Standard name
Human Ortholog
Description Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0.05 0.05 0 0.05 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.1 0.28 0.18 0.19 0.11 0.07 0.06 0 0.05 0.05 0 0 0.61 0.64 0.78 0.74 0.84 0.84 0 0.05 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0.06 0.09 0.05 0 0 0 0 0 0
Endosome 0 0.08 0.11 0.09 0.06 0 0 0 0 0 0 0 0 0.1 0.05 0.05 0.05 0 0.05 0.09 0.09 0.11 0.06 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.84 0.57 0.7 0.77 0.82 0.92 0.93 0.94 0.96 0.94 0.95 0.96 0.1 0.11 0 0.1 0.07 0 0.73 0.66 0.69 0.65 0.68 0.62
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0.18 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.07 0 0 0
SpindlePole 0 0.05 0.06 0.07 0.05 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.11 0 0 0.05 0 0 0 0 0 0 0 0 0.12 0.09 0 0 0 0 0.07 0 0.06 0.09 0.12
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 0 0 0 0 0 0 10 1 1 1 2 2 7 9 9 2 10 10
Bud 10 5 11 8 12 26 32 29 30 29 22 25 5 1 2 1 1 1 0 4 1 0 4 4
Bud Neck 1 2 0 0 0 0 2 0 0 2 0 0 4 1 5 1 3 5 2 3 4 3 2 10
Bud Site 9 0 2 0 1 8 10 6 8 15 5 12 0 0 0 0 0 1 – – – – – –
Cell Periphery 6 11 2 5 3 2 1 7 1 5 1 4 7 3 2 5 1 2 0 1 0 0 0 1
Cytoplasm 26 79 55 43 36 35 38 23 29 31 19 23 101 126 202 124 92 98 2 19 4 2 5 12
Endoplasmic Reticulum 1 7 2 0 8 7 6 1 4 0 3 2 14 8 8 10 10 6 1 1 1 1 7 4
Endosome 6 22 35 20 19 3 0 2 1 0 0 1 7 19 12 9 6 2 13 33 31 22 18 15
Golgi 1 1 0 0 0 0 0 0 0 0 0 0 4 0 2 2 0 1 12 6 3 6 5 6
Mitochondria 222 161 218 176 267 449 566 621 552 556 443 581 17 21 5 16 8 5 209 247 236 131 215 220
Nucleus 4 0 0 1 4 14 20 18 17 17 5 9 1 1 2 1 0 1 0 1 0 0 2 1
Nuclear Periphery 4 3 0 0 1 5 9 3 3 8 7 6 0 0 0 0 1 0 2 0 2 3 1 1
Nucleolus 4 0 2 0 1 6 5 10 8 6 6 10 0 0 0 0 0 1 1 1 1 3 0 1
Peroxisomes 4 2 55 4 8 2 3 5 8 7 1 2 0 7 4 2 0 0 13 4 24 5 7 8
SpindlePole 11 13 20 16 15 14 24 28 24 26 17 14 6 7 10 10 0 3 3 6 6 1 4 6
Vac/Vac Membrane 9 30 13 6 17 13 17 20 16 21 14 8 6 24 23 3 1 5 8 26 4 12 29 41
Unique Cell Count 263 282 310 230 326 487 607 660 575 594 468 606 165 198 258 167 110 116 289 376 341 202 319 354
Labelled Cell Count 318 337 415 279 392 584 733 773 701 723 543 697 182 219 278 185 125 133 289 376 341 202 319 354


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.0 4.5 3.9 3.8 3.6 3.7 3.1 3.3 3.1 3.2 3.1 3.2 5.3 5.1 5.2 5.4 5.0 5.1 6.0 6.1 6.1
Std Deviation (1e-4) 1.6 0.9 0.9 1.2 0.8 1.0 0.8 0.9 0.7 0.8 0.7 0.7 0.7 1.0 1.0 1.8 1.5 1.6 1.4 1.6 1.6
Intensity Change (Log2) – – – -0.07 -0.13 -0.1 -0.36 -0.27 -0.33 -0.32 -0.33 -0.29 0.43 0.37 0.41 0.44 0.35 0.37 0.61 0.62 0.63


