Standard name
Human Ortholog
Description Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs; SEC14 has a paralog, YKL091C, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.09 0.05 0 0.12 0.07 0 0 0 0 0.06 0.06 0.07 0.05 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 1.0 0.98 0.96 0.92 0.95 0.87 0.86 0.83 0.8 0.83 0.81 0.98 0.98 0.97 0.98 0.98 0.97 0.98 0.96 0.94 0.94 0.92 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 0.11 0.11 0.12 0.14 0.1 0.12 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 2 5 8 3 6 10 0 0 0 0 0 0 0 0 0 3 0 2
Bud 6 0 4 0 9 3 3 8 2 5 4 11 3 2 2 0 0 0 0 1 0 1 3 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 29 6 11 34 33 22 17 17 19 37 34 52 15 13 17 0 6 1 0 0 1 0 0 0
Cytoplasm 329 120 267 276 421 526 528 528 452 501 455 585 292 437 395 110 163 107 337 106 264 272 221 246
Endoplasmic Reticulum 0 0 3 5 13 20 69 68 64 86 56 85 4 7 10 6 5 3 1 0 5 4 2 5
Endosome 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Mitochondria 2 0 1 1 1 1 3 1 11 3 21 11 1 0 0 0 0 1 0 0 1 0 0 1
Nucleus 4 0 0 2 3 3 6 5 4 13 3 5 1 1 0 0 0 0 0 0 0 0 2 0
Nuclear Periphery 0 0 0 0 0 0 1 2 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 1 0 0 0 0 1 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 13 0 3 3 6 19 4 7 0 1 1 0 2 2 1 0 2 1 3 4
Unique Cell Count 335 120 273 287 456 554 609 612 542 629 551 722 299 447 406 112 166 110 344 110 281 290 241 268
Labelled Cell Count 370 126 287 319 493 576 632 637 567 667 586 767 316 461 425 117 176 114 344 110 281 290 241 268


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 45.9 50.3 34.3 32.2 28.4 24.4 23.7 25.4 23.7 24.2 22.8 23.2 40.0 40.3 41.5 45.8 48.3 50.1 44.0 44.1 44.3
Std Deviation (1e-4) 8.1 11.1 7.4 6.6 6.6 5.0 4.7 5.6 5.2 5.2 5.0 4.7 8.3 9.2 7.8 13.5 14.1 13.1 10.9 12.1 12.3
Intensity Change (Log2) – – – -0.09 -0.28 -0.49 -0.53 -0.43 -0.54 -0.51 -0.59 -0.56 0.22 0.23 0.27 0.42 0.49 0.55 0.36 0.36 0.37

