Standard name
Human Ortholog
Description Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0
Bud 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.05 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.08 0.06 0 0 0 0 0 0
Cytoplasm 0.92 – 0.96 0.95 0.97 0.95 0.92 0.91 0.88 0.86 0.78 0.78 1.0 0.99 0.98 0.91 0.92 0.93 0.79 0.7 0.79 0.87 0.82 0.84
Endoplasmic Reticulum 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 – 0.07 0.06 0.06 0.11 0.2 0.23 0.32 0.39 0.41 0.38 0 0 0 0.05 0 0 0 0.05 0.08 0 0 0
Nucleus 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 10 – 0 2 0 1 2 0 0 0 0 0 0 0 0 5 2 2 13 1 5 3 7 6
Bud 6 – 2 5 2 5 12 8 2 11 13 10 2 0 5 2 0 1 3 1 1 3 1 3
Bud Neck 0 – 0 0 1 3 3 4 0 2 0 1 0 0 0 0 0 0 7 1 0 2 8 4
Bud Site 0 – 0 0 0 0 0 0 2 0 2 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 13 – 0 6 10 3 2 3 2 3 2 1 1 4 8 19 10 10 2 0 1 0 1 3
Cytoplasm 255 – 106 199 238 225 366 438 261 284 228 238 204 355 381 193 110 153 240 33 98 130 209 177
Endoplasmic Reticulum 8 – 1 0 0 0 0 0 0 0 1 0 0 2 5 10 4 2 7 0 1 2 2 2
Endosome 1 – 0 0 0 0 0 1 0 0 0 0 0 0 0 3 3 3 3 1 0 1 1 1
Golgi 1 – 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 2 1 0 0 0 2
Mitochondria 1 – 8 12 14 27 80 112 94 130 121 116 0 0 8 10 2 2 9 2 10 3 8 5
Nucleus 0 – 1 0 0 0 2 0 2 0 3 4 1 0 0 2 0 0 0 1 0 0 2 0
Nuclear Periphery 1 – 0 0 0 0 0 2 0 0 1 0 0 0 0 0 1 0 1 0 0 0 1 0
Nucleolus 0 – 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
SpindlePole 0 – 0 1 0 0 2 3 3 5 8 7 0 0 1 0 0 0 1 0 0 0 0 1
Vac/Vac Membrane 0 – 0 0 1 0 1 0 0 1 2 3 0 0 0 2 3 5 5 2 1 0 3 1
Unique Cell Count 277 110 210 246 237 398 480 296 330 292 306 204 357 388 213 119 164 303 48 124 150 254 212
Labelled Cell Count 296 118 225 266 264 470 572 366 436 381 382 208 362 408 247 135 178 303 48 124 150 254 212


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.5 – 3.8 3.6 3.9 3.5 3.2 3.2 2.9 2.8 2.8 2.4 5.0 5.0 4.4 7.4 8.2 8.2 5.1 4.9 5.7
Std Deviation (1e-4) 0.8 – 1.4 1.1 1.7 1.2 1.5 1.3 1.5 1.3 1.3 0.9 1.0 1.1 1.1 1.3 1.8 1.3 1.4 1.2 2.1
Intensity Change (Log2) – – – -0.1 0.04 -0.15 -0.26 -0.27 -0.4 -0.46 -0.46 -0.69 0.37 0.39 0.21 0.94 1.1 1.09 0.42 0.34 0.58


