Standard name
Human Ortholog
Description Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0.05 0.06 0.08 0.05 0.09 0 0 0 0.07 0 0.07 0 0 0 0 0 0
Cytoplasm 0.97 0.98 0.98 0.98 0.96 0.9 – 0.8 0.71 0.71 0.71 0.63 0.99 1.0 0.99 1.0 0.93 0.93 0.97 0.94 0.96 0.92 0.93 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.06 – 0.1 0.28 0.2 0.35 0.39 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0.07 0.1 0.05 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 – 10 7 7 6 10 0 0 0 0 0 0 0 1 0 0 0 1
Bud 1 0 4 3 5 1 – 7 6 12 8 15 2 0 1 0 0 0 1 1 0 0 1 3
Bud Neck 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 2 1
Bud Site 0 0 0 0 0 0 – 0 0 0 0 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 6 10 1 5 10 11 – 25 33 39 21 50 3 7 6 3 0 2 0 0 0 0 0 0
Cytoplasm 393 331 128 232 407 451 – 399 400 351 304 342 242 380 420 40 25 26 394 320 124 82 274 307
Endoplasmic Reticulum 1 7 1 3 10 19 – 17 3 18 7 20 1 0 4 1 1 1 0 1 0 0 2 2
Endosome 0 0 0 0 1 0 – 0 3 7 2 3 0 0 0 0 0 0 0 5 1 3 2 1
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 0 0 0 1 2 0 0 4 2
Mitochondria 2 0 3 6 4 28 – 50 158 101 150 209 1 0 1 0 0 0 0 1 0 0 0 0
Nucleus 14 3 2 0 2 2 – 9 6 13 6 7 2 0 1 1 0 1 0 0 1 0 1 1
Nuclear Periphery 0 1 0 1 0 0 – 2 3 1 1 2 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 1 0 0 1 0 0 0 0 0 1 0 0 0 0 1 0
Peroxisomes 0 0 0 0 0 0 – 1 3 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 1 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 0 0 0 11 16 – 35 55 25 15 13 0 1 2 0 2 1 5 3 0 0 4 6
Unique Cell Count 404 339 130 236 426 500 498 561 496 427 542 245 381 426 40 27 28 408 342 130 90 297 333
Labelled Cell Count 418 353 139 250 450 528 556 678 576 520 676 251 388 436 45 28 32 408 342 130 90 297 333


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.4 11.4 6.0 7.4 8.1 7.0 – 6.7 6.0 6.7 5.9 5.6 10.0 10.8 10.3 13.3 13.8 14.0 8.6 10.2 10.1
Std Deviation (1e-4) 1.4 1.6 1.0 1.0 1.5 1.2 – 1.3 1.2 7.4 1.3 1.2 1.6 1.6 1.4 4.0 2.3 3.5 1.2 1.6 1.8
Intensity Change (Log2) – – – 0.3 0.43 0.22 – 0.16 -0.0 0.15 -0.02 -0.1 0.74 0.85 0.77 1.14 1.2 1.22 0.52 0.76 0.75


