Standard name
Human Ortholog
Description Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; eIF3 is also involved in programmed stop codon readthrough
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 – 0 0.07 0.05 0.06 – 0.05 – – 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 – 0 0 0.08 0 – 0.16 – – 0 0.05 0 0 0.06 0 0 0 0 0 0 0
Cytoplasm 0.94 0.96 0.9 – 0.81 0.75 0.71 0.59 – 0.58 – – 0.97 0.95 0.96 0.91 0.87 0.96 0.92 0.93 0.8 0.86 0.85 0.81
Endoplasmic Reticulum 0.06 0 0 – 0.05 0.11 0.16 0.12 – 0.16 – – 0 0 0 0 0 0 0 0 0.07 0.05 0.07 0.1
Endosome 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0.05 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 – 0.05 0.11 0.08 0.17 – 0.26 – – 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 – 0.11 0 0.05 0.09 – 0 – – 0 0 0 0 0.05 0 0 0 0.06 0.05 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 2 – 1 2 2 4 – 1 – – 0 0 2 1 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 1 0 1 – 0 – – 0 0 0 0 1 0 4 1 0 0 1 1
Bud Neck 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 1 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 – – – – – –
Cell Periphery 12 7 0 – 0 1 3 2 – 3 – – 1 11 7 8 6 3 0 0 0 0 0 1
Cytoplasm 409 219 57 – 30 21 27 41 – 11 – – 169 213 218 227 93 121 415 219 68 100 252 230
Endoplasmic Reticulum 26 8 2 – 2 3 6 8 – 3 – – 4 4 3 10 3 4 9 1 6 6 21 28
Endosome 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 1 1 0 1 0 0 0 2 0
Golgi 2 0 0 – 0 0 2 3 – 0 – – 0 0 0 10 3 3 0 0 0 0 1 6
Mitochondria 0 1 1 – 2 3 3 12 – 5 – – 1 0 2 2 0 1 1 0 3 0 1 0
Nucleus 1 0 0 – 0 0 0 0 – 0 – – 0 1 0 0 0 0 1 1 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 1 0 0 0 0 1
Nucleolus 0 0 0 – 0 0 1 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 – 0 – – 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 2 2 2 – 4 0 2 6 – 0 – – 1 0 1 10 5 3 7 8 5 5 9 9
Unique Cell Count 436 227 63 37 28 38 69 19 174 224 228 250 107 126 450 235 85 117 295 284
Labelled Cell Count 452 237 64 39 31 46 77 23 176 229 233 269 112 135 450 235 85 117 295 284


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 41.6 41.8 20.3 – 16.3 19.3 19.3 14.1 – 11.8 – – 40.3 37.3 32.0 36.9 39.7 39.9 40.2 45.0 47.0
Std Deviation (1e-4) 10.6 9.8 4.5 – 5.7 3.7 4.4 5.1 – 3.7 – – 7.5 7.9 6.7 12.1 12.6 13.9 8.6 11.0 12.4
Intensity Change (Log2) – – – – -0.32 -0.07 -0.08 -0.53 – -0.78 – – 0.99 0.88 0.65 0.86 0.97 0.97 0.98 1.14 1.21

