Standard name
Human Ortholog
Description Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability; relocalizes to the cytosol in response to hypoxia
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0.05 0.05 – 0 0 0 0 0.09 0.14 0.18 0.15 – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Mitochondria 0.17 0 0 0 0 0 0.06 – 0.23 0.11 0.39 0.16 0 0 0 0.05 – – 0 0 0 0 0 0
Nucleus 0.94 0.89 0.92 0.92 0.91 0.84 0.84 – 0.78 0.85 0.75 0.77 0.89 0.81 0.77 0.65 – – 0.8 0.83 0.76 0.85 0.77 0.77
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Nucleolus 0.29 0.14 0.05 0 0 0.13 0.1 – 0.15 0.11 0.22 0.21 0 0.09 0.07 0.17 – – 0.14 0.11 0.1 0.07 0.09 0.08
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 – – 0 0 0.05 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 1 0 1 0
Bud 0 0 0 0 0 0 1 – 3 1 6 1 0 0 0 0 – – 0 2 0 0 1 3
Bud Neck 0 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Site 0 0 0 2 0 1 2 – 4 4 10 7 0 0 0 1 – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Cytoplasm 0 7 5 5 8 15 17 – 8 9 5 10 16 34 52 6 – – 0 0 1 2 6 3
Endoplasmic Reticulum 0 1 1 0 0 0 2 – 0 0 0 0 0 0 1 1 – – 0 0 0 0 0 0
Endosome 0 1 3 1 2 4 4 – 0 1 0 2 2 2 2 0 – – 1 2 2 1 3 7
Golgi 0 0 3 0 2 0 0 – 0 0 0 0 0 0 2 1 – – 1 2 1 0 0 0
Mitochondria 18 7 0 1 3 10 21 – 53 39 128 48 0 2 0 2 – – 0 2 1 1 2 1
Nucleus 100 334 148 134 208 228 301 – 182 300 249 229 159 198 229 26 – – 87 346 133 139 196 212
Nuclear Periphery 0 0 0 1 2 3 1 – 1 5 2 3 0 1 1 0 – – 0 1 0 0 0 0
Nucleolus 31 51 8 6 9 36 36 – 36 38 72 63 5 21 21 7 – – 15 45 18 11 23 21
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 3 0 – – 0 0 0 0 0 0
SpindlePole 0 1 7 1 4 3 6 – 4 10 3 9 1 2 5 1 – – 0 3 2 0 5 7
Vac/Vac Membrane 1 10 4 1 3 1 7 – 2 1 0 4 2 1 1 2 – – 1 7 8 3 10 11
Unique Cell Count 106 374 161 145 229 273 358 233 352 330 296 178 244 297 40 110 418 175 164 257 277
Labelled Cell Count 150 412 179 152 241 301 398 293 408 476 376 185 261 317 47 110 418 175 164 257 277


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.9 7.9 7.7 7.6 7.6 6.3 6.7 – 5.7 5.6 4.7 5.4 8.1 8.2 7.9 9.2 – – 7.1 7.7 7.9
Std Deviation (1e-4) 0.8 1.2 1.6 2.2 1.9 1.7 2.7 – 2.1 1.1 0.8 1.4 1.7 1.9 1.9 2.9 – – 1.0 1.7 1.5
Intensity Change (Log2) – – – -0.01 -0.02 -0.28 -0.2 – -0.43 -0.45 -0.7 -0.52 0.08 0.09 0.04 0.26 – – -0.11 0.0 0.04