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 2.2 2.4 2.9 2.1 3.3 0 0 0 0 0 0
Cytoplasm -0.1 -1.5 -3.1 – -5.1 -6.6 -6.6 -6.5 -7.9 0.3 1.6 0.1 0.8 -1.8 -1.7
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 1.5 – 2.8 6.3 4.9 7.3 8.0 0 0 0 0 0 0
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 – 3.1 3.7 2.6 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.1086 5.6592 4.6725 4.9164 4.4868 5.5769 4.8423 5.8067 4.9127 3.9713 4.5696 5.1445 6.5334 8.0543 7.3297 6.4975 6.5231 6.8554
Actin 0.0549 0.0009 0.0765 0.1975 0.018 0.0009 0.0085 0.0043 0.0291 0.0153 0.0013 0.0087 0.0285 0.001 0.0124 0.0009 0.0303 0.0013
Bud 0.0029 0.0001 0.002 0.0008 0.0005 0 0.0004 0.0002 0.0011 0.0013 0.0004 0.0002 0.0006 0.0001 0.0008 0.0006 0.0002 0
Bud Neck 0.0053 0.0004 0.0039 0.0038 0.0038 0.0013 0.0014 0.0004 0.0024 0.0043 0.0026 0.0031 0.0005 0.0002 0.0015 0.0009 0.0011 0.0026
Bud Periphery 0.0062 0.0001 0.0019 0.0007 0.0004 0 0.0005 0.0001 0.0011 0.0015 0.0006 0.0002 0.0009 0.0001 0.0007 0.0003 0.0003 0
Bud Site 0.0133 0.0011 0.0124 0.0022 0.0093 0 0.003 0.0012 0.0073 0.0015 0.0029 0.0007 0.0009 0.0006 0.002 0.001 0.0008 0.0001
Cell Periphery 0.0006 0.0002 0.0005 0.0002 0.0002 0.0001 0.0003 0.0002 0.0003 0.0003 0.0004 0.0001 0.0002 0.0002 0.0001 0 0.0001 0
Cytoplasm 0.6531 0.9652 0.7086 0.7425 0.7351 0.9268 0.8368 0.9776 0.8574 0.8111 0.9098 0.9007 0.8436 0.9799 0.9133 0.93 0.7824 0.9677
Cytoplasmic Foci 0.0452 0.0015 0.0491 0.0053 0.0424 0.0024 0.0177 0.0025 0.0224 0.0189 0.0045 0.0167 0.0065 0.0018 0.0227 0.0079 0.0247 0.009
Eisosomes 0.0004 0 0.0005 0.0003 0.0002 0 0.0001 0 0.0002 0 0 0 0.0004 0 0.0001 0 0.0003 0
Endoplasmic Reticulum 0.0314 0.001 0.0021 0.0022 0.0038 0.0025 0.006 0.0022 0.0039 0.0146 0.0026 0.0041 0.0056 0.0013 0.0013 0.0029 0.0005 0.0016
Endosome 0.042 0.001 0.0486 0.0069 0.0038 0.0108 0.0224 0.0007 0.017 0.0847 0.0286 0.0278 0.0088 0.0004 0.0071 0.0174 0.0145 0.0018
Golgi 0.0149 0.0018 0.0233 0.0251 0.0065 0.03 0.0135 0.0005 0.0162 0.0244 0.012 0.0111 0.0094 0.0001 0.0095 0.0014 0.0242 0.0022
Lipid Particles 0.0139 0.0009 0.009 0.0022 0.0206 0.0001 0.0168 0.0001 0.0029 0.0017 0.0019 0.0029 0.0173 0 0.0098 0.0002 0.0323 0.0015
Mitochondria 0.0058 0.0136 0.0178 0.0027 0.0126 0.0152 0.0097 0.0001 0.0132 0.0044 0.0131 0.0028 0.011 0 0.0068 0.0016 0.0222 0.0002
None 0.0735 0.0064 0.0219 0.0029 0.0013 0.008 0.0361 0.0078 0.0088 0.0013 0.0052 0.0028 0.0309 0.0123 0.0029 0.0248 0.0008 0.0012
Nuclear Periphery 0.0091 0.0004 0.0009 0.0008 0.0005 0.0002 0.0087 0.0003 0.0033 0.004 0.0006 0.0049 0.0174 0.0003 0.0004 0.0022 0.0002 0.0003
Nucleolus 0.0011 0 0.0005 0 0.0003 0 0.0027 0 0.0002 0.0001 0.0004 0.0002 0.0002 0 0 0.0001 0.0001 0
Nucleus 0.0032 0.0028 0.0024 0.0012 0.0008 0.0008 0.0058 0.0014 0.0027 0.0024 0.0016 0.0077 0.0064 0.0011 0.0015 0.0038 0.0008 0.0017
Peroxisomes 0.0079 0.0022 0.0125 0.0017 0.1389 0.0001 0.0019 0.0001 0.0038 0.0012 0.0005 0.0005 0.007 0 0.0042 0.0008 0.0617 0.0083
Punctate Nuclear 0.0099 0.0002 0.0022 0.0005 0.0006 0.0001 0.0037 0.0003 0.0045 0.0005 0.0002 0.0023 0.0019 0.0003 0.0024 0.0007 0.0018 0.0003
Vacuole 0.004 0.0003 0.0028 0.0002 0.0004 0.0003 0.0026 0.0001 0.0014 0.0038 0.0088 0.0019 0.0007 0.0002 0.0003 0.002 0.0004 0.0002
Vacuole Periphery 0.0016 0.0001 0.0007 0.0002 0.0001 0.0003 0.0015 0 0.0006 0.0028 0.002 0.0007 0.0013 0 0.0001 0.0006 0.0003 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10.5086 25.0508 16.2652 22.8159 22.7081 24.5065 25.3289 35.259 25.6553 31.8453
Translational Efficiency 4.0136 1.5805 1.7141 1.843 1.968 2.1681 1.9153 1.3492 2.7539 1.6734