WT3RAP140RAP220RAP300RAP380RAP54002040WT3HU80HU120HU16002040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302040WT1AF100AF140AF18002040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Bud – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Bud Neck – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Bud Site – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Cell Periphery – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Cytoplasm – -1.3 -1.9 -2.5 -4.1 – -3.3 – – 2.1 1.4 1.6 0.1 -0.7 1.5
Endoplasmic Reticulum – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Endosome – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Golgi – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Mitochondria – 0 0 0 3.0 – 0 – – 0 0 0 0 0 0
Nucleus – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Nuclear Periphery – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Nucleolus – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 – 0 – – 0 0 0 0 0 0
SpindlePole – 0 0 0 0 – 0 – – 0 0 0 0 0 0
Vacuole – 0 0 0 0 – 0 – – 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 31.3447 44.9511 38.6422 35.9928 36.2822 37.1838 31.9282 47.5807 42.0363 40.0103 37.67 43.949 35.0319 50.7849 43.8175 44.7134 41.192 44.4928
Actin 0.0041 0.0017 0.0065 0.0118 0.0055 0.0077 0.0153 0.0018 0.0074 0.0091 0.0317 0.0019 0.0142 0.0006 0.0012 0.0015 0.0014 0.0024
Bud 0.002 0.0025 0.0028 0.0087 0.0042 0.002 0.0017 0.0006 0.0013 0.0039 0.0014 0.0009 0.0022 0.0004 0.0014 0.0017 0.0011 0.0008
Bud Neck 0.0011 0.0015 0.0025 0.002 0.0059 0.0028 0.0082 0.0004 0.0008 0.0011 0.0009 0.0018 0.0006 0.0003 0.0006 0.0008 0.0005 0.0011
Bud Periphery 0.0016 0.0016 0.0018 0.0044 0.0068 0.0016 0.0014 0.0004 0.0013 0.0039 0.0014 0.0003 0.0021 0.0001 0.0005 0.0003 0.0004 0.0005
Bud Site 0.0011 0.0025 0.0026 0.0016 0.001 0.0004 0.0099 0.0005 0.0012 0.0136 0.0006 0.0001 0.0015 0.0002 0.0003 0.0003 0.0002 0.0001
Cell Periphery 0.0037 0.0098 0.0084 0.0022 0.0081 0.0017 0.0011 0.0016 0.0013 0.0033 0.0003 0.0003 0.0045 0.0003 0.0002 0.0001 0.0001 0.0003
Cytoplasm 0.5968 0.8157 0.7015 0.527 0.4922 0.5772 0.7613 0.9529 0.8797 0.7162 0.7864 0.803 0.6565 0.9419 0.8558 0.8083 0.7513 0.7205
Cytoplasmic Foci 0.0056 0.006 0.0078 0.0118 0.0091 0.0132 0.0147 0.0051 0.0101 0.0156 0.0125 0.0205 0.0388 0.0072 0.0133 0.02 0.0301 0.0225
Eisosomes 0 0 0 0 0 0.0001 0.0003 0 0.0001 0 0.0001 0 0.0002 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0797 0.0303 0.0292 0.0371 0.0082 0.065 0.0402 0.0059 0.0081 0.0082 0.0199 0.036 0.0215 0.0058 0.0084 0.0123 0.0067 0.0469
Endosome 0.0476 0.0274 0.0395 0.064 0.114 0.0958 0.0461 0.0099 0.0317 0.0847 0.0527 0.0928 0.0886 0.0201 0.0596 0.0929 0.1237 0.1253
Golgi 0.0065 0.0044 0.0107 0.0119 0.0234 0.0333 0.0064 0.0037 0.0096 0.01 0.0167 0.0074 0.0233 0.0043 0.0097 0.0125 0.0125 0.0319
Lipid Particles 0.0009 0.0007 0.0016 0.0009 0.0005 0.0003 0.0021 0.0003 0.0014 0.0009 0.0009 0.0002 0.0098 0.0002 0.0038 0.0001 0.0005 0.0001
Mitochondria 0.0046 0.0038 0.0037 0.0179 0.0045 0.0246 0.0178 0.0024 0.0099 0.0193 0.009 0.0023 0.0194 0.0107 0.0107 0.0035 0.0061 0.0153
None 0.0008 0.0003 0.0006 0.0008 0.0004 0.0007 0.0047 0.0006 0.0018 0.0006 0.0007 0.0003 0.0034 0.0002 0.0009 0.0003 0.0021 0.0004
Nuclear Periphery 0.0503 0.005 0.0109 0.0259 0.0226 0.0211 0.0181 0.001 0.0039 0.0035 0.0142 0.0036 0.015 0.0011 0.002 0.002 0.0049 0.0035
Nucleolus 0.0002 0.0001 0.0003 0.0006 0.0005 0.0001 0.0005 0.0001 0.0009 0.0001 0.0005 0 0.0006 0 0.0004 0 0.0004 0
Nucleus 0.0096 0.0026 0.0064 0.0112 0.0048 0.0039 0.0066 0.0009 0.002 0.0018 0.0037 0.0011 0.0047 0.0005 0.001 0.0009 0.0036 0.0008
Peroxisomes 0.0001 0.0001 0.0002 0.0014 0.0002 0.0002 0.0004 0.0001 0.0006 0.0007 0.0004 0.0002 0.0022 0 0.0013 0.0003 0.0003 0.0002
Punctate Nuclear 0.0002 0.0001 0.0002 0.0009 0.0001 0.0001 0.0088 0.0001 0.0028 0.0004 0.0007 0.0001 0.0033 0 0.0002 0.0001 0.0013 0
Vacuole 0.1192 0.065 0.1261 0.181 0.1941 0.0719 0.026 0.0103 0.0181 0.0711 0.0275 0.0138 0.0626 0.0042 0.0181 0.0259 0.0337 0.0134
Vacuole Periphery 0.0644 0.0188 0.0368 0.0768 0.094 0.0766 0.0084 0.0015 0.006 0.0318 0.0176 0.0132 0.0252 0.0018 0.0106 0.0162 0.0188 0.014