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_10510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 – –
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 – –
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 – –
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 – –
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 – –
Cytoplasm 0 0.2 1.1 0.9 – 0.2 0 0 0.2 2.2 3.6 4.5 0 – –
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 – –
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 – –
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 – –
Mitochondria 0 0 0 3.1 – 6.5 4.4 0 5.4 0 0 0 0 – –
Nucleus 0.2 -0.4 -2.5 -2.4 – -3.7 -2.1 -4.4 -3.9 -0.8 -3.0 -4.0 -4.5 – –
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 – –
Nucleolus -0.3 -0.5 2.7 1.9 – 3.2 2.1 0 4.6 -1.0 1.4 0.9 0 – –
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 – –
SpindlePole 0 0 0 0 – 0 -0.9 0 -0.7 0 0 0 0 – –
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.5593 2.439 2.3468 1.6755 1.2427 2.2926 2.0557 3.0875 2.2522 1.9953 1.7301 2.1161 3.3713 3.5975 3.135 3.3956 3.2437 3.1672
Actin 0.0159 0.0001 0.0055 0.0167 0 0.0005 0.0142 0 0.0003 0.0629 0 0 0.0321 0.0001 0.005 0.0535 0.0005 0
Bud 0.0004 0 0.0004 0.0004 0.0001 0.0001 0.0007 0 0.0001 0.0008 0 0 0.0005 0 0.0004 0.0002 0.0002 0
Bud Neck 0.0003 0 0.0002 0.0001 0.0005 0.0008 0.0008 0.0001 0.0005 0.0049 0.0002 0.0006 0.0015 0 0.0006 0.0029 0.0006 0.0005
Bud Periphery 0.0004 0.0001 0.0006 0.0007 0.0002 0.0001 0.0012 0 0.0001 0.0013 0.0001 0 0.0011 0 0.0005 0.0005 0.0003 0
Bud Site 0.0015 0 0.001 0.001 0.0003 0.0001 0.0022 0 0.0003 0.0033 0.0001 0 0.0017 0 0.0028 0.0007 0.0004 0
Cell Periphery 0.0002 0 0.0001 0.0001 0.0001 0 0.0003 0 0 0.0003 0 0 0.0004 0 0.0002 0.0001 0 0
Cytoplasm 0.0216 0.0002 0.0035 0.0005 0 0.0126 0.0012 0 0.0005 0.0019 0 0 0.0054 0.0014 0.0015 0.0031 0.0003 0.0002
Cytoplasmic Foci 0.0302 0 0.0162 0.009 0 0.0123 0.0052 0 0.0003 0.0603 0 0 0.0151 0.0007 0.0046 0.0025 0.0107 0.0002
Eisosomes 0 0 0.0001 0.0001 0 0 0.0001 0 0 0.0004 0 0 0.0003 0 0 0.0003 0 0
Endoplasmic Reticulum 0.0031 0 0.0013 0.0021 0 0.0012 0.0014 0 0.0002 0.006 0 0 0.0053 0.0003 0.0003 0.0021 0.0001 0.0001
Endosome 0.0227 0.0001 0.0201 0.0224 0.0001 0.002 0.0155 0 0.0004 0.0425 0 0 0.0198 0.0009 0.0023 0.0145 0.0094 0.0004
Golgi 0.0082 0 0.0082 0.0237 0 0.0009 0.0079 0 0.0001 0.0318 0 0 0.0062 0 0.0014 0.0051 0.0026 0
Lipid Particles 0.0131 0 0.0155 0.0249 0.0001 0.0044 0.0094 0 0.0001 0.0439 0 0 0.0184 0.0002 0.0079 0.0026 0.0111 0.0001
Mitochondria 0.005 0.0113 0.0354 0.0807 0.0008 0.0002 0.0033 0.0001 0.0003 0.0127 0.0004 0.0001 0.0056 0.0001 0.004 0.0029 0.0021 0.0001
None 0.0014 0.0001 0.0032 0.0005 0.0001 0.0003 0.0006 0 0.0001 0.001 0 0 0.0071 0.0037 0.0005 0.002 0.0005 0.0001
Nuclear Periphery 0.0141 0.0012 0.0042 0.0148 0.0005 0.0048 0.0081 0.0007 0.0033 0.0173 0.0006 0.0001 0.0249 0.0031 0.0017 0.0092 0.0032 0.0017
Nucleolus 0.0513 0.0188 0.0337 0.0084 0.3841 0.0982 0.0274 0.0297 0.0191 0.0434 0.1622 0.0776 0.0323 0.0248 0.0299 0.0085 0.1893 0.086
Nucleus 0.7387 0.9619 0.8313 0.7814 0.6053 0.834 0.8903 0.9689 0.9687 0.5911 0.8341 0.9206 0.7786 0.9594 0.916 0.8825 0.7497 0.9083
Peroxisomes 0.0148 0 0.0128 0.0085 0 0.0037 0.0024 0 0.0001 0.0624 0 0 0.0074 0 0.0038 0.001 0.0095 0
Punctate Nuclear 0.0511 0.005 0.003 0.0019 0.007 0.0234 0.0028 0.0004 0.0052 0.0078 0.0022 0.0009 0.0293 0.0048 0.0137 0.0047 0.0087 0.0022
Vacuole 0.0037 0.0003 0.0019 0.0006 0.0003 0.0003 0.0039 0 0.0001 0.0021 0.0001 0 0.0044 0.0002 0.0023 0.0005 0.0004 0.0001
Vacuole Periphery 0.0022 0.0006 0.0017 0.0014 0.0002 0.0001 0.0012 0 0.0001 0.0024 0 0 0.0025 0.0001 0.0005 0.0006 0.0004 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 23.3266 28.1268 11.875 27.1953 23.2105 21.145 20.7163 17.8706 19.3476 29.014
Translational Efficiency 1.0598 0.7824 1.721 0.7221 0.9492 1.0787 0.8434 0.9984 1.0655 0.8905

