Standard name
Human Ortholog
Description Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.05 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0.06 0.06 0 0 0 0.15 0 0
Bud 0 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.13 0.14 – 0.18 0.22 0.16 0.14 – 0.06 0.13 0.08 0.1 – 0.17 0.23 0.1 0.1 0.17 0 0 0 0 0.09 0.19
Endoplasmic Reticulum 0.74 0.74 – 0.6 0.8 0.71 0.48 – 0.33 0.26 0.07 0.13 – 0.72 0.58 0 0 0.05 0.84 0.82 0.78 0.57 0.44 0.43
Endosome 0 0 – 0 0 0 0 – 0 0 0 0 – 0.06 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 – 0.07 0 0 0 – 0 0 0 0 – 0.06 0 0.66 0.52 0.43 0 0 0 0 0.06 0
Mitochondria 0.16 0 – 0 0 0.06 0.08 – 0.29 0.24 0.59 0.39 – 0 0 0.06 0.06 0.05 0 0 0 0.19 0.12 0
Nucleus 0 0 – 0 0 0 0 – 0.06 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.06 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.09 0.15 – 0.18 0.12 0.11 0.4 – 0.31 0.48 0.27 0.38 – 0.17 0.21 0.35 0.43 0.4 0 0 0.07 0 0.13 0.22
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 6 7 – 2 1 3 2 – 1 0 0 0 – 0 0 9 11 8 6 2 0 1 0 0
Bud 1 1 – 0 1 0 1 – 0 1 0 0 – 0 0 0 0 0 1 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 – – – – – –
Cell Periphery 0 3 – 0 1 3 3 – 0 1 0 0 – 0 0 9 7 5 0 0 0 0 0 0
Cytoplasm 19 21 – 8 11 13 15 – 3 12 5 8 – 3 10 28 20 22 1 3 0 0 4 12
Endoplasmic Reticulum 105 111 – 27 41 57 51 – 16 23 4 10 – 13 25 8 6 6 150 134 16 4 21 28
Endosome 3 0 – 0 0 1 0 – 0 1 1 1 – 1 0 2 6 3 3 3 0 0 2 1
Golgi 3 6 – 3 1 2 1 – 1 1 0 0 – 1 0 185 104 56 2 5 0 0 2 0
Mitochondria 22 3 – 2 0 5 8 – 14 21 35 31 – 0 0 17 11 7 5 5 0 1 5 1
Nucleus 0 0 – 0 0 0 1 – 3 4 1 3 – 0 1 2 1 0 0 0 0 0 0 1
Nuclear Periphery 8 0 – 0 1 0 0 – 2 3 2 2 – 0 0 4 0 1 0 0 0 0 1 0
Nucleolus 0 0 – 1 0 0 0 – 0 0 0 0 – 0 0 1 0 2 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 0 – 0 0 0 0 – 0 0 0 0 1 0 0 0 0 0 0
Vac/Vac Membrane 13 22 – 8 6 9 42 – 15 43 16 30 – 3 9 100 86 52 7 6 1 0 6 14
Unique Cell Count 141 150 45 51 80 106 48 89 59 79 18 43 282 200 129 180 165 21 8 49 66
Labelled Cell Count 180 174 51 63 93 124 55 110 64 85 21 45 365 252 163 180 165 21 8 49 66


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.9 11.3 – 9.0 10.3 8.6 8.7 – 7.6 7.7 7.2 7.4 – 11.4 10.9 18.2 16.9 16.3 – – 9.9
Std Deviation (1e-4) 1.6 2.1 – 1.3 1.3 1.3 1.4 – 1.2 1.3 1.2 1.2 – 1.2 1.5 4.5 3.4 4.7 – – 1.4
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –

RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70005101520HU120HU16005101520rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.0432 6.1161 5.6453 5.0814 4.2418 5.5561 6.3782 6.7447 6.6001 5.9523 5.0457 6.3626 5.1991 5.61 5.1644 5.1263 3.949 5.5572
Actin 0.0055 0.0012 0.0043 0.0044 0.0058 0.0024 0.0137 0.0013 0.0074 0.0051 0.0033 0.0122 0.0198 0.0016 0.0215 0.0012 0.0582 0.001
Bud 0.0005 0.0005 0.0018 0.0007 0.001 0.0007 0.0003 0.0001 0.0002 0.0003 0.0002 0.0004 0.0002 0.0001 0.0006 0.0002 0.0008 0.0001
Bud Neck 0.0006 0.0005 0.0004 0.0014 0.0014 0.0011 0.0005 0.0002 0.0005 0.0008 0.0004 0.0149 0.0008 0.0006 0.0007 0.0009 0.0019 0.0005
Bud Periphery 0.0007 0.0007 0.0014 0.0007 0.0018 0.0006 0.0006 0.0001 0.0004 0.0008 0.0004 0.001 0.0005 0.0002 0.0005 0.0008 0.0011 0.0001
Bud Site 0.0013 0.008 0.0019 0.0038 0.0025 0.0004 0.0014 0.0007 0.0027 0.0014 0.0003 0.0004 0.0009 0.0017 0.002 0.0002 0.0024 0.0001
Cell Periphery 0.001 0.0016 0.0011 0.0006 0.0008 0.0009 0.0008 0.0008 0.0009 0.001 0.0005 0.0015 0.0008 0.0012 0.0007 0.0014 0.0007 0.0005
Cytoplasm 0.0306 0.0404 0.0147 0.0083 0.0165 0.0196 0.0257 0.0556 0.0481 0.0233 0.0256 0.047 0.0236 0.0467 0.0421 0.0095 0.0338 0.035
Cytoplasmic Foci 0.033 0.0112 0.0174 0.014 0.0419 0.0195 0.0382 0.0244 0.0174 0.0277 0.0308 0.0182 0.0186 0.0191 0.0244 0.0033 0.0387 0.0101
Eisosomes 0.0002 0.0001 0.0001 0.0001 0.0005 0.0001 0.0002 0 0.0001 0.0001 0.0001 0.0002 0.0003 0 0.0005 0.0001 0.0005 0
Endoplasmic Reticulum 0.4249 0.6621 0.6369 0.6172 0.3271 0.6133 0.5392 0.6463 0.6607 0.5739 0.5732 0.6078 0.562 0.6332 0.674 0.7724 0.4984 0.6237
Endosome 0.1232 0.0805 0.1163 0.1104 0.1648 0.0864 0.0878 0.1076 0.0945 0.1177 0.135 0.0821 0.0959 0.1169 0.0831 0.0782 0.1003 0.1014
Golgi 0.023 0.0135 0.0328 0.0509 0.083 0.0252 0.0275 0.015 0.0268 0.0511 0.07 0.0265 0.0145 0.0186 0.0233 0.0141 0.0453 0.0204
Lipid Particles 0.0903 0.0732 0.0592 0.0501 0.0935 0.0815 0.0862 0.0766 0.0653 0.1141 0.0653 0.0322 0.0672 0.0794 0.0374 0.0159 0.0656 0.061
Mitochondria 0.0296 0.0068 0.0267 0.0299 0.1481 0.0144 0.0093 0.0032 0.0054 0.0066 0.0134 0.0227 0.0132 0.003 0.0123 0.0096 0.024 0.005
None 0.0211 0.0022 0.0013 0.0004 0.002 0.0048 0.0083 0.0011 0.0008 0.0016 0.0008 0.0007 0.0076 0.0007 0.0022 0.0005 0.0024 0.0006
Nuclear Periphery 0.1247 0.0502 0.0468 0.0344 0.023 0.0731 0.0879 0.044 0.046 0.0195 0.0416 0.1005 0.1165 0.0455 0.0473 0.0653 0.0481 0.1089
Nucleolus 0.0052 0.0011 0.0016 0.0006 0.004 0.0036 0.0007 0.0001 0.0001 0.0008 0.0001 0.0002 0.0006 0.0005 0.0003 0 0.0014 0.0001
Nucleus 0.0137 0.016 0.0035 0.0467 0.0149 0.0132 0.0137 0.0021 0.002 0.0017 0.0012 0.0035 0.0044 0.003 0.002 0.0018 0.006 0.0055
Peroxisomes 0.0176 0.0006 0.0013 0.0027 0.011 0.0013 0.0088 0.0007 0.001 0.0153 0.0214 0.0028 0.017 0.0006 0.006 0.0001 0.0064 0.0002
Punctate Nuclear 0.015 0.0022 0.0021 0.0052 0.0224 0.0107 0.0289 0.0012 0.0024 0.0117 0.0009 0.0016 0.0048 0.0021 0.0036 0.0002 0.026 0.0011
Vacuole 0.0232 0.0216 0.0206 0.011 0.0233 0.0168 0.0149 0.0153 0.0118 0.0187 0.0071 0.0153 0.0198 0.0208 0.0096 0.015 0.0293 0.0159
Vacuole Periphery 0.015 0.0058 0.0076 0.0064 0.0106 0.0104 0.0056 0.0035 0.0056 0.0068 0.0082 0.0085 0.0109 0.0044 0.0057 0.0092 0.009 0.0089

