Standard name
Human Ortholog
Description Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation, controls eisosome length and shape; diffusely distributed, forms heterogeneous patches at plasma membrane in small buds, also found in medium and large buds; expression repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes; SEG1 has a paralog, SEG2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.59 0.51 0.68 0.63 0.57 0.56 0.44 0.32 0.44 – 0.39 0.36 0.7 0.63 0.68 0.24 0.18 0.15 0.1 0.16 0.21 0.22 0.23 0.18
Bud 0.05 0 0.14 0.1 0.08 0.1 0.07 0.08 0.06 – 0.08 0.06 0.05 0.07 0.11 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.7 0.68 0.54 0.55 0.57 0.5 0.38 0.21 0.43 – 0.41 0.42 0.65 0.59 0.69 0.8 0.8 0.84 0.85 0.73 0.68 0.73 0.69 0.76
Cytoplasm 0 0.06 0.08 0.08 0.11 0.06 0.07 0.07 0 – 0.08 0.05 0 0.06 0 0.09 0.08 0.11 0 0 0 0 0 0
Endoplasmic Reticulum 0.06 0.06 0.05 0.06 0 0 0 0.05 0.08 – 0 0.05 0.11 0.07 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.06 0.09 0 0 0 0 0 0 0
Mitochondria 0.29 0.25 0.36 0.68 0.55 0.65 0.68 0.67 0.74 – 0.74 0.78 0.34 0.26 0.54 0.09 0.09 0.07 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.06 0 0.2 0.13 0.38 0.26 0.22 0.18 0.07 – 0.09 0.08 0.11 0.23 0.13 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 111 71 152 160 170 226 236 186 184 – 134 150 172 234 269 76 35 30 21 23 54 40 57 44
Bud 9 6 32 26 23 38 36 49 26 – 29 27 12 25 45 9 1 3 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 3 4 2 1 0
Bud Site 0 0 0 0 0 1 0 2 1 – 0 0 0 0 1 0 0 0 – – – – – –
Cell Periphery 130 95 122 138 169 201 207 122 177 – 142 175 160 221 275 254 160 165 177 108 176 133 173 187
Cytoplasm 4 8 17 20 32 23 37 41 17 – 27 21 10 23 16 28 15 22 0 1 6 0 2 3
Endoplasmic Reticulum 12 8 11 15 4 14 23 30 34 – 9 20 26 25 11 12 10 8 5 4 4 1 6 2
Endosome 0 0 0 0 0 0 0 2 0 – 0 1 0 0 0 1 0 0 1 1 0 0 2 1
Golgi 3 0 5 0 4 1 1 9 0 – 0 0 4 3 0 19 17 7 0 1 1 0 0 0
Mitochondria 54 35 80 171 162 261 366 386 305 – 254 327 84 99 215 29 17 13 1 0 3 1 1 1
Nucleus 0 0 0 1 2 2 0 4 0 – 1 0 0 0 1 0 0 2 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 1 0 0 2 0 – 0 0 0 0 0 0 0 0 0 1 0 0 1 0
Nucleolus 0 0 2 0 0 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 11 2 45 34 112 102 120 106 27 – 31 32 26 87 53 0 1 1 0 0 2 0 0 1
SpindlePole 1 0 0 0 0 0 1 3 0 – 2 0 0 0 0 1 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 1 0 0 0 0 1 0 – 2 3 0 1 1 3 1 3 0 1 1 0 0 0
Unique Cell Count 187 140 224 253 296 400 538 577 414 345 417 247 374 397 316 199 196 209 149 259 184 250 246