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 – –
Bud Neck – – – – – – – – – – – – 0 – –
Bud Site – – – – – – – – – – – – 0 – –
Cell Periphery – – – – – – – – – – – – 0 – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 – –
Endosome – – – – – – – – – – – – 0 – –
Golgi – – – – – – – – – – – – 0 – –
Mitochondria – – – – – – – – – – – – 0 – –
Nuclear Periphery – – – – – – – – – – – – 0 – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 – –
Peroxisomes – – – – – – – – – – – – 0 – –
SpindlePole – – – – – – – – – – – – 0 – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 – –
Cytoplasm – – – – – – – – – – – – 0 – –
Nucleus – – – – – – – – – – – – 0 – –
Vacuole – – – – – – – – – – – – -1.4 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.2888 0.2201 -0.023 -0.1506 -0.495 0.1082 2.1035 2.1877 2.3179 2.2902 1.9272 2.3896 -0.2774 0.1145 -0.2036 0.0947 0.1844 -0.2265
Actin 0.0064 0.0063 0.0033 0.003 0.0015 0.0025 0.0299 0.0376 0.0316 0.0342 0.0285 0.0113 0.0077 0.0061 0.0133 0.0022 0.0313 0.0059
Bud 0.0007 0.004 0.0023 0.0029 0.0011 0.0025 0.0018 0.0079 0.0055 0.0092 0.0041 0.0024 0.0017 0.0035 0.0043 0.0011 0.0038 0.001
Bud Neck 0.002 0.0039 0.0021 0.0145 0.0012 0.0049 0.002 0.0041 0.0141 0.002 0.0017 0.0113 0.006 0.0022 0.0027 0.0013 0.0013 0.0045
Bud Periphery 0.0027 0.01 0.0085 0.0122 0.0035 0.0034 0.006 0.0158 0.0088 0.019 0.0184 0.0103 0.0059 0.0107 0.0146 0.0027 0.0146 0.0028
Bud Site 0.007 0.0433 0.0062 0.0028 0.0016 0.0017 0.0149 0.0435 0.0177 0.0128 0.0073 0.0024 0.007 0.0289 0.0219 0.0016 0.0041 0.0011
Cell Periphery 0.0015 0.0022 0.0012 0.0011 0.0003 0.0006 0.0027 0.0021 0.0016 0.001 0.0059 0.002 0.0014 0.0023 0.0036 0.0006 0.0005 0.0007
Cytoplasm 0.0727 0.0962 0.088 0.0953 0.0623 0.0996 0.0513 0.1125 0.0557 0.0446 0.0375 0.0644 0.0578 0.093 0.0719 0.0346 0.0964 0.0975
Cytoplasmic Foci 0.1149 0.1146 0.1121 0.1084 0.1281 0.1265 0.1277 0.1584 0.1289 0.1033 0.0863 0.1332 0.1446 0.1333 0.1181 0.1355 0.1092 0.1455
Eisosomes 0.0011 0.0015 0.0008 0.0009 0.0003 0.0003 0.002 0.0011 0.0012 0.0005 0.0009 0.0009 0.0014 0.0009 0.0013 0.0002 0.0008 0.0005
Endoplasmic Reticulum 0.0027 0.0057 0.0039 0.003 0.0028 0.004 0.0063 0.0023 0.0026 0.0035 0.0031 0.0018 0.0038 0.0024 0.003 0.002 0.0021 0.0026
Endosome 0.0919 0.1051 0.099 0.1185 0.1713 0.1184 0.1336 0.0969 0.1128 0.1277 0.0655 0.1141 0.1359 0.1127 0.0932 0.1307 0.1172 0.1003
Golgi 0.0194 0.0184 0.0183 0.023 0.0264 0.0213 0.0475 0.057 0.0435 0.0587 0.0396 0.0487 0.0409 0.0307 0.0264 0.0524 0.0336 0.0276
Lipid Particles 0.0317 0.0146 0.0201 0.0269 0.0495 0.0225 0.0311 0.0107 0.018 0.0105 0.0141 0.0148 0.0516 0.0167 0.0236 0.0159 0.0229 0.0263
Mitochondria 0.1327 0.1863 0.1903 0.1368 0.2078 0.1992 0.2806 0.1762 0.2928 0.29 0.468 0.326 0.1916 0.246 0.2515 0.3376 0.2328 0.289
None 0.4475 0.3307 0.3938 0.3541 0.2552 0.3175 0.1907 0.1799 0.1831 0.1452 0.1342 0.1803 0.2482 0.2588 0.2693 0.1893 0.2259 0.2056
Nuclear Periphery 0.0021 0.0036 0.0021 0.0019 0.0033 0.002 0.0025 0.0005 0.0026 0.001 0.0066 0.0008 0.0016 0.0008 0.0012 0.0006 0.0021 0.0016
Nucleolus 0.002 0.0026 0.0018 0.0026 0.0019 0.0022 0.0014 0.0013 0.0014 0.0012 0.0009 0.0007 0.0026 0.002 0.0018 0.0009 0.0024 0.0018
Nucleus 0.0021 0.0041 0.0024 0.0045 0.0045 0.0053 0.0013 0.0017 0.0018 0.0022 0.0016 0.001 0.0017 0.0024 0.0027 0.0011 0.0029 0.0025
Peroxisomes 0.0389 0.0208 0.0264 0.0581 0.0466 0.0414 0.0486 0.0789 0.0601 0.1215 0.0613 0.0625 0.0624 0.0297 0.0558 0.0719 0.0452 0.0687
Punctate Nuclear 0.0029 0.0049 0.0039 0.0048 0.0124 0.0056 0.002 0.0033 0.0014 0.0008 0.0022 0.0014 0.0056 0.0009 0.0023 0.0008 0.033 0.0037
Vacuole 0.0139 0.0161 0.01 0.0182 0.0126 0.013 0.0124 0.0064 0.0109 0.0083 0.0077 0.0063 0.0162 0.0121 0.0133 0.01 0.012 0.0073
Vacuole Periphery 0.0031 0.0049 0.0037 0.0064 0.0058 0.0057 0.0039 0.0018 0.0038 0.0027 0.0046 0.0034 0.0045 0.004 0.0041 0.007 0.0059 0.0033

