Standard name
Human Ortholog
Description HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0.05 0.06 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.09 0 0.05 0 – 0 0 0 0 0.05 0.12 0.14 0.19 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 – 0 0 0 0.08 0 0 0 0.08 0.1 0 0.06 0.17 0.11 0.09 0.06
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0.05 0 0 0 0 0.05 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.05 0.07 0.08 0.09 0.07 – 0.21 0.21 0.09 0 0 0 0.07 0.05 0.05 0 0 0 0 0 0
Nucleus 0.05 0.08 0 0 0 0.12 0.11 0.14 – 0.28 0.3 0.24 0 0.08 0.08 0.11 0.16 0 0 0 0 0 0 0
Nuclear Periphery 0.7 0.52 0.8 0.73 0.62 0.61 0.63 0.56 – 0.42 0.44 0.49 0.59 0.56 0.44 0.47 0.38 0.3 0.89 0.68 0.73 0.67 0.63 0.54
Nucleolus 0 0 0.05 0 0.11 0.15 0.2 0.21 – 0.2 0.21 0.24 0.1 0 0.12 0.05 0.05 0.1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.43 0.46 0.27 0.3 0.31 0.23 0.15 0.16 – 0.11 0.07 0.14 0.33 0.33 0.34 0.4 0.38 0.55 0 0.13 0 0.1 0.16 0.24
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 1 0 0 0 1 0 – 0 1 0 7 6 2 0 0 0 1 1 4 1 2 1
Bud 0 0 0 1 1 1 3 3 – 3 1 3 0 0 1 1 0 0 3 4 1 1 4 5
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1
Bud Site 0 0 0 0 0 0 1 0 – 3 5 3 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 1 0 0 0 0 0 0 – 0 1 0 4 5 6 0 0 0 0 0 0 0 0 0
Cytoplasm 10 6 9 4 21 11 18 13 – 4 6 4 6 5 17 8 7 0 0 1 0 0 1 0
Endoplasmic Reticulum 10 3 5 4 2 1 2 1 – 0 1 0 12 2 3 1 3 2 16 18 54 16 29 15
Endosome 1 0 1 1 4 1 2 6 – 0 0 5 8 1 1 2 1 1 2 2 3 1 5 11
Golgi 0 0 0 0 1 0 1 0 – 0 0 0 0 0 2 0 0 0 0 2 3 2 2 1
Mitochondria 0 8 12 9 18 24 31 35 – 84 72 33 0 0 1 4 2 1 4 5 3 3 11 11
Nucleus 24 20 6 2 5 35 40 70 – 112 104 86 0 8 12 6 6 0 1 10 1 2 3 2
Nuclear Periphery 316 123 238 125 152 186 231 284 – 170 151 177 90 53 63 27 14 6 426 191 236 96 198 152
Nucleolus 10 6 15 7 26 44 74 107 – 79 73 89 15 2 17 3 2 2 1 0 1 1 3 6
Peroxisomes 0 0 0 0 0 1 1 2 – 0 0 0 1 1 1 0 0 0 0 0 1 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 – 0 0 0 2 1 4 0 0 0 0 1 0 0 0 0
Vac/Vac Membrane 195 109 80 52 76 69 54 80 – 45 23 52 50 31 48 23 14 11 20 37 11 14 52 67
Unique Cell Count 451 237 298 171 245 303 364 506 400 346 364 152 95 142 57 37 20 481 283 325 143 318 281
Labelled Cell Count 569 276 367 205 306 373 459 602 500 438 452 195 115 178 75 49 23 481 283 325 143 318 281


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.4 13.0 13.7 14.6 13.6 12.1 11.6 11.4 – 9.1 9.7 10.8 14.4 14.8 15.2 8.8 8.1 12.0 14.9 16.6 16.3
Std Deviation (1e-4) 4.5 3.5 3.3 3.6 3.4 2.7 3.3 3.0 – 3.3 3.6 3.1 3.1 3.2 3.9 2.8 2.4 3.5 4.0 4.5 3.9
Intensity Change (Log2) – – – 0.1 -0.0 -0.18 -0.24 -0.26 – -0.59 -0.49 -0.34 0.08 0.12 0.16 -0.64 -0.75 -0.18 0.13 0.29 0.25