Labelled Cell Count 335 225 467 565 679 869 1028 943 771 631 756 494 718 887 432 257 254 209 149 259 184 250 246


Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.1 9.4 8.1 7.6 8.8 8.1 7.8 7.6 6.8 – 6.4 6.5 9.0 8.9 8.0 14.4 15.9 16.3 9.2 9.1 9.5
Std Deviation (1e-4) 1.2 1.4 2.6 1.4 1.7 1.4 1.4 1.6 1.2 – 1.1 1.3 1.3 1.4 1.5 3.9 3.8 4.6 1.3 1.6 1.5
Intensity Change (Log2) – – – -0.11 0.11 -0.01 -0.07 -0.1 -0.27 – -0.34 -0.32 0.14 0.12 -0.02 0.82 0.97 1.0 0.18 0.16 0.23


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.1 -2.4 -2.8 -6.0 -9.2 -5.7 – -6.8 -7.7 0.4 -1.3 0 -10.2 -10.4 -10.8
Bud -1.3 -2.4 -1.8 -3.3 -2.4 -3.4 – -2.2 -3.3 -3.5 -3.1 -1.1 -4.9 -5.3 -4.7
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0.6 -1.0 -4.1 -9.2 -2.8 – -3.1 -3.0 2.3 1.1 3.7 6.5 5.6 6.5
Cytoplasm 0.1 1.2 -0.9 -0.3 -0.2 -1.9 – 0.1 -1.3 -1.7 -0.7 -1.9 0.5 0 1.3
Endoplasmic Reticulum 0.5 -2.4 -0.9 -0.4 0.2 1.6 – -1.5 -0.1 2.3 0.9 -1.4 -0.6 0.1 -0.4
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 2.1 2.9 0.8
Mitochondria 7.0 4.3 7.1 8.2 8.0 9.4 – 9.0 10.7 -0.4 -2.4 4.4 -7.6 -6.6 -7.2
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes -2.0 4.4 1.5 0.7 -0.6 -5.2 – -3.8 -4.6 -2.9 0.9 -2.2 -8.3 -6.5 -6.4
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.883 7.2655 7.1967 5.4322 6.1464 7.0255 7.0618 7.8543 7.442 6.4105 7.179 7.2612 6.7237 6.8945 7.5445 6.9896 6.2693 7.1876
Actin 0.0706 0.015 0.0252 0.023 0.0651 0.008 0.0558 0.0106 0.0137 0.0142 0.0059 0.0088 0.0374 0.0099 0.0336 0.0181 0.0211 0.0061
Bud 0.0009 0.0004 0.0008 0.0011 0.0014 0.0004 0.0013 0.0003 0.0004 0.0006 0.0005 0.0004 0.0013 0.0006 0.0078 0.0137 0.0005 0.0002
Bud Neck 0.0054 0.0071 0.0086 0.0064 0.0126 0.0132 0.0047 0.0047 0.0089 0.0148 0.0072 0.0024 0.0045 0.0044 0.0063 0.0094 0.0037 0.0052
Bud Periphery 0.0059 0.0029 0.0086 0.0094 0.0257 0.0085 0.008 0.0023 0.0052 0.006 0.0102 0.0075 0.012 0.0031 0.0079 0.0281 0.0088 0.0035
Bud Site 0.0061 0.1154 0.0267 0.006 0.0165 0.0034 0.0106 0.0741 0.014 0.0052 0.0026 0.0009 0.0363 0.0656 0.0116 0.02 0.0048 0.001
Cell Periphery 0.4652 0.6076 0.6869 0.6391 0.7209 0.736 0.5618 0.6477 0.7399 0.7592 0.7004 0.8222 0.5324 0.5803 0.6692 0.7408 0.5785 0.7904
Cytoplasm 0.0224 0.0499 0.0422 0.0652 0.0363 0.0256 0.0286 0.0518 0.0266 0.0495 0.018 0.0239 0.0199 0.0881 0.0393 0.0371 0.0211 0.0204
Cytoplasmic Foci 0.0052 0.0005 0.001 0.0154 0.0005 0.0028 0.0065 0.0002 0.0006 0.0056 0.0017 0.0007 0.0026 0.0004 0.0051 0.0004 0.0012 0.0001
Eisosomes 0.2735 0.1834 0.1675 0.066 0.0897 0.1558 0.2353 0.2016 0.1728 0.0383 0.1877 0.1178 0.3049 0.237 0.1862 0.1156 0.2363 0.1648
