Standard name
Human Ortholog
Description HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.06 0.06 0 0 0 0 0 0 0.06 0 0.1 0.24 0.1 0.07 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0.15 0 0.07 0 0 0 0 0 0 0 0 0.05
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.11 0.09 0.08 0 0.13 0.09 0.09 0.15 0.15 0.13 0.13 0.15 0 0 0.07 0.06 0.06 0 0 0 0 0 0.06
Nucleus 0.06 0.07 0 0.05 0.07 0.06 0.12 0.17 0.22 0.21 0.19 0.2 0.08 0.12 0.09 0.12 0.15 0.08 0 0 0 0 0 0
Nuclear Periphery 0.79 0.8 0.81 0.77 0.71 0.69 0.67 0.61 0.57 0.61 0.58 0.59 0.33 0.53 0.41 0.55 0.54 0.54 0.92 0.86 0.9 0.85 0.74 0.52
Nucleolus 0.06 0 0.09 0.1 0.11 0.21 0.19 0.21 0.19 0.23 0.26 0.2 0.46 0.09 0.17 0.13 0.13 0.13 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.06 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.41 0.27 0.24 0.2 0.21 0.15 0.11 0.12 0.08 0 0.08 0.06 0.18 0.29 0.29 0.24 0.32 0.33 0 0 0 0.07 0.15 0.22
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 1 0 0 0
Bud 0 0 0 0 1 1 2 1 0 3 0 0 0 0 0 1 0 0 1 2 2 1 1 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 2 2 1 1 2 2 1 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 1 0 0 1 0 0 0 3 1 0 0 0 0 0 0 0 0
Cytoplasm 2 2 9 13 20 8 14 14 6 8 2 15 0 7 30 30 18 13 0 0 0 0 0 5
Endoplasmic Reticulum 2 1 2 0 3 3 0 3 0 2 0 0 0 1 0 7 7 3 0 1 2 1 1 5
Endosome 4 0 3 2 11 2 4 4 2 0 3 0 6 3 9 11 5 3 0 4 2 1 3 10
Golgi 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 1 1
Mitochondria 3 15 18 18 13 31 33 31 37 51 24 36 6 0 0 22 15 12 1 2 2 5 4 13
Nucleus 16 9 6 11 24 14 42 60 53 73 35 54 3 8 11 36 37 15 4 3 0 0 2 5
Nuclear Periphery 200 108 161 179 239 161 238 215 138 208 105 161 13 36 51 166 134 101 243 127 180 129 106 108
Nucleolus 16 6 18 24 37 49 67 75 47 77 46 55 18 6 21 40 32 24 0 0 0 0 0 6
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 1 0 0 2 1 7 5 3 1 0 0 1 0 1 0
Vac/Vac Membrane 103 37 48 46 71 34 39 43 20 14 15 17 7 20 36 73 80 62 9 5 5 10 22 45
Unique Cell Count 252 135 200 232 336 233 357 355 242 342 180 271 39 68 123 300 247 187 266 148 201 152 144 210
Labelled Cell Count 346 178 265 293 420 303 441 449 304 438 233 340 57 82 168 396 331 234 266 148 201 152 144 210


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.1 8.3 9.2 9.1 9.8 9.6 9.1 9.2 8.6 8.4 8.7 8.7 7.5 8.8 8.9 10.4 11.5 14.8 9.9 10.9 11.5
Std Deviation (1e-4) 1.6 1.6 2.3 2.1 2.7 2.8 2.7 3.2 2.5 3.2 2.8 3.0 1.3 1.5 2.0 3.2 3.9 4.1 1.9 2.1 2.6
Intensity Change (Log2) – – – -0.03 0.08 0.06 -0.02 0.0 -0.1 -0.13 -0.08 -0.09 -0.31 -0.07 -0.04 0.17 0.32 0.68 0.1 0.24 0.32


