Standard name
Human Ortholog
Description Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; contains a nucleoplasmin-like fold and can form pentamers
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.1 0.12 0.09 0.05 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.13 0.16 0.24 0.15 0.12 0.24 0.24 0.13 0.19 0.2 0.18 0.19 0.15 0.07 0.1 0.1 0.15 0.05 0 0 0 0 0 0.05
Nucleus 0.42 0.47 0.15 0 0.13 0.1 0.08 0.06 0.07 0.07 0.09 0.06 0 0.05 0.07 0.12 0.15 0.1 0.26 0.28 0.08 0.1 0.08 0.07
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.64 0.73 0.85 0.95 0.83 0.82 0.79 0.79 0.79 0.79 0.8 0.8 0.87 0.82 0.77 0.79 0.83 0.91 0.61 0.66 0.79 0.7 0.66 0.63
Peroxisomes 0 0 0 0 0 0 0 0.07 0.06 0.07 0.06 0.06 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0.09 0.06 0.1 0.15 0.18 0.2 0.2 0.23 0.23 0.05 0.06 0.07 0 0 0 0 0 0.05 0.05 0.07 0.08
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0.05 0.06 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0
Bud 0 0 0 0 0 1 6 1 2 8 3 4 0 0 1 0 0 0 1 0 1 0 5 2
Bud Neck 0 0 0 3 0 5 5 2 1 3 2 5 1 2 3 0 0 0 0 0 1 0 1 3
Bud Site 0 0 1 0 5 6 19 12 19 16 16 31 0 0 3 0 0 0 – – – – – –
Cell Periphery 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Cytoplasm 3 1 6 4 5 8 6 5 9 4 7 2 22 50 52 29 12 5 0 0 0 0 4 2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 2 1 0 0 0 0 0 0
Endosome 0 0 1 2 6 7 2 6 8 1 2 3 1 6 3 2 0 0 7 0 3 7 12 16
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 5
Mitochondria 39 26 95 31 45 102 132 64 88 118 73 101 42 35 43 32 37 12 0 0 4 2 16 23
Nucleus 125 77 58 4 50 41 44 31 33 43 37 35 11 27 29 40 36 22 81 47 33 20 37 31
Nuclear Periphery 1 0 3 1 2 2 5 3 5 4 1 2 0 0 1 0 0 1 7 0 5 0 3 4
Nucleolus 191 119 329 197 307 340 432 398 357 459 326 437 246 421 337 255 204 207 188 112 314 134 320 292
Peroxisomes 0 0 3 4 4 13 24 34 25 40 23 34 3 5 10 3 4 4 0 0 1 0 6 4
SpindlePole 3 0 4 19 23 40 83 90 89 113 96 125 14 31 30 4 1 0 4 0 19 10 32 35
Vac/Vac Membrane 1 3 4 1 4 2 6 4 3 2 2 1 3 3 2 2 0 1 15 7 8 10 27 31
Unique Cell Count 298 163 389 208 372 417 550 506 453 579 409 544 282 512 439 324 247 228 308 170 397 194 483 461
Labelled Cell Count 363 226 506 266 451 567 764 650 639 811 588 780 343 580 515 370 296 254 308 170 397 194 483 461


Nucleolus, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 19.2 29.5 23.2 20.6 17.7 15.4 14.2 14.2 14.5 13.3 12.8 13.4 26.2 26.5 24.2 44.2 40.3 43.5 26.4 27.6 29.1
Std Deviation (1e-4) 5.5 7.8 6.7 6.8 5.0 5.7 5.3 5.4 8.2 6.0 5.1 6.3 13.2 13.9 14.9 22.9 15.6 16.2 9.3 8.9 10.4
Intensity Change (Log2) – – – -0.17 -0.39 -0.6 -0.71 -0.71 -0.68 -0.8 -0.86 -0.79 0.17 0.19 0.06 0.93 0.79 0.9 0.18 0.25 0.33