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000204060WT3HU80HU120HU1600204060WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30204060WT1AF100AF140AF1800204060
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 3.4 1.8 0 -1.0 -1.0 -0.4 1.1 1.3 1.8 0.6 -0.8 0.1 0 -0.2 0
Cytoplasm -1.1 -3.1 -1.9 -5.1 -5.2 -6.0 -7.0 -6.2 -6.7 -0.1 0 -0.4 0.3 0.3 -0.3
Endoplasmic Reticulum 0 1.6 2.1 5.1 5.1 5.3 5.8 4.8 5.3 0 0 1.3 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 2.9 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 2.9 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 30.8927 40.3192 36.4718 35.3111 30.1898 38.111 35.7403 45.1604 41.485 38.2656 38.0118 39.2932 32.4491 41.3635 36.7276 34.696 24.2948 38.0533
Actin 0.0034 0.0006 0.002 0.0124 0.0026 0.0015 0.0033 0.0003 0.0097 0.0027 0.0456 0.0007 0.0027 0.0005 0.0156 0.0007 0.0637 0.0013
Bud 0.0007 0 0.0007 0.0005 0.0007 0.0006 0.0002 0 0.0002 0.0035 0.0002 0.0001 0.0002 0 0.001 0.0002 0.0015 0
Bud Neck 0.0009 0.0005 0.0006 0.0013 0.0013 0.0031 0.0003 0.0003 0.0005 0.0008 0.0007 0.0064 0.0044 0.0005 0.0004 0.0005 0.0021 0.0026
Bud Periphery 0.0006 0 0.0005 0.0008 0.0007 0.0004 0.0002 0 0.0002 0.0049 0.0001 0.0001 0.0002 0 0.0011 0.0004 0.0021 0
Bud Site 0.0012 0.0003 0.0006 0.0015 0.0008 0.0001 0.0002 0.0001 0.0006 0.0009 0.0005 0 0.0089 0 0.005 0.0001 0.0163 0
Cell Periphery 0.001 0.0001 0.0006 0.0006 0.0005 0.0003 0.0002 0.0002 0.0002 0.0005 0.0001 0.0001 0.0003 0 0.0001 0.0002 0.0008 0
Cytoplasm 0.8483 0.992 0.936 0.9187 0.8467 0.9802 0.9177 0.9973 0.9546 0.8955 0.9095 0.9662 0.9143 0.9964 0.9412 0.9265 0.6118 0.9656
Cytoplasmic Foci 0.0277 0.0005 0.0122 0.0237 0.0341 0.0008 0.009 0.0002 0.008 0.0129 0.0083 0.002 0.0162 0.0001 0.0059 0.019 0.0627 0.0018
Eisosomes 0.0001 0 0 0.0007 0 0 0 0 0.0001 0.0001 0.0001 0 0.0001 0 0.0001 0 0.0008 0
Endoplasmic Reticulum 0.0068 0.0029 0.0049 0.0033 0.0046 0.0073 0.0059 0.0005 0.0014 0.0019 0.0076 0.0049 0.0024 0.0008 0.0025 0.0115 0.0024 0.0043
Endosome 0.0225 0.0001 0.0073 0.0055 0.028 0.0002 0.013 0 0.0024 0.008 0.0103 0.001 0.0078 0 0.0045 0.0044 0.0412 0.0002
Golgi 0.0033 0 0.002 0.0045 0.0185 0.0001 0.0023 0 0.0019 0.0008 0.0017 0.0001 0.0013 0 0.0021 0.0006 0.0307 0.0003
Lipid Particles 0.0124 0.0001 0.0073 0.0107 0.0127 0.0001 0.0041 0 0.008 0.0041 0.0062 0.0003 0.0097 0 0.0024 0.0108 0.0716 0.0049
Mitochondria 0.0119 0 0.0024 0.0057 0.0085 0.0002 0.0026 0 0.0027 0.0175 0.0011 0.0089 0.0073 0 0.0053 0.0025 0.0375 0.0053
None 0.0052 0.0002 0.0067 0.0026 0.0043 0.0003 0.0049 0.0001 0.0016 0.004 0.0014 0.0012 0.0045 0.0001 0.0036 0.0031 0.0035 0.0001
Nuclear Periphery 0.0063 0.0007 0.0017 0.0014 0.0036 0.001 0.0111 0.0002 0.0007 0.009 0.0024 0.0005 0.0017 0.0004 0.0029 0.0074 0.0087 0.0009
Nucleolus 0.0034 0 0.0008 0.0003 0.0007 0.0001 0.0002 0 0.0001 0.0022 0 0.0017 0.0005 0 0.0002 0.0005 0.001 0
Nucleus 0.0139 0.0017 0.0029 0.0024 0.0038 0.0031 0.0052 0.0007 0.0011 0.0038 0.0014 0.0024 0.003 0.001 0.0022 0.0038 0.0021 0.0027
Peroxisomes 0.002 0 0.0023 0.0015 0.0056 0 0.0064 0 0.0036 0.0009 0.001 0.0002 0.009 0 0.0006 0.0008 0.0273 0.0095
Punctate Nuclear 0.0114 0.0001 0.0024 0.0008 0.001 0.0002 0.0061 0 0.0008 0.0061 0.0008 0.0005 0.0033 0 0.0019 0.0017 0.0053 0.0001
Vacuole 0.0134 0.0001 0.0049 0.001 0.0158 0.0003 0.0045 0 0.0013 0.0125 0.0007 0.0022 0.0016 0 0.0009 0.0033 0.0045 0.0001
Vacuole Periphery 0.0036 0 0.0011 0.0003 0.0055 0.0001 0.0026 0 0.0002 0.0076 0.0004 0.0005 0.0006 0 0.0006 0.002 0.0022 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 268.9171 293.2178 222.3799 192.7911 229.836 278.4102 235.7063 179.1326 174.9152 214.9034
Translational Efficiency 2.0614 1.9452 1.692 2.0608 1.9863 2.0086 1.8868 2.2033 1.8108 1.9534

