Standard name
Human Ortholog
Description Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical (Ile) start codon at -372 relative to the annotated start codon
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.07 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0.05 0.05
Bud 0 0 0.09 0.07 0.07 0 0.05 0.07 0.08 – 0.05 0.06 0.05 0 0.05 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0.18 0.41 0.39 0.34 0.2 0.19 0.16 0.15 0.12 – 0.07 0.08 0.56 0.67 0.69 – – – 0 0.08 0 0.06 0.05 0
Endoplasmic Reticulum 0.07 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Endosome 0.2 0.08 0.05 0 0.07 0 0 0 0 – 0 0 0.1 0.14 0 – – – 0.21 0.13 0.11 0.1 0.11 0.11
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0.21 0.38 0.43 0.69 0.57 0.78 0.77 0.77 0.87 – 0.93 0.92 0.21 0.07 0.33 – – – 0.53 0.54 0.56 0.56 0.56 0.53
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0.07 0.05 0 0.1 0 0.05 0 0 – 0 0 0.08 0.09 0 – – – 0.08 0 0.05 0 0 0.05
SpindlePole 0.2 0.08 0.16 0.06 0.19 0.1 0.15 0.12 0.05 – 0.09 0.06 0.12 0.07 0.06 – – – 0.05 0.06 0.09 0.08 0.07 0.06
Vac/Vac Membrane 0.13 0.13 0 0 0.05 0 0 0 0 – 0 0 0 0 0 – – – 0 0.06 0 0.06 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 10 1 0 0 1 0 0 1 0 – 0 0 2 2 1 – – – 4 17 13 14 26 24
Bud 6 12 30 21 25 15 31 41 31 – 11 19 19 12 28 – – – 0 2 3 4 5 9
Bud Neck 2 2 8 0 6 3 3 3 1 – 0 0 2 3 2 – – – 1 5 3 8 6 12
Bud Site 2 1 5 1 2 8 9 15 15 – 6 8 1 0 4 – – – – – – – – –
Cell Periphery 3 3 4 1 1 1 2 2 4 – 1 3 8 7 0 – – – 0 2 1 0 0 1
Cytoplasm 27 139 127 110 72 76 91 93 50 – 16 28 227 329 380 – – – 4 36 17 23 25 20
Endoplasmic Reticulum 10 5 1 4 3 3 3 4 3 – 3 3 2 6 2 – – – 0 1 3 3 3 5
Endosome 30 26 17 4 26 7 9 14 0 – 0 0 42 70 19 – – – 53 59 40 40 56 53
Golgi 2 0 0 0 0 0 0 0 0 – 0 1 1 0 0 – – – 5 6 4 2 7 7
Mitochondria 32 129 138 222 202 319 438 465 357 – 219 314 86 33 182 – – – 132 247 217 231 282 263
Nucleus 1 0 1 0 3 3 7 7 1 – 0 1 0 0 0 – – – 0 1 1 1 1 0
Nuclear Periphery 2 1 0 0 1 0 1 0 1 – 4 3 1 0 0 – – – 2 0 1 1 0 0
Nucleolus 0 0 1 1 1 1 0 5 3 – 2 3 0 0 1 – – – 0 0 1 1 1 1
Peroxisomes 3 24 15 8 35 4 26 23 6 – 1 1 34 46 9 – – – 20 15 19 16 19 26
SpindlePole 30 26 52 18 68 40 83 74 22 – 20 22 49 35 32 – – – 13 26 33 32 35 32
Vac/Vac Membrane 20 43 6 6 18 17 12 13 10 – 4 8 18 18 17 – – – 3 26 10 23 18 19
Unique Cell Count 149 337 323 320 356 410 569 603 409 235 340 409 492 552 250 458 386 417 503 494
Labelled Cell Count 180 412 405 396 464 497 715 760 504 287 414 492 561 677 250 458 386 417 503 494


Ambiguous, Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.0 3.9 3.4 3.4 3.8 3.4 3.2 3.3 2.8 – 3.4 2.9 4.2 4.5 3.7 – – – 4.3 4.5 5.0
Std Deviation (1e-4) 0.7 0.6 1.3 1.1 1.4 1.1 1.1 1.1 0.6 – 5.5 3.2 1.0 1.2 1.0 – – – 1.1 1.3 1.6
Intensity Change (Log2) – – – -0.0 0.14 -0.01 -0.09 -0.07 -0.3 – -0.01 -0.22 0.3 0.38 0.1 – – – 0.34 0.38 0.55


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.9541 3.2532 3.1009 2.8412 3.3521 3.0748 0.1287 -1.1974 -0.8365 -1.064 -0.4616 -0.7448 3.9494 3.5988 3.1516 3.2504 3.5852 3.8345
Actin 0.0986 0.012 0.028 0.0088 0.0258 0.0237 0.0062 0.0187 0.0146 0.0048 0.0028 0.0184 0.0523 0.0295 0.0456 0.0163 0.0343 0.0153
Bud 0.0024 0.003 0.0038 0.0049 0.0052 0.0012 0.0015 0.003 0.0113 0.0381 0.0006 0.0056 0.0019 0.0071 0.0081 0.0071 0.003 0.0022
Bud Neck 0.0085 0.0032 0.0098 0.0083 0.0033 0.0287 0.0058 0.0026 0.0051 0.0018 0.0013 0.0074 0.0016 0.0057 0.0028 0.0031 0.0011 0.0085
Bud Periphery 0.0065 0.0062 0.0142 0.0137 0.0251 0.0037 0.0023 0.0047 0.0082 0.018 0.0018 0.0101 0.0047 0.0128 0.0113 0.0258 0.0133 0.0052
Bud Site 0.0135 0.0532 0.0343 0.0165 0.0124 0.004 0.0118 0.04 0.0538 0.0085 0.0013 0.0019 0.0056 0.0617 0.0314 0.0026 0.0022 0.0018
Cell Periphery 0.0074 0.0076 0.0106 0.0069 0.008 0.0111 0.0007 0.0022 0.0017 0.0026 0.001 0.0013 0.0042 0.0051 0.0019 0.0054 0.0017 0.0037
Cytoplasm 0.0887 0.2095 0.1882 0.0984 0.1423 0.1317 0.0149 0.0685 0.0819 0.0925 0.0354 0.0975 0.0778 0.1221 0.0682 0.1061 0.0862 0.1101
Cytoplasmic Foci 0.0928 0.1324 0.0973 0.079 0.1046 0.1188 0.145 0.1425 0.0922 0.1114 0.1668 0.1097 0.1671 0.143 0.1581 0.1107 0.1963 0.1689
Eisosomes 0.0022 0.0015 0.0018 0.0016 0.0019 0.001 0.0006 0.0009 0.0008 0.0005 0.0001 0.0004 0.0012 0.0016 0.0023 0.0003 0.0044 0.0007
Endoplasmic Reticulum 0.0308 0.02 0.0138 0.0088 0.0419 0.019 0.0044 0.0078 0.0064 0.0067 0.0045 0.0104 0.0054 0.0028 0.0035 0.005 0.0031 0.0039
Endosome 0.1588 0.1255 0.1026 0.074 0.1454 0.1269 0.1836 0.2234 0.1456 0.1665 0.1793 0.1563 0.1636 0.1665 0.1083 0.1349 0.1066 0.1233
Golgi 0.0521 0.0453 0.0431 0.0292 0.0724 0.0569 0.0538 0.0686 0.0703 0.0486 0.0543 0.0371 0.079 0.0744 0.0629 0.0635 0.0433 0.0618
Lipid Particles 0.0652 0.019 0.0279 0.023 0.036 0.0379 0.0812 0.0445 0.027 0.0618 0.0514 0.0349 0.051 0.01 0.0171 0.0081 0.0252 0.0294
Mitochondria 0.1355 0.113 0.2201 0.3882 0.2209 0.2514 0.277 0.1927 0.3011 0.2445 0.3105 0.2967 0.1622 0.1691 0.2766 0.3142 0.2343 0.1908
None 0.1342 0.1937 0.1444 0.1694 0.0773 0.1212 0.0623 0.1106 0.0953 0.1386 0.0217 0.1351 0.1079 0.1473 0.0941 0.1411 0.1242 0.205
Nuclear Periphery 0.0154 0.0025 0.0016 0.0045 0.0073 0.0025 0.03 0.0027 0.0135 0.0028 0.0731 0.003 0.0042 0.001 0.0083 0.0009 0.0004 0.0008
Nucleolus 0.0042 0.0009 0.0014 0.002 0.0071 0.001 0.0053 0.0019 0.0042 0.0029 0.0016 0.0036 0.001 0.0012 0.0011 0.0008 0.0004 0.0007
Nucleus 0.0073 0.0017 0.0022 0.0034 0.0094 0.0019 0.0304 0.002 0.0161 0.0035 0.0143 0.0072 0.0026 0.0023 0.0039 0.001 0.0006 0.0101
Peroxisomes 0.036 0.0289 0.036 0.028 0.0167 0.0355 0.0439 0.034 0.025 0.0218 0.0473 0.023 0.0793 0.0203 0.0822 0.0366 0.109 0.0467
Punctate Nuclear 0.0043 0.002 0.0025 0.0069 0.0163 0.0083 0.0128 0.0022 0.0079 0.0046 0.0029 0.0067 0.0164 0.0023 0.0028 0.0009 0.0011 0.0015
Vacuole 0.0289 0.0151 0.013 0.0185 0.0158 0.0098 0.0177 0.0205 0.0122 0.0134 0.0151 0.0245 0.0081 0.0113 0.0052 0.0115 0.0053 0.0067
Vacuole Periphery 0.0069 0.0038 0.0033 0.0059 0.0051 0.0037 0.0088 0.0059 0.0058 0.006 0.0128 0.0093 0.0028 0.003 0.0043 0.0042 0.0039 0.0028

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 8.0522 8.2043 9.0745 10.4934 11.7871 6.9227 10.291 11.3033 10.4495 12.5021
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
221 336 210 1257 1168 1450 1292 1040 1389 1786 1502 2297

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 633.98 744.23 947.18 797.50 602.83 715.46 782.68 711.89 607.79 720.87 805.68 758.74
Standard Deviation 65.94 99.47 109.74 108.28 78.24 94.77 92.43 110.45 77.26 96.33 110.85 117.28
Intensity Change Log 2 — 0.231311 0.579201 0.331047 — 0.247120 0.376671 0.239903 — 0.239038 0.484031 0.287342

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000721 0.001572 0.003102 0.008500 0.000950 0.001686 0.001362 0.000899 0.000914 0.001664 0.001605 0.005059
Bud Neck 0.061895 0.036617 0.009220 0.032180 0.045956 0.033752 0.025772 0.044577 0.048492 0.034291 0.023458 0.037793
Bud Site 0.012283 0.027627 0.031597 0.081084 0.016214 0.026791 0.018295 0.030455 0.015588 0.026949 0.020155 0.058161
Cell Periphery 0.000454 0.000257 0.000316 0.000262 0.000370 0.000156 0.000194 0.000329 0.000383 0.000175 0.000211 0.000292
Cytoplasm 0.193942* 0.051862 0.219918* 0.237139* 0.062120 0.046475 0.289911* 0.191873* 0.083094 0.047488 0.280125* 0.216644*
Cytoplasmic Foci 0.343429* 0.231179* 0.066185 0.138409 0.249637* 0.228895* 0.096151 0.153571 0.264560* 0.229325* 0.091962 0.145274
Eisosomes 0.000647 0.000237 0.000156 0.000149 0.000249 0.000175 0.000112 0.000177 0.000312 0.000187 0.000118 0.000162
Endoplasmic Reticulum 0.001148 0.001375 0.014282 0.003093 0.000867 0.000386 0.004885 0.002925 0.000912 0.000572 0.006199 0.003017
Endosome 0.057254 0.122763 0.023385 0.030662 0.093656 0.106234 0.014249 0.064842 0.087864 0.109343 0.015526 0.046137
Golgi 0.013782 0.090792 0.000679 0.011568 0.062967 0.112425* 0.002006 0.009976 0.055141 0.108355 0.001820 0.010847
Lipid Particles 0.047500 0.009740 0.010102 0.005274 0.028642 0.009172 0.009563 0.026087 0.031642 0.009279 0.009638 0.014698
Mitochondria 0.054715 0.177734* 0.000763 0.018391 0.276293* 0.244427* 0.009477 0.034451 0.241038* 0.231880* 0.008259 0.025662
Mitotic Spindle 0.002077 0.033061 0.006537 0.069599 0.008662 0.033782 0.026004 0.039424 0.007615 0.033646 0.023282 0.055936
None 0.001843 0.002109 0.002374 0.002313 0.002573 0.000991 0.006016 0.009263 0.002457 0.001201 0.005507 0.005459
Nuclear Periphery 0.000691 0.000276 0.003508 0.001374 0.000364 0.000219 0.003274 0.002729 0.000416 0.000230 0.003307 0.001987
Nuclear Periphery Foci 0.000353 0.000324 0.008252 0.001283 0.000505 0.000473 0.001807 0.002481 0.000480 0.000445 0.002708 0.001825
Nucleolus 0.004890 0.001579 0.002089 0.001923 0.004657 0.001784 0.005337 0.012626 0.004694 0.001745 0.004883 0.006769
Nucleus 0.093509 0.011632 0.390568* 0.098734 0.020814 0.008360 0.372639* 0.163846* 0.032381 0.008976 0.375145* 0.128214
Peroxisomes 0.060425 0.153284* 0.007731 0.074768 0.080637 0.105415* 0.025723 0.041116 0.077421 0.114420* 0.023207 0.059531
Vacuole 0.041895 0.036770 0.198278 0.179970 0.034106 0.031670 0.085603 0.160835 0.035346 0.032630 0.101357 0.171306
Vacuole Periphery 0.006546 0.009209 0.000958 0.003326 0.009763 0.006734 0.001620 0.007520 0.009251 0.007200 0.001527 0.005225

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.37 -2.63 -5.57 -4.75 -2.64 -2.41 -2.08 0.20 2.82 2.84 -2.91 -3.20 -5.33 -3.84 -4.00
Bud Neck 2.64 6.08 3.71 1.23 -9.28 3.08 5.53 1.07 -2.09 -4.76 3.87 7.35 3.85 -0.36 -5.32
Bud Site -3.28 -2.00 -9.86 -7.08 -4.74 -4.26 -0.61 -4.09 -0.46 -3.41 -5.19 -1.54 -11.60 -6.65 -9.46
Cell Periphery 2.25 2.16 4.00 0.57 2.76 3.09 2.65 1.03 -4.32 -3.59 3.47 3.01 2.22 -2.46 -1.57
Cytoplasm 9.16 -0.11 -2.69 -18.49 -2.47 3.53 -26.92 -15.76 -19.05 9.20 7.45 -24.05 -20.20 -29.79 6.43
Cytoplasmic Foci 6.10 17.50 14.55 10.46 -7.71 2.72 21.27 12.13 10.36 -8.98 4.90 25.98 20.07 17.15 -8.86
Eisosomes 4.07 5.44 5.76 1.77 1.72 3.71 8.55 4.50 -0.18 -7.68 5.26 9.63 7.86 1.80 -4.96
Endoplasmic Reticulum -0.39 -11.27 -6.56 -3.88 9.56 3.38 -13.33 -9.04 -12.33 6.13 2.12 -16.65 -12.23 -14.12 9.46
Endosome -5.53 4.76 4.72 10.53 -0.52 -2.33 19.68 6.68 9.27 -14.02 -4.29 20.09 12.34 17.39 -12.54
Golgi -9.30 5.53 2.62 10.51 -6.24 -9.28 18.91 15.57 23.15 -4.73 -11.34 19.19 16.36 25.98 -7.00
Lipid Particles 4.87 5.06 5.72 1.97 3.83 7.55 7.84 1.52 -6.84 -7.23 8.94 9.29 7.20 -3.30 -3.85
Mitochondria -7.12 5.52 4.31 11.72 -8.14 2.63 30.25 26.52 26.87 -6.67 0.81 29.53 27.54 31.19 -7.12
Mitotic Spindle -6.11 -2.24 -12.57 -3.97 -8.94 -8.26 -5.51 -7.34 -1.07 -2.56 -9.83 -5.87 -13.51 -4.30 -6.64
None -0.24 -0.45 -0.10 0.19 0.54 2.28 -2.84 -3.38 -4.49 -1.48 1.82 -2.90 -2.49 -3.98 0.29
Nuclear Periphery 2.18 -8.50 -5.72 -10.22 4.99 1.89 -11.55 -8.56 -8.99 1.76 2.62 -13.05 -12.21 -13.27 4.16
Nuclear Periphery Foci 0.24 -6.96 -7.22 -6.85 5.95 0.22 -7.28 -5.57 -5.11 -1.52 0.26 -9.85 -7.41 -6.13 3.07
Nucleolus 1.66 1.30 1.42 -1.09 0.48 3.23 -1.03 -5.09 -7.14 -4.74 3.67 -0.51 -2.41 -6.46 -2.31
Nucleus 7.56 -12.61 -1.96 -19.38 12.71 5.81 -41.37 -20.77 -23.30 19.28 9.00 -42.39 -22.49 -31.34 27.09
Peroxisomes -6.55 6.46 0.57 8.12 -12.13 -4.15 12.48 8.25 12.07 -4.10 -6.62 13.73 6.73 13.36 -8.44
Vacuole 0.21 -11.89 -23.58 -23.93 -1.33 0.87 -14.88 -21.11 -21.58 -9.96 0.79 -18.21 -34.23 -34.79 -15.01
Vacuole Periphery -1.24 4.39 3.34 4.25 -4.29 3.57 12.28 3.43 0.43 -6.68 2.59 12.99 7.45 4.96 -6.92
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical (Ile) start codon at -372 relative to the annotated start codon
Localization
Cell Percentages mitochondrion (59%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Hfa1

Hfa1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hfa1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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