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.5 0.7 -0.6 -0.3 -0.3 -1.2 -1.4 -2.0 0.5 0 0 5.3 2.2 1.2 1.0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 1.2 0 0 0 0 0 0 0 0 0 0 1.4 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -0.5 -2.5 1.4 0.1 -0.1 2.0 2.0 1.3 1.4 0 0 -3.4 -0.7 -1.2 -0.9
Nucleus 0.9 2.0 1.5 3.5 4.9 5.8 5.8 5.2 5.4 0 0 2.3 3.6 4.3 2.2
Nuclear Periphery -0.8 -2.4 -2.7 -3.5 -4.8 -5.3 -4.7 -4.7 -4.9 -6.1 -4.4 -7.2 -5.8 -5.8 -5.6
Nucleolus 0.5 0.7 3.5 3.1 3.7 3.1 4.0 4.3 3.3 5.9 0 2.2 1.5 1.3 1.2
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.0 -0.8 -2.5 -4.1 -3.6 -4.6 -7.0 -4.1 -5.5 -0.8 0.9 1.0 0.1 2.0 2.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.844 7.1792 6.3397 5.2856 5.5605 5.6892 6.8568 6.6244 6.9831 6.4829 6.4338 6.8237 6.1098 5.8929 6.6838 5.1042 5.6659 5.8559
Actin 0.0247 0.0003 0.0045 0.0053 0.0004 0.0068 0.0201 0.0001 0.0085 0.0019 0.0009 0.0001 0.0001 0.0005 0.0007 0.0932 0.0002 0.0001
Bud 0.0002 0 0 0.0002 0 0 0.0001 0 0.0001 0 0.0001 0 0 0.0001 0 0.0001 0 0
Bud Neck 0.0007 0.0001 0.0001 0.0002 0 0.0009 0.0003 0 0.0006 0 0.0002 0 0 0 0 0.0001 0 0.0001
Bud Periphery 0.0004 0.0002 0.0001 0.0003 0.0001 0.0001 0.0003 0.0001 0.0002 0.0001 0.0002 0 0 0.0004 0.0004 0.0002 0.0001 0.0001
Bud Site 0.0015 0.0001 0.0002 0.0018 0 0.0001 0.0006 0 0.0002 0 0.001 0 0 0 0 0.0005 0 0
Cell Periphery 0.0001 0.0001 0.0001 0.0001 0 0 0.0001 0.0001 0.0001 0 0.0003 0 0 0.0001 0.0001 0.0001 0 0
Cytoplasm 0.0032 0.0002 0.0055 0.0057 0.0001 0.0003 0.0006 0.0001 0.0003 0.0005 0.0017 0 0 0.0013 0.0001 0.0002 0.0001 0
Cytoplasmic Foci 0.0093 0 0.0036 0.0232 0.0037 0.0012 0.0122 0 0.0009 0.0062 0.005 0 0 0 0 0.0165 0 0
Eisosomes 0.0003 0 0.0001 0.0001 0 0 0.0002 0 0 0 0 0 0 0 0.0001 0.0001 0 0
Endoplasmic Reticulum 0.0056 0.005 0.0056 0.0165 0.0052 0.0026 0.0039 0.0066 0.0098 0.0069 0.021 0.0012 0.002 0.0276 0.0267 0.011 0.0085 0.0043
Endosome 0.0144 0.0009 0.0071 0.031 0.0022 0.0057 0.016 0.0005 0.0034 0.0125 0.0262 0.0003 0.0005 0.0016 0.0012 0.0015 0.0017 0.0005
Golgi 0.0051 0.0001 0.0012 0.005 0.0009 0.0025 0.0086 0.0001 0.0008 0.0026 0.0023 0.0002 0.0001 0.0002 0.0002 0.004 0.0002 0.0001
Lipid Particles 0.015 0.0008 0.0027 0.0495 0.0236 0.0106 0.0477 0.0005 0.0057 0.0123 0.0309 0.0016 0.0009 0.0006 0.0009 0.0077 0.0005 0.0006
Mitochondria 0.0052 0.0046 0.0021 0.0059 0.0014 0.0009 0.0049 0.0011 0.0017 0.0015 0.0019 0.0002 0.0007 0.0034 0.0133 0.0017 0.0013 0.0013
None 0.013 0.0001 0.0031 0.009 0.0002 0.0001 0.0009 0.0001 0.0003 0.0007 0.0005 0 0.0002 0.002 0.0004 0.0003 0.0001 0.0001
Nuclear Periphery 0.8326 0.864 0.8685 0.7652 0.9137 0.9266 0.8157 0.9092 0.8891 0.8801 0.8331 0.9746 0.9338 0.8672 0.8427 0.7522 0.9264 0.9631
Nucleolus 0.0016 0.0063 0.0003 0.0013 0.0005 0.0006 0.0004 0.0005 0.0004 0.0002 0.0018 0.0002 0.0002 0.0004 0.0002 0.0001 0.0001 0.0004
Nucleus 0.0239 0.0693 0.039 0.0172 0.0128 0.0164 0.0032 0.0139 0.0047 0.0028 0.0066 0.0021 0.0033 0.0202 0.0084 0.0026 0.0063 0.0046
Peroxisomes 0.0062 0.0001 0.0021 0.0049 0.0006 0.0018 0.0188 0 0.0002 0.0031 0.0004 0 0 0 0 0.0512 0 0
Punctate Nuclear 0.0065 0.0005 0.003 0.0122 0.0013 0.001 0.0043 0.0001 0.001 0.0087 0.0029 0.0003 0.0003 0.0007 0.0003 0.0007 0.0002 0.0003
Vacuole 0.0019 0.0022 0.0017 0.0023 0.001 0.0019 0.0014 0.0025 0.0025 0.001 0.0208 0.0004 0.0008 0.0029 0.0035 0.0014 0.0029 0.0008
Vacuole Periphery 0.0285 0.0449 0.0494 0.043 0.0323 0.0199 0.0398 0.0645 0.0696 0.0588 0.042 0.0188 0.0569 0.0708 0.1008 0.0549 0.0515 0.0236