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1264 996 1472 140 1369 1786 164 2012 2633 2782 1636 2152

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2133.80 2823.99 3953.80 4405.62 2193.67 2630.91 3619.94 4163.35 2164.93 2700.04 3920.33 4179.11
Standard Deviation 417.71 600.71 689.12 703.33 490.92 525.06 523.56 752.84 458.22 561.03 681.78 752.09
Intensity Change Log 2 — 0.404310 0.889815 1.045920 — 0.262215 0.722619 0.924398 — 0.334029 0.807482 0.985598

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000478 0.000633 0.000345 0.001441 0.000591 0.001078 0.002274 0.001510 0.000537 0.000919 0.000538 0.001505
Bud Neck 0.001551 0.002699 0.003660 0.009619 0.001436 0.002391 0.022113 0.003096 0.001491 0.002501 0.005510 0.003520
Bud Site 0.008252 0.012434 0.004606 0.021307 0.009466 0.018427 0.045968 0.026550 0.008883 0.016281 0.008752 0.026209
Cell Periphery 0.004041 0.021208 0.007429 0.129958 0.008844 0.011960 0.101413 0.052216 0.006538 0.015271 0.016850 0.057274
Cytoplasm 0.848939 0.793038 0.690424 0.375155 0.856888 0.819816 0.169819 0.761635 0.853072 0.810229 0.638236 0.736492
Cytoplasmic Foci 0.014493 0.010493 0.015235 0.018835 0.007659 0.013385 0.020841 0.002158 0.010940 0.012349 0.015797 0.003243
Eisosomes 0.000008 0.000023 0.000010 0.000159 0.000014 0.000030 0.000199 0.000051 0.000011 0.000027 0.000029 0.000058
Endoplasmic Reticulum 0.000606 0.000312 0.000093 0.000039 0.000512 0.000557 0.000152 0.000061 0.000557 0.000469 0.000099 0.000059
Endosome 0.000453 0.000305 0.000236 0.000127 0.000352 0.000774 0.001195 0.000178 0.000401 0.000606 0.000332 0.000175
Golgi 0.003304 0.002485 0.000849 0.000448 0.003282 0.004038 0.000949 0.000660 0.003292 0.003482 0.000859 0.000646
Lipid Particles 0.014160 0.031387 0.014025 0.084211 0.014303 0.027091 0.164989 0.018918 0.014234 0.028629 0.029159 0.023166
Mitochondria 0.000070 0.000063 0.000165 0.000016 0.000109 0.000167 0.000018 0.000111 0.000090 0.000130 0.000151 0.000105
Mitotic Spindle 0.001135 0.000400 0.000664 0.000185 0.000409 0.001209 0.000424 0.000169 0.000758 0.000919 0.000640 0.000170
None 0.011767 0.009017 0.015334 0.002639 0.014550 0.009595 0.000333 0.003018 0.013214 0.009388 0.013831 0.002993
Nuclear Periphery 0.000139 0.000234 0.000506 0.000780 0.000152 0.000161 0.000706 0.000201 0.000146 0.000187 0.000526 0.000239
Nuclear Periphery Foci 0.025306 0.021922 0.007523 0.013929 0.019619 0.015658 0.020731 0.003028 0.022349 0.017901 0.008847 0.003737
Nucleolus 0.000128 0.000473 0.000119 0.000053 0.000171 0.000124 0.000033 0.000082 0.000150 0.000249 0.000111 0.000080
Nucleus 0.044672 0.040367 0.195347 0.036119 0.037100 0.033960 0.012029 0.019483 0.040735 0.036254 0.176970 0.020565
Peroxisomes 0.000056 0.000259 0.000020 0.000096 0.000066 0.000186 0.000183 0.000200 0.000061 0.000212 0.000036 0.000194
Vacuole 0.019604 0.051462 0.043255 0.304662 0.023784 0.038226 0.435399 0.105985 0.021778 0.042964 0.082565 0.118911
Vacuole Periphery 0.000838 0.000786 0.000155 0.000224 0.000695 0.001168 0.000234 0.000690 0.000764 0.001031 0.000163 0.000660