Endoplasmic Reticulum 0.0107 0.0025 0.006 0.0107 0.0058 0.0082 0.0055 0.0023 0.0032 0.0073 0.0044 0.0032 0.0027 0.0025 0.0024 0.0091 0.0055 0.0046
Endosome 0.0161 0.0001 0.0043 0.0289 0.0008 0.0054 0.0083 0.0001 0.0007 0.0319 0.0126 0.0024 0.0078 0 0.0032 0 0.0103 0.0001
Golgi 0.0058 0.0008 0.0042 0.0133 0.0038 0.0047 0.0078 0.0002 0.0031 0.0179 0.0097 0.0027 0.0025 0.0005 0.0095 0.0012 0.0252 0.0005
Lipid Particles 0.0041 0.0006 0.001 0.0333 0.0007 0.0031 0.014 0.0002 0.0007 0.0129 0.0033 0.002 0.0061 0.0006 0.0007 0.0006 0.0058 0.0004
Mitochondria 0.0321 0.0106 0.0106 0.0181 0.0162 0.0123 0.0139 0.0014 0.0064 0.0241 0.0022 0.0014 0.002 0.0001 0.0035 0.0001 0.0115 0.0001
None 0.0059 0.0014 0.0018 0.0022 0.0012 0.0012 0.0089 0.0012 0.0013 0.001 0.0297 0.0007 0.0021 0.0048 0.0024 0.0014 0.0515 0.001
Nuclear Periphery 0.0409 0.0004 0.0016 0.0045 0.0006 0.0011 0.0068 0.0004 0.0004 0.0032 0.0012 0.0005 0.0058 0.0006 0.0004 0.0008 0.0046 0.0007
Nucleolus 0.0006 0.0001 0.0001 0.0013 0.0001 0.0011 0.0005 0 0.0001 0.0003 0.0001 0.0001 0.004 0.0001 0.0001 0.0002 0.0012 0.0001
Nucleus 0.0051 0.0001 0.0007 0.0153 0.0001 0.0007 0.0078 0.0001 0.0001 0.0005 0.0003 0.0001 0.0029 0.0002 0.0001 0.0005 0.0026 0.0001
Peroxisomes 0.0013 0.0001 0.0002 0.0103 0.0003 0.0027 0.0087 0 0.0002 0.0025 0.0003 0.0007 0.0012 0 0.0092 0 0.0003 0
Punctate Nuclear 0.0124 0 0.0002 0.0039 0 0.0037 0.0016 0 0 0.0007 0.0005 0.0004 0.0092 0.0001 0.0004 0 0.0027 0.0001
Vacuole 0.0041 0.001 0.0016 0.0232 0.0017 0.0017 0.0027 0.0006 0.0014 0.003 0.0012 0.0011 0.0018 0.0008 0.0009 0.0027 0.002 0.0008
Vacuole Periphery 0.0056 0 0.0002 0.0034 0.0002 0.0004 0.0008 0 0.0002 0.0015 0.0004 0.0001 0.0006 0 0.0001 0.0001 0.001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.8832 17.791 13.4556 23.2441 23.0744 17.9783 20.2371 20.6631 21.0235 27.1439
Translational Efficiency 1.3958 1.3152 1.5524 1.1311 1.2855 1.4156 0.9292 1.1093 1.2479 1.1529

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
271 407 403 1012 1868 1652 245 176 2139 2059 648 1188

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 879.85 1024.36 1384.03 1067.38 954.38 982.38 1356.75 1171.68 944.94 990.68 1373.72 1082.83
Standard Deviation 94.16 139.72 178.71 143.90 128.77 141.08 156.52 166.75 127.35 141.80 171.17 152.09
Intensity Change Log 2 — 0.219393 0.653546 0.278744 — 0.041717 0.507519 0.295943 — 0.129679 0.579412 0.287719

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.099610 0.102134* 0.075596 0.222011* 0.021179 0.033418 0.058419 0.164291* 0.031116 0.047001 0.069102 0.213460*