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 3.2 0 0
Cytoplasm -0.6 0.2 -0.6 -1.6 -1.8 -2.5 -2.9 -4.4 -4.4 2.7 2.5 1.2 -1.9 -1.3 -1.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 -1.0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.0682 1.522 1.6401 1.7652 1.1119 1.2306 1.936 2.231 2.402 2.199 2.6943 1.9112 0.4959 0.5611 0.703 1.1738 0.6037 0.6947
Actin 0.0314 0.0055 0.0192 0.0047 0.008 0.0138 0.0276 0.002 0.0061 0.0074 0.0467 0.0035 0.0237 0.0002 0.0143 0.001 0.0091 0.0051
Bud 0.0007 0.001 0.0011 0.0009 0.0033 0.0033 0.003 0.0012 0.0013 0.0018 0.0182 0.0013 0.0005 0.0001 0.0006 0.0004 0.0129 0.0019
Bud Neck 0.0024 0.0003 0.0091 0.0025 0.0014 0.0082 0.0048 0.0002 0.0045 0.0006 0.0025 0.0142 0.0008 0.0001 0.0002 0.0024 0.0006 0.0026
Bud Periphery 0.0015 0.0031 0.0022 0.0009 0.039 0.009 0.0037 0.0015 0.0022 0.0043 0.0756 0.0098 0.0013 0.0001 0.001 0.0008 0.1086 0.0269
Bud Site 0.0188 0.0047 0.0052 0.0105 0.0011 0.0017 0.0193 0.0056 0.0108 0.0041 0.0081 0.0009 0.0036 0.0003 0.0029 0.0004 0.0016 0.0001
Cell Periphery 0.0016 0.0029 0.0022 0.0008 0.0148 0.001 0.0014 0.0011 0.0006 0.0005 0.001 0.0027 0.0019 0.0003 0.0007 0.0012 0.0085 0.0016
Cytoplasm 0.4168 0.5888 0.5525 0.5351 0.5789 0.6355 0.4145 0.6219 0.6398 0.6241 0.3945 0.7157 0.1706 0.3412 0.3255 0.4941 0.5044 0.3471
Cytoplasmic Foci 0.0152 0.0053 0.0223 0.0133 0.0139 0.0101 0.0388 0.0067 0.0179 0.0084 0.0436 0.0067 0.0166 0.0017 0.0162 0.0059 0.0112 0.0137
Eisosomes 0.0004 0.0002 0.0006 0.0001 0.0004 0.0002 0.0003 0.0001 0.0001 0.0002 0.0002 0.0001 0.0008 0.0001 0.0005 0.0003 0.0006 0.0002
Endoplasmic Reticulum 0.0075 0.0047 0.0031 0.0026 0.0066 0.0029 0.0059 0.0022 0.0034 0.0065 0.0028 0.0018 0.0052 0.0008 0.0036 0.0043 0.0027 0.0012
Endosome 0.0201 0.002 0.022 0.028 0.0176 0.0048 0.0374 0.0034 0.0141 0.0158 0.0437 0.009 0.0113 0.0002 0.0082 0.0045 0.0026 0.0015
Golgi 0.0066 0.0011 0.0075 0.0147 0.0098 0.003 0.0085 0.0016 0.0072 0.0091 0.0305 0.0021 0.0046 0.0001 0.0028 0.0003 0.0024 0.0008
Lipid Particles 0.0226 0.0007 0.0133 0.0054 0.0031 0.0006 0.0217 0.0005 0.0027 0.0075 0.0075 0.0003 0.0031 0.0001 0.0034 0.0004 0.0146 0.0006
Mitochondria 0.0057 0.0013 0.014 0.0072 0.1054 0.0024 0.004 0.0093 0.0161 0.0119 0.0067 0.0005 0.0036 0.0001 0.0007 0.0005 0.009 0.0005
None 0.4118 0.3717 0.3122 0.3137 0.1765 0.2995 0.3369 0.3334 0.2649 0.2798 0.2957 0.2293 0.7211 0.6537 0.6137 0.4736 0.2745 0.5942
Nuclear Periphery 0.0113 0.0028 0.0012 0.0031 0.0008 0.0006 0.0101 0.0003 0.0009 0.003 0.0026 0.0003 0.0091 0.0001 0.0005 0.0009 0.0002 0.0001
Nucleolus 0.0004 0.0002 0.0002 0.0173 0.0002 0.0001 0.0013 0.0001 0.0002 0.0007 0.0004 0 0.0003 0.0001 0.0001 0.0004 0.0001 0
Nucleus 0.0047 0.0007 0.0007 0.0183 0.0008 0.0007 0.0169 0.0006 0.0008 0.0011 0.0023 0.0005 0.0009 0.0002 0.0005 0.0031 0.0004 0.0002
Peroxisomes 0.0085 0.0003 0.0064 0.002 0.0027 0.0011 0.0255 0.0055 0.0025 0.0094 0.0071 0.0004 0.016 0 0.0028 0.0002 0.0337 0.0011
Punctate Nuclear 0.006 0.0006 0.0026 0.0084 0.0002 0.0005 0.0093 0.0002 0.0007 0.0013 0.0078 0.0003 0.0006 0.0001 0.0005 0.0013 0.0003 0.0001
Vacuole 0.0037 0.0016 0.0021 0.0083 0.0111 0.001 0.008 0.0024 0.0027 0.0019 0.0019 0.0006 0.0024 0.0005 0.001 0.0036 0.0016 0.0005
Vacuole Periphery 0.0025 0.0004 0.0005 0.002 0.0044 0.0002 0.0013 0.0001 0.0005 0.0008 0.0006 0.0001 0.002 0 0.0002 0.0003 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 25.5472 13.9466 9.5728 12.3695 15.6766 21.8298 13.7489 9.8744 9.9982 19.7408
Translational Efficiency 1.2474 1.2445 0.895 0.8433 1.0745 1.4485 0.9372 0.8224 0.9842 0.9204