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm 0 2.8 0.4 1.2 -0.4 – -2.0 -1.1 -1.8 0.5 0 3.7 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 – 0 0 0 3.3 0 0 0 0 0
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 0.6 1.7 2.0 2.3 1.7 – 6.4 6.3 2.6 0 0 0 0 0 0
Nucleus 0 0 4.6 4.5 5.5 – 9.1 9.4 8.0 0 0 3.2 0 0 0
Nuclear Periphery -1.7 -4.6 -5.0 -4.6 -6.8 – -9.9 -9.4 -8.3 -4.7 -4.7 -7.5 -5.2 -5.6 -5.1
Nucleolus -0.5 2.4 3.9 5.7 6.2 – 5.6 5.9 6.8 1.9 0 2.6 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 0.8 1.1 -1.2 -3.8 -3.8 – -5.3 -7.0 -4.0 1.3 1.1 1.5 2.1 1.4 2.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 13.6578 12.1428 13.0989 10.8182 11.8708 12.2794 14.4153 17.5498 15.7674 16.8519 14.3247 15.1691 13.4747 17.6308 15.298 15.7169 14.2493 14.8318
Actin 0.0144 0.0002 0.0168 0.0059 0.0062 0.0006 0.0235 0.0005 0.0005 0.0038 0.0087 0.0051 0.0027 0.0002 0.0205 0.0006 0.0011 0.0002
Bud 0.0001 0 0.0002 0.0001 0.0001 0 0.0001 0 0 0.0002 0.0001 0.0001 0.0002 0 0.0008 0 0.0006 0
Bud Neck 0.0024 0.0002 0.0042 0.0004 0.001 0.0001 0.0004 0.0001 0.0001 0.0004 0.0002 0.0005 0.0003 0 0.0002 0.0001 0.0003 0.0001
Bud Periphery 0.0002 0.0001 0.0005 0.0004 0.0003 0.0001 0.0002 0.0002 0.0002 0.0007 0.0001 0.0002 0.0007 0.0002 0.0011 0.0004 0.0019 0
Bud Site 0.0008 0.0001 0.001 0.0003 0.0001 0 0.0007 0 0 0.0018 0.0002 0.0001 0.0003 0 0.0036 0 0.0012 0
Cell Periphery 0.0002 0.0003 0.0006 0.0005 0.0002 0.0002 0.0002 0.0005 0.0006 0.0008 0.0001 0.0001 0.0009 0.0017 0.0008 0.0003 0.0007 0
Cytoplasm 0.0037 0.01 0.0017 0.0027 0.002 0.0005 0.003 0.0005 0.0007 0.0003 0.0005 0.0001 0.0224 0.0003 0.0109 0.0002 0.0009 0.0003
Cytoplasmic Foci 0.0014 0.0002 0.0008 0.0028 0.0005 0.0003 0.0118 0 0.0045 0.0011 0.0078 0.0012 0.009 0 0.0039 0 0.0014 0.0001
Eisosomes 0.0002 0 0.0006 0.0001 0.0001 0 0.0003 0 0 0.0001 0 0 0.0007 0 0.0001 0 0.0001 0.0002
Endoplasmic Reticulum 0.0087 0.0396 0.0517 0.0858 0.0486 0.0092 0.042 0.2841 0.2353 0.254 0.1143 0.0677 0.056 0.403 0.3075 0.2678 0.5308 0.0402
Endosome 0.0063 0.0025 0.0047 0.0077 0.0125 0.0016 0.0146 0.001 0.0029 0.0032 0.0056 0.0017 0.0488 0.001 0.0183 0.001 0.0353 0.0002
Golgi 0.0017 0 0.002 0.0043 0.002 0.0002 0.0044 0.0001 0.0008 0.0031 0.0055 0.0038 0.0023 0.0002 0.0195 0.0002 0.0048 0.0001
Lipid Particles 0.0017 0.0002 0.0017 0.0194 0.0012 0.0002 0.0162 0.0004 0.0125 0.0064 0.0088 0.0003 0.0356 0.0005 0.0018 0.0003 0.0062 0.0002
Mitochondria 0.0026 0.0003 0.0022 0.0055 0.003 0.0004 0.0013 0.0008 0.0011 0.0398 0.0017 0.002 0.0022 0.0008 0.0078 0.001 0.0237 0.0003
None 0.001 0.0001 0.0009 0.0007 0.0006 0.0001 0.0013 0.0001 0.0005 0.0001 0.0001 0 0.1248 0.0001 0.0008 0.0001 0.0014 0.0233
Nuclear Periphery 0.8308 0.7389 0.7824 0.7686 0.8089 0.9205 0.7777 0.6399 0.6633 0.6142 0.7702 0.8815 0.6146 0.5225 0.5325 0.6717 0.3355 0.8896
Nucleolus 0.0008 0.0009 0.001 0.0007 0.0015 0.0003 0.0005 0 0.0001 0.0002 0.0001 0 0.0012 0 0.0001 0 0.0009 0.0019
Nucleus 0.0909 0.1638 0.082 0.0271 0.0691 0.0373 0.0394 0.0077 0.0061 0.0122 0.0146 0.0027 0.0124 0.0101 0.0067 0.004 0.0037 0.0041
Peroxisomes 0.0003 0 0.0003 0.004 0.0001 0.0001 0.0011 0 0.0001 0.0052 0.0051 0.001 0.0007 0 0.001 0 0.0007 0
Punctate Nuclear 0.0032 0.0004 0.0013 0.0015 0.0016 0.0012 0.0137 0 0.0005 0.0001 0.0002 0.0001 0.0177 0.0001 0.0014 0.0001 0.0004 0.0032
Vacuole 0.0017 0.0174 0.0057 0.0257 0.0075 0.0066 0.0024 0.0088 0.0082 0.0062 0.0041 0.0018 0.0062 0.0082 0.0071 0.0041 0.0149 0.0006
Vacuole Periphery 0.0272 0.0248 0.0376 0.0356 0.0331 0.0205 0.0451 0.0553 0.062 0.0461 0.0523 0.03 0.0402 0.0511 0.0536 0.048 0.0338 0.0353