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000204060WT3HU80HU120HU1600204060WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30204060WT1AF100AF140AF1800204060
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 3.3 2.6 3.7 2.9 3.6 4.5 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 -0.2 0.4 0 0 0.5 0 0.2 0 4.0 5.1 5.8 4.6 2.5 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -2.7 -4.4 0 -0.1 -4.6 -1.8 -1.5 -2.3 -2.2 -3.0 -7.4 -5.6 -5.1 -2.9 -6.1
Nucleus -5.0 -0.6 -2.2 -3.4 -4.4 -3.6 -3.7 -2.6 -4.3 -4.6 -4.9 -3.9 -1.0 -0.1 -1.9
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 3.6 -0.8 -1.1 -2.3 -2.2 -2.1 -2.1 -1.8 -1.7 1.0 -0.9 -2.8 -2.0 -0.7 2.2
Peroxisomes 0 0 2.4 3.2 4.4 3.8 4.5 3.9 4.2 0 0 1.7 0 0 0
SpindlePole 4.9 3.8 5.3 7.3 8.1 8.6 8.7 9.6 9.6 3.1 3.9 4.2 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 16.5159 17.7839 17.4329 15.873 14.6593 17.9454 20.357 26.9536 23.94 20.8406 18.0963 23.3091 23.5348 28.9081 24.1549 23.5865 22.8126 23.0115
Actin 0.0062 0 0 0 0.0001 0 0.0099 0 0.0045 0.0366 0.0079 0.0022 0.0012 0 0 0 0 0
Bud 0.0001 0 0 0 0.0001 0 0.0004 0.0001 0 0.0003 0.0002 0.0001 0.0001 0 0 0 0 0.0001
Bud Neck 0.0006 0 0.0001 0.0001 0.0002 0.0001 0.0006 0.0001 0.0001 0.0035 0.0002 0.0001 0.0001 0 0 0 0 0.0001
Bud Periphery 0.0001 0 0 0.0002 0.0002 0.0001 0.0007 0.0001 0 0.0004 0.0004 0.0001 0.0001 0 0 0 0 0.0002
Bud Site 0.002 0.0001 0.0001 0.0001 0.0001 0 0.0054 0.0001 0.0002 0.0015 0.0009 0.0001 0.0004 0 0 0 0 0.0001
Cell Periphery 0.0002 0.0001 0.0001 0.0003 0.0004 0.0004 0.0006 0.0001 0.0002 0.0004 0.0007 0.0002 0.0002 0.0001 0 0.0001 0.0001 0.0003
Cytoplasm 0.0007 0 0.0007 0.0001 0.0002 0 0.0086 0 0.0008 0.0008 0.0006 0.0017 0.0074 0 0.0063 0 0 0
Cytoplasmic Foci 0.0055 0.0106 0.0011 0.0002 0.0157 0.002 0.0202 0.0006 0.0093 0.0132 0.0163 0.0016 0.0011 0 0.0023 0.0002 0.0007 0.002
Eisosomes 0.0001 0 0 0 0.0001 0 0.0002 0 0.0001 0.0003 0.0004 0 0.0002 0 0 0 0.0001 0
Endoplasmic Reticulum 0.0002 0 0.0001 0.0002 0 0 0.0088 0 0.0001 0.0023 0.0005 0.0003 0.0003 0 0 0 0 0
Endosome 0.0021 0 0.0019 0.0023 0.0004 0 0.0249 0 0.0017 0.0196 0.0325 0.002 0.0001 0 0 0 0 0
Golgi 0.0011 0.0001 0.0001 0.0003 0.0004 0.0001 0.0043 0 0.0044 0.0051 0.0132 0.0014 0.0001 0 0 0 0.0001 0.0001
Lipid Particles 0.0074 0.0289 0.0013 0.0055 0.0197 0.0112 0.0176 0.0008 0.0063 0.017 0.0199 0.0034 0.0011 0.0001 0.0009 0.0004 0.0059 0.0106
Mitochondria 0.0031 0.0001 0.0009 0.0007 0.0049 0.0018 0.0115 0.0002 0.0073 0.006 0.0525 0.0052 0.0084 0.0008 0.0004 0.0006 0.0028 0.003
None 0.001 0 0.0008 0.0001 0.0006 0 0.0036 0 0.0008 0.0019 0.0008 0.001 0.0007 0 0.0001 0 0 0.0001
Nuclear Periphery 0.0056 0.0014 0.0159 0.0211 0.0267 0.0023 0.0248 0.0007 0.0036 0.0078 0.0029 0.004 0.0004 0.0001 0.0001 0.0061 0.0011 0.0006
Nucleolus 0.8426 0.8508 0.9165 0.8043 0.7847 0.8991 0.7437 0.8664 0.8745 0.6992 0.7172 0.8681 0.8915 0.8856 0.9266 0.8484 0.9206 0.8893
Nucleus 0.1107 0.0984 0.0573 0.1406 0.1064 0.0768 0.0766 0.1275 0.0802 0.1679 0.1188 0.0991 0.0836 0.1124 0.0618 0.1417 0.0634 0.0844
Peroxisomes 0.0035 0.0002 0.0001 0.0001 0.0002 0.0001 0.0018 0 0.0017 0.0025 0.0025 0.0006 0.0001 0 0 0 0.0001 0.0001
Punctate Nuclear 0.0056 0.009 0.0018 0.0021 0.025 0.0023 0.0253 0.0026 0.0017 0.005 0.002 0.0016 0.0024 0.0007 0.001 0.0019 0.0038 0.0069
Vacuole 0.0009 0.0001 0.0006 0.008 0.0015 0.0007 0.0047 0.0002 0.0006 0.0038 0.0047 0.001 0.0003 0.0001 0.0001 0.0001 0.0001 0.0006
Vacuole Periphery 0.0006 0.0002 0.0007 0.0136 0.0124 0.003 0.0058 0.0005 0.002 0.0049 0.0048 0.0061 0.0003 0.0001 0.0002 0.0002 0.001 0.0013

