Standard name
Human Ortholog
Description Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0.08 0.09 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0.06 0.09 0 0.11 – 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.97 0.98 1.0 0.96 0.94 0.95 0.81 0.7 0.77 0.8 0.79 – 0.95 0.99 0.99 0.96 0.99 0.99 0.94 0.88 0.91 0.78 0.85 0.9
Endoplasmic Reticulum 0 0 0 0 0.05 0 0.13 0.2 0.12 0.05 0.08 – 0.07 0 0 0 0 0 0 0 0.06 0 0.08 0.05
Endosome 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0.06 0 0.07 0.13 – 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.06 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 1 4 8 8 3 1 – 0 0 1 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 1 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 2 1 3 3 3 3 6 8 3 4 – 0 1 2 3 6 2 0 0 0 0 0 1
Cytoplasm 62 57 25 78 114 97 104 69 69 68 30 – 52 94 153 196 228 207 83 66 65 28 76 131
Endoplasmic Reticulum 2 1 0 2 6 3 17 20 11 4 3 – 4 1 2 7 10 8 2 1 4 1 7 7
Endosome 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 3 1 0 4 0 – 0 0 1 4 1 1 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 1 6 3 6 5 – 0 0 0 2 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 2 3 0 – 0 0 0 0 0 0 0 1 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 2 0 – 0 0 0 0 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 1 1 0 – 0 0 0 3 0 3 0 4 0 1 0 1
Unique Cell Count 64 58 25 81 121 102 129 99 90 85 38 55 95 155 205 231 210 89 75 72 36 91 147
Labelled Cell Count 64 61 26 83 123 104 132 110 102 95 43 56 96 159 215 245 222 89 75 72 36 91 147


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 73.6 110.2 72.5 65.7 58.2 44.5 40.5 40.8 33.9 34.5 35.0 – 77.7 77.1 76.2 118.7 135.4 130.1 – 76.5 84.4
Std Deviation (1e-4) 14.0 28.1 20.4 18.3 14.4 11.1 10.7 12.9 13.9 11.6 13.2 – 18.6 20.7 21.8 41.5 40.5 40.0 – 23.8 22.8
Intensity Change (Log2) – – – -0.14 -0.32 -0.7 -0.84 -0.83 -1.1 -1.07 -1.05 – 0.1 0.09 0.07 0.71 0.9 0.84 – 0.08 0.22