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 27.9781 16.2991 21.6869 20.5605 22.0094 36.4456 25.5724 23.0129 24.8259 25.2031
Translational Efficiency 0.7705 1.2101 0.9365 1.0976 0.8677 0.6493 0.7188 0.9542 0.9432 0.8495

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
141 1149 738 1340 1804 1860 1543 306 1945 3009 2281 1646

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1103.69 1012.70 1397.68 1321.20 985.59 942.96 1281.88 1434.65 994.15 969.59 1319.35 1342.29
Standard Deviation 241.20 162.52 203.47 224.36 135.29 140.18 172.94 197.06 148.77 152.91 191.21 223.94
Intensity Change Log 2 — -0.124128 0.340699 0.259514 — -0.063791 0.379202 0.541639 — -0.095350 0.358990 0.399492

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003069 0.003009 0.002204 0.004435 0.001762 0.002250 0.003819 0.001901 0.001856 0.002540 0.003296 0.003964
Bud Neck 0.003470 0.000846 0.001822 0.002929 0.000454 0.000877 0.001824 0.004570 0.000673 0.000865 0.001823 0.003234
Bud Site 0.012475 0.009928 0.016242 0.023131 0.004235 0.006605 0.005826 0.022064 0.004833 0.007874 0.009196 0.022933
Cell Periphery 0.001507 0.000775 0.001735 0.006594 0.000747 0.000648 0.000461 0.003153 0.000802 0.000696 0.000873 0.005955
Cytoplasm 0.002645 0.014480 0.030810 0.024083 0.015797 0.016702 0.017236 0.018325 0.014844 0.015854 0.021627 0.023013
Cytoplasmic Foci 0.064239 0.081092 0.014514 0.021103 0.053288 0.079266 0.014910 0.019992 0.054082 0.079963 0.014782 0.020897
Eisosomes 0.000117 0.000136 0.000045 0.000287 0.000379 0.000155 0.000058 0.000186 0.000360 0.000148 0.000054 0.000268
Endoplasmic Reticulum 0.169630 0.575207 0.753035 0.714199 0.679077 0.514682 0.656323 0.626861 0.642145 0.537793 0.687613 0.697963
Endosome 0.261915 0.092075 0.039453 0.042783 0.065499 0.080479 0.065677 0.064018 0.079737 0.084907 0.057193 0.046731
Golgi 0.143235 0.071481 0.016504 0.029879 0.065343 0.084398 0.016514 0.027500 0.070990 0.079465 0.016511 0.029437
Lipid Particles 0.047295 0.030100 0.016676 0.074664 0.043737 0.059149 0.059527 0.095112 0.043995 0.048057 0.045663 0.078465
Mitochondria 0.019265 0.018239 0.000632 0.001778 0.010976 0.028825 0.000783 0.000651 0.011577 0.024782 0.000734 0.001568
Mitotic Spindle 0.007926 0.002675 0.002953 0.004500 0.000722 0.005039 0.006514 0.011083 0.001244 0.004136 0.005362 0.005723
None 0.000377 0.001347 0.002148 0.001313 0.002238 0.001975 0.001219 0.000215 0.002103 0.001735 0.001520 0.001109
Nuclear Periphery 0.005178 0.004219 0.005559 0.000537 0.003158 0.008674 0.008706 0.001524 0.003304 0.006973 0.007688 0.000721
Nuclear Periphery Foci 0.038735 0.041299 0.059354 0.017723 0.030268 0.041674 0.117209 0.048233 0.030882 0.041531 0.098490 0.023395
Nucleolus 0.004789 0.000099 0.000024 0.000043 0.000097 0.000301 0.000028 0.000087 0.000437 0.000224 0.000027 0.000051
Nucleus 0.010353 0.000684 0.000794 0.001207 0.000507 0.001353 0.001095 0.000822 0.001221 0.001098 0.000998 0.001135
Peroxisomes 0.005374 0.001408 0.000103 0.000847 0.001641 0.002901 0.000319 0.000340 0.001911 0.002331 0.000249 0.000753
Vacuole 0.142959 0.028615 0.030551 0.023282 0.009252 0.036168 0.020207 0.047972 0.018945 0.033284 0.023554 0.027872
Vacuole Periphery 0.055448 0.022287 0.004842 0.004682 0.010822 0.027879 0.001746 0.005389 0.014058 0.025744 0.002747 0.004813

