Standard name
Human Ortholog
Description Protein involved in telomeric silencing; required for quiescent cell telomere hypercluster localization at nuclear membrane vicinity; interacts with PAD4-domain of Sir4p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0.11 0.16 0.14 0.14 0.12 0.13 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0
Endosome 0.24 0 0 0 0.07 0 0 0 0 0 0 0 0.16 0.06 0 0.16 0.14 0.18 0.1 0.16 0.15 0.16 0.17 0.19
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.18 0.48 0.73 0.79 0.54 0.67 0.6 0.7 0.74 0.78 0.73 0.82 0.17 0.3 0.47 0.1 0.08 0.13 0 0.05 0.05 0.09 0 0.09
Nucleus 0.07 0.07 0 0.1 0.13 0.11 0.13 0.17 0.06 0.14 0.11 0.12 0 0.09 0.07 0.05 0 0.06 0 0 0 0.06 0 0
Nuclear Periphery 0.54 0.53 0.3 0.41 0.41 0.4 0.4 0.3 0.41 0.27 0.32 0.4 0.61 0.42 0.42 0.5 0.48 0.41 0.72 0.51 0.61 0.45 0.5 0.46
Nucleolus 0.24 0.2 0.13 0.16 0.11 0.18 0.19 0.15 0.24 0.19 0.21 0.2 0.27 0.12 0.15 0.25 0.18 0.2 0 0.09 0 0.05 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0.05 0 0.05 0.06 0.06
Vac/Vac Membrane 0.19 0.17 0.08 0.05 0.08 0.07 0.06 0 0.05 0 0 0.06 0.2 0.15 0.1 0.26 0.31 0.26 0 0 0 0.05 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 2 1 2 2
Bud 0 1 3 1 1 5 7 4 3 9 6 6 0 0 0 0 0 1 2 1 1 0 4 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 1 2 3 4 9 14 2 9 4 3 0 0 3 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 2 0 0 0 0 0 0 0
Cytoplasm 3 9 9 8 10 5 7 11 9 5 7 5 19 34 34 17 36 41 0 1 0 1 5 0
Endoplasmic Reticulum 0 1 0 0 0 0 1 0 1 1 0 0 0 0 1 6 15 12 0 1 1 1 1 0
Endosome 36 8 7 2 19 2 9 2 4 1 2 1 28 12 3 19 42 58 21 35 41 21 37 43
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 2 2 0 3 2 6
Mitochondria 27 100 187 164 151 233 249 294 236 258 165 175 29 62 113 12 22 43 6 12 15 12 8 21
Nucleus 10 14 11 21 37 39 53 73 20 46 24 26 6 18 17 6 10 18 2 10 5 7 6 2
Nuclear Periphery 80 110 78 85 116 137 164 125 131 90 73 85 105 87 100 61 140 135 148 116 172 58 110 104
Nucleolus 36 41 34 34 32 62 79 61 76 62 48 43 47 26 35 30 51 65 5 19 7 6 7 7
Peroxisomes 1 0 6 0 1 1 4 3 0 0 0 0 1 6 6 0 3 1 2 1 6 1 4 10
SpindlePole 3 6 5 4 4 3 6 6 3 2 4 0 3 10 15 2 7 12 8 10 11 6 13 13
Vac/Vac Membrane 29 35 21 10 23 24 25 10 15 11 6 13 34 31 24 31 89 85 1 8 7 6 6 7
Unique Cell Count 149 207 257 208 280 346 413 420 319 330 226 213 173 209 240 121 291 327 205 227 281 132 220 230
Labelled Cell Count 225 325 362 331 397 515 613 603 501 494 339 357 272 286 352 186 419 472 205 227 281 132 220 230