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Cytoplasm -1.0 -1.2 -1.1 -2.4 -3.2 -2.7 -2.4 -2.5 – -1.2 -0.5 -0.6 -1.1 -0.6 -0.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 52.8726 105.2113 89.1982 78.0593 76.2238 88.0607 87.2053 130.7961 105.1877 86.8347 115.8124 99.8349 109.1815 147.8694 137.4147 125.4146 115.6374 133.8221
Actin 0.0224 0.0005 0.0367 0.0005 0.0005 0.0055 0.0048 0.0003 0.0087 0.0019 0.0002 0.0016 0.006 0.0005 0.0024 0.0003 0.0007 0.0007
Bud 0.0041 0.0007 0.0038 0.0023 0.0033 0.005 0.0037 0.0006 0.0046 0.0043 0.0011 0.0017 0.0031 0.0021 0.0019 0.0012 0.0019 0.0018
Bud Neck 0.0018 0.0007 0.0014 0.0005 0.0011 0.0038 0.001 0.0007 0.001 0.001 0.0012 0.0012 0.001 0.0006 0.0009 0.0006 0.0004 0.0024
Bud Periphery 0.0065 0.0009 0.0035 0.0016 0.0013 0.0056 0.0032 0.0004 0.0043 0.0063 0.0006 0.0016 0.0051 0.0019 0.0019 0.0007 0.0023 0.0019
Bud Site 0.0069 0.0009 0.006 0.001 0.0005 0.0015 0.0026 0.0007 0.0056 0.0177 0.0001 0.0003 0.002 0.0009 0.0011 0.0008 0.0003 0.0005
Cell Periphery 0.0185 0.036 0.0354 0.0269 0.0073 0.0338 0.0345 0.0126 0.0264 0.0087 0.0006 0.0157 0.0598 0.0384 0.0484 0.0643 0.0228 0.031
Cytoplasm 0.55 0.8563 0.721 0.6087 0.7497 0.6731 0.5882 0.8887 0.734 0.4403 0.7242 0.701 0.5853 0.8256 0.7336 0.5093 0.5332 0.7412
Cytoplasmic Foci 0.0403 0.001 0.0047 0.0256 0.0107 0.0114 0.0139 0.0012 0.0036 0.0035 0.0035 0.0398 0.005 0.0008 0.0017 0.0048 0.0021 0.0037
Eisosomes 0.0017 0 0.0004 0.0009 0.0002 0.0001 0.0006 0 0.0002 0.0002 0 0 0.0009 0.0001 0.0003 0.0009 0 0
Endoplasmic Reticulum 0.034 0.0061 0.0061 0.0021 0.0021 0.0126 0.0498 0.0096 0.0091 0.007 0.0094 0.0242 0.0481 0.0085 0.0143 0.0013 0.0092 0.0305
Endosome 0.0362 0.0019 0.0155 0.0064 0.0107 0.0557 0.0161 0.0026 0.0103 0.0585 0.0167 0.0385 0.0095 0.0018 0.0055 0.0056 0.0221 0.0241
Golgi 0.0065 0.0006 0.0048 0.0005 0.0006 0.0107 0.0029 0.0004 0.0014 0.0032 0.0004 0.0274 0.0021 0.0003 0.0025 0.0004 0.0012 0.0037
Lipid Particles 0.0127 0.0024 0.003 0.0141 0.0018 0.017 0.0069 0.001 0.0019 0.0031 0.0001 0.0027 0.0041 0.0016 0.0052 0.0088 0.0014 0.0023
Mitochondria 0.0173 0.0007 0.0033 0.006 0.0063 0.0205 0.0116 0.0002 0.0031 0.0303 0.0005 0.0111 0.0224 0.0012 0.0045 0.0032 0.0095 0.0022
None 0.0478 0.0003 0.0016 0.073 0.0329 0.0044 0.0127 0.0002 0.0023 0.0015 0.0002 0.0016 0.0039 0.0002 0.0005 0.0077 0.0006 0.0007
Nuclear Periphery 0.0353 0.0034 0.006 0.0065 0.0036 0.028 0.0366 0.0019 0.0043 0.0476 0.0051 0.0047 0.0419 0.0029 0.0105 0.0108 0.0221 0.0076
Nucleolus 0.0091 0.0005 0.0012 0.0176 0.0133 0.0016 0.0049 0.0002 0.0027 0.0053 0.0001 0.0005 0.0042 0.0003 0.0007 0.0131 0.0007 0.0006
Nucleus 0.0222 0.0023 0.0054 0.0086 0.0133 0.0056 0.0126 0.0018 0.0058 0.0143 0.0025 0.0028 0.0117 0.0021 0.0037 0.0116 0.0063 0.0039
Peroxisomes 0.0015 0 0.0003 0.0007 0.0005 0.0017 0.0007 0 0.0002 0.0006 0.0001 0.0003 0.0004 0 0.0001 0.0003 0.0001 0.0001
Punctate Nuclear 0.0123 0 0.0003 0.002 0.0006 0.0126 0.0011 0 0.0001 0.0006 0 0.0049 0.0006 0 0.0001 0.0004 0.0001 0.0001
Vacuole 0.096 0.0804 0.1234 0.1611 0.1204 0.0698 0.172 0.0729 0.1469 0.2496 0.1898 0.0935 0.1559 0.1042 0.1482 0.2813 0.2828 0.1087
Vacuole Periphery 0.017 0.0045 0.0161 0.0334 0.0195 0.0201 0.0196 0.0042 0.0234 0.0945 0.0435 0.0247 0.027 0.0059 0.0119 0.0725 0.0802 0.0323

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 1388.1952 1269.5027 1599.4106 1542.1548 1650.8336 1110.4519 1284.17 1247.3095 1335.9248 1324.7944
Translational Efficiency 1.4925 1.6186 1.4436 1.2159 1.4209 2.0288 1.6465 1.5947 1.5831 1.8119

