Standard name
Human Ortholog
Description Dehydrogenase involved in ubiquinone and sphingolipid metabolism; oxidizes 4-hydroxybenzaldehyde into 4-hydroxybenzoic acid in ubiquinone biosynthesis; converts hexadecenal to hexadecenoic acid in sphingosine 1-phosphate breakdown pathway; located in the mitochondrial outer membrane and also in lipid particles; human homolog ALDH3A2, a fatty aldehyde dehydrogenase (FALDH) mutated in neurocutaneous disorder Sjogren-Larsson syndrome, can complement yeast hfd1 mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.06 0 0 0.06 0 0 0.05 0.05 0.05 0 0 0.08 0 0 0 0 0.05 0.06 0.13 0.13 0.1 0.12
Bud 0 0 0.06 0.05 0.05 0 0.05 0 0.05 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0.06 0 0 0 0 0 0 0 0.07 0.07 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.83 0.77 0.65 0.61 0.46 0.33 0.2 0.22 0.1 0.12 0.12 0.14 0.62 0.52 0.55 0.3 0.26 0.3 0.25 0.36 0.17 0.45 0.28 0.25
Endoplasmic Reticulum 0 0.07 0.15 0.09 0.16 0.36 0.16 0.09 0.2 0.22 0.15 0.08 0.31 0.27 0 0.05 0.07 0.08 0.31 0.14 0.18 0.11 0.13 0.07
Endosome 0.07 0.08 0.06 0.13 0.21 0.07 0.25 0.21 0.05 0 0.06 0 0.1 0.2 0.4 0.4 0.42 0.38 0.07 0.11 0.14 0 0.15 0.16
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.18 0 0.06 0.2 0.14 0.39 0.43 0.47 0.72 0.74 0.7 0.8 0 0 0 0.08 0 0.05 0.17 0.12 0.23 0.09 0.13 0.14
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0.06 0.1 0.08 0 0 0 0 0 0
Peroxisomes 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0.17 0.07 0.05 0 0 0 0 0 0 0
SpindlePole 0 0 0.07 0.06 0 0 0 0.05 0 0 0 0 0 0 0.06 0.27 0.31 0.23 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.12 0.1 0.17 0.06 0.08 0 0.05 0 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 9 1 11 20 9 16 17 26 11 8 3 6 0 2 1 0 7 10 25 6 12 12
Bud 1 1 9 10 14 8 22 16 17 19 10 7 0 1 0 1 1 0 2 3 0 0 1 2
Bud Neck 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 2 5 4 0 2 3
Bud Site 0 0 0 0 0 0 2 3 4 2 3 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 0 4 6 18 11 13 6 5 8 0 5 5 5 3 0 0 0 0 3 3 1 1 0
Cytoplasm 112 104 106 130 136 101 94 106 33 57 25 50 45 39 42 51 27 19 34 60 35 21 34 24
Endoplasmic Reticulum 0 9 24 20 47 111 75 42 67 107 32 28 22 20 1 8 7 5 44 23 37 5 15 7
Endosome 9 11 9 27 62 21 118 100 17 5 13 3 7 15 31 69 44 24 9 17 28 1 18 15
Golgi 0 0 1 1 0 0 0 0 0 0 0 1 0 0 0 0 0 1 2 0 2 0 4 2
Mitochondria 24 3 9 42 40 121 206 222 244 355 146 279 0 2 0 13 3 3 24 19 46 4 16 13
Nucleus 0 0 0 0 0 1 1 2 2 3 0 4 0 0 0 1 1 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 2 3 11 1 3 0 0 0 0 0 0 0 0 1 0 0 0
Nucleolus 1 0 0 2 1 1 4 9 3 8 3 21 0 0 0 11 10 5 0 0 0 1 1 0
Peroxisomes 5 0 0 10 7 4 13 10 4 2 2 1 0 0 13 12 5 1 0 0 4 0 1 1
SpindlePole 3 3 11 12 5 7 18 26 7 5 6 2 3 3 5 46 33 15 1 5 4 0 4 3
Vac/Vac Membrane 1 3 1 3 9 1 16 20 6 5 7 6 0 1 1 21 11 11 8 12 5 2 4 8
Unique Cell Count 135 135 163 212 295 309 480 474 339 481 208 349 72 75 77 172 105 64 142 167 206 48 124 98
Labelled Cell Count 159 137 183 264 350 407 591 580 429 613 259 420 85 92 97 235 143 84 142 167 206 48 124 98