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.1 5.3 4.7 4.6 5.5 4.9 4.9 4.7 4.3 4.2 4.3 4.1 6.5 5.9 5.3 7.8 8.8 8.7 6.3 6.4 6.9
Std Deviation (1e-4) 1.1 1.1 1.0 1.1 1.2 0.9 1.1 1.0 1.2 1.0 1.2 1.2 1.7 1.6 1.4 1.5 1.9 2.1 1.5 1.9 1.7
Intensity Change (Log2) – – – -0.02 0.21 0.07 0.07 -0.02 -0.13 -0.17 -0.12 -0.2 0.46 0.33 0.16 0.72 0.9 0.88 0.43 0.44 0.56

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.2 0 -1.7 -1.5 -0.7 -0.5 -1.6 -0.2 -0.7 3.1 4.7 4.2 3.8 3.8 3.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 3.7 3.1
Endosome 0 2.2 0 -0.4 0 0 0 0 0 5.0 1.6 0 4.7 4.8 5.7
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 -4.5 -1.4 -3.3 0 0 0 0 0 -11.4 -9.3 -5.8 -11.4 -15.7 -14.6
Nucleus 2.5 3.6 3.1 3.7 5.0 1.1 3.9 2.7 3.2 -0.4 1.9 1.4 0.3 -0.5 0.7
Nuclear Periphery 0 2.7 2.3 2.5 0 0 0 0 0 6.2 2.5 2.6 3.8 4.2 2.7
Nucleolus 0 -0.6 1.6 2.0 0 0 0 0 0 3.6 -0.3 0.4 2.8 1.4 2.1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0.4 0.1 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 1.7 2.4 0 0.4 1.2
Vacuole -1.4 0 -0.6 -1.1 -3.5 -1.7 -2.6 -2.6 -0.9 3.5 2.3 0.7 4.6 6.5 5.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.0758 3.2953 3.1536 3.0316 2.6398 3.1275 2.6814 3.6036 3.4366 2.6215 2.2004 3.0699 3.7309 4.1897 4.5399 4.0435 3.5163 3.9237
Actin 0.0473 0.0018 0.0101 0.013 0.0793 0.0096 0.0401 0.0031 0.0059 0.0058 0.0014 0.0086 0.0121 0.0074 0.007 0.0096 0.0006 0.0013
Bud 0.0005 0.0002 0.0002 0.0009 0.0013 0.0002 0.0002 0.0002 0.0003 0.0002 0 0 0.0007 0.0002 0.0002 0.0003 0 0
Bud Neck 0.0019 0.0008 0.0018 0.0271 0.0066 0.0013 0.0006 0.0002 0.0004 0.0006 0.0002 0.0007 0.0009 0.0004 0.0055 0.0004 0.0001 0.0003
Bud Periphery 0.0015 0.0004 0.0006 0.0018 0.0023 0.0004 0.0004 0.0006 0.0008 0.0006 0.0002 0.0001 0.0019 0.0006 0.0003 0.0014 0.0001 0.0002
Bud Site 0.002 0.0045 0.0045 0.0173 0.0071 0.0007 0.002 0.0008 0.0027 0.0007 0.0001 0.0001 0.0038 0.0013 0.0174 0.0003 0 0.0001
Cell Periphery 0.0006 0.0001 0.0002 0.0006 0.0007 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0 0.0003 0.0002 0.0002 0.0002 0 0
Cytoplasm 0.0037 0.0012 0.0012 0.0006 0.003 0.0003 0.0034 0.0004 0.0005 0.0004 0.0001 0.0002 0.0009 0.0094 0.0126 0.0009 0.0001 0.0004
Cytoplasmic Foci 0.0061 0.003 0.0029 0.0055 0.0046 0.0033 0.0175 0.0036 0.0063 0.0039 0.0032 0.0012 0.0039 0.0222 0.0121 0.0016 0.0056 0.0012
Eisosomes 0.0011 0.0001 0.0003 0.0004 0.0007 0.0001 0.0004 0.0001 0.0002 0.0003 0.0001 0 0.0005 0.0003 0.0002 0.0006 0.0001 0.0001