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 39.9178 38.3331 43.4766 51.5701 37.7428 33.7981 43.4064 50.1921 47.9035 48.0421
Translational Efficiency 0.6508 0.6644 0.7976 0.6477 0.5517 0.7021 0.6129 0.4528 0.5763 0.5187

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
497 1379 1149 1017 890 2132 2599 2110 1387 3511 3748 3127

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1138.96 1486.13 1593.68 1485.87 1071.75 1364.86 1589.40 1554.90 1095.83 1412.49 1590.71 1532.45
Standard Deviation 199.99 307.56 288.65 271.91 232.52 264.43 252.45 274.63 223.75 288.31 264.08 275.65
Intensity Change Log 2 — 0.383843 0.484645 0.383591 — 0.348785 0.568514 0.536853 — 0.366953 0.525914 0.459927

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002505 0.000767 0.000664 0.000583 0.002119 0.000695 0.000445 0.000319 0.002257 0.000723 0.000512 0.000405
Bud Neck 0.000877 0.000852 0.002934 0.006815 0.001843 0.000375 0.000755 0.001168 0.001497 0.000562 0.001423 0.003005
Bud Site 0.001823 0.000344 0.000275 0.002950 0.001869 0.000455 0.000177 0.000189 0.001853 0.000411 0.000207 0.001087
Cell Periphery 0.000180 0.000293 0.000081 0.000232 0.000635 0.000233 0.000073 0.000093 0.000472 0.000257 0.000075 0.000138
Cytoplasm 0.003004 0.000321 0.000282 0.003290 0.003360 0.000786 0.000514 0.000449 0.003232 0.000604 0.000443 0.001373
Cytoplasmic Foci 0.003677 0.000602 0.000696 0.003075 0.001608 0.000554 0.000361 0.000334 0.002349 0.000573 0.000464 0.001226
Eisosomes 0.000010 0.000026 0.000015 0.000012 0.000027 0.000007 0.000005 0.000004 0.000021 0.000015 0.000008 0.000007
Endoplasmic Reticulum 0.123359 0.062181 0.004403 0.014295 0.130897 0.067041 0.021995 0.021250 0.128196 0.065132 0.016602 0.018988
Endosome 0.018437 0.005367 0.001707 0.009006 0.009762 0.005987 0.003077 0.003213 0.012871 0.005744 0.002657 0.005097
Golgi 0.004494 0.000462 0.000245 0.003938 0.001276 0.000593 0.000314 0.000348 0.002429 0.000542 0.000293 0.001515
Lipid Particles 0.011042 0.012062 0.001770 0.006521 0.011597 0.006698 0.001305 0.003445 0.011398 0.008805 0.001448 0.004446
Mitochondria 0.004102 0.009607 0.002986 0.004891 0.016152 0.006175 0.002188 0.001711 0.011834 0.007523 0.002432 0.002745
Mitotic Spindle 0.007661 0.000118 0.002459 0.028271 0.000802 0.000436 0.001028 0.001233 0.003260 0.000311 0.001467 0.010027
None 0.002495 0.001200 0.000397 0.000787 0.008069 0.001710 0.000394 0.000520 0.006072 0.001509 0.000395 0.000606
Nuclear Periphery 0.366049 0.701239 0.667279 0.466071 0.570975 0.724440 0.812986 0.713787 0.497545 0.715327 0.768317 0.633222
Nuclear Periphery Foci 0.427869 0.127787 0.228165 0.372474 0.174898 0.161974 0.138221 0.231517 0.265544 0.148547 0.165795 0.277361
Nucleolus 0.002789 0.003206 0.046408 0.024294 0.010742 0.002593 0.001908 0.004220 0.007892 0.002834 0.015550 0.010749
Nucleus 0.004667 0.002002 0.030880 0.020238 0.024782 0.005248 0.005843 0.003356 0.017574 0.003973 0.013518 0.008847
Peroxisomes 0.000408 0.000374 0.000693 0.000499 0.002011 0.000244 0.000070 0.000076 0.001437 0.000295 0.000261 0.000213
Vacuole 0.010468 0.033926 0.003005 0.018950 0.015213 0.007114 0.004312 0.005283 0.013513 0.017645 0.003912 0.009728
Vacuole Periphery 0.004082 0.037266 0.004656 0.012808 0.011365 0.006640 0.004031 0.007485 0.008755 0.018669 0.004222 0.009217