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 51.1617 36.7769 25.6573 30.5481 27.5819 50.6062 35.4371 34.8576 34.4312 35.033
Translational Efficiency 0.7107 0.6277 0.7355 0.6387 0.6007 0.6351 0.599 0.476 0.5313 0.5442

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
179 1308 195 180 980 249 1978 1784 1159 1557 2173 1964

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1013.67 1029.24 1549.42 1181.30 756.60 1011.34 1099.96 1093.41 796.30 1026.38 1140.29 1101.47
Standard Deviation 141.22 179.05 253.65 172.90 133.80 133.14 158.82 175.93 163.85 172.65 212.69 177.48
Intensity Change Log 2 — 0.021991 0.612140 0.220787 — 0.418665 0.539848 0.531232 — 0.205010 0.581685 0.361713

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000404 0.000306 0.000219 0.000150 0.000472 0.000175 0.000296 0.000217 0.000462 0.000285 0.000289 0.000211
Bud Neck 0.001561 0.000265 0.001356 0.000784 0.000358 0.000099 0.001469 0.000744 0.000544 0.000239 0.001459 0.000748
Bud Site 0.002418 0.000083 0.000119 0.000039 0.000247 0.000056 0.000170 0.000160 0.000582 0.000079 0.000165 0.000148
Cell Periphery 0.000040 0.000068 0.000021 0.000014 0.000244 0.000025 0.000037 0.000042 0.000212 0.000061 0.000036 0.000040
Cytoplasm 0.001761 0.000555 0.000050 0.000053 0.005209 0.000196 0.001463 0.000602 0.004677 0.000497 0.001336 0.000551
Cytoplasmic Foci 0.005825 0.000496 0.001771 0.000356 0.002388 0.002588 0.000096 0.000769 0.002919 0.000831 0.000247 0.000731
Eisosomes 0.000008 0.000005 0.000015 0.000003 0.000011 0.000004 0.000007 0.000005 0.000010 0.000005 0.000008 0.000005
Endoplasmic Reticulum 0.006585 0.011297 0.002125 0.003356 0.048058 0.016739 0.007044 0.004191 0.041653 0.012167 0.006602 0.004115
Endosome 0.009631 0.002085 0.000507 0.000602 0.005948 0.002793 0.001245 0.001995 0.006517 0.002198 0.001178 0.001867
Golgi 0.007988 0.000238 0.000332 0.000118 0.000420 0.002794 0.000080 0.000252 0.001588 0.000647 0.000103 0.000240
Lipid Particles 0.004246 0.002772 0.001024 0.000793 0.010342 0.003659 0.000389 0.001505 0.009401 0.002914 0.000446 0.001440
Mitochondria 0.011696 0.003052 0.000826 0.000532 0.008389 0.005134 0.002526 0.001350 0.008900 0.003385 0.002373 0.001275
Mitotic Spindle 0.031174 0.000891 0.003401 0.003581 0.000355 0.001121 0.004542 0.007086 0.005115 0.000928 0.004439 0.006765
None 0.000184 0.001102 0.000131 0.000071 0.010345 0.000102 0.001147 0.000351 0.008776 0.000942 0.001056 0.000325
Nuclear Periphery 0.258737* 0.586710* 0.607484* 0.585755* 0.463570* 0.489006* 0.551604* 0.456748* 0.431935* 0.571085* 0.556619* 0.468571*
Nuclear Periphery Foci 0.624246* 0.348090* 0.316036* 0.372529* 0.377270* 0.462663* 0.277890* 0.477438* 0.415414* 0.366413* 0.281314* 0.467823*
Nucleolus 0.003766 0.013319 0.042974 0.016053 0.020697 0.003639 0.047600 0.024678 0.018082 0.011771 0.047185 0.023887
Nucleus 0.005201 0.017983 0.014434 0.011319 0.035499 0.004729 0.098054 0.016876 0.030819 0.015863 0.090550 0.016367
Peroxisomes 0.000191 0.000417 0.001113 0.000188 0.000717 0.000370 0.000227 0.000253 0.000635 0.000409 0.000307 0.000247
Vacuole 0.014435 0.005357 0.002892 0.001407 0.005548 0.002383 0.002263 0.002367 0.006920 0.004881 0.002319 0.002279
Vacuole Periphery 0.009900 0.004909 0.003172 0.002297 0.003914 0.001724 0.001850 0.002372 0.004838 0.004400 0.001969 0.002365