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
190 548 2220 594 1790 383 1960 310 1980 931 4180 904

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 4605.79 4938.19 8848.80 6677.99 4212.11 5106.55 7181.41 5866.63 4249.89 5007.45 8066.96 6399.76
Standard Deviation 970.80 1303.26 1664.79 1683.34 900.34 1058.08 1612.98 1371.72 914.72 1211.27 1839.64 1629.57
Intensity Change Log 2 — 0.100534 0.942033 0.535965 — 0.277806 0.769724 0.477989 — 0.187933 0.862286 0.508562

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000172 0.000164 0.000081 0.000231 0.000049 0.000100 0.000079 0.000255 0.000060 0.000138 0.000080 0.000239
Bud Neck 0.001119 0.000588 0.000570 0.002431 0.000191 0.000839 0.001152 0.005420 0.000280 0.000691 0.000843 0.003456
Bud Site 0.009053 0.005250 0.002966 0.010462 0.003141 0.008543 0.004164 0.008368 0.003708 0.006604 0.003528 0.009744
Cell Periphery 0.047775 0.032095 0.020320 0.058530 0.010269 0.024017 0.013957 0.035460 0.013868 0.028772 0.017337 0.050619
Cytoplasm 0.365587* 0.546297* 0.696826* 0.515612* 0.594174* 0.486995* 0.618729* 0.560478* 0.572239* 0.521901* 0.660206* 0.530997*
Cytoplasmic Foci 0.028623 0.018079 0.011853 0.015514 0.020200 0.023321 0.007722 0.026416 0.021008 0.020236 0.009916 0.019252
Eisosomes 0.000008 0.000004 0.000002 0.000006 0.000001 0.000003 0.000002 0.000005 0.000002 0.000003 0.000002 0.000006
Endoplasmic Reticulum 0.001251 0.001494 0.001625 0.000938 0.001636 0.001377 0.000699 0.000664 0.001599 0.001446 0.001191 0.000844
Endosome 0.002175 0.001351 0.000745 0.001961 0.000962 0.001881 0.000865 0.003929 0.001078 0.001569 0.000801 0.002636
Golgi 0.209990* 0.123749* 0.056664 0.060724 0.102966 0.166540* 0.036015 0.044111 0.113236* 0.141353* 0.046982 0.055027
Lipid Particles 0.033749 0.020432 0.014264 0.037434 0.005836 0.020299 0.013736 0.039623 0.008515 0.020377 0.014017 0.038184
Mitochondria 0.000277 0.000395 0.000315 0.000342 0.000522 0.000274 0.000252 0.001066 0.000498 0.000345 0.000285 0.000590
Mitotic Spindle 0.002521 0.003648 0.001272 0.003677 0.001497 0.002479 0.001026 0.014901 0.001595 0.003167 0.001157 0.007526
None 0.001443 0.004284 0.001638 0.002081 0.001846 0.002859 0.001972 0.002136 0.001808 0.003697 0.001794 0.002100
Nuclear Periphery 0.001061 0.000737 0.000963 0.001370 0.000472 0.001662 0.000634 0.001664 0.000528 0.001117 0.000809 0.001471
Nuclear Periphery Foci 0.017098 0.014958 0.010856 0.018410 0.007401 0.016280 0.010385 0.019999 0.008332 0.015502 0.010635 0.018955
Nucleolus 0.000088 0.001236 0.000068 0.000202 0.000077 0.000170 0.000130 0.000801 0.000078 0.000797 0.000097 0.000408
Nucleus 0.004750 0.010421 0.006502 0.022936 0.002186 0.004032 0.009305 0.024876 0.002432 0.007793 0.007816 0.023601
Peroxisomes 0.000035 0.000097 0.000031 0.000073 0.000017 0.000031 0.000035 0.000137 0.000019 0.000070 0.000033 0.000095
Vacuole 0.133687 0.094318 0.086504 0.176928 0.043820 0.092460 0.204010* 0.173002 0.052444 0.093554 0.141602 0.175581
Vacuole Periphery 0.139541* 0.120403* 0.085936 0.070139 0.202738* 0.145839* 0.075130 0.036688 0.196673* 0.130867* 0.080869 0.058668

