 1.6 | 2.1 | 1.6 | – | 0.9 | 1.9 | 3.2 | 5.6 | 6.2 | 2.5 | 2.0 | 1.9 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 3.2 | 3.2 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | -8.3 | -7.6 | -6.7 | -10.4 | -12.5 | -7.4 |
Nucleus | -1.4 | -0.8 | -4.7 | -6.4 | -9.0 | -9.6 | – | -9.1 | -11.0 | -0.4 | -2.9 | -3.8 | -1.5 | -0.7 | 0.4 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 3.7 | 2.3 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 2.4 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 1.8 | 0.6 | 0 | 1.1 | 1.8 | – | 1.5 | 2.4 | 0 | 0 | 0 | 3.3 | 3.2 | 2.3 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.6832 | 5.1989 | 4.8328 | 4.5502 | 4.2696 | 4.6689 | 1.0389 | 1.0621 | 0.8838 | 0.6856 | 0.5893 | 0.9669 | 5.6992 | 6.1047 | 5.7857 | 5.8235 | 6.0636 | 5.9695 |
Actin | 0.057 | 0.0007 | 0.0008 | 0 | 0.0451 | 0.0009 | 0.0256 | 0 | 0.0099 | 0 | 0 | 0.0026 | 0.0116 | 0 | 0.0026 | 0.0063 | 0.0008 | 0.0003 |
Bud | 0.0007 | 0 | 0.0001 | 0 | 0.0014 | 0.0001 | 0.0004 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0003 | 0 | 0.0001 | 0.0001 | 0.0004 | 0.0001 |
Bud Neck | 0.0037 | 0.0003 | 0.0002 | 0.0001 | 0.0024 | 0.0015 | 0.0017 | 0.0002 | 0.0003 | 0.0002 | 0.0002 | 0.01 | 0.0007 | 0.0001 | 0.0041 | 0.0001 | 0.004 | 0.0011 |
Bud Periphery | 0.001 | 0.0001 | 0.0008 | 0 | 0.0031 | 0.0004 | 0.0008 | 0 | 0.0001 | 0.0001 | 0 | 0.0002 | 0.0007 | 0 | 0.0002 | 0.0001 | 0.0006 | 0.0001 |
Bud Site | 0.0092 | 0.0003 | 0.0002 | 0 | 0.0085 | 0.0002 | 0.0008 | 0.0002 | 0.0003 | 0 | 0 | 0.0002 | 0.002 | 0.0001 | 0.0006 | 0.0001 | 0.0119 | 0.0001 |
Cell Periphery | 0.0007 | 0 | 0.0002 | 0 | 0.0012 | 0.0003 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0.0003 | 0 |
Cytoplasm | 0.0197 | 0.0002 | 0.0001 | 0 | 0.0015 | 0.0001 | 0.0021 | 0.0003 | 0.0001 | 0 | 0 | 0.0002 | 0.0039 | 0.0003 | 0.001 | 0.0014 | 0.0009 | 0.0021 |
Cytoplasmic Foci | 0.014 | 0.0002 | 0.0002 | 0 | 0.0141 | 0.0003 | 0.0075 | 0.0014 | 0.001 | 0 | 0 | 0.0007 | 0.0046 | 0 | 0.0004 | 0.0061 | 0.0002 | 0.0002 |
Eisosomes | 0.0007 | 0 | 0.0001 | 0 | 0.0009 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0048 | 0.0001 | 0.0008 | 0 | 0.0029 | 0.0002 | 0.0024 | 0 | 0.0002 | 0 | 0 | 0.0004 | 0.0028 | 0.0001 | 0.0006 | 0.0011 | 0.001 | 0.0006 |
