Standard name
Human Ortholog
Description Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; putative regulator of cytokinesis; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.55 0.43 0.54 0.6 0.42 0.46 0.42 0.32 0.4 0.41 0.44 0.4 0.29 0.36 0.32 0.28 0.23 0.26 0.63 0.59 0.53 0.45 0.49 0.5
Bud 0.13 0.1 0.1 0.13 0.12 0.12 0.08 0.08 0.11 0.09 0.1 0.08 0.05 0.05 0.07 0.07 0.08 0.06 0.05 0.08 0.05 0.06 0.05 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.05 0 0.05 0 0 0 0 0 0 0 0 0.05 0.09 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.19 0.19 0.14 0.07 0.09 0.08 0.07 0.07 0.05 0.05 0 0.05 0.19 0.36 0.25 0.11 0.1 0.15 0 0 0 0 0 0
Endoplasmic Reticulum 0.12 0.19 0.1 0.17 0.14 0.12 0.15 0.11 0.09 0.11 0.13 0.09 0 0.05 0 0 0.05 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0.07 0.08 0.1 0.08 0 0.08
Golgi 0.43 0.48 0.6 0.68 0.73 0.65 0.69 0.66 0.68 0.73 0.62 0.64 0.62 0.41 0.68 0.77 0.8 0.74 0.14 0.14 0.2 0.23 0.31 0.29
Mitochondria 0.05 0 0 0 0 0.1 0.1 0 0.2 0.16 0.47 0.21 0.05 0 0.07 0.1 0.07 0 0 0 0 0.05 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0.06 0 0 0 0 0.05 0 0 0 0.05 0 0.05 0 0.06 0.06 0 0 0 0 0.05 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 263 159 113 118 86 122 121 146 96 122 109 104 6 8 9 73 60 69 361 270 125 18 39 50
Bud 62 37 20 25 24 31 24 38 26 26 26 21 1 1 2 19 20 15 31 35 12 2 4 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 1 1 0 0 0
Bud Site 0 3 0 0 0 1 0 0 0 1 1 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 11 19 6 9 5 7 1 10 4 7 9 7 1 2 0 6 5 5 0 0 0 0 0 0
Cytoplasm 92 69 29 14 18 22 21 32 12 15 9 14 4 8 7 29 25 41 21 12 6 0 1 1
Endoplasmic Reticulum 58 69 21 33 29 31 42 50 21 32 33 24 0 1 1 8 12 17 7 7 3 0 0 1
Endosome 12 0 4 1 1 3 0 2 1 4 1 5 1 0 0 0 1 1 40 38 23 3 2 7
Golgi 205 176 126 134 149 170 196 304 165 220 154 167 13 9 19 199 211 200 79 61 46 9 25 28
Mitochondria 26 6 1 8 2 25 28 20 49 48 116 54 1 0 2 26 19 8 5 3 2 2 1 0
Nucleus 0 0 1 1 1 0 2 1 0 1 0 1 1 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 1 0 1 0 0 2 0 1 0 0 0 0 0 0 2 1 0 0 0 0
Nucleolus 8 5 2 2 1 6 7 20 8 12 7 16 0 0 0 7 3 4 0 0 0 0 0 0
Peroxisomes 3 0 0 3 0 1 3 0 0 0 0 1 0 0 0 0 0 0 6 5 4 0 3 3
SpindlePole 2 0 0 2 0 1 1 5 3 1 0 0 0 0 0 8 3 2 5 6 2 0 0 0
Vac/Vac Membrane 9 11 12 4 5 7 3 24 6 11 4 14 0 1 0 15 15 10 2 7 2 1 0 0
Unique Cell Count 476 368 210 196 204 263 286 458 243 301 248 259 21 22 28 260 263 270 571 455 236 41 81 100
Labelled Cell Count 751 554 335 354 322 427 450 652 391 502 469 430 28 30 40 390 374 372 571 455 236 41 81 100


Actin