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.06 -1.35 -4.26 -3.16 -3.90 -5.26 -6.55 -7.57 -2.90 2.96 -6.28 -3.76 -8.74 -4.55 -6.74
Bud Neck -4.59 -15.29 -7.87 -6.59 -2.37 -6.09 -12.14 -8.67 -3.49 11.04 -7.32 -19.32 -10.40 -4.83 12.54
Bud Site -3.19 1.69 -3.37 -1.97 -4.19 -6.62 -6.13 -9.67 -4.16 3.49 -7.62 -1.56 -11.26 -5.97 -9.94
Cell Periphery -8.62 -5.37 -6.32 -4.63 -5.97 -2.67 -5.46 -15.17 -13.69 0.42 -8.58 -4.87 -17.90 -13.24 -14.77
Cytoplasm 7.20 32.83 22.21 19.04 10.25 6.90 36.35 15.75 9.38 -30.01 9.59 41.43 19.96 11.99 -20.43
Cytoplasmic Foci 2.94 -8.20 -4.86 -5.86 -1.15 -7.25 -8.49 8.24 13.70 9.56 -2.72 -13.40 9.69 11.95 18.25
Eisosomes -7.04 -5.35 -5.75 -4.84 -5.31 -9.43 -9.16 -11.28 -5.16 6.51 -12.34 -8.48 -13.48 -7.42 -6.76
Endoplasmic Reticulum 2.28 4.43 5.06 5.51 8.09 0.23 2.18 2.60 3.12 4.46 0.87 4.00 4.49 4.02 4.45
Endosome 1.69 1.26 4.80 4.33 4.86 -2.68 -3.73 2.31 3.97 4.47 -1.98 -0.98 3.61 4.28 4.40
Golgi 1.66 5.11 6.12 9.54 7.77 -0.71 4.34 4.28 4.50 0.85 -0.17 6.49 5.81 5.34 1.26
Lipid Particles -6.50 -1.98 -8.73 -5.80 -8.17 -7.10 -12.33 -3.28 4.29 11.71 -9.53 -7.78 -5.62 3.71 3.00
Mitochondria 0.47 -7.27 2.97 7.04 20.88 -0.86 2.95 0.08 0.85 -2.10 -0.92 -4.97 -0.24 0.53 2.19
Mitotic Spindle 1.40 0.27 2.04 4.17 6.10 -3.17 -2.16 0.80 3.72 2.45 -0.69 -1.08 1.92 3.85 4.94
None 2.00 0.38 6.43 5.00 9.22 3.21 10.20 7.79 7.31 -4.72 3.65 2.89 9.74 8.22 9.87
Nuclear Periphery -5.99 -19.75 -11.38 -9.27 2.16 -0.68 -11.48 -2.75 -2.55 10.79 -3.69 -20.85 -6.74 -3.33 18.18
Nuclear Periphery Foci 1.95 11.33 3.29 1.96 -3.25 2.94 -0.30 14.64 14.16 7.92 4.10 12.59 19.76 17.89 11.56
Nucleolus -0.93 -0.33 1.29 1.07 8.61 1.05 2.48 1.79 3.97 -3.97 -0.76 0.46 1.92 1.18 6.60
Nucleus 1.54 -40.32 -2.03 -2.52 21.05 1.02 5.60 5.18 4.88 -2.21 2.51 -39.00 7.30 5.44 41.31
Peroxisomes -1.16 2.25 -0.78 1.10 -3.58 -5.89 -1.70 -5.80 0.53 0.82 -2.10 0.66 -6.33 0.81 -6.02
Vacuole -11.23 -17.65 -17.35 -15.40 -13.51 -8.04 -27.29 -27.12 -22.05 20.95 -13.75 -22.35 -30.93 -23.55 -1.32
Vacuole Periphery 0.17 1.85 1.92 1.18 1.45 -1.24 3.11 0.38 1.32 -1.29 -0.72 3.09 0.65 1.17 -1.32
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs; SEC14 has a paralog, YKL091C, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Sec14

Sec14


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sec14-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available