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1004 1091 268 449 2014 977 1763 169 3018 2068 2031 618

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 768.97 766.94 1053.84 1034.41 817.25 857.77 971.46 1096.66 801.19 809.85 982.33 1051.43
Standard Deviation 100.53 130.81 111.84 175.32 113.43 127.52 131.97 144.86 111.65 136.99 132.46 169.82
Intensity Change Log 2 — -0.003814 0.454657 0.427809 — 0.069813 0.249377 0.424267 — 0.034589 0.352543 0.425985

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000878 0.001308 0.001343 0.002131 0.000391 0.000978 0.000538 0.017505 0.000553 0.001153 0.000644 0.006335
Bud Neck 0.005076 0.007356 0.016441 0.038447 0.005856 0.007777 0.024587 0.034283 0.005596 0.007555 0.023512 0.037309
Bud Site 0.002087 0.004235 0.001678 0.022779 0.000724 0.002582 0.000970 0.011617 0.001177 0.003454 0.001063 0.019726
Cell Periphery 0.000128 0.000196 0.000037 0.000296 0.000064 0.000065 0.000030 0.000197 0.000085 0.000134 0.000031 0.000269
Cytoplasm 0.038434 0.021535 0.000126 0.009313 0.006495 0.002764 0.000437 0.002932 0.017120 0.012667 0.000396 0.007568
Cytoplasmic Foci 0.003316 0.003122 0.000028 0.004783 0.000531 0.003652 0.000010 0.009462 0.001457 0.003372 0.000012 0.006062
Eisosomes 0.000029 0.000041 0.000060 0.000047 0.000023 0.000032 0.000031 0.000060 0.000025 0.000037 0.000034 0.000051
Endoplasmic Reticulum 0.002494 0.003974 0.002846 0.004327 0.001895 0.002486 0.001945 0.003212 0.002094 0.003271 0.002064 0.004022
Endosome 0.001397 0.001725 0.000101 0.010458 0.000272 0.001921 0.000094 0.014216 0.000646 0.001818 0.000095 0.011486
Golgi 0.001157 0.002008 0.000201 0.005087 0.000424 0.002044 0.000116 0.018378 0.000668 0.002025 0.000127 0.008722
Lipid Particles 0.000736 0.000917 0.000071 0.000350 0.000111 0.000457 0.000019 0.000401 0.000319 0.000699 0.000026 0.000364
Mitochondria 0.002040 0.002927 0.001256 0.010845 0.001296 0.006696 0.000980 0.038468 0.001544 0.004708 0.001017 0.018399
Mitotic Spindle 0.005202 0.002611 0.001377 0.052048 0.001818 0.008392 0.001923 0.049752 0.002944 0.005342 0.001851 0.051420
None 0.032265 0.030626 0.001355 0.005822 0.007368 0.004129 0.001665 0.004196 0.015650 0.018108 0.001624 0.005378
Nuclear Periphery 0.000286 0.000202 0.000125 0.002434 0.000157 0.000410 0.000280 0.000706 0.000200 0.000300 0.000260 0.001962
Nuclear Periphery Foci 0.002309 0.002803 0.000075 0.001945 0.000735 0.000848 0.000087 0.000740 0.001259 0.001879 0.000086 0.001615
Nucleolus 0.098515 0.118232 0.109820 0.032626 0.100159 0.124117 0.067878 0.021167 0.099612 0.121012 0.073412 0.029492
Nucleus 0.799725 0.789687 0.860354 0.767264 0.870553 0.825684 0.897773 0.743681 0.846991 0.806693 0.892836 0.760815
Peroxisomes 0.001241 0.001953 0.001865 0.001020 0.000383 0.001212 0.000256 0.001127 0.000668 0.001603 0.000469 0.001050
Vacuole 0.001875 0.003461 0.000648 0.018655 0.000487 0.001667 0.000234 0.014391 0.000949 0.002613 0.000289 0.017489
Vacuole Periphery 0.000810 0.001081 0.000197 0.009322 0.000258 0.002087 0.000146 0.013510 0.000442 0.001556 0.000153 0.010467