Endoplasmic Reticulum 0.0077 0.0022 0.0029 0.0023 0.0031 0.001 0.0018 0.0035 0.0016 0.0014 0.0013 0.0008 0.0036 0.0031 0.005 0.0028 0.0022 0.0013
Endosome 0.0235 0.0065 0.0056 0.0077 0.0175 0.0095 0.0281 0.0028 0.0101 0.0031 0.0034 0.0031 0.0206 0.0117 0.0153 0.0044 0.0017 0.0024
Golgi 0.0108 0.0018 0.003 0.0059 0.0141 0.0095 0.0085 0.0016 0.0085 0.0025 0.0042 0.0031 0.0054 0.0045 0.0056 0.0021 0.0038 0.0016
Lipid Particles 0.0399 0.0189 0.0329 0.0215 0.082 0.0261 0.0271 0.0255 0.0435 0.0237 0.122 0.0321 0.0243 0.0465 0.0194 0.0245 0.1373 0.0479
Mitochondria 0.0144 0.0019 0.0029 0.0115 0.0179 0.0138 0.0149 0.0022 0.0107 0.0023 0.0032 0.0019 0.0246 0.0066 0.0034 0.0039 0.0011 0.0007
None 0.0104 0.001 0.0042 0.0017 0.0133 0.0008 0.009 0.0014 0.0029 0.0029 0.0009 0.0003 0.0037 0.0052 0.0036 0.0131 0.0006 0.002
Nuclear Periphery 0.6847 0.7563 0.7239 0.7181 0.6063 0.8159 0.7686 0.8311 0.7852 0.7793 0.6878 0.8974 0.8005 0.6382 0.7329 0.7931 0.7152 0.8644
Nucleolus 0.012 0.0326 0.0212 0.0171 0.041 0.0175 0.0171 0.0352 0.0176 0.0267 0.0482 0.0057 0.0127 0.0204 0.0114 0.0106 0.0114 0.015
Nucleus 0.0414 0.0914 0.0953 0.0624 0.0313 0.0248 0.0287 0.0292 0.0287 0.0126 0.0158 0.0172 0.0142 0.0702 0.0675 0.024 0.004 0.0153
Peroxisomes 0.0036 0.0016 0.0038 0.0081 0.0032 0.004 0.0043 0.001 0.0052 0.0031 0.0015 0.0006 0.0042 0.0064 0.0075 0.0018 0.0016 0.0004
Punctate Nuclear 0.0648 0.0547 0.0611 0.0605 0.045 0.0503 0.0127 0.0374 0.0496 0.1172 0.0931 0.0176 0.0403 0.134 0.0509 0.0769 0.0998 0.0347
Vacuole 0.004 0.0023 0.0024 0.002 0.0074 0.0009 0.0015 0.0009 0.0023 0.0006 0.0007 0.0003 0.0031 0.0015 0.0012 0.0016 0.0003 0.0006
Vacuole Periphery 0.0181 0.0167 0.0189 0.0141 0.0123 0.0098 0.013 0.019 0.0169 0.0122 0.0126 0.0088 0.0176 0.0098 0.0208 0.0256 0.0145 0.0101

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.7408 15.0622 12.0592 16.1833 17.8216 17.7262 16.5319 21.572 21.1794 21.1689
Translational Efficiency 1.6504 1.3329 1.5486 1.3892 1.1897 1.2914 1.165 0.9603 1.0982 1.1064

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
71 504 841 1238 1931 1972 373 1491 2002 2476 1214 2729

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 905.93 794.93 1092.43 974.53 745.40 840.59 1043.86 954.39 751.09 831.30 1077.51 963.53
Standard Deviation 1485.58 137.99 160.31 135.18 114.72 113.86 125.01 138.26 303.06 120.58 152.01 137.24
Intensity Change Log 2 — -0.188572 0.270069 0.105307 — 0.173387 0.485842 0.356564 — -0.013879 0.371479 0.224165