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1919 217 365 86 1435 707 1356 501 3354 924 1721 587

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 702.30 743.58 1036.30 951.23 661.92 746.09 914.36 919.79 685.02 745.50 940.22 924.40
Standard Deviation 73.19 100.77 101.36 117.75 93.41 99.10 110.99 121.61 84.83 99.50 119.87 121.56
Intensity Change Log 2 — 0.082401 0.561282 0.437707 — 0.172693 0.466105 0.474648 — 0.126916 0.515886 0.455749

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000382 0.001765 0.000505 0.000901 0.000287 0.000775 0.000520 0.001833 0.000342 0.001008 0.000517 0.001697
Bud Neck 0.021103 0.031862 0.001438 0.005662 0.020069 0.048406 0.005066 0.012712 0.020660 0.044521 0.004297 0.011679
Bud Site 0.017817 0.025000 0.009202 0.027046 0.008044 0.025357 0.021965 0.063193 0.013636 0.025273 0.019258 0.057897
Cell Periphery 0.000314 0.000174 0.000261 0.000151 0.000233 0.000231 0.000213 0.000169 0.000280 0.000218 0.000223 0.000167
Cytoplasm 0.589684* 0.378371* 0.633128* 0.520934* 0.494473* 0.415626* 0.607055* 0.428635* 0.548949* 0.406876* 0.612585* 0.442157*
Cytoplasmic Foci 0.173351 0.277572* 0.047236 0.081109 0.261730* 0.233732* 0.033869 0.054899 0.211164* 0.244028* 0.036704 0.058739
Eisosomes 0.000370 0.000244 0.000055 0.000049 0.000375 0.000358 0.000060 0.000079 0.000372 0.000331 0.000059 0.000075
Endoplasmic Reticulum 0.000767 0.000670 0.003662 0.000263 0.001140 0.000517 0.001815 0.000814 0.000927 0.000553 0.002207 0.000733
Endosome 0.014508 0.046547 0.005248 0.008587 0.021615 0.039592 0.004497 0.009514 0.017549 0.041225 0.004656 0.009378
Golgi 0.004008 0.003143 0.000197 0.012342 0.005181 0.006145 0.000509 0.001617 0.004510 0.005440 0.000443 0.003188
Lipid Particles 0.004320 0.004194 0.001922 0.000510 0.012359 0.004194 0.001482 0.000905 0.007759 0.004194 0.001575 0.000847
Mitochondria 0.003159 0.002642 0.000117 0.000037 0.006935 0.004741 0.001729 0.000913 0.004775 0.004248 0.001387 0.000784
Mitotic Spindle 0.001914 0.000649 0.000410 0.002321 0.002504 0.011689 0.008992 0.014842 0.002166 0.009096 0.007172 0.013007
None 0.003823 0.000478 0.002163 0.000596 0.002147 0.000380 0.003538 0.000707 0.003106 0.000403 0.003246 0.000691
Nuclear Periphery 0.000131 0.000262 0.000689 0.000184 0.000349 0.000272 0.000714 0.000653 0.000224 0.000270 0.000709 0.000584
Nuclear Periphery Foci 0.000556 0.000627 0.009185 0.000864 0.000351 0.000272 0.001557 0.001402 0.000468 0.000355 0.003175 0.001323
Nucleolus 0.000770 0.000734 0.000154 0.000050 0.000889 0.000684 0.000191 0.000138 0.000821 0.000696 0.000183 0.000125
Nucleus 0.066831 0.043519 0.134581* 0.014070 0.078339 0.051035 0.133351* 0.031680 0.071755 0.049270 0.133612* 0.029100
Peroxisomes 0.003037 0.018013 0.000303 0.002799 0.005691 0.013487 0.002083 0.006222 0.004173 0.014550 0.001705 0.005721
Vacuole 0.092029 0.161618 0.149370 0.321454* 0.075643 0.139697 0.169591 0.361790* 0.085018 0.144845 0.165303 0.355880*
Vacuole Periphery 0.001123 0.001915 0.000174 0.000071 0.001646 0.002811 0.001203 0.007284 0.001347 0.002600 0.000985 0.006228