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 18.2 26.2 20.1 18.7 22.1 22.6 21.6 22.3 20.5 21.7 20.7 21.9 30.0 25.5 25.4 39.2 42.0 38.4 – 27.4 26.9
Std Deviation (1e-4) 4.5 6.3 4.6 4.0 5.4 5.9 5.4 5.6 5.8 6.7 6.1 6.8 10.8 9.3 8.3 13.9 14.2 13.1 – 8.8 12.9
Intensity Change (Log2) – – – -0.1 0.14 0.17 0.1 0.15 0.03 0.11 0.04 0.12 0.58 0.34 0.34 0.96 1.06 0.93 – 0.45 0.42

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002040WT3HU80HU120HU16002040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302040WT1AF140AF18002040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 1.3 -2.4 -1.6 -2.5 -5.4 -3.0 -3.0 -2.1 -2.9 -2.2 -1.6 -2.2 -5.7 -7.0 -6.3
Bud 1.0 0.7 0.8 -0.4 -0.5 0.4 -0.3 0.3 -0.5 0 0 0 -0.9 -0.7 -1.7
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.9 -0.3 -0.1 0 -0.5 0 -0.4 0.5 -0.1 0 0 0 -0.4 0 0
Cytoplasm -2.2 -1.6 -1.9 -2.4 -2.8 -3.3 -3.5 -3.9 -3.1 0 0 0 -0.9 -1.5 0.4
Endoplasmic Reticulum 2.0 1.3 0.6 1.5 0.4 -0.5 0.2 1.1 -0.3 0 0 0 -3.1 -2.3 -1.5
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 1.8 2.8 1.0 2.0 1.6 1.7 3.1 0.5 1.0 0.2 -1.7 0.8 3.9 4.8 3.3
Mitochondria 0 0 4.3 4.4 2.7 6.7 5.8 11.3 6.8 0 0 0 4.4 3.6 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 2.3 0 2.1 0 2.9 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.9 -1.7 -1.7 -3.0 -0.3 -1.8 -1.1 -2.4 -0.1 0 0 0 0 0 -1.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 15.4491 15.3667 16.1763 14.531 13.8738 15.0051 24.6628 20.8958 23.5461 22.862 22.5148 21.4372 20.6307 18.2925 18.1602 16.8367 18.6626 19.1425
Actin 0.6109 0.6079 0.8188 0.8083 0.7589 0.6826 0.6047 0.6121 0.7864 0.6931 0.6631 0.6048 0.7046 0.6649 0.8783 0.7914 0.8391 0.7315
Bud 0.0021 0.0074 0.0225 0.0169 0.0038 0.0019 0.002 0.004 0.0098 0.0108 0.0039 0.0007 0.0027 0.0064 0.0245 0.0248 0.0155 0.0009
Bud Neck 0.0021 0.0016 0.0015 0.0021 0.001 0.0038 0.0011 0.0014 0.0008 0.0009 0.0013 0.0031 0.0012 0.0036 0.0007 0.0041 0.0012 0.0068
Bud Periphery 0.0018 0.0058 0.0143 0.0091 0.0024 0.0019 0.0019 0.0021 0.0104 0.0271 0.0031 0.0006 0.002 0.0027 0.0227 0.0298 0.0218 0.0007
Bud Site 0.0043 0.0285 0.0161 0.0053 0.0015 0.0013 0.0033 0.0352 0.0115 0.0016 0.0022 0.0006 0.0054 0.0379 0.0082 0.004 0.0024 0.0006
Cell Periphery 0.0002 0.0004 0.0003 0.0009 0.0001 0.0002 0.0008 0.0004 0.0004 0.0003 0.0002 0.0002 0.0002 0.0004 0.0003 0.0004 0.0005 0.0002
Cytoplasm 0.0077 0.0727 0.0194 0.0547 0.0088 0.0068 0.0148 0.0376 0.0174 0.1384 0.0187 0.0059 0.0087 0.07 0.0026 0.0549 0.0328 0.0043
Cytoplasmic Foci 0.0438 0.0777 0.025 0.0206 0.021 0.0274 0.0321 0.0551 0.0251 0.0083 0.0275 0.0239 0.028 0.0655 0.0091 0.0128 0.0085 0.0262