Bud Neck 0.003416 0.003015 0.014742 0.006550 0.000859 0.001945 0.019140 0.009105 0.001183 0.002156 0.016405 0.006928
Bud Site 0.001975 0.004885 0.019759 0.020452 0.000555 0.004323 0.017166 0.029373 0.000735 0.004434 0.018778 0.021774
Cell Periphery 0.560099* 0.679905* 0.608635* 0.274069* 0.494696* 0.787449* 0.728245* 0.521695* 0.502982* 0.766191* 0.653858* 0.310754*
Cytoplasm 0.001161 0.003420 0.009605 0.013044 0.000641 0.002305 0.000811 0.007224 0.000707 0.002525 0.006280 0.012182
Cytoplasmic Foci 0.006796 0.002159 0.001678 0.015262 0.000979 0.001620 0.000275 0.001964 0.001716 0.001727 0.001148 0.013292
Eisosomes 0.293719* 0.163915* 0.106821* 0.162684* 0.406381* 0.139092* 0.138250* 0.168878* 0.392107* 0.143999* 0.118704* 0.163602*
Endoplasmic Reticulum 0.001577 0.005054 0.073290 0.025244 0.001567 0.003662 0.025964 0.017667 0.001568 0.003937 0.055397 0.024121
Endosome 0.001509 0.004209 0.005764 0.022805 0.002288 0.002145 0.001521 0.007284 0.002189 0.002553 0.004160 0.020506
Golgi 0.001016 0.003424 0.009781 0.049662 0.001688 0.001332 0.001446 0.008314 0.001603 0.001745 0.006630 0.043536
Lipid Particles 0.000763 0.001573 0.052985 0.072540 0.001688 0.000793 0.002764 0.020323 0.001571 0.000947 0.033997 0.064804
Mitochondria 0.014686 0.001084 0.000287 0.002347 0.000527 0.002365 0.000257 0.000387 0.002321 0.002112 0.000276 0.002057
Mitotic Spindle 0.001097 0.000467 0.001118 0.000768 0.000906 0.000699 0.001156 0.000302 0.000931 0.000653 0.001132 0.000699
None 0.000846 0.000105 0.000068 0.000171 0.000426 0.000142 0.000091 0.000080 0.000479 0.000135 0.000077 0.000157
Nuclear Periphery 0.000110 0.000106 0.000640 0.000076 0.000518 0.000233 0.000274 0.000082 0.000466 0.000208 0.000502 0.000077
Nuclear Periphery Foci 0.000017 0.000034 0.000550 0.000215 0.000007 0.000053 0.000206 0.000108 0.000008 0.000049 0.000420 0.000199
Nucleolus 0.000003 0.000003 0.000005 0.000006 0.000004 0.000180 0.000003 0.000002 0.000004 0.000145 0.000005 0.000006
Nucleus 0.000158 0.000096 0.000376 0.000252 0.000190 0.000665 0.000228 0.000151 0.000186 0.000553 0.000320 0.000237
Peroxisomes 0.010452 0.024216 0.013748 0.107907* 0.064834 0.016946 0.002003 0.040935 0.057944 0.018383 0.009307 0.097985
Vacuole 0.000104 0.000124 0.004447 0.002737 0.000043 0.000324 0.001746 0.001290 0.000051 0.000285 0.003426 0.002523
Vacuole Periphery 0.000887 0.000073 0.000105 0.001197 0.000023 0.000308 0.000035 0.000546 0.000133 0.000261 0.000079 0.001101

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.17 1.75 -8.60 -9.13 -12.89 -3.44 -4.24 -7.70 -7.00 -5.20 -4.06 -6.14 -22.59 -19.97 -15.01