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000267 0.000501 0.000444 0.000199 0.000225 0.000191 0.000336 0.000169 0.000226 0.000254 0.000411 0.000183
Bud Neck 0.001401 0.000557 0.001875 0.001206 0.000340 0.000456 0.001051 0.001548 0.000378 0.000476 0.001622 0.001393
Bud Site 0.000416 0.000336 0.000188 0.000880 0.000198 0.000186 0.000197 0.002286 0.000206 0.000217 0.000191 0.001648
Cell Periphery 0.000108 0.000072 0.000025 0.000020 0.000053 0.000033 0.000019 0.000021 0.000055 0.000041 0.000023 0.000021
Cytoplasm 0.023390 0.004022 0.000920 0.001945 0.002728 0.001794 0.000316 0.002130 0.003461 0.002247 0.000734 0.002046
Cytoplasmic Foci 0.010264 0.004809 0.000264 0.001309 0.003729 0.004770 0.000121 0.000903 0.003961 0.004778 0.000220 0.001087
Eisosomes 0.000053 0.000025 0.000008 0.000004 0.000016 0.000012 0.000007 0.000005 0.000017 0.000015 0.000008 0.000004
Endoplasmic Reticulum 0.006525 0.006061 0.002930 0.002323 0.003470 0.003291 0.003265 0.001931 0.003578 0.003855 0.003033 0.002109
Endosome 0.008747 0.006922 0.000561 0.002413 0.003870 0.007883 0.000617 0.002243 0.004043 0.007687 0.000578 0.002320
Golgi 0.001159 0.003587 0.000220 0.001814 0.002376 0.003455 0.000103 0.001111 0.002333 0.003482 0.000184 0.001430
Lipid Particles 0.157773 0.058332 0.000449 0.001162 0.055950 0.038844 0.001013 0.002261 0.059561 0.042811 0.000622 0.001762
Mitochondria 0.013950 0.008876 0.001021 0.001726 0.006414 0.007695 0.000695 0.001242 0.006681 0.007935 0.000921 0.001462
Mitotic Spindle 0.023541 0.054226 0.173408 0.279013 0.020686 0.053335 0.151126 0.220963 0.020787 0.053516 0.166562 0.247297
None 0.008739 0.006520 0.000519 0.000282 0.004829 0.001213 0.000268 0.000536 0.004968 0.002293 0.000442 0.000421
Nuclear Periphery 0.051906 0.045394 0.240826 0.174929 0.051630 0.066128 0.184163 0.163631 0.051640 0.061908 0.223416 0.168756
Nuclear Periphery Foci 0.574580 0.744378 0.448867 0.508196 0.795735 0.757647 0.590275 0.570404 0.787892 0.754946 0.492315 0.542183
Nucleolus 0.068488 0.023425 0.055230 0.007155 0.028419 0.025302 0.031161 0.009297 0.029840 0.024920 0.047835 0.008325
Nucleus 0.038806 0.027007 0.070616 0.009872 0.017290 0.021091 0.033786 0.012701 0.018054 0.022296 0.059300 0.011418
Peroxisomes 0.003881 0.002814 0.000516 0.000161 0.001020 0.001047 0.000270 0.000148 0.001122 0.001406 0.000440 0.000154
Vacuole 0.002568 0.001311 0.000636 0.003635 0.000476 0.003678 0.001000 0.004032 0.000550 0.003196 0.000748 0.003852
Vacuole Periphery 0.003436 0.000827 0.000478 0.001757 0.000547 0.001948 0.000210 0.002438 0.000649 0.001720 0.000396 0.002129