Eisosomes 0.0004 0.0001 0.0002 0.0001 0.0002 0.0003 0.0005 0.0003 0.0002 0.0002 0.0003 0.0005 0.0015 0.0002 0.0002 0.0001 0.0017 0.0008
Endoplasmic Reticulum 0.0029 0.0011 0.0007 0.0004 0.0004 0.0008 0.001 0.001 0.0017 0.0014 0.0022 0.001 0.0005 0.0004 0.0001 0.0019 0.0011 0.0004
Endosome 0.047 0.0402 0.0162 0.0114 0.0227 0.0304 0.0258 0.0208 0.0122 0.0043 0.022 0.0217 0.0203 0.0171 0.0029 0.0085 0.0125 0.0181
Golgi 0.2271 0.1224 0.0515 0.0605 0.096 0.2282 0.2969 0.2065 0.1098 0.1095 0.2429 0.3267 0.2033 0.1027 0.043 0.0609 0.0542 0.2007
Lipid Particles 0.0099 0.0043 0.0011 0.0006 0.0288 0.0042 0.0054 0.0031 0.0028 0.0007 0.001 0.0009 0.0066 0.0013 0.0012 0.002 0.004 0.0015
Mitochondria 0.0124 0.0021 0.0024 0.0016 0.0048 0.0047 0.0046 0.0037 0.0018 0.0008 0.0027 0.0042 0.0042 0.0026 0.0008 0.0009 0.0016 0.0025
None 0.0026 0.0004 0.0008 0.0002 0.0014 0.0001 0.0001 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001 0.0003 0 0.0002 0.0001 0.0001
Nuclear Periphery 0.0074 0.0006 0.0007 0.0003 0.0056 0.0006 0.0002 0.0002 0.0002 0.0002 0.0006 0.0001 0.0001 0.0002 0.0001 0.0002 0.0004 0.0001
Nucleolus 0.0004 0.0001 0.0001 0.0001 0.0015 0 0.0001 0 0.0001 0 0 0 0 0.0001 0 0 0 0
Nucleus 0.0015 0.0004 0.0007 0.0008 0.0015 0.0001 0.0001 0.0002 0.0003 0.0001 0.0002 0.0001 0.0001 0.0005 0.0001 0.0001 0.0001 0
Peroxisomes 0.0095 0.0232 0.0053 0.0031 0.006 0.0034 0.0033 0.0152 0.0079 0.0015 0.007 0.0044 0.0096 0.0219 0.0044 0.002 0.0014 0.0038
Punctate Nuclear 0.0027 0.001 0.001 0.0003 0.0319 0.0003 0.0001 0.0002 0.0002 0.0001 0.0003 0.0001 0.0001 0.0006 0.0001 0.0002 0.0002 0.0001
Vacuole 0.0017 0.0013 0.0009 0.0023 0.0006 0.0005 0.0005 0.0004 0.0007 0.0001 0.0004 0.0002 0.0002 0.0004 0.0004 0.0005 0.0003 0.0004
Vacuole Periphery 0.0017 0.0005 0.0004 0.0004 0.0009 0.0004 0.0005 0.0003 0.0002 0.0001 0.0003 0.0003 0.0003 0.0002 0.0001 0.0001 0.0003 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 72.2467 54.9766 60.9945 81.4023 61.5442 73.4002 62.1978 73.7598 86.3206 83.3591
Translational Efficiency 1.2573 1.2255 1.1263 1.2764 1.4092 1.2828 1.244 1.0784 1.2141 1.1624

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1422 1449 2094 1493 470 2264 1665 2742 1892 3713 3759 4235

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1428.05 1324.83 3060.19 2561.43 1533.29 1464.53 2473.63 3014.48 1454.19 1410.01 2800.38 2854.76
Standard Deviation 241.06 303.79 625.80 656.83 258.23 299.03 462.21 778.13 249.61 308.52 630.62 768.74