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.23 -5.23 -6.21 -4.29 -3.45 -3.97 -7.78 -1.52 -1.40 -1.47 -6.52 -4.63 -2.41 -1.97 -2.29
Bud Neck -2.71 -11.73 -11.51 -10.84 -6.38 -2.90 -19.66 -5.54 -5.22 -1.80 -3.75 -21.57 -12.48 -11.78 -4.33
Bud Site -2.38 0.19 -4.01 -3.42 -4.04 -2.13 -4.07 -3.89 -3.02 -3.70 -3.88 -0.40 -5.26 -4.30 -5.24
Cell Periphery -3.11 6.64 -2.46 -0.55 -5.04 -0.15 3.74 -2.89 -2.71 -4.13 -3.75 7.38 -4.23 -2.28 -6.37
Cytoplasm 3.77 10.50 8.01 4.90 -3.39 2.44 5.35 2.24 -0.13 -2.68 2.08 11.51 6.05 3.82 -3.74
Cytoplasmic Foci 0.63 4.25 1.92 1.43 -2.65 -2.86 2.82 -1.58 0.06 -1.92 -2.33 5.02 -0.67 1.23 -3.25
Eisosomes -3.16 -8.39 -6.77 -3.69 1.70 -5.29 -8.14 -6.16 -4.67 -4.83 -6.61 -8.65 -10.86 -6.52 -7.48
Endoplasmic Reticulum -5.40 -2.00 -5.71 -3.00 -4.55 -3.03 -1.89 -5.94 -4.68 -5.58 -7.20 -1.22 -8.32 -5.28 -8.06
Endosome 0.34 3.68 -1.89 -2.15 -3.69 -2.66 3.18 -2.31 -1.54 -2.39 -2.61 4.29 -3.64 -2.60 -4.41
Golgi -2.06 4.14 -0.88 0.02 -1.98 -3.14 2.17 -1.68 -1.26 -1.76 -4.33 4.62 -2.16 -1.05 -2.61
Lipid Particles -0.38 4.55 2.50 1.36 -5.87 -2.24 3.79 -3.27 0.35 -4.46 -1.61 5.67 -0.72 1.42 -8.25
Mitochondria -1.58 1.34 -3.32 -2.70 -3.82 -3.31 0.23 -2.19 -1.41 -2.21 -3.78 0.93 -3.66 -2.16 -3.85
Mitotic Spindle 1.77 0.96 -5.08 -5.74 -5.46 -3.16 -0.87 -3.14 -2.53 -3.05 -1.63 0.28 -6.37 -5.99 -6.42
None 0.58 11.92 10.18 8.25 -4.67 2.90 6.59 3.69 0.42 -3.24 -1.12 13.24 9.26 7.64 -5.29
Nuclear Periphery 2.84 3.61 -7.27 -7.69 -7.77 -2.48 -4.54 -5.34 -4.00 -4.38 -1.75 -3.41 -8.82 -8.24 -8.07
Nuclear Periphery Foci -0.46 7.40 3.72 2.88 -4.63 -0.96 3.65 0.33 1.14 -2.64 -1.86 7.82 1.51 2.73 -5.38
Nucleolus -2.40 -1.91 11.93 16.13 9.69 -4.55 6.91 13.87 15.63 8.33 -5.12 6.13 18.33 21.88 11.68
Nucleus -0.16 -4.71 -1.45 -1.38 2.20 6.07 -3.36 2.98 0.91 3.73 6.26 -8.16 3.14 -0.08 6.59
Peroxisomes -1.65 -1.90 1.64 3.48 5.50 -3.82 1.83 -3.99 0.63 -4.79 -4.22 1.85 -1.75 3.46 -5.31
Vacuole -1.39 3.91 -4.24 -3.70 -4.85 -2.93 1.40 -3.69 -3.28 -3.75 -3.31 4.72 -5.70 -4.89 -6.06
Vacuole Periphery -1.13 3.16 -2.36 -2.15 -2.83 -2.70 1.78 -1.72 -1.07 -1.76 -3.31 3.79 -3.10 -2.13 -3.34
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability; relocalizes to the cytosol in response to hypoxia
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Rna14

Rna14


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rna14-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available