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.21 2.53 -1.70 -2.07 -5.81 -4.21 -4.40 -4.20 -3.18 -3.36 -4.03 -3.45 -7.45 -3.77 -6.49
Bud Neck 2.29 2.01 -6.40 -8.17 -8.04 -4.96 -5.90 -6.82 -6.48 -6.17 -5.60 -6.81 -9.48 -8.92 -8.45
Bud Site 2.06 3.54 -0.75 -3.25 -4.99 -3.31 -2.62 -5.33 -1.37 -4.49 -3.49 0.16 -6.17 -3.21 -6.34
Cell Periphery 2.90 5.62 -0.42 -3.80 -7.18 -6.17 -2.71 -4.06 -0.37 -3.18 -7.51 -3.14 -9.10 -3.79 -8.11
Cytoplasm -6.26 -13.00 -4.96 1.88 11.40 5.29 -0.97 4.85 -0.14 5.40 3.54 -8.07 5.09 1.25 11.64
Cytoplasmic Foci 2.52 4.51 1.68 -0.89 -3.30 -1.47 10.19 -5.07 -4.54 -6.57 0.32 9.76 -4.00 -3.96 -7.33
Eisosomes 2.53 3.37 0.86 -3.12 -5.14 -4.59 -4.32 -4.80 -2.84 -4.01 -4.41 -1.69 -6.99 -4.26 -6.58
Endoplasmic Reticulum -0.86 -1.76 1.75 2.39 3.82 0.79 5.48 5.36 2.80 1.16 0.68 2.61 4.56 3.43 3.29
Endosome 3.15 6.17 0.52 -1.20 -2.58 -4.84 0.89 -1.99 -1.23 -2.05 -4.17 4.07 -2.60 -1.63 -3.11
Golgi 5.98 11.85 11.83 9.44 0.96 -6.59 19.06 14.18 13.64 0.23 -4.37 19.10 15.91 15.75 0.01
Lipid Particles 2.79 4.36 -0.24 -4.31 -7.19 -7.25 -7.70 -6.88 -3.04 -4.89 -7.75 -6.50 -11.13 -5.32 -8.74
Mitochondria -0.38 -0.01 -0.33 0.15 -0.90 2.26 2.99 -0.92 -1.47 -1.50 1.59 2.73 -0.37 -1.31 -1.72
Mitotic Spindle -0.81 2.47 -2.88 -1.29 -3.97 -2.47 1.12 -4.64 -4.43 -4.69 -1.80 1.67 -5.71 -4.41 -5.88
None -3.31 -1.34 -3.34 2.36 -2.97 -0.77 -0.27 -2.27 0.19 -1.07 -2.57 0.02 -3.09 1.78 -1.97
Nuclear Periphery 1.44 0.06 -2.43 -5.20 -3.72 -1.68 -3.14 -3.97 -0.64 -3.43 -1.94 -4.70 -7.02 -2.13 -5.25
Nuclear Periphery Foci 0.92 3.57 -0.73 -1.59 -4.27 -4.15 -4.57 -5.64 -1.67 -4.29 -5.20 -4.48 -7.77 -2.22 -6.05
Nucleolus -2.08 1.14 -5.26 1.72 -6.21 -1.21 -4.43 -3.55 -3.35 -3.42 -2.20 -2.35 -4.24 -0.16 -4.08
Nucleus -2.52 -1.78 -8.14 -6.51 -7.76 -2.24 -9.85 -8.95 -8.44 -6.72 -4.65 -11.25 -12.39 -10.11 -9.93
Peroxisomes -1.71 0.64 -2.29 0.73 -2.66 -2.18 -3.69 -4.43 -4.06 -4.01 -2.31 -4.92 -5.54 -1.41 -4.75
Vacuole 2.75 3.40 -3.30 -8.06 -9.95 -6.91 -28.01 -10.92 -6.48 1.54 -7.93 -23.77 -17.32 -10.42 -4.75
Vacuole Periphery 1.45 4.70 6.65 7.14 4.92 5.37 21.37 27.03* 11.98 10.75 8.72 21.39 24.59 12.57 8.40
Standard name
Human Ortholog
Description Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Rps16a

Rps16a


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rps16a-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available