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 145.0617 174.8538 187.4843 134.1508 154.1033 170.2362 109.5449 105.3366 102.0721 100.9054
Translational Efficiency 2.4756 2.1266 1.7336 2.5574 1.7948 1.456 1.7635 1.7637 1.529 1.8309

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1841 340 198 571 2246 1726 133 1148 4087 2066 331 1719

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1636.08 2049.68 2713.87 2968.93 1730.14 1962.76 2731.64 2952.83 1687.77 1977.06 2721.01 2958.18
Standard Deviation 469.09 557.39 544.18 864.50 415.59 462.12 528.32 929.79 442.98 480.18 537.93 908.66
Intensity Change Log 2 — 0.325155 0.730108 0.859700 — 0.181995 0.658879 0.771210 — 0.253350 0.693938 0.814897

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000603 0.000463 0.000499 0.001227 0.000509 0.000638 0.000598 0.001000 0.000552 0.000609 0.000539 0.001076
Bud Neck 0.000984 0.000833 0.002703 0.003919 0.000923 0.002539 0.004179 0.004653 0.000951 0.002259 0.003296 0.004409
Bud Site 0.000211 0.000119 0.000540 0.000754 0.000163 0.000400 0.000724 0.001459 0.000184 0.000354 0.000614 0.001225
Cell Periphery 0.000024 0.000011 0.000012 0.000056 0.000018 0.000054 0.000018 0.000255 0.000021 0.000047 0.000015 0.000189
Cytoplasm 0.000124 0.000029 0.000022 0.000121 0.000060 0.000419 0.000033 0.000262 0.000089 0.000355 0.000026 0.000215
Cytoplasmic Foci 0.006185 0.002120 0.009474 0.013533 0.003859 0.001894 0.009676 0.013858 0.004907 0.001931 0.009555 0.013750
Eisosomes 0.000244 0.000121 0.000188 0.000206 0.000299 0.000167 0.000189 0.000226 0.000274 0.000159 0.000188 0.000219
Endoplasmic Reticulum 0.000179 0.000078 0.000083 0.000136 0.000139 0.000197 0.000093 0.000170 0.000157 0.000177 0.000087 0.000159
Endosome 0.000020 0.000010 0.000019 0.000787 0.000026 0.000063 0.000017 0.000784 0.000023 0.000054 0.000018 0.000785
Golgi 0.000134 0.000074 0.000286 0.000521 0.000082 0.000093 0.000238 0.000423 0.000105 0.000090 0.000267 0.000455
Lipid Particles 0.000091 0.000015 0.000329 0.000613 0.000030 0.000041 0.000013 0.000185 0.000057 0.000036 0.000202 0.000327
Mitochondria 0.001425 0.001049 0.002407 0.005779 0.001107 0.001470 0.002393 0.006034 0.001250 0.001401 0.002401 0.005949
Mitotic Spindle 0.004129 0.004408 0.018813 0.008118 0.002720 0.003162 0.003309 0.009279 0.003355 0.003367 0.012583 0.008893
None 0.001138 0.000687 0.000316 0.000728 0.000448 0.000642 0.000396 0.000887 0.000759 0.000649 0.000348 0.000834
Nuclear Periphery 0.000305 0.000177 0.000481 0.003367 0.000245 0.000336 0.001231 0.003254 0.000272 0.000310 0.000783 0.003292
Nuclear Periphery Foci 0.000739 0.000181 0.000186 0.002192 0.000415 0.000375 0.000250 0.001777 0.000561 0.000343 0.000212 0.001915
Nucleolus 0.619787 0.602893 0.699718 0.709980 0.655288 0.528559 0.688488 0.691419 0.639297 0.540792 0.695206 0.697584
Nucleus 0.291176 0.344078 0.130772 0.173013 0.270847 0.438297 0.185780 0.190527 0.280004 0.422791 0.152875 0.184709
Peroxisomes 0.070847 0.041070 0.131984 0.061394 0.060295 0.018585 0.101192 0.061275 0.065048 0.022285 0.119611 0.061314
Vacuole 0.000464 0.000304 0.000482 0.002834 0.000638 0.000581 0.000426 0.002613 0.000560 0.000535 0.000459 0.002686
Vacuole Periphery 0.001191 0.001281 0.000685 0.010723 0.001890 0.001489 0.000757 0.009661 0.001575 0.001455 0.000714 0.010014