Endosome | 0.0125 | 0.0011 | 0.0012 | 0 | 0.0338 | 0.0015 | 0.014 | 0.0005 | 0.0011 | 0 | 0 | 0.0042 | 0.0071 | 0.0001 | 0.0014 | 0.0017 | 0.0011 | 0.0024 |
Golgi | 0.0098 | 0.0011 | 0.0015 | 0 | 0.0393 | 0.0007 | 0.0046 | 0.0001 | 0.002 | 0 | 0 | 0.0037 | 0.0026 | 0 | 0.0005 | 0.0035 | 0.0002 | 0.0004 |
Lipid Particles | 0.0167 | 0.0018 | 0.0023 | 0 | 0.041 | 0.0042 | 0.0083 | 0.0006 | 0.0019 | 0 | 0 | 0.0073 | 0.0118 | 0 | 0.0003 | 0.0014 | 0.0001 | 0.0004 |
Mitochondria | 0.0068 | 0.0039 | 0.0079 | 0.0001 | 0.0742 | 0.0115 | 0.0029 | 0.0001 | 0.0008 | 0.0001 | 0.0003 | 0.0062 | 0.0043 | 0.0001 | 0.0013 | 0.0018 | 0.0037 | 0.0003 |
None | 0.0031 | 0.0001 | 0.0001 | 0 | 0.0013 | 0.0001 | 0.0008 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0.0028 | 0.0001 | 0.0009 | 0.006 | 0.0002 | 0.0001 |
Nuclear Periphery | 0.0124 | 0.0031 | 0.002 | 0.0004 | 0.0129 | 0.0032 | 0.0238 | 0.0014 | 0.0056 | 0.0003 | 0.0364 | 0.0063 | 0.0206 | 0.0029 | 0.0071 | 0.0344 | 0.0127 | 0.0019 |
Nucleolus | 0.0126 | 0.0103 | 0.0123 | 0.0064 | 0.0133 | 0.033 | 0.0184 | 0.0154 | 0.0112 | 0.0116 | 0.0206 | 0.0199 | 0.0093 | 0.0094 | 0.0074 | 0.0025 | 0.0223 | 0.0254 |
Nucleus | 0.795 | 0.9742 | 0.9667 | 0.9927 | 0.6493 | 0.9364 | 0.8732 | 0.9712 | 0.9539 | 0.9872 | 0.9402 | 0.9349 | 0.903 | 0.9849 | 0.9654 | 0.9038 | 0.9327 | 0.9631 |
Peroxisomes | 0.0095 | 0.0001 | 0.0001 | 0 | 0.0398 | 0.0006 | 0.0016 | 0.0001 | 0.0017 | 0 | 0 | 0.0013 | 0.0035 | 0 | 0.0001 | 0.0274 | 0 | 0.0001 |
Punctate Nuclear | 0.0063 | 0.0016 | 0.0004 | 0.0001 | 0.0042 | 0.0005 | 0.0079 | 0.0081 | 0.0095 | 0.0002 | 0.0017 | 0.001 | 0.0056 | 0.0015 | 0.0044 | 0.0011 | 0.0027 | 0.0009 |
Vacuole | 0.0025 | 0.0003 | 0.0007 | 0.0001 | 0.0069 | 0.0018 | 0.0017 | 0.0003 | 0.0001 | 0.0001 | 0 | 0.0003 | 0.0014 | 0.0002 | 0.0006 | 0.0005 | 0.0016 | 0.0004 |
Vacuole Periphery | 0.0013 | 0.0004 | 0.001 | 0 | 0.003 | 0.0022 | 0.0012 | 0 | 0.0001 | 0.0001 | 0.0005 | 0.0005 | 0.0011 | 0.0001 | 0.0009 | 0.0006 | 0.0026 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 41.526 | 27.8413 | 30.3879 | 33.9172 | 28.7362 | 30.9625 | 34.6665 | 34.0283 | 31.5369 | 37.1021 |
Translational Efficiency | 0.4326 | 0.459 | 0.4054 | 0.3927 | 0.4181 | 0.499 | 0.3681 | 0.3111 | 0.3636 | 0.3382 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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