Endosome, Lipid Particles

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.3 5.0 4.7 4.8 5.8 5.5 5.4 5.9 5.6 5.5 5.7 5.5 6.1 5.6 5.8 7.3 8.0 8.9 – 5.7 6.5
Std Deviation (1e-4) 0.9 0.7 1.0 1.2 1.4 1.1 1.1 1.7 1.1 1.2 1.3 1.4 1.1 1.2 1.8 2.3 2.0 2.8 – 2.8 1.9
Intensity Change (Log2) – – – 0.03 0.29 0.22 0.18 0.31 0.23 0.21 0.25 0.21 0.36 0.25 0.3 0.61 0.75 0.91 – 0.28 0.46


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 -0.9 0.4 0 -1.2 -0.2 -0.1 -0.1 -1.9 0 0 0 -2.2 0 0
Bud 0 -0.4 -1.6 -0.5 -1.2 -0.2 -0.9 -0.3 -2.1 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 1.7 0.7 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.7 -3.9 -6.7 -10.8 -10.0 -13.0 -13.5 -10.6 -11.6 -0.4 -1.9 -1.6 -6.5 -6.3 -4.8
Endoplasmic Reticulum 0 0.3 4.8 0.3 -2.1 1.4 2.1 0.2 -2.3 2.8 2.2 -3.2 -3.1 -2.0 -1.4
Endosome 0 4.4 0.5 5.3 4.6 -0.2 0 0.3 0 0 3.4 6.7 7.5 7.3 6.2
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 2.7 7.8 8.7 9.5 13.9 15.2 12.5 15.8 0 0 0 0.8 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 3.2 0 0 0 3.3 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 3.4 0 0
SpindlePole 0 -2.8 -2.4 -1.6 -0.6 -2.6 0 -1.8 0 0 0 -0.1 4.9 5.3 3.6
Vacuole 0 0 0 0 2.2 0 0 0 0 0 0 0 4.3 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.9976 3.2482 2.435 1.6602 1.9816 2.2265 2.3133 3.3624 2.8328 2.6318 2.9884 2.7064 4.2654 5.26 4.704 4.5281 4.9096 4.5137
Actin 0.0945 0.0172 0.0488 0.0181 0.0413 0.0177 0.0612 0.002 0.0545 0.0017 0.0746 0.0312 0.0761 0.0096 0.0292 0.0347 0.1446 0.0042
Bud 0.0003 0.0001 0.0001 0.0003 0.0003 0 0.0017 0.0005 0.0008 0 0.0005 0.0002 0.0006 0.0004 0.0021 0.0005 0.0002 0.0001
Bud Neck 0.0099 0.0014 0.0017 0.0029 0.0046 0.0148 0.0091 0.0023 0.0191 0.0006 0.0023 0.0046 0.0023 0.02 0.0019 0.0077 0.0006 0.005
Bud Periphery 0.0006 0.0002 0.0003 0.0017 0.001 0.0001 0.0053 0.0006 0.0017 0.0008 0.0013 0.0008 0.0011 0.0005 0.0032 0.0011 0.0004 0.0001
Bud Site 0.0116 0.0143 0.0018 0.0008 0.0026 0.0003 0.0225 0.0455 0.0539 0.0005 0.002 0.0008 0.0035 0.0295 0.0079 0.003 0.0005 0.0004
Cell Periphery 0.0145 0.0072 0.0094 0.0172 0.0022 0.0062 0.0257 0.0087 0.0282 0.0602 0.0263 0.0123 0.0225 0.0155 0.0124 0.0117 0.0009 0.0039
Cytoplasm 0.1338 0.1266 0.0821 0.1252 0.0929 0.1158 0.1406 0.122 0.2397 0.1512 0.1696 0.1819 0.211 0.132 0.2162 0.1437 0.0648 0.1204
Cytoplasmic Foci 0.1864 0.2514 0.3076 0.1641 0.3004 0.232 0.148 0.2185 0.1494 0.1959 0.1274 0.1556 0.1212 0.1774 0.1854 0.2608 0.1654 0.2509
Eisosomes 0.0021 0.0001 0.0004 0.001 0.0008 0.0001 0.0021 0.0003 0.0011 0.0003 0.0031 0.0006 0.0019 0.0002 0.0002 0.0004 0.0005 0.0001