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.09 0.88 -1.32 -1.70 -2.57 -0.91 -3.16 -0.58 0.31 2.55 -1.51 -2.87 -3.24 -2.22 -0.89
Bud Neck 5.00 2.89 0.01 -4.97 -2.87 -3.86 -7.13 -5.68 -5.16 -3.76 -1.94 -7.45 -6.79 -6.40 -3.90
Bud Site 1.11 -1.25 -3.90 -5.48 -2.22 -2.72 -2.30 -4.34 -3.78 -3.88 -3.75 -4.32 -9.09 -7.53 -6.41
Cell Periphery 4.11 -0.84 -6.65 -7.73 -6.22 0.92 3.64 -5.47 -5.68 -6.19 1.19 -0.76 -8.31 -8.50 -8.18
Cytoplasm -8.14 -8.97 -10.61 -4.71 1.79 -0.64 -1.23 -1.49 -1.29 -1.00 -0.81 -4.41 -4.77 -4.55 -0.99
Cytoplasmic Foci -1.86 5.87 5.10 14.56 -2.70 -7.06 14.16 9.01 14.92 -1.57 -8.05 15.57 12.15 21.99 -3.35
Eisosomes -0.89 4.18 -3.26 -2.88 -4.78 0.89 1.28 0.77 -0.63 -2.85 0.91 1.32 0.39 -2.81 -5.12
Endoplasmic Reticulum -18.55 -26.12 -25.39 -9.89 2.91 14.47 2.51 3.04 -4.35 1.69 10.27 -3.82 -4.28 -14.60 -0.79
Endosome 10.14 13.39 13.26 13.24 -1.05 -4.57 -0.20 0.25 3.14 0.37 -1.59 6.76 10.34 14.82 4.25
Golgi 4.74 8.58 7.65 9.47 -4.44 -4.21 14.96 7.54 10.76 -2.44 -2.15 17.06 11.59 15.52 -5.65
Lipid Particles 1.87 3.30 -2.78 -9.89 -12.73 -4.18 -4.12 -4.92 -3.39 -3.24 -1.38 -0.72 -7.76 -7.06 -7.13
Mitochondria 0.16 3.07 2.87 7.85 -2.74 -8.84 9.58 9.77 16.24 0.56 -7.75 10.10 8.96 16.94 -2.32
Mitotic Spindle 1.48 1.35 0.87 -1.44 -1.04 -4.63 -5.99 -2.79 -1.71 -1.21 -4.37 -5.57 -3.65 -1.35 -0.17
None -3.76 -1.32 -2.33 0.06 0.59 0.43 1.74 4.93 3.75 2.25 0.77 0.95 2.02 1.43 0.64
Nuclear Periphery 0.57 -0.20 2.89 6.67 5.68 -6.14 -6.46 3.59 8.17 8.62 -5.62 -6.31 7.24 11.17 11.46
Nuclear Periphery Foci -0.34 -2.62 2.85 7.01 8.95 -3.56 -16.56 -3.01 -1.26 8.39 -4.01 -16.67 2.53 6.51 18.34
Nucleolus 1.74 1.77 1.76 2.61 -2.61 -3.35 1.77 -0.63 1.49 -1.49 1.06 2.05 1.85 4.56 -2.20
Nucleus 1.84 1.81 1.65 -1.48 -1.24 -5.06 -2.84 -1.72 -0.25 -0.42 0.31 0.28 -0.59 -0.95 -0.90
Peroxisomes 1.17 1.55 1.33 2.47 -5.14 -3.41 7.53 6.79 7.29 -0.46 -1.16 5.67 3.71 6.37 -3.98
Vacuole 6.85 6.63 7.11 1.50 1.97 -13.24 -6.85 -7.00 -2.55 -4.93 -6.81 -2.62 -4.27 1.51 -2.10
Vacuole Periphery 4.89 7.64 7.66 9.86 0.18 -11.25 11.60 4.64 13.99 -3.78 -8.67 12.28 8.53 17.33 -2.95
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis
Localization
Cell Percentages ER (92%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Ubx2

Ubx2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ubx2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available