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.34 -2.14 -0.49 1.23 0.40 -2.45 -1.95 -1.49 -0.56 -1.18 -2.35 -1.96 -1.43 -0.02 -1.14
Bud Neck -1.96 17.32 8.59 5.37 -1.60 -6.72 10.43 6.05 9.71 -1.70 -7.01 17.49 8.54 10.72 -2.08
Bud Site -1.44 4.64 -0.26 0.75 -2.05 -6.58 -3.70 -5.92 -1.86 -3.84 -4.96 -0.46 -4.76 -1.70 -4.30
Cell Periphery 5.09 2.23 8.48 3.24 5.74 0.15 2.09 4.40 5.05 3.67 2.65 4.56 9.46 5.70 5.51
Cytoplasm 11.67 1.03 6.96 0.52 6.17 6.36 -2.43 9.05 3.03 10.46 14.35 2.22 14.84 2.83 12.39
Cytoplasmic Foci -6.89 26.64 12.73 13.46 -0.41 3.24 42.94 37.37 24.66 -4.77 -4.30 52.51 41.03 28.51 -3.98
Eisosomes 3.47 14.01 14.33 5.77 0.90 0.29 9.44 9.35 4.42 -0.56 0.86 16.44 16.29 5.20 -0.33
Endoplasmic Reticulum 0.36 -7.81 1.08 0.73 8.03 3.86 -5.80 2.18 -2.86 10.57 3.67 -11.02 1.67 -2.26 13.05
Endosome -5.38 9.49 6.90 7.14 1.11 -5.77 13.55 9.89 11.47 -1.57 -8.87 16.97 10.64 13.36 -1.19
Golgi 1.25 8.54 0.51 0.11 -0.96 -0.74 10.31 7.24 4.63 -0.79 -0.89 12.48 5.76 4.38 -1.26
Lipid Particles 0.16 5.81 10.32 7.01 6.39 9.07 12.71 13.39 9.75 4.52 7.21 14.37 16.17 11.68 6.50
Mitochondria 0.56 5.16 5.30 2.34 4.95 1.57 4.55 5.41 5.29 1.17 0.67 5.38 7.02 5.70 1.14
Mitotic Spindle 1.50 1.80 0.02 -2.11 -2.58 -2.77 -3.02 -2.22 0.74 -0.23 -2.77 -3.12 -2.39 0.43 -0.52
None 5.56 3.22 4.07 -0.66 1.54 4.14 -0.78 3.19 -2.43 4.05 7.34 1.26 6.14 -2.23 4.40
Nuclear Periphery -3.75 -12.21 -4.73 -2.84 2.73 1.15 -11.97 -2.47 -2.99 3.32 -1.72 -18.66 -4.10 -3.38 3.58
Nuclear Periphery Foci -0.88 -11.70 -3.05 -2.59 9.75 1.44 -12.58 -6.56 -6.84 1.71 1.14 -13.90 -6.10 -7.03 8.22
Nucleolus 0.15 5.03 5.75 4.48 4.12 0.93 3.19 3.38 5.88 1.67 0.86 5.36 5.76 7.13 2.13
Nucleus 3.18 -10.15 3.74 1.34 9.56 6.22 -14.35 10.60 3.40 22.05 6.42 -19.13 11.32 3.59 24.36
Peroxisomes -5.44 11.78 1.61 5.71 -2.07 -4.36 5.93 2.30 5.14 -1.34 -6.94 5.97 1.40 6.69 -1.64
Vacuole -6.35 -10.04 -12.59 -9.83 -8.92 -9.80 -23.93 -29.78 -23.14 -15.29 -10.90 -25.41 -32.00 -25.03 -17.86
Vacuole Periphery -1.42 7.14 7.95 3.73 7.75 -1.65 2.92 -0.69 0.02 -1.29 -2.26 3.06 -0.74 0.14 -1.30
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (80%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Zds2

Zds2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Zds2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available