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
161 302 1402 1146 935 1697 2404 1765 1096 1999 3806 2911

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 884.23 1119.75 1321.00 1313.19 805.00 1071.47 1278.65 1242.15 816.64 1078.76 1294.25 1270.12
Standard Deviation 124.22 172.62 233.92 202.88 128.34 154.25 158.56 187.50 130.78 158.11 190.93 196.79
Intensity Change Log 2 — 0.340683 0.579137 0.570582 — 0.412531 0.667561 0.625779 — 0.375369 0.621952 0.597149

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000801 0.002251 0.000529 0.005448 0.000581 0.000900 0.001120 0.004180 0.000614 0.001105 0.000902 0.004679
Bud Neck 0.014852 0.011234 0.002923 0.003797 0.005918 0.008706 0.003999 0.007863 0.007231 0.009088 0.003602 0.006262
Bud Site 0.027575 0.065513 0.014357 0.033011 0.019762 0.027124 0.010745 0.040941 0.020910 0.032924 0.012076 0.037819
Cell Periphery 0.000585 0.000238 0.000267 0.000351 0.000191 0.000178 0.000108 0.000157 0.000249 0.000187 0.000167 0.000233
Cytoplasm 0.457506* 0.581928* 0.674727* 0.661883* 0.615729* 0.615570* 0.768941* 0.656290* 0.592486* 0.610488* 0.734236* 0.658492*
Cytoplasmic Foci 0.305649* 0.186993* 0.031715 0.040024 0.168787 0.161952 0.017601 0.034242 0.188892* 0.165735 0.022801 0.036518
Eisosomes 0.000295 0.000060 0.000031 0.000040 0.000082 0.000079 0.000018 0.000032 0.000114 0.000076 0.000022 0.000035
Endoplasmic Reticulum 0.002186 0.000967 0.002616 0.001326 0.001620 0.001027 0.000616 0.000879 0.001703 0.001018 0.001353 0.001055
Endosome 0.027601 0.009985 0.004102 0.005673 0.013163 0.011442 0.001821 0.011323 0.015284 0.011222 0.002661 0.009099
Golgi 0.005847 0.004390 0.000357 0.004159 0.002140 0.004614 0.001165 0.009383 0.002684 0.004580 0.000867 0.007326
Lipid Particles 0.007994 0.001796 0.002129 0.003160 0.003014 0.002284 0.000901 0.001576 0.003746 0.002210 0.001353 0.002199
Mitochondria 0.001505 0.000977 0.000282 0.000952 0.001566 0.001663 0.000716 0.005306 0.001557 0.001560 0.000556 0.003592
Mitotic Spindle 0.000293 0.001391 0.006948 0.022891 0.000773 0.001713 0.014802 0.027032 0.000702 0.001664 0.011909 0.025401
None 0.000422 0.000915 0.003564 0.002964 0.003530 0.000892 0.002519 0.003260 0.003073 0.000896 0.002904 0.003143
Nuclear Periphery 0.000140 0.000071 0.000513 0.000226 0.000575 0.000092 0.000232 0.000450 0.000511 0.000089 0.000336 0.000361
Nuclear Periphery Foci 0.003504 0.003900 0.007043 0.005558 0.004034 0.002335 0.001874 0.002151 0.003956 0.002572 0.003778 0.003492
Nucleolus 0.000247 0.000346 0.000139 0.000162 0.000874 0.000311 0.000162 0.000219 0.000782 0.000316 0.000153 0.000197
Nucleus 0.032338 0.026865 0.107007 0.070871 0.047936 0.035851 0.089766 0.062356 0.045645 0.034493 0.096117 0.065708
Peroxisomes 0.007452 0.006345 0.000314 0.003926 0.002205 0.003860 0.001531 0.004610 0.002975 0.004235 0.001083 0.004340
Vacuole 0.101222 0.093087 0.139803 0.133305 0.106586 0.118623 0.081151 0.125415 0.105798 0.114765 0.102756 0.128521
Vacuole Periphery 0.001986 0.000748 0.000635 0.000273 0.000935 0.000784 0.000212 0.002335 0.001089 0.000778 0.000368 0.001524