Endoplasmic Reticulum 0.0414 0.0097 0.0063 0.0124 0.0168 0.0499 0.0143 0.0125 0.0376 0.0503 0.0337 0.0399 0.0462 0.029 0.0367 0.0135 0.0373 0.0255
Endosome 0.0522 0.0224 0.0479 0.0506 0.0472 0.0318 0.0746 0.0737 0.0362 0.0508 0.0562 0.0427 0.1269 0.0683 0.0614 0.0748 0.0345 0.0377
Golgi 0.0155 0.008 0.0147 0.0329 0.0319 0.0107 0.0183 0.0095 0.017 0.0133 0.0271 0.0094 0.0282 0.0142 0.0273 0.0172 0.0184 0.0108
Lipid Particles 0.3352 0.445 0.4116 0.4132 0.3279 0.4656 0.3194 0.4446 0.2319 0.2947 0.2784 0.4234 0.268 0.3637 0.358 0.3808 0.4339 0.4764
Mitochondria 0.0014 0.0002 0.0015 0.0007 0.0252 0.0003 0.0022 0.0003 0.0098 0.0005 0.0031 0.0021 0.0124 0.0006 0.0108 0.0011 0.0012 0.014
None 0.0738 0.046 0.0264 0.1503 0.0336 0.0283 0.0871 0.0304 0.0895 0.0949 0.1429 0.0779 0.0238 0.0479 0.0131 0.0159 0.0591 0.0161
Nuclear Periphery 0.0026 0.0007 0.0007 0.0005 0.0366 0.0006 0.0157 0.0007 0.0023 0.0007 0.0013 0.0014 0.0088 0.0016 0.0014 0.0005 0.0004 0.0006
Nucleolus 0.0005 0.0027 0.0006 0.0001 0.0023 0.0001 0.0031 0.0023 0.0007 0.0002 0.0004 0.0003 0.0004 0.0225 0.0012 0.0008 0.0002 0.0009
Nucleus 0.0007 0.0143 0.0003 0.0003 0.0023 0.0002 0.0078 0.0008 0.0007 0.0002 0.001 0.0005 0.0009 0.0024 0.0012 0.0003 0.0001 0.0005
Peroxisomes 0.0095 0.0178 0.0244 0.0043 0.0106 0.0156 0.021 0.0055 0.0065 0.0718 0.0372 0.0057 0.0125 0.0092 0.0127 0.0152 0.0316 0.0152
Punctate Nuclear 0.0057 0.0051 0.01 0.0016 0.0126 0.0034 0.0106 0.0095 0.0125 0.0011 0.0016 0.0025 0.0191 0.0108 0.0094 0.0098 0.0019 0.0127
Vacuole 0.0073 0.0094 0.0033 0.0015 0.0028 0.0063 0.0079 0.0096 0.0062 0.01 0.0096 0.0057 0.0095 0.0432 0.0075 0.0062 0.0035 0.0042
Vacuole Periphery 0.0006 0.0001 0.0002 0.0002 0.0044 0.0002 0.0019 0.0002 0.0006 0.0002 0.0003 0.0003 0.0029 0.0016 0.0004 0.0003 0.0001 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 30.3626 17.2724 21.514 26.9991 18.3412 28.2768 29.0029 28.8362 32.0822 24.5803
Translational Efficiency 1.1366 1.8149 1.2219 1.0905 1.4044 1.7596 1.3837 1.3661 1.318 1.1754

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2099 949 1030 1931 1906 2263 340 1220 4005 3212 1370 3151

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 637.51 744.86 1092.85 1116.20 713.90 793.11 1062.69 1054.92 673.86 778.85 1085.37 1092.47
Standard Deviation 68.96 97.06 142.82 177.29 80.09 109.31 128.42 159.53 83.67 108.10 139.99 173.22
Intensity Change Log 2 — 0.224521 0.777576 0.808076 — 0.151799 0.573927 0.563340 — 0.186562 0.673584 0.683974