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 3.58 1.94 -6.34 -7.62 -6.85 -3.91 -1.24 -10.74 -6.89 -4.04 -2.25 0.03 -11.73 -9.28 -8.68
Bud Neck 1.68 -5.32 -8.45 -8.90 -2.48 -8.05 -3.98 -11.51 -5.61 -0.59 -7.77 -6.12 -14.04 -7.20 -2.49
Bud Site 3.76 -4.13 -5.79 -6.86 -1.64 -4.02 -5.13 -3.04 -2.42 -1.70 -3.51 -6.63 -3.60 -2.91 -2.08
Cell Periphery 4.86 4.37 -2.90 -4.03 -3.89 -2.15 -0.15 -1.57 -1.28 -1.56 -1.95 1.97 -1.67 -1.33 -1.72
Cytoplasm 3.67 3.98 -0.02 -2.23 -2.39 -1.52 1.11 -2.87 0.83 -3.32 -1.40 3.66 -2.60 0.87 -3.94
Cytoplasmic Foci 4.28 -0.89 -2.75 -4.39 -0.72 2.38 -1.29 -5.67 -7.04 -0.82 4.43 -1.59 -6.00 -8.20 -1.12
Eisosomes 3.40 1.32 0.96 -3.82 -0.54 9.04 5.47 3.66 -3.51 -1.64 6.31 3.73 2.61 -4.40 -1.55
Endoplasmic Reticulum 6.78 5.19 1.01 -1.38 -1.14 -1.92 1.62 -0.62 0.54 -1.33 -0.96 4.45 -0.07 0.52 -1.78
Endosome 2.56 0.16 -1.39 -1.41 -1.40 -1.79 0.58 -1.68 -1.59 -1.70 -2.04 0.57 -2.16 -2.06 -2.18
Golgi 3.47 -5.25 -1.85 -2.15 -1.09 -0.88 -4.51 -4.17 -3.97 -2.03 0.96 -7.37 -3.98 -4.11 -2.03
Lipid Particles 1.20 -0.76 -1.13 -1.31 -0.54 -1.00 1.57 -3.56 -3.09 -4.01 0.50 -0.78 -1.72 -1.84 -0.56
Mitochondria 2.93 -2.09 -6.29 -6.83 -4.05 -3.10 -2.90 -9.45 -8.64 -5.07 -1.61 -3.51 -11.26 -10.73 -6.58
Mitotic Spindle -0.06 -2.58 -1.64 -1.04 1.78 -0.43 -0.51 -3.46 -2.90 -2.73 -0.03 -2.67 -3.66 -3.16 1.11
None 1.61 3.77 1.82 -0.23 -6.18 -1.55 0.66 -4.90 -1.70 -5.87 0.68 3.90 -0.71 -1.53 -8.48
Nuclear Periphery 2.76 -1.09 -4.20 -4.38 -3.89 -0.93 -0.92 -3.62 -3.47 -1.53 -0.49 -1.16 -4.99 -4.87 -3.40
Nuclear Periphery Foci 2.99 3.02 -2.29 -3.41 -3.41 -0.09 0.97 -3.17 -3.07 -3.38 1.36 3.12 -3.75 -4.26 -4.88
Nucleolus 0.99 -4.92 -7.41 -5.66 -0.83 13.89 -1.20 -3.58 -14.99 -0.27 12.50 -3.95 -7.63 -16.89 -0.43
Nucleus -3.04 12.67 10.68 9.23 -2.91 -17.82 3.86 9.15 24.02 -0.13 -17.55 11.02 13.85 26.76 -2.57
Peroxisomes 5.94 -6.54 1.55 -3.42 6.90 17.33 -3.92 -0.62 -13.50 3.64 20.59 -7.79 0.82 -14.26 7.87
Vacuole 2.60 -0.29 -3.87 -4.14 -3.66 0.09 1.21 -5.21 -5.38 -6.02 -0.08 0.56 -6.64 -6.52 -6.73
Vacuole Periphery -0.33 2.24 -6.43 -6.39 -6.84 0.76 2.30 -5.68 -6.34 -6.98 0.35 2.97 -8.26 -8.61 -9.48
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; contains a nucleoplasmin-like fold and can form pentamers
Localization
Cell Percentages nucleolus (61%)
Cell Cycle Regulation No
Subcompartmental Group nucleolus-2

Fpr4

Fpr4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Fpr4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available