Intensity Change Log 2 — -0.108239 1.099575 0.842903 — -0.066193 0.689999 0.975279 — -0.086316 0.902026 0.912957

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.457213 0.434409 0.544278 0.538164 0.481174 0.378636 0.630925 0.740330 0.463165 0.400401 0.582657 0.669059
Bud Neck 0.003353 0.003235 0.010051 0.008262 0.004981 0.002057 0.011900 0.001945 0.003757 0.002517 0.010870 0.004172
Bud Site 0.070092 0.045177 0.120862 0.148362 0.066094 0.045719 0.162285 0.080665 0.069099 0.045507 0.139210 0.104530
Cell Periphery 0.000536 0.000475 0.002118 0.004220 0.000611 0.000295 0.001554 0.004110 0.000555 0.000365 0.001868 0.004149
Cytoplasm 0.020801 0.018682 0.030461 0.030599 0.009141 0.021607 0.029923 0.049326 0.017905 0.020466 0.030222 0.042724
Cytoplasmic Foci 0.104637 0.097302 0.027524 0.034583 0.083894 0.147637 0.026716 0.014216 0.099484 0.127994 0.027166 0.021396
Eisosomes 0.000442 0.000451 0.000851 0.001502 0.000608 0.000337 0.000524 0.002144 0.000483 0.000382 0.000706 0.001918
Endoplasmic Reticulum 0.002493 0.002579 0.004986 0.004350 0.003890 0.001159 0.001860 0.001856 0.002840 0.001713 0.003602 0.002735
Endosome 0.067235 0.118742 0.041205 0.042801 0.084164 0.111697 0.028181 0.017280 0.071441 0.114446 0.035436 0.026277
Golgi 0.189507 0.160990 0.135381 0.094160 0.206339 0.178467 0.046505 0.040679 0.193688 0.171647 0.096015 0.059533
Lipid Particles 0.015137 0.070469 0.032537 0.046566 0.017049 0.019104 0.020569 0.007749 0.015612 0.039149 0.027236 0.021434
Mitochondria 0.009719 0.002289 0.010192 0.006079 0.003526 0.009245 0.004139 0.013236 0.008181 0.006530 0.007511 0.010713
Mitotic Spindle 0.006487 0.006186 0.016813 0.012626 0.007467 0.022304 0.014017 0.002584 0.006730 0.016014 0.015574 0.006124
None 0.000113 0.000124 0.000325 0.000163 0.000059 0.000342 0.000102 0.000197 0.000100 0.000257 0.000226 0.000185
Nuclear Periphery 0.000029 0.000038 0.000267 0.000123 0.000037 0.000044 0.000109 0.000017 0.000031 0.000041 0.000197 0.000055
Nuclear Periphery Foci 0.000153 0.000523 0.000842 0.000473 0.000220 0.000265 0.000438 0.000072 0.000170 0.000365 0.000663 0.000213
Nucleolus 0.000014 0.000056 0.000036 0.000032 0.000005 0.000012 0.000014 0.000004 0.000012 0.000029 0.000026 0.000014
Nucleus 0.000081 0.000141 0.000643 0.000205 0.000052 0.000050 0.000303 0.000124 0.000074 0.000086 0.000493 0.000153
Peroxisomes 0.049245 0.034543 0.007264 0.012999 0.027159 0.056846 0.011563 0.022087 0.043759 0.048143 0.009168 0.018883
Vacuole 0.001798 0.002744 0.010313 0.011523 0.002583 0.003122 0.007430 0.000898 0.001993 0.002975 0.009036 0.004644