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000728 0.004998 0.010155 0.064453 0.001672 0.003813 0.015322 0.057859 0.001177 0.004163 0.011437 0.061900
Bud Neck 0.024032 0.022710 0.013052 0.014406 0.016155 0.032493 0.006224 0.012776 0.020283 0.029603 0.011358 0.013775
Bud Site 0.007567 0.015737 0.031359 0.054382 0.003804 0.015968 0.009749 0.046888 0.005776 0.015900 0.025996 0.051481
Cell Periphery 0.000743 0.000571 0.007176 0.000927 0.000800 0.001299 0.000293 0.000935 0.000770 0.001084 0.005468 0.000930
Cytoplasm 0.430033* 0.214923* 0.268510* 0.044721 0.407864* 0.195964* 0.055823 0.054965 0.419482* 0.201565* 0.215727* 0.048687
Cytoplasmic Foci 0.250801* 0.349062* 0.047984 0.168055 0.261471* 0.294720* 0.135462 0.198597* 0.255879* 0.310776* 0.069694 0.179881
Eisosomes 0.002851 0.001794 0.001817 0.000752 0.003613 0.002704 0.000248 0.000973 0.003214 0.002435 0.001427 0.000838
Endoplasmic Reticulum 0.005102 0.015771 0.274941* 0.012152 0.006567 0.010365 0.014974 0.012034 0.005799 0.011962 0.210423* 0.012106
Endosome 0.008068 0.060747 0.015691 0.094591 0.012395 0.064298 0.138042 0.116651 0.010127 0.063249 0.046055 0.103132
Golgi 0.013896 0.042992 0.003790 0.027633 0.017956 0.042437 0.006755 0.033623 0.015828 0.042601 0.004526 0.029952
Lipid Particles 0.030996 0.107724* 0.085510 0.169384* 0.062903 0.122516* 0.219691* 0.168844* 0.046181 0.118145* 0.118810* 0.169175*
Mitochondria 0.007516 0.010877 0.000481 0.003792 0.004347 0.016022 0.000335 0.002179 0.006008 0.014502 0.000445 0.003167
Mitotic Spindle 0.000219 0.001906 0.002148 0.226570* 0.001821 0.004334 0.091150 0.148005* 0.000981 0.003617 0.024236 0.196151*
None 0.008314 0.001086 0.001254 0.000278 0.002748 0.001494 0.000812 0.000154 0.005665 0.001374 0.001144 0.000230
Nuclear Periphery 0.000297 0.000605 0.001357 0.001512 0.000581 0.000359 0.003120 0.000835 0.000432 0.000432 0.001795 0.001250
Nuclear Periphery Foci 0.000547 0.002841 0.065892 0.024660 0.001608 0.002253 0.140759 0.022019 0.001052 0.002427 0.084473 0.023638
Nucleolus 0.000976 0.001069 0.000198 0.000419 0.000733 0.000918 0.001805 0.000533 0.000861 0.000963 0.000596 0.000463
Nucleus 0.166440* 0.038925 0.073316 0.006324 0.143573* 0.037078 0.022237 0.006507 0.155557* 0.037624 0.060639 0.006394
Peroxisomes 0.008963 0.031422 0.001351 0.033086 0.016126 0.032554 0.028299 0.042037 0.012372 0.032220 0.008039 0.036552
Vacuole 0.031151 0.071323 0.093829 0.048208 0.032578 0.114808 0.108453 0.069389 0.031830 0.101960 0.097458 0.056409
Vacuole Periphery 0.000760 0.002917 0.000189 0.003695 0.000687 0.003601 0.000448 0.004197 0.000725 0.003399 0.000254 0.003889