Bud Neck 0.80 -9.78 -3.80 -4.28 6.15 -6.41 -7.68 -4.39 -3.79 3.31 -6.02 -13.40 -8.24 -6.72 7.13
Bud Site -1.70 -7.43 -8.67 -5.76 -0.23 -4.67 -6.79 -3.89 -3.37 -1.57 -5.06 -10.34 -9.97 -7.79 -1.10
Cell Periphery -4.54 -1.84 12.27 21.45* 17.75 -28.91* -12.98 -0.97 9.65 6.60 -27.55 -10.85 15.68 39.17* 22.28
Cytoplasm -2.81 -4.74 -9.00 -6.65 -1.64 -6.05 -1.32 -3.52 -2.61 -3.43 -6.77 -5.06 -10.23 -8.45 -3.81
Cytoplasmic Foci 2.27 2.61 -3.45 -7.89 -8.68 -1.76 10.12 -1.62 -0.48 -2.78 -0.04 1.71 -8.67 -8.57 -9.14
Eisosomes 6.54 10.19 7.24 0.11 -6.45 31.87* 21.49 15.75 -2.11 -1.82 31.92* 31.66 27.14 -2.90 -5.81
Endoplasmic Reticulum -3.73 -10.18 -10.20 -8.38 6.50 -3.00 -4.65 -3.18 -2.74 1.14 -4.03 -11.02 -10.83 -9.37 5.89
Endosome -2.58 -5.60 -9.41 -7.61 -7.30 0.44 3.31 -1.74 -1.78 -2.00 -1.13 -4.38 -9.34 -9.06 -8.15
Golgi -2.80 -5.51 -13.61 -12.72 -10.30 0.84 0.43 -2.59 -2.72 -2.65 -0.41 -4.93 -13.58 -13.51 -11.41
Lipid Particles -1.72 -7.45 -16.66 -16.45 -2.38 3.98 -1.19 -4.32 -4.52 -3.99 3.01 -7.25 -16.82 -16.99 -5.27
Mitochondria 2.13 2.25 1.92 -2.05 -3.55 -2.77 4.04 1.12 2.94 -1.07 0.20 2.50 0.27 0.08 -3.60
Mitotic Spindle 3.51 -0.11 0.95 -1.05 1.12 2.57 -2.26 10.94 5.40 7.94 3.95 -2.61 0.89 -0.20 1.66
None 5.81 6.13 3.55 -0.65 -0.93 8.30 10.18 10.29 3.79 0.76 10.18 12.36 2.56 -0.35 -0.87
Nuclear Periphery 0.31 -10.08 3.18 3.21 10.81 11.91 7.52 18.35 8.74 6.87 12.44 -0.91 20.67 11.54 12.23
Nuclear Periphery Foci -3.50 -9.74 -5.73 -5.23 5.17 -2.78 -11.43 -4.60 -1.91 3.50 -3.07 -11.69 -6.46 -4.56 4.79
Nucleolus 0.81 -2.48 -2.11 -3.05 -0.66 -1.50 1.43 4.10 1.51 2.37 -1.50 -2.37 -1.82 1.48 -1.00
Nucleus 2.84 -6.18 -2.64 -5.20 3.00 -1.34 -0.40 0.46 1.48 2.66 -1.29 -1.67 -0.62 1.16 2.60
Peroxisomes -3.00 -0.80 -16.04 -12.65 -14.99 13.19 18.04 2.46 -2.59 -4.23 12.15 13.75 -7.02 -15.62 -16.80
Vacuole -0.82 -10.15 -4.42 -4.39 2.30 -2.28 -7.38 -2.32 -1.72 0.78 -2.36 -11.87 -4.81 -4.25 1.51
Vacuole Periphery 1.36 1.31 -0.47 -3.55 -3.45 -2.37 -3.26 -1.05 -0.44 -1.02 -1.10 0.71 -3.34 -2.79 -3.66
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation, controls eisosome length and shape; diffusely distributed, forms heterogeneous patches at plasma membrane in small buds, also found in medium and large buds; expression repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes; SEG1 has a paralog, SEG2, that arose from the whole genome duplication
Localization
Cell Percentages cell periphery (60%)
Cell Cycle Regulation No
Subcompartmental Group cell periphery-2

Seg1

Seg1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Seg1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available