Vacuole Periphery 0.000912 0.000844 0.003052 0.002207 0.000948 0.001055 0.000944 0.000479 0.000921 0.000973 0.002118 0.001088

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.66 -5.33 -4.94 -6.62 -0.08 5.52 -6.37 -14.16 -36.53 -12.41 6.02 -9.29 -19.73 -32.17 -12.85
Bud Neck 0.26 -11.06 -7.98 -8.43 2.89 4.76 -7.24 4.80 0.34 12.31 3.73 -13.58 -1.43 -6.35 13.28
Bud Site 4.73 -10.07 -11.93 -17.13 -3.56 2.83 -11.88 -2.03 -9.43 14.33 5.75 -15.91 -8.29 -18.31 9.23
Cell Periphery 1.32 -16.39 -7.68 -7.80 -4.04 6.02 -7.31 -6.31 -6.91 -4.29 6.08 -16.62 -9.06 -9.55 -5.34
Cytoplasm 0.68 -5.07 -3.63 -4.11 1.23 -4.75 -8.25 -12.49 -9.27 -2.60 -1.32 -8.07 -10.53 -10.10 -2.15
Cytoplasmic Foci 1.37 18.86 15.95 15.16 -2.91 -9.34 8.97 11.85 35.99 8.54 -6.90 20.86 23.24 38.20 5.46
Eisosomes -0.44 -10.41 -4.23 -4.19 -2.63 6.19 2.00 -5.30 -6.31 -5.69 5.67 -7.22 -6.94 -7.46 -5.95
Endoplasmic Reticulum -0.26 -5.24 -2.96 -3.11 1.02 3.03 2.29 2.01 -2.65 -0.54 3.31 -1.83 0.10 -3.85 2.23
Endosome -11.29 9.29 7.64 18.01 -0.96 -4.67 10.46 12.62 32.84 6.05 -13.35 14.50 17.93 36.73 6.25
Golgi 3.45 7.47 12.47 9.68 5.80 2.29 13.64 14.17 27.84 1.17 3.43 16.06 22.69 27.70 9.06
Lipid Particles -11.90 -7.81 -8.92 3.89 -3.75 -0.83 -1.77 3.88 6.77 7.00 -10.21 -7.21 -3.58 7.05 3.32
Mitochondria 5.30 -0.20 2.46 -4.63 3.75 -4.86 -0.60 -7.78 -2.66 -7.46 1.37 0.70 -1.93 -4.19 -3.58
Mitotic Spindle 0.30 -8.32 -3.95 -4.00 2.85 -5.67 -3.63 2.43 10.49 8.96 -6.70 -9.13 0.24 7.09 9.68
None -0.47 -11.05 -2.33 -1.57 5.57 -1.04 -6.30 -2.32 0.44 -1.54 -0.95 -10.54 -2.29 0.31 1.01
Nuclear Periphery -1.47 -11.36 -8.75 -8.26 6.42 -0.90 -9.36 2.96 3.50 12.38 -1.89 -13.64 -4.89 -2.83 11.37
Nuclear Periphery Foci -2.65 -6.27 -4.91 -0.38 2.98 -0.70 -2.49 2.59 1.67 3.39 -2.02 -6.15 -1.43 1.41 5.63
Nucleolus -1.03 -3.71 -2.88 0.47 0.81 -2.55 -8.68 0.71 2.76 9.40 -1.07 -4.10 -1.05 0.84 3.28
Nucleus -1.77 -4.83 -4.74 -2.49 4.05 0.13 -5.52 -3.40 -3.42 4.43 -0.85 -6.33 -4.92 -3.99 5.46
Peroxisomes 3.95 14.20 11.61 8.46 -4.45 -7.10 4.67 1.47 12.13 -6.90 -1.47 14.51 9.91 14.43 -9.33
Vacuole -2.20 -11.33 -9.43 -8.78 -0.14 -1.11 -7.86 3.04 6.67 10.43 -2.89 -13.99 -6.35 -4.76 8.51
Vacuole Periphery 0.47 -8.82 -5.00 -5.81 2.83 -0.69 -0.16 3.58 4.45 4.32 -0.43 -7.65 -1.36 -1.11 6.80
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; putative regulator of cytokinesis; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
Localization
Cell Percentages actin (75%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Aip1

Aip1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Aip1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available