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 241.1719 201.1858 182.888 216.2579 192.7259 175.7451 198.5413 188.1208 177.7911 208.287
Translational Efficiency 0.9175 1.0674 1.0358 0.8566 0.884 1.1821 0.9087 0.7695 0.8388 0.826

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2081 168 344 1205 2211 1681 918 204 4292 1849 1262 1409

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2371.60 3100.70 4734.67 2572.02 2638.03 2722.46 3574.20 3032.62 2508.85 2756.83 3890.52 2638.71
Standard Deviation 398.08 546.31 717.63 621.87 448.63 525.58 718.76 733.01 445.25 538.58 884.98 659.39
Intensity Change Log 2 — 0.386733 0.997403 0.117041 — 0.045450 0.438159 0.201104 — 0.217098 0.729948 0.161918

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000018 0.000193 0.000102 0.000244 0.000037 0.000060 0.000098 0.000279 0.000028 0.000072 0.000099 0.000249
Bud Neck 0.000038 0.001012 0.004882 0.001904 0.000121 0.000182 0.002989 0.002369 0.000081 0.000257 0.003505 0.001971
Bud Site 0.003812 0.013820 0.004178 0.016891 0.005575 0.005307 0.005576 0.014749 0.004720 0.006081 0.005195 0.016581
Cell Periphery 0.001377 0.008571 0.003849 0.001455 0.001859 0.001002 0.003135 0.006665 0.001625 0.001690 0.003330 0.002210
Cytoplasm 0.627933 0.311708 0.225546 0.234871 0.495601 0.563534 0.230944 0.136779 0.559762 0.540653 0.229473 0.220668
Cytoplasmic Foci 0.061203 0.052943 0.029702 0.015883 0.093514 0.054177 0.017704 0.017577 0.077848 0.054065 0.020974 0.016128
Eisosomes 0.000001 0.000003 0.000003 0.000005 0.000001 0.000001 0.000002 0.000006 0.000001 0.000001 0.000003 0.000005
Endoplasmic Reticulum 0.002861 0.002333 0.000284 0.000609 0.002783 0.000755 0.000465 0.000747 0.002821 0.000898 0.000416 0.000629
Endosome 0.001251 0.006931 0.002624 0.011391 0.003460 0.003066 0.004639 0.011058 0.002389 0.003417 0.004090 0.011343
Golgi 0.068785 0.349600 0.137949 0.057194 0.192195 0.142235 0.114663 0.115470 0.132359 0.161076 0.121010 0.065631
Lipid Particles 0.000588 0.007536 0.007469 0.005312 0.002576 0.001035 0.004746 0.014924 0.001612 0.001626 0.005488 0.006703
Mitochondria 0.001203 0.000125 0.000186 0.001695 0.001435 0.000843 0.000299 0.002722 0.001322 0.000778 0.000268 0.001844
Mitotic Spindle 0.001463 0.005347 0.008466 0.009862 0.002011 0.003065 0.005080 0.010034 0.001745 0.003272 0.006003 0.009887
None 0.001937 0.000707 0.000936 0.002222 0.000840 0.000768 0.000903 0.000459 0.001372 0.000762 0.000912 0.001967
Nuclear Periphery 0.000109 0.000509 0.004703 0.000724 0.000170 0.000117 0.002912 0.000515 0.000140 0.000152 0.003400 0.000693
Nuclear Periphery Foci 0.002458 0.010238 0.028419 0.010516 0.004789 0.004319 0.028513 0.012323 0.003658 0.004856 0.028487 0.010778
Nucleolus 0.000027 0.000064 0.000269 0.000646 0.000029 0.000044 0.000344 0.001101 0.000028 0.000046 0.000323 0.000712
Nucleus 0.000636 0.000831 0.008364 0.004094 0.000523 0.000932 0.008485 0.003190 0.000578 0.000923 0.008452 0.003963
Peroxisomes 0.000022 0.000056 0.000024 0.000453 0.000033 0.000041 0.000025 0.000260 0.000028 0.000043 0.000025 0.000425
Vacuole 0.015020 0.064087 0.295241 0.452621 0.030448 0.047217 0.322738 0.485608 0.022968 0.048750 0.315243 0.457397
Vacuole Periphery 0.209261 0.163385 0.236802 0.171409 0.161999 0.171302 0.245742 0.163165 0.184915 0.170582 0.243305 0.170215