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.64 0.92 1.14 3.74 1.82 3.88 2.87 4.71 -0.74 3.00 2.72 2.54 3.96 2.19 3.21
Bud Neck 2.75 0.98 1.93 -2.55 1.86 2.33 -5.68 -2.57 -7.45 4.39 2.78 -4.37 -0.59 -6.18 4.63
Bud Site 2.15 2.11 2.18 1.93 1.70 2.91 0.64 1.12 -2.08 0.74 2.71 2.16 2.36 -1.52 0.91
Cell Periphery -1.57 2.29 2.99 4.77 1.60 6.35 6.03 5.76 -1.77 -0.52 5.05 6.08 5.82 1.75 -0.43
Cytoplasm 2.11 2.60 2.60 2.89 0.06 5.06 3.56 4.50 -1.73 2.87 5.02 3.87 4.85 -0.26 2.88
Cytoplasmic Foci 2.29 1.71 2.37 0.65 4.13 -0.06 2.94 1.99 1.02 -2.47 2.54 3.54 2.77 0.25 -1.93
Eisosomes 1.84 -0.91 2.56 2.90 3.63 4.00 2.85 4.58 -0.87 2.20 5.39 2.35 5.01 -0.40 3.30
Endoplasmic Reticulum -2.91 4.14 2.32 5.65 -1.15 6.26 13.23 14.13 3.16 4.63 10.47 13.16 14.07 7.31 4.38
Endosome 3.86 4.62 4.59 4.18 -0.55 2.19 6.61 5.11 0.60 -1.91 5.87 7.92 6.43 0.69 -1.93
Golgi 1.93 1.91 1.97 1.45 5.07 -1.21 2.85 1.10 1.30 -1.62 1.30 2.37 2.13 1.25 -1.41
Lipid Particles 1.26 3.17 3.38 2.96 0.94 4.33 7.92 6.93 2.30 -4.60 5.29 8.34 7.29 2.50 -4.47
Mitochondria 1.63 2.08 2.13 5.34 2.30 1.00 5.76 6.99 1.21 5.06 4.18 5.54 6.54 3.24 5.18
Mitotic Spindle 3.67 3.37 3.40 -2.19 0.16 -1.62 -4.60 -4.85 -4.12 -1.08 3.24 0.71 -0.15 -4.54 -1.06
None -3.14 0.73 1.98 3.68 1.22 5.59 4.91 5.45 -3.44 2.82 4.99 4.85 5.44 2.51 2.84
Nuclear Periphery -15.13* -12.76 -11.67 0.04 0.72 -1.34 -7.34 0.63 1.81 9.75 -12.86 -11.27 -3.55 11.42 9.50
Nuclear Periphery Foci 10.12 10.20 7.65 -1.27 -2.43 -4.54 9.84 -9.50 -0.80 -23.73* 4.38 13.22 -5.28 -11.70 -23.43
Nucleolus -4.63 -4.41 -2.62 -0.58 2.81 6.15 -7.61 -1.27 -8.45 6.80 2.54 -8.97 -2.02 -5.04 7.31
Nucleus -4.14 -2.28 -1.36 1.81 0.81 7.51 -10.60 4.52 -5.49 16.48 4.17 -11.28 4.10 -0.37 16.39
Peroxisomes -1.41 -3.56 0.79 1.94 3.87 2.06 4.23 3.99 0.85 -0.55 1.53 3.31 4.00 1.64 1.67
Vacuole 2.82 3.20 3.53 4.20 1.12 1.99 2.68 2.61 -0.00 -0.11 2.11 4.13 4.19 3.02 0.13
Vacuole Periphery 1.36 1.86 2.12 3.03 0.99 2.39 3.59 2.45 -0.79 -1.32 0.44 3.90 3.20 3.01 -1.08
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant
Localization
Cell Percentages nuclear periphery (74%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Hmg2

Hmg2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hmg2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available