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.52 -8.14 -15.48 -14.08 -12.23 -4.01 -3.32 -11.61 -11.10 -7.12 -7.94 -7.98 -19.31 -18.14 -14.52
Bud Neck 0.68 6.38 4.94 3.50 -2.14 -8.35 6.64 1.89 10.31 -5.13 -6.04 7.34 4.78 10.58 -3.37
Bud Site -4.05 -9.22 -17.56 -12.93 -6.98 -10.06 -5.79 -14.50 -10.15 -11.90 -9.43 -10.49 -22.96 -17.09 -9.89
Cell Periphery 2.89 -7.69 -0.85 -1.85 7.36 -2.56 7.32 -0.52 1.39 -3.02 -2.30 -7.39 -0.95 0.97 7.05
Cytoplasm 24.83 18.27 67.46* 20.57 25.79 30.04 33.61 49.84 20.60 0.31 41.31 27.20 83.51* 31.03 22.59
Cytoplasmic Foci -11.96 41.70 14.02 22.28 -24.28 -5.21 14.30 9.91 14.39 -6.27 -11.03 44.92 17.48 26.05 -24.51
Eisosomes 3.40 3.61 8.46 5.40 6.33 2.48 11.74 8.07 6.02 -3.43 3.07 8.05 11.99 8.50 4.36
Endoplasmic Reticulum -5.79 -28.92 -5.32 2.03 28.05 -4.03 -3.52 -3.25 -0.57 1.20 -7.35 -26.68 -6.07 0.47 25.80
Endosome -16.34 -7.88 -24.52* -5.29 -21.51 -21.30 -12.44 -22.82 -8.75 1.62 -27.30 -12.23 -33.17 -9.31 -14.25
Golgi -10.89 13.20 -5.58 6.75 -13.22 -11.95 8.51 -4.44 5.05 -9.82 -16.91 16.54 -6.78 9.23 -16.88
Lipid Particles -13.84 -10.86 -22.70 -6.19 -9.64 -12.26 -8.96 -12.72 -3.91 1.91 -19.96 -12.16 -24.69 -6.73 -6.95
Mitochondria -2.24 10.54 4.45 5.12 -4.39 -9.31 9.80 4.15 11.10 -3.27 -8.40 13.92 5.45 11.42 -5.33
Mitotic Spindle -3.24 -3.53 -31.00* -30.67* -30.58* -2.69 -8.00 -19.08 -18.73 -4.97 -4.39 -7.84 -36.06 -35.45* -28.45*
None 8.01 8.24 9.49 2.24 4.06 1.99 1.17 5.12 4.16 1.73 7.59 7.78 10.72 4.58 3.94
Nuclear Periphery -3.50 -13.39 -4.67 -3.42 -0.75 3.71 -6.03 -3.73 -6.25 5.19 -0.23 -10.63 -5.25 -5.19 2.61
Nuclear Periphery Foci -7.20 -20.43 -14.76 -13.31 10.42 -2.00 -11.88 -10.86 -10.35 9.88 -5.02 -21.18 -18.22 -16.82 14.10
Nucleolus -0.43 10.67 2.45 1.90 -3.63 -2.32 -3.33 -0.01 1.17 3.18 -1.62 0.04 1.54 2.52 0.92
Nucleus 30.87* 19.40 45.55* 12.53 19.52 28.44 18.58 37.68 15.15 3.74 43.10* 24.76 59.01* 20.49 18.74
Peroxisomes -12.38 14.73 -10.84 0.45 -15.22 -9.34 -2.38 -7.46 -1.88 -2.90 -15.72 4.68 -12.47 -0.63 -14.11
Vacuole -9.78 -17.01 -10.45 1.36 7.37 -15.95 -8.88 -12.42 2.80 3.67 -18.36 -18.27 -16.06 5.46 7.09
Vacuole Periphery -6.96 9.80 -3.56 -0.28 -4.46 -8.43 1.92 -3.42 -0.00 -3.79 -10.57 6.86 -4.93 0.17 -5.91
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Dehydrogenase involved in ubiquinone and sphingolipid metabolism; oxidizes 4-hydroxybenzaldehyde into 4-hydroxybenzoic acid in ubiquinone biosynthesis; converts hexadecenal to hexadecenoic acid in sphingosine 1-phosphate breakdown pathway; located in the mitochondrial outer membrane and also in lipid particles; human homolog ALDH3A2, a fatty aldehyde dehydrogenase (FALDH) mutated in neurocutaneous disorder Sjogren-Larsson syndrome, can complement yeast hfd1 mutant
Localization
Cell Percentages ER (25%), cytoplasm (8%), mixed (61%)
Cell Cycle Regulation Yes
cytoplasm - MA (9.2e-06)
Subcompartmental Group N/A

Hfd1

Hfd1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hfd1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available