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.1187 4.2425 7.8703 4.85 8.4606 10.6722 7.5067 8.3236 9.2564 7.0017
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
793 1888 423 1670 2594 2071 1647 2102 3387 3959 2070 3772

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 661.04 750.43 795.54 747.66 696.15 683.90 754.22 832.49 687.93 715.63 762.66 794.93
Standard Deviation 76.41 100.25 87.52 102.58 78.41 92.11 92.48 101.22 79.35 101.66 93.00 110.20
Intensity Change Log 2 — 0.182980 0.267197 0.177645 — -0.025613 0.115587 0.258035 — 0.079754 0.191422 0.219439

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000638 0.001576 0.000308 0.000982 0.000760 0.001282 0.000410 0.003167 0.000732 0.001422 0.000389 0.002200
Bud Neck 0.053187 0.035691 0.002844 0.022976 0.047416 0.035936 0.018910 0.028396 0.048767 0.035819 0.015627 0.025996
Bud Site 0.016121 0.035312 0.004166 0.027184 0.030887 0.024638 0.018087 0.046123 0.027430 0.029728 0.015242 0.037738
Cell Periphery 0.000137 0.000374 0.000142 0.000251 0.000188 0.000339 0.000152 0.000188 0.000176 0.000356 0.000150 0.000216
Cytoplasm 0.205399* 0.067313 0.219025* 0.380348* 0.136326* 0.046072 0.460672* 0.439484* 0.152498* 0.056202 0.411292* 0.413303*
Cytoplasmic Foci 0.312644* 0.217457* 0.020503 0.067684 0.257348* 0.178824 0.031591 0.077836 0.270295* 0.197247* 0.029326 0.073341
Eisosomes 0.000305 0.000181 0.000066 0.000121 0.000215 0.000227 0.000038 0.000116 0.000236 0.000205 0.000044 0.000118
Endoplasmic Reticulum 0.002595 0.000745 0.005475 0.002061 0.002019 0.000536 0.002398 0.001945 0.002154 0.000636 0.003027 0.001996
Endosome 0.043896 0.081962 0.003344 0.012951 0.066353 0.085010 0.003238 0.005281 0.061095 0.083557 0.003260 0.008676
Golgi 0.021987 0.089697 0.000198 0.002231 0.052702 0.097599 0.001180 0.002375 0.045511 0.093830 0.000979 0.002311
Lipid Particles 0.034078 0.007106 0.002901 0.006686 0.012091 0.009071 0.001440 0.002206 0.017238 0.008134 0.001739 0.004190
Mitochondria 0.127866* 0.303045* 0.000550 0.004882 0.250427* 0.384805* 0.002313 0.005246 0.221732* 0.345815* 0.001953 0.005084
Mitotic Spindle 0.008001 0.025459 0.001211 0.015273 0.011131 0.013561 0.012604 0.015844 0.010398 0.019235 0.010276 0.015591
None 0.001246 0.000887 0.003966 0.008268 0.001785 0.001067 0.004137 0.002312 0.001658 0.000981 0.004102 0.004949
Nuclear Periphery 0.000527 0.000197 0.002172 0.001954 0.000441 0.000183 0.001514 0.000840 0.000461 0.000190 0.001648 0.001333
Nuclear Periphery Foci 0.000145 0.000205 0.001419 0.000958 0.000243 0.000177 0.000775 0.000462 0.000220 0.000190 0.000906 0.000682
Nucleolus 0.001196 0.001239 0.001320 0.003153 0.001300 0.001731 0.001232 0.000770 0.001276 0.001496 0.001250 0.001825
Nucleus 0.057859 0.012640 0.664615* 0.305796* 0.026789 0.008191 0.386711* 0.230250* 0.034064 0.010313 0.443500* 0.263697*
Peroxisomes 0.026840 0.059657 0.000554 0.008170 0.032202 0.061800 0.002659 0.017811 0.030947 0.060778 0.002229 0.013543
Vacuole 0.079113 0.047580 0.064631 0.126130 0.057796 0.037423 0.049468 0.118644 0.062787 0.042267 0.052567 0.121958
Vacuole Periphery 0.006224 0.011679 0.000590 0.001942 0.011581 0.011526 0.000469 0.000705 0.010327 0.011599 0.000494 0.001253

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.23 0.67 -1.19 1.29 -2.80 -1.85 3.06 -4.67 -2.76 -5.72 -3.15 2.73 -4.62 -1.59 -6.34
Bud Neck 4.51 14.89 8.63 5.57 -11.37 4.08 11.88 8.91 3.98 -4.03 5.87 16.20 12.47 6.64 -5.76
Bud Site -6.61 4.33 -2.30 3.85 -6.57 2.95 6.57 -1.63 -3.92 -6.77 -1.34 7.33 -1.29 -0.19 -7.62
Cell Periphery -1.86 -0.84 -4.71 1.26 -3.53 -4.14 1.41 1.27 5.68 -0.68 -2.79 1.25 -0.46 2.73 -1.87
Cytoplasm 16.18 0.79 -15.21 -39.32 -13.64 20.04 -34.25 -35.88 -53.86 2.40 23.84 -29.89 -39.71 -65.81 -1.17
Cytoplasmic Foci 10.34 36.28 30.45 29.50 -13.10 13.20 49.08 37.63 22.27 -13.46 14.86 59.83 48.66 36.33 -16.96
Eisosomes 4.37 9.12 7.76 4.32 -4.41 -0.66 12.87 7.26 8.16 -12.85 2.02 15.77 10.13 8.79 -15.01
Endoplasmic Reticulum 3.38 -6.38 0.37 -7.61 8.81 3.40 -2.23 -0.57 -13.25 3.62 4.21 -4.52 -0.46 -13.86 7.69
Endosome -9.90 14.82 11.75 24.77 -7.85 -5.29 29.47 28.59 28.55 -3.44 -8.50 32.69 29.73 37.95 -8.75
Golgi -18.58 12.34 11.14 27.33 -3.31 -11.70 26.37 25.89 28.66 -1.32 -17.36 28.34 27.78 39.55 -2.08
Lipid Particles 9.39 11.01 10.06 1.85 -4.40 2.68 13.64 12.79 8.28 -4.41 8.72 17.11 14.73 7.68 -7.71
Mitochondria -17.13 17.65 17.11 41.02* -5.59 -14.54 42.93* 42.44* 52.52* -3.16 -17.54 45.59* 44.99* 65.91* -4.89
Mitotic Spindle -6.44 3.19 -2.70 3.58 -6.41 -1.48 -0.73 -1.66 -0.39 -0.81 -5.88 0.02 -2.77 2.60 -2.46
None 1.40 -5.29 -4.62 -4.90 -2.67 1.39 -4.92 -1.27 -3.34 6.70 1.90 -6.30 -4.30 -5.80 -0.92
Nuclear Periphery 4.36 -14.41 -10.77 -13.89 1.36 2.00 -10.02 -5.39 -15.99 8.11 2.74 -13.37 -10.03 -19.49 4.04
Nuclear Periphery Foci -2.44 -7.64 -4.00 -3.72 2.45 0.97 -4.80 -4.70 -7.31 2.68 0.60 -7.42 -4.99 -5.57 2.09
Nucleolus -0.32 -0.55 -5.27 -4.84 -3.97 -1.10 0.37 2.39 2.18 1.04 -0.97 0.24 -2.38 -0.68 -1.88
Nucleus 12.34 -42.55 -32.14 -42.94 23.80 11.02 -51.08 -41.82 -46.27 18.56 15.24 -61.16 -54.82 -62.72 24.36
Peroxisomes -9.50 11.68 8.03 18.57 -6.02 -9.31 18.88 8.70 15.25 -8.74 -12.91 21.86 12.72 23.39 -9.79
Vacuole 6.58 -2.36 -13.11 -21.32 -7.38 7.23 -3.73 -22.84 -27.13 -18.10 8.68 -4.20 -27.48 -34.31 -20.50
Vacuole Periphery -6.93 13.40 10.02 13.82 -3.14 0.06 19.97 19.55 18.86 -1.34 -2.03 22.42 20.49 22.98 -3.93
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
Localization
Cell Percentages mitochondrion (55%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Aac1

Aac1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Aac1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available