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.25 -7.32 -3.77 -0.65 -1.94 -1.60 -6.84 -2.91 -2.62 -1.99 -3.24 -9.76 -4.25 -3.27 -2.42
Bud Neck -4.05 -9.04 -11.06 -4.27 5.17 -1.99 -11.16 -5.81 -5.67 1.28 -5.00 -14.35 -12.27 -11.16 5.48
Bud Site -3.45 -0.98 -7.10 -0.74 -6.40 0.26 -1.14 -3.96 -4.02 -3.64 -2.75 -2.15 -7.54 -6.44 -6.61
Cell Periphery -4.13 -8.70 0.34 4.15 8.32 6.00 -2.22 -4.40 -5.29 -2.83 -0.35 -4.31 -1.90 -1.24 3.02
Cytoplasm 11.88 22.79 33.35 2.03 -1.69 -6.10 21.17 19.01 22.22 4.47 2.03 33.14 34.05 26.59 -0.52
Cytoplasmic Foci 1.51 7.52 18.98 7.25 5.77 12.28 26.35 23.28 13.12 -0.06 9.60 26.30 32.02 19.08 4.47
Eisosomes -4.02 -7.33 -5.36 -1.46 -0.99 3.74 -4.69 -2.34 -2.57 -1.69 -0.59 -8.38 -5.46 -5.31 -2.51
Endoplasmic Reticulum 0.37 10.74 9.48 1.23 -4.17 5.95 6.84 5.38 0.18 -1.28 7.66 11.47 10.45 2.05 -2.80
Endosome -8.15 -7.42 -10.03 -3.31 -8.29 1.90 -4.88 -3.30 -3.46 -2.56 -6.22 -8.46 -9.60 -8.31 -7.05
Golgi -14.23 -8.65 4.93 15.17 11.18 7.92 13.91 8.39 3.58 0.16 -5.30 4.11 19.07 19.42 12.59
Lipid Particles -5.40 -11.12 -5.58 0.95 1.86 6.60 -6.48 -5.09 -5.73 -3.98 -0.11 -13.09 -6.26 -6.20 -1.32
Mitochondria 13.11 12.07 -0.44 -2.24 -2.10 2.07 3.86 -0.64 -1.03 -1.35 3.17 6.43 -0.50 -1.47 -2.31
Mitotic Spindle -3.60 -5.64 -5.09 -2.32 -0.23 -2.69 -5.96 -2.37 -2.09 -1.36 -4.33 -8.43 -5.47 -4.33 -1.94
None 10.91 7.95 -0.09 -1.93 -1.52 1.09 -0.51 2.54 2.01 2.14 9.95 3.59 -0.72 -1.79 -1.46
Nuclear Periphery -1.50 -7.98 -5.77 -0.80 6.84 1.83 -5.17 -3.28 -3.67 4.20 -0.50 -7.82 -6.07 -5.77 6.35
Nuclear Periphery Foci -5.28 -13.38 -8.19 -0.56 7.95 0.85 -10.12 -4.11 -4.32 5.71 -3.04 -13.88 -8.06 -6.42 8.72
Nucleolus -2.73 -12.89 -3.39 -3.17 -1.85 -3.12 -7.66 -1.81 -1.78 -1.25 -4.20 -9.76 -3.84 -3.73 -1.94
Nucleus -1.24 -6.64 -7.30 -6.86 3.29 -3.74 -6.57 -2.22 -2.06 1.73 -3.48 -8.30 -7.34 -6.75 4.10
Peroxisomes -2.88 -2.06 -2.16 -1.96 -2.12 -0.77 1.29 -2.52 -2.40 -2.58 -1.55 -0.30 -2.33 -2.22 -2.33
Vacuole -7.29 -21.88 -55.25 -37.54 -9.79 -7.17 -36.81 -22.45 -21.51 -7.01 -12.40 -43.39 -58.78 -53.57 -13.48
Vacuole Periphery 3.55 -0.85 8.35 1.07 5.66 -1.47 -7.95 1.19 1.90 5.84 2.65 -5.77 6.41 3.32 9.98
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; eIF3 is also involved in programmed stop codon readthrough
Localization
Cell Percentages cytoplasm (94%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Clu1

Clu1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Clu1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available