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.90 0.94 0.96 1.03 0.39 5.36 5.01 6.79 2.60 0.85 2.18 2.35 2.59 2.94 0.87
Bud Neck 0.42 -4.84 -7.37 -7.74 -5.09 2.66 1.85 0.93 -3.59 -1.77 2.61 0.10 -3.79 -8.27 -5.36
Bud Site 1.69 1.72 -0.90 -3.55 -3.59 2.45 2.98 3.02 1.19 0.30 2.94 3.30 1.26 -2.71 -3.45
Cell Periphery -2.54 2.73 -1.55 0.79 -4.71 4.08 5.86 5.63 4.49 -1.40 3.34 6.27 5.08 4.41 -4.56
Cytoplasm 2.07 2.08 0.07 -3.59 -3.61 2.86 3.11 3.25 1.60 0.93 3.49 3.62 2.26 -2.81 -3.20
Cytoplasmic Foci 2.34 2.28 0.23 -4.92 -4.93 2.62 3.02 3.05 0.82 -0.22 3.36 3.55 1.85 -3.63 -4.09
Eisosomes -2.99 -0.78 -0.51 3.34 0.45 4.35 3.97 5.01 2.95 0.42 2.16 3.52 4.49 4.72 0.45
Endoplasmic Reticulum 5.75 12.08 10.85 11.31 -4.94 8.27 15.19 15.23 12.60 0.43 10.10 19.20 18.64 16.64 -1.37
Endosome 6.17 8.08 4.03 -3.40 -7.19 3.33 6.53 6.48 3.95 -0.33 6.77 10.21 7.38 0.90 -5.40
Golgi 2.29 2.41 0.26 -3.43 -3.66 1.43 2.15 2.18 0.96 -0.25 2.70 3.10 1.23 -2.65 -3.53
Lipid Particles -0.42 4.19 1.71 2.89 -3.25 3.44 7.89 5.85 3.84 -4.05 2.06 8.68 5.48 5.03 -5.06
Mitochondria -2.77 0.62 -0.55 3.03 -1.98 5.59 8.27 8.56 6.27 1.32 3.16 7.50 7.05 6.70 -0.85
Mitotic Spindle 2.62 1.93 -4.18 -8.91 -8.11 1.30 -0.78 -1.23 -2.08 -0.42 2.78 1.75 -3.92 -8.97 -7.61
None 1.66 2.61 2.13 1.12 -2.44 3.32 4.05 3.98 4.01 -1.04 3.65 4.57 4.39 4.03 -2.24
Nuclear Periphery -22.51 -19.23 -5.77 21.37 16.92 -13.16 -21.69 -12.29 1.57 15.55 -22.78 -28.58 -13.36 13.08 21.71
Nuclear Periphery Foci 21.53 13.61 3.65 -27.70 -14.41 2.03 6.14 -8.42 -12.67 -17.98 16.30 13.72 -1.48 -26.80 -22.55
Nucleolus 0.38 -10.85 -6.29 -6.90 4.18 4.83 5.26 3.51 -1.79 -2.54 4.50 -4.33 -1.78 -6.73 2.49
Nucleus 1.81 -7.62 -5.32 -7.96 2.64 5.43 5.19 5.99 1.59 2.26 5.75 1.53 3.35 -5.16 3.11
Peroxisomes 0.62 -1.32 -0.86 -2.18 0.40 2.76 3.01 3.00 6.62 -0.60 2.81 2.86 2.85 0.52 -0.01
Vacuole -6.35 3.30 -2.53 4.14 -7.84 4.01 5.39 4.94 2.14 -1.26 -1.85 6.23 2.08 5.73 -7.18
Vacuole Periphery -12.58 -0.39 -4.37 9.26 -5.43 4.35 7.02 3.14 -0.93 -4.02 -7.92 5.25 -0.44 7.98 -6.57
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant
Localization
Cell Percentages nuclear periphery (28%), ER (12%), mixed (55%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Hmg1

Hmg1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hmg1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available