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.95 0.27 -2.77 0.18 -2.99 -1.09 -1.02 -2.55 -1.60 -1.74 -1.83 -1.12 -3.86 -1.91 -3.05
Bud Neck 1.54 4.47 4.76 4.65 2.66 -2.74 3.25 2.36 5.59 -1.08 -1.76 4.93 4.71 7.39 -0.20
Bud Site -4.68 3.66 2.21 6.61 -2.71 -2.84 5.29 1.59 4.97 -4.09 -4.68 5.56 1.84 7.46 -5.01
Cell Periphery 2.80 2.39 2.36 -2.10 -0.11 1.12 5.33 5.76 5.97 1.35 2.90 2.88 2.81 -0.22 0.03
Cytoplasm -4.70 -4.54 -3.67 2.25 1.58 -0.02 -4.78 4.27 5.14 11.51 -1.70 -3.43 3.69 6.76 10.16
Cytoplasmic Foci 6.80 17.79 17.70 15.24 -0.70 1.02 26.36 25.32 33.05 -3.70 3.64 29.86 29.09 36.02 -3.39
Eisosomes 4.14 4.54 4.52 3.09 -0.48 0.60 12.89 11.34 7.94 -3.68 3.59 8.95 8.47 7.90 -3.26
Endoplasmic Reticulum 3.36 0.06 3.94 0.70 4.98 2.67 4.29 5.14 5.16 2.16 3.47 2.19 5.53 4.16 5.29
Endosome 4.42 6.40 6.70 4.01 2.89 1.47 10.73 8.17 9.67 -2.29 3.47 11.96 10.88 11.92 -1.09
Golgi 0.77 3.42 2.98 1.42 -1.85 -2.51 3.23 0.45 2.58 -1.91 -1.91 4.81 2.09 3.39 -2.36
Lipid Particles 2.38 2.06 1.84 -4.01 -2.07 1.48 4.58 3.63 1.54 -1.60 2.68 3.82 2.91 -0.28 -2.83
Mitochondria 0.65 1.54 1.51 0.91 -0.22 -0.06 1.66 0.50 0.71 -2.11 0.07 1.99 1.14 1.37 -2.10
Mitotic Spindle -2.56 -6.11 -4.90 -4.22 -0.47 -1.83 -6.06 -6.14 -5.24 -0.43 -2.16 -8.12 -7.73 -6.51 -0.61
None -1.89 -11.24 -7.81 -5.88 3.04 2.57 0.91 0.42 -10.06 -2.36 2.49 0.36 0.34 -11.41 -0.14
Nuclear Periphery 1.76 -17.75 -9.22 -16.53 11.66 1.82 0.27 -0.11 -13.24 -2.43 1.86 -0.65 -0.17 -18.06 3.67
Nuclear Periphery Foci -0.69 -4.09 -1.81 -1.07 3.81 1.87 2.17 2.35 1.74 0.86 1.71 0.13 1.08 -2.10 3.24
Nucleolus -0.72 3.19 2.36 1.62 -0.14 2.61 3.37 3.11 2.44 -2.12 2.53 3.46 3.26 3.33 -1.77
Nucleus 1.16 -21.24 -11.96 -15.76 10.95 3.70 -19.87 -11.01 -19.42 9.79 3.88 -25.57 -13.58 -24.20 14.51
Peroxisomes 0.98 5.08 4.46 4.79 -2.00 -4.03 3.82 1.98 4.94 -1.09 -2.64 6.96 4.55 7.06 -1.80
Vacuole -0.93 -11.64 -16.02 -15.77 -6.07 -2.00 -8.87 -20.63 -20.79 -14.34 -2.19 -14.62 -26.53 -27.17 -15.07
Vacuole Periphery 1.47 1.88 2.13 2.85 1.26 0.80 4.79 1.74 1.31 -1.76 1.55 4.41 3.30 2.76 -1.03
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (92%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Coa6

Coa6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Coa6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available