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.45 -2.37 0.60 3.69 4.42 0.76 -2.57 0.57 -0.25 2.98 -0.75 -4.69 0.39 1.49 5.94
Bud Neck 1.82 -1.19 0.01 -4.25 2.42 -1.65 -4.38 -6.07 -5.54 -0.06 -1.48 -9.91 -7.66 -7.16 1.64
Bud Site 0.75 1.12 -1.22 -1.72 -1.92 0.03 -1.73 -2.45 -2.46 -1.91 -0.18 -1.57 -2.93 -2.93 -2.59
Cell Periphery 1.32 3.31 3.52 5.38 1.67 3.87 3.25 5.98 2.79 0.74 2.62 5.57 6.97 5.70 1.63
Cytoplasm 1.78 1.95 1.87 1.11 -1.36 1.18 3.65 -0.30 -1.21 -2.88 1.66 3.13 1.07 -0.65 -2.56
Cytoplasmic Foci 1.09 1.83 1.72 2.61 -2.47 -0.77 5.62 4.31 5.98 -3.15 -0.63 5.70 4.50 6.20 -3.48
Eisosomes 2.22 3.72 4.09 5.93 3.87 2.60 1.64 7.73 6.04 2.11 1.35 4.79 9.49 8.93 4.08
Endoplasmic Reticulum 0.12 1.44 1.64 4.84 1.13 0.39 -0.85 4.35 2.95 3.44 -0.83 0.87 4.09 4.28 3.34
Endosome 0.71 3.38 2.57 3.04 -5.02 -3.69 5.69 2.68 5.32 -3.38 -3.82 7.28 3.17 6.05 -6.46
Golgi -2.46 4.13 -0.71 1.67 -2.11 -1.26 5.36 1.99 2.81 -1.79 -1.60 5.31 1.70 3.04 -2.71
Lipid Particles 3.47 5.69 5.66 9.30 -3.97 4.22 17.29 16.93 13.90 -1.94 4.16 18.33 17.94 16.85 -4.22
Mitochondria 1.02 3.24 3.03 2.78 -1.27 -0.99 9.26 8.09 5.95 -2.86 -1.04 9.46 7.87 6.29 -2.04
Mitotic Spindle -3.25 -13.59 -22.13 -18.73 -8.09 -7.87 -10.38 -24.48 -19.54 -4.31 -8.63 -19.22 -34.92 -28.11 -8.39
None 0.33 2.44 2.55 2.91 2.22 4.65 5.90 5.38 1.91 -0.65 2.91 6.01 6.09 3.76 0.59
Nuclear Periphery 0.52 -15.62 -11.16 -21.25 7.32 -5.29 -14.00 -23.96 -20.45 1.79 -4.08 -28.58 -30.62 -28.21 8.07
Nuclear Periphery Foci -3.93 2.57 1.30 14.22 -4.46 4.10 14.05 23.23 18.94 0.65 3.80 30.34 29.31 25.86 -5.04
Nucleolus 2.28 0.67 3.29 4.69 12.21 1.25 -0.58 7.93 7.09 5.19 1.76 -4.87 9.16 8.84 13.08
Nucleus 0.91 -3.16 2.61 3.88 12.24 -1.86 -4.36 1.39 3.06 4.87 -2.20 -11.17 2.97 5.14 12.84
Peroxisomes 0.81 3.44 3.75 3.57 3.62 0.12 3.76 5.25 4.18 1.60 -1.02 4.24 6.08 5.48 4.18
Vacuole 0.89 1.13 -1.40 -3.04 -3.39 -4.27 -2.09 -4.75 -1.91 -0.63 -4.36 -2.40 -6.11 -2.47 -3.23
Vacuole Periphery 1.23 1.40 0.75 -1.80 -2.60 -4.02 3.40 -2.97 -0.72 -3.43 -3.68 2.14 -3.52 -0.86 -4.15
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in telomeric silencing; required for quiescent cell telomere hypercluster localization at nuclear membrane vicinity; interacts with PAD4-domain of Sir4p
Localization
Cell Percentages nuclear periphery (60